
Holiday rentals in Isthmus of Panama
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Top-rated holiday rentals in Isthmus of Panama
Guests agree: these stays are highly rated for location, cleanliness and more.

Puntita Manzanillo, fantastic sea and jungle
Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.

The Retreat in El Valle - Casita del Jardin
Welcome to your serene retreat in El Valle, Panama! Nestled amid lush nature, our two-bedroom casitas offer a peaceful escape with breathtaking views, exotic wildlife, and flora. Each casita features a queen bed, choice of king or twin beds in the second room, a small fridge, coffee station, Wi-Fi, and large terrace. Enjoy the shared pool, meditation and healing sessions by appointment, and explore world-class hiking nearby. Just a short walk to restaurants and El Valle’s famous artisan market!

Beachfront Gem w/ Ocean Views & Prime Surf Access
Welcome to your slice of beachfront paradise! Our home sits right on Cambutal's beautiful shoreline. Gorgeous ocean views greet you from every window, while the gentle rhythm of waves creates the perfect soundtrack for your stay. We've equipped the house with Starlink WiFi and a large dining table that doubles as an ideal workspace, making this a perfect retreat for both vacationers and remote workers. The house feels like a real home – comfortable, clean, and ready for your beach memories.

Cozy open space, unique jungle views, river access
An open-style jungle home with mesmerizing treetop and mountain views. Located 10 minute walk to the beach, with a trail that leads to the River. The house is not childproof! It has three individual bedrooms, each with its own key. The price is based on the number of guests. The entire house is always yours. The house offers fiber optic WiFi and two dedicated workspaces. The property is surrounded by large trees, naturally keep the house cool and provide shelter for birds and wildlife.

Aqeel cabin in the nature
Relax at this unique and tranquil getaway surrounded by nature. If you're lucky, you may wake up to see white-faced capuchins from your bedroom window and spot an abundance of birds, such as the crested oropendola or a toucan. The property offers river access with a sandy, beach-like area, and there is a 1 km walking trail alongside the river. With satellite high-speed internet access, you'll stay connected, though the river and sandy area may not be accessible during rainy days.

2bdr house w. private plunge pool in jungle garden
COMFORTABLE HOME IN RAINFOREST GARDEN Fully equipped 2-bedroom house in wonderful tropical setting. Enjoy nature & spot wildlife at Casa Lirio. Walking distance from gorgeous beaches (1.5km), 5 min drive to lively Puerto Viejo & 20 min to Cahuita National Park. Fiber optic wifi, airco, fully fitted kitchen with all basics & 18L bottled water. AC. Breakfast US$15 pp per day, paid laundry service. The house is on the outskirts of the property, so there is some street noise.

Patty’s Casco 2BR Loft | Balcony & Personal Touch
“Feel at home in Casco Viejo—personally welcomed by your hosts, Patty & Rudy.” Stay in the Heart of Casco Viejo with Patty’s Casitas! Prime Casco Viejo Location | Quiet, Convenient & Charming Stay steps from restaurants, cafés, bars, and plazas—right by the El Rey boutique supermarket and the waterfront promenade. This peaceful spot is rare in Casco, tucked away from rooftop noise and perfectly located at the entrance of the neighborhood for easy in & out access!

Casa Rosie - Dream Home on Tabogá Island
Casa Rosie is a gorgeous villa on Taboga island with an intimate vibe and spectacular views of the ocean. The perfect place for couples, small groups, and families to unwind and make magical memories! . With great wifi, fully equipped kitchen, 3 inviting bedrooms, and a spacious yet personal feel… Casa Rosie is your home away from home. Included in every stay is free pick up and drop off to the ferry terminal - please let us know the details of your arrival.

Villa Acuario
Relaxation is guaranteed in this one-of-a-kind glass house nestled in the lush mountains of Altos del María. Surrounded by nature and designed with floor-to-ceiling glass walls on all sides— as if you’re living inside a crystal ball. With no direct neighbors, panoramic forest views, it is perfect for a family getaway, a quiet reset, or an extended stay. The home offers light-filled interiors during the day and unforgettable stargazing nights from the rooftop.

Mountain retreat
Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Mundo Novo Casita @ Finca Panda
Mundo Novo is one of our new, one-room casitas and has one of the most incredible views on the property. Perfect for couples, singles or family with a small child, Geisha sleeps 2 people comfortably in one king bed (maximum 3 guests when using sofa). Geisha was designed with every amenity needed to have a perfect and relaxing stay. Custom-built jacuzzi, fire-pit, kitchen, incredible shower, high-speed WiFi and more

Blue Sky Lodge; la mejor vista en Altos del María
Esta cabaña de lujo en la montaña ofrece un diseño moderno, acabados de calidad y vistas panorámicas de 180° de montañas y mar. Se encuentra en una comunidad cerrada segura, rodeada de un jardín verde, con amplias ventanas de vidrio que favorecen la conexión con la naturaleza. El clima es agradable, con temperaturas entre 23°C y 28°C. .
Popular amenities for Isthmus of Panama holiday rentals
Other great holiday rentals in Isthmus of Panama

La Florecita - Casa de campo en Valle de Antón

Entire Villa with pool in front of beach!

Luxury Centric 2BR Apartment in Casco Viejo

La Casita Encantada #3 by AcoModo

CASA STARE | Frente al mar: Playa, Jacuzzi y Surf

Casa Condal - Your Private Nature Eco-Retreat

Villa Bambu with ocean view near Playa Venao

Escapa de la ciudad! Clima y hogar acogedor.





