Guest house holiday rentals in La Mesa

Find and book unique guest house rentals on Airbnb

Top-rated guest house rentals in La Mesa

Guests agree: these guest house rentals are highly rated for location, cleanliness and more.

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Guest favourite

Guest house in La Mesa

4.97 out of 5 average rating, 130 reviews

Da Hui Hut-Beachy home/La Mesa’s best view and spa

Da Hui Hut is a very private oasis uniquely situated at the top of San Diego county's magnificent Mt. Helix. At roughly 1,300 feet above sea level, Mt. Helix is the crown jewel of natural landmarks in the area. The landscape provides bountiful views, and the large deck is positioned perfectly to see it all. It feels like you're on top of the city! Inside, guests will encounter Californian and Hawaiian inspired decor as they collide with wooden walls to compose a symphony of color and good vibes.

13–20 Sep

$233 SGD per night

Guest favourite

Guest house in San Diego

4.97 out of 5 average rating, 506 reviews

Central & Serene Secret Garden Guesthouse

My cozy & stylish Garden Guesthouse features colorful decor that gives a fun, relaxed vibe. Relax in style inside or outside in my peaceful garden w a cup of coffee, or glass of wine. I love to say a hi to my guests yet your privacy is #1. Reach me via Airbnb app if I can help! Kensington is a central, 1920’s historic neighborhood w shops & great local eateries. Close to downtown, Gaslamp, Zoo, airport, beaches, Balboa Park. Bus stop, & trolley nearby. Reserved off street parking space too!

16–23 Oct

$202 SGD per night

Guest favourite

Guest house in San Diego

4.91 out of 5 average rating, 114 reviews

Charming Granny Flat Near SDSU & Transit Center

This is a charming studio in San Diego, located .5 m from the trolley, SDSU, Alvarado Hospital, and 17 min from Downtown. It is clean, cozy and is a true home away from home. Also, .3 mi to Ralph's (groceries) and 1 mi from Trader Joe's, Eureka Burger, Poke and TheBrokenYolk. Separate entrance, shared back yard,&grill. Hi-speed internet, Netflix,LiveTV+HBO. It has Queen bed, and a sofa with a pull-out bed, kitchen (stove, oven, and microwave) and washer/dryer (EV220 plug available upon request)

6–13 Jun

$182 SGD per night

Guest favourite

Guest house in La Mesa

4.92 out of 5 average rating, 205 reviews

Fig Tree Bungalow

Enjoy your stay in San Diego in this newly renovated guesthouse. Centrally located about a mile from Hwy 8, Hwy 125, and the Grossmont Trolley Station & Transit Center. Only a 15-20 minute drive to downtown, the airport, the beaches, and most of San Diego's other popular tourist attractions. This cozy, two-story, detached unit is located behind my home, and has its own private entrance and partitioned yard for your enjoyment. There's plenty of street parking directly in front of the house.

22–29 Jun

$175 SGD per night

Guest favourite

Guest house in La Mesa

4.93 out of 5 average rating, 136 reviews

Granny Flat with Bedroom/Bathroom/Kitchen

My place is family friendly, close to comic con, , restaurants and dining, , the beach, , family-friendly activities , public transportation (trolley). You’ll love my place because of the peace and quiet. It's very quiet and private. PLEASE DO NOT BOOK IF YOU ARE PLANNING ON PARTYING. THIS IS NOT APPROPRIATE FOR MORE THAN 2 PEOPLE. There is a private entrance that you may use once you meet us.. We like to meet all our guests first and then you may come and go as needed. NO SMOKING NO PETS

4–11 Sep

$153 SGD per night

Guest favourite

Guest house in La Mesa

4.97 out of 5 average rating, 169 reviews

Cozy Coop with a View

This house is perfect for a private get away. There is a patio bar & a large picture frame window that commands the best views in the area. Sit & enjoy the large patio right off the entryway to the house. I have been told our home used to be a chicken coop in the 50-60's. It is far different now, we just finished a complete remodel. Everything is updated, upgraded & ready for you. Being on the top of the hill you get the nice views, but sounds carries as well, please respect the neighbors.

15–22 Oct

$196 SGD per night

Guest favourite

Guest house in La Mesa

4.99 out of 5 average rating, 167 reviews

SDCannaBnB #1 *420 *parking *dog-friendly *hot tub

Welcome to SDCannaBnB - San Diego's premier cannabis-friendly rental! Our casita is newly remodeled with luxury ammenities. We proudly cater to the cannabis community and non-users alike. Our casita has HEPA air purifiers, is fully ventilated and receives deep cleanings between each guest. This ensures that every guest checks into a clean, fresh-smelling place that feels like home. Our casita is located in our quiet, fully fenced in backyard, close to San Diego's attractions

$135 SGD per night

Guest favourite

Guest house in El Cajon

4.98 out of 5 average rating, 190 reviews

Fletcher Hills - modern 1 BR.Easy, no step access.

** 48 hours between check-ins. Thorough cleaning and sanitizing.. Four night minimum stay. Dogs ONLY are welcomed on a case by case basis. They must be house trained and are not permitted on any furniture. If you instant book, you must contact me about your pet within 24 hours. Smoking is permitted in the outside areas - patio, gazebo, yard. Easy freeway access helps any commute to downtown and area attractions. Having your own vehicle is the best way to get around..

24 Apr – 1 May

$163 SGD per night

Guest favourite

Guest house in La Mesa

4.99 out of 5 average rating, 133 reviews

Stunning Guest House 15 min. from Zoo, Downtown

Stunning guest house that's 15 minutes to San Diego Zoo + downtown San Diego and 18 minutes to a beach. Unique private property with mid-century and one-of-a kind furniture in a comfortable living space. Enjoy IPAs on your private deck or coffee in bright Fiesta cups, watch TV while leaning back in the handcrafted Nicaraguan rocker or the 1950s Danish slipper chair. The cottage also has a comfy queen-sized bed. Like eclectic? This place exudes it.

26 Sep – 3 Oct

$221 SGD per night

Guest favourite

Guest house in La Mesa

4.9 out of 5 average rating, 142 reviews

La Cabana

Perfect getaway for the wandering individual, couple, or young family. This rustic casita is surrounded by beautiful mountain and ocean views! Enjoy swimming in the pool, stargazing, lounging, or casual day trips around San Diego (All the amenities are shared with the main house) . The casita has one queen bed and a sofa bed, small kitchenette. Plenty of parking in driveway. Please read entire listing for details.

1–8 Jan

$219 SGD per night

Guest favourite

Guest house in San Diego

4.94 out of 5 average rating, 333 reviews

The BEST NEST Clean, peaceful, private, affordable

This lovely private & separate unit is comfortable, clean and convenient. Your completely private suite is accessible via your own entrance. Minutes from major attractions, away from the hustle and bustle. Newly remodeled living room and FULL kitchen. Located in a nice neighborhood just off major freeways. Sip your morning coffee, relax and enjoy the gorgeous San Diego weather in the quaint, outdoor garden.

20–27 Feb

$154 SGD per night

Guest favourite

Guest house in San Diego

4.9 out of 5 average rating, 191 reviews

STUNNING Casita with a View!!

Recently renovated two story Casita located just 20 minutes away from Downtown San Diego. Experience the crafty layout of this 500 square foot Casita. If you’re looking to unwind and refresh, then this quiet and cozy home at the end of the cul-de-sac is the right choice for you. Enjoy beautiful valley views from your living room. Perfect for a peaceful and relaxing getaway or extended stay.

13–20 Oct

$177 SGD per night