
House holiday rentals in La Mesa
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Top-rated house rentals in La Mesa
Guests agree: these houses are highly rated for location, cleanliness and more.

SDSU Beach Cottage
Welcome to our stunning SDSU Beach Cottage. Our home is 10 minutes away from everything amazing in San Diego! Our home is Centrally located in San Diego and in a desirable neighborhood. We are steps away from a Local favorite Eatery, Wine Bar, Beer Pub, Natural-Holistic Market, Pizza shop, Liquor Store, Nail shop, and Einstein's Bagels. Play in San Diego or stay and relax in our tropical yard that is set up to entertain you and your family with outside games and Ping Pong. 25 Yr's of age req'd

Family Fun! Game Garage + Big Yard + Free Parking
Embodying the epitome of cool! This home has the perfect blend of a vintage feel with a modern touch. Stepping inside, you’re greeted by an atmosphere of fun & creativity. A large private serene retreat in the backyard w/abundant seating and fire pit. Huge 3-car garage bonus space with games. Located just minutes from downtown La Mesa, many dining options & conveniences. Everything you need & more! Distance to: San Diego Zoo: 18 min Sea World: 23 min SDSU: 13 min Airport: 19 min Gaslamp: 18 min

2 Bed Hidden Oasis | Garden, Laundry, Parking
Capture the essence of San Diego in our Hidden King Suite with Garden hosted by Ethos Vacation Homes. The peaceful property features elite comfort for up to 4 guests with beautiful outdoors and garden, off-street parking, A/C and heating, FREE laundry, comfortable king and queen size beds, plenty of sheets and towels, a large HDTV, Netflix, Max, Hulu, Showtime, Disney+, Apple+, and ESPN+. This spacious San Diego vacation rental home has everything you need for your California Dreaming Vacation!

Tropical Oasis: spa, solar heated pool, waterslide
This home is ideal for FAMILY trips and QUIET friend groups Hours of entertainment in the private backyard that includes heated pool, waterslide, grotto, spa, gazebo, half bath, BBQ, and more. Clean and spacious home with over 2,100 sqft of living space. Minutes from everything San Diego has to offer. Distance to main attractions: SDSU- 5 mi Downtown/PetcoPark park-11 mi SD Zoo/balboa park-12 mi SD Airport- 13 mi Old town- 14 mi Coronado-15 mi Belmont park/Mission beach-18mi Sea world- 18mi

Sunnyside Resort Spa, Beach, Zoo, Arcade
SEND US A MESSAGE FOR SPECIAL OFFER! Imagine booking the most memorable experience with your party! Kick back and relax in a safe, stylish casita. Check in contactless and enjoy! Cozy, comfy, and a perfect base for exploring the city. Cook your own meal in the alluring kitchen or enjoy your meal at the cute dining area outside. Great for family's or trips with friends! The entire guest house is is 5 minutes from SDSU, 15 minutes from the beach and 15 minutes from downtown San Diego! Enjoy

Classic Mid-Century Mount Helix Home with Views
Located in the exclusive Mount Helix neighborhood of La Mesa, this property is conveniently located near the 8 and 94 freeways for easy access to explore the greater San Diego area. Attractions like the historic Balboa Park with the San Diego Zoo or Sea World are a 15-25 minute drive away. With spacious interior and exterior spaces at the property, though, you may not want to leave. The property includes 4 bedrooms and 2.5 bathrooms with furnished living room, family room and kitchen.

Cottage in the Garden! New! Modern!
COTTAGE IN THE GARDEN - New! Modern! Find beauty and serenity in this special guest house in one of San Diego's most desirable areas! Flowering bushes, plants, olive tree and fruit trees seen from all windows. All amenities: WiFi, Cable, serving dishes and tableware, full coffee bar, Ninja Blender, Flat screen TVs, 100% Egyptian Cotton Sheets or Boll and Branch Sheets (used by 3 Presidents), Japanese Toilette and more. 15 minutes to Downtown San Diego and 20 minutes to the beach!

Zen Retreat: 3-Bedroom Oasis near La Mesa Village
Relax in this charming 3-bedroom, 1-bathroom home located just 1 mile from the heart of Historic Downtown La Mesa Village. Nestled in a quiet, central neighborhood, this cozy retreat offers easy access to major freeways, top-rated restaurants, and the local trolley line making it a breeze to explore the best of San Diego. Within 10 to 15 miles, you’ll find yourself in iconic destinations like Downtown San Diego, Balboa Park, Coronado Island, scenic beaches, and beautiful mountain trails.

Mid-Century Style Family House with Spa
This home is the epitome of 1950’s luxury. A perfect family oasis, you won’t even want to leave the property. Beautiful Mt. Helix mid-century modern family home with incredible views, designed by architect of original Las Vegas Desert Inn situated on nearly an acre. Less than 20 minute drive to beaches/Zoo/Sea World/Downtown. With a swimming pool, jacuzzi, and AC. Surrounded by orange, lemon, pomegranate trees and herb garden. No loud parties please, this is a quiet community.

Palm Cottage San Diego
Palm Cottage sits in the heart of La Mesa Village, San Diego. Enjoy the charm of a historic home with a fully remodeled and stylish interior featuring both Dutch & French doors letting in plenty of sunshine. A large private yard w/ covered outdoor living area creates the ultimate indoor/outdoor lifestyle. You're steps from the local grocery store, village shopping, coffee shops, restaurants, bars and the trolley. You could not ask for a better location!

Charming La Mesa Home
**Home cleaned and disinfected following COVID-19 guidelines provided by CDC/Airbnb** Charming 3 bed, 1 bath. Feel at home with your own private laundry, full size kitchen, spa like bathroom and private office/workspace. This place is perfect for both work and leisure getaways. Walking distance from stores, shops, restaurants, and parks. 3 minutes from Highways 125, 94, and 8. Centrally located and less than 15 minutes from downtown San Diego.

Sunny & Spacious 3BR Retreat w/ Parking & A/C
Discover your La Mesa retreat! This newly refurbished home offers a perfect blend of comfort and convenience. Enjoy a gourmet kitchen, stylish dining, three bedrooms, two modern bathrooms, and an expansive yard. Explore nearby attractions like the Grossman Center (10-min walk) with shopping and dining, or venture to San Diego's heart (20-min drive). Perfect for families and groups seeking a relaxing getaway.
Popular amenities for house rentals in La Mesa
House rentals with a pool

Modern Central SD Home w/ Pool & Spa Near Beach

Travelers Oasis w/ Private Pool + Hot Tub

Views - Quiet Mt. Helix Home - Pool -Sleeps 11

San Diego Pool | Fire Pit | Sunshine | Sleeps 10

University Heights Oasis Getaway

Designer Luxury Rental With Pool

Modern Hilltop Home: Roomy, Views, Family-Friendly

Luxe Home w. Serene Backyard Spa
Weekly house rentals

Cozy SoCal Oasis

Airbnb Luxe: Designer Pool, Office and Fitness

Discover La Mesa: Your Perfect Cozy Base

Tiny Home Two w/ Garden View

Guest house with patio, full kitchen

Private Mountaintop Retreat

Downtown La Mesa gem

Luxury Hilltop Getaway • Scenic Views
Private house rentals

5br Home with Pool, Hot Tub, BBQ, Putting green

Luxury 4 BR w/ Serene Lake Views

Newly Updated & Beautiful Home 5 bedrooms • 5 beds

Helix Haven

Gorgeous Home | 15 Min Downtown | Deck + BBQ

San Diego Oasis: Private Pool & Sunny Escape!

Techie Family Stay | Heart of San Diego

Beautiful Mid-Century Home on Tree Lined Street!
When is the best time to visit La Mesa?
| Month | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Avg. price | $228 SGD | $228 SGD | $242 SGD | $229 SGD | $234 SGD | $273 SGD | $318 SGD | $269 SGD | $236 SGD | $239 SGD | $250 SGD | $253 SGD |
| Avg. temp | 15°C | 15°C | 16°C | 17°C | 18°C | 20°C | 21°C | 22°C | 22°C | 20°C | 17°C | 14°C |
Quick stats about house rentals in La Mesa

Total holiday rentals
Explore 320 holiday rentals in La Mesa

Nightly prices starting at
La Mesa holiday rentals start at $38 SGD per night before taxes and fees

Verified guest reviews
Over 14,030 verified reviews to help you choose

Family-friendly holiday rentals
210 properties offer extra space & child-friendly amenities

Pet-friendly holiday rentals
Find 110 rentals that welcome pets

Holiday rentals with a pool
80 properties feature pools

Rentals with dedicated workspaces
190 properties have a dedicated workspace

Wifi availability
320 of La Mesa holiday rentals include wifi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across La Mesa rentals

4.9 Average rating
La Mesa stays are highly rated by guests – averaging 4.9 out of 5!
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- Rosarito Beach
- LEGOLAND California
- SeaWorld San Diego
- San Diego Convention Center E Ent
- Oceanside City Beach
- University of California-San Diego
- San Diego Zoo Safari Park
- Petco Park
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- San Diego Zoo
- Pechanga Resort Casino
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