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Holiday rentals in Osborn Medical Center, Phoenix

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Osborn Medical Center, Phoenix

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top guest favourite
An inviting pool area features a spacious swimming pool surrounded by lounge chairs and tropical palm trees. A shaded patio with seating overlooks the pool, providing a relaxing outdoor space. The area is enclosed by a wooden fence and has landscaped greenery for added privacy.
Home in Encanto
4.97 out of 5 average rating, 233 reviews

Paradise Found, Conferences, Concerts, GCU, Pool

The historic Willo district of Central Phoenix is the perfect location to relax. Close to many attractions and major freeways, this completely renovated mid-century home offers the ultimate in both luxury and high-end fixtures. Inside, you can pamper yourself in the deep tub (with endless hot water) or multi-faucet shower, snuggle in the luxurious beds, or just laze in front of the 65" 4K TV. Outside, you can relax beside the pool (ask about heating), or just gather under the shaded patio.

Top guest favourite
A modern kitchen space is highlighted by a red retro-style refrigerator and a large island with two black stools. Greenery is present, adding a touch of nature, while natural light fills the area through nearby windows. Warm wood accents frame the space.
Guest house in Encanto
4.99 out of 5 average rating, 107 reviews

Luxe Historic Casita w/ Free Parking: Casa Pascual

NEW! Welcome to Casa Pascual, a 1938 casita in Phoenix’s historic Willo neighborhood. This elevated cozy retreat blends Southwest style with Latin warmth, featuring clean lines, earthy tones, and natural accents. Enjoy a serene escape while being close to Encanto Park, the Heard Museum, and downtown Phoenix. Experience a perfect mix of comfort and cultural richness, with easy access to local attractions and a peaceful atmosphere to return to after exploring the vibrant area. IG: casapascualphx

Top guest favourite
Guest house in Encanto
4.96 out of 5 average rating, 252 reviews

PHX's Modern Midtown Carriage House, Free Parking

Experience the perfect blend of historic charm and modern comfort in the heart of Phoenix's Midtown. Our beautifully designed Carriage House offers a unique guest quarters, complete with a full kitchen, luxurious queen bedding, and a private patio. Step outside and explore the vibrant neighborhood, filled with local restaurants, shops, and cultural attractions. Book your stay at the Midtown Carriage House today and discover the best of Phoenix living. check out on insta @midtowncarriagehouse

Guest favourite
The exterior of a charming studio guesthouse is visible, showcasing a brown brick facade and a well-kept entrance. A small pathway leads to the door, and palm trees can be seen in the background against a bright blue sky.
Guest house in Encanto
4.97 out of 5 average rating, 1,334 reviews

Private, Sparkling Clean Historic DTPHX Guesthouse

This charming studio guesthouse in the Campus Vista historic district is a fantastic find! Situated in a friendly neighborhood in the heart of Phoenix, this newly remodeled living space is cozy and practical, surpassing many of the similar properties in quality and character. A short ten-minute drive from the Sky Harbor Airport, and located within walking distance to two major bus lines and the light rail, the guests are sure to enjoy the easy access to all the popular downtown destinations.

Top guest favourite
A modern sleeping area features a spacious bed adorned with textured pillows. Natural light illuminates the room, enhancing the minimalist decor of framed artwork on the walls. A cozy bench and nightstand complement the design, while a private entrance is visible in the background.
Guest house in Central City
5 out of 5 average rating, 129 reviews

Downtown Phoenix Private Casita - Story & Sol

Story & Sol is a new, fully equipped casita in the heart of FQ Story neighborhood in Downtown Phoenix. Stroll palm-lined streets and admire historic Arizona homes with charming landscapes as you discover all that Phoenix has to offer. Truly a cozy oasis in the heart of the City... minutes from restaurants, coffee shops, bars, farmers markets, & museums. Located off the I-10, Story & Sol is the perfect launch pad for adventures across the Valley of the Sun in our beautiful Grand Canyon state.

Top guest favourite
A cozy bedroom featuring a spacious bed with a custom leather headboard. A large black and white mural of cacti adds character to the room. A modern pendant light hangs above, complementing the warm tones of the wooden bed frame and the textured beige bedding.
Guest suite in Encanto
4.99 out of 5 average rating, 400 reviews

Private, desert-chic casita in vibrant Midtown PHX

Welcome to Casita Amelia, a modern rustic retreat central to all the action Phoenix has to offer. Welcoming and cozy, this newly updated private guest suite has all the luxuries of a modern hotel suite while being quietly tucked away in a cute Midtown neighborhood. Walk to Melrose District. You're also just 5-10 mins by car to Uptown & Camelback Corridor, 10 mins to Downtown (Footprint Center, Chase Field, Arizona Financial), 15 mins to Sky Harbor Airport, and 20 mins to State Farm Stadium.

Top guest favourite
The exterior of the Spanish Colonial Revival home features a spacious pool area with a large swimming pool surrounded by lounge chairs and shaded seating. Lush greenery and palm trees line the background, while shade awnings provide additional comfort.
Home in Encanto
4.96 out of 5 average rating, 192 reviews

Central PHX Lux Historic Villa + Heated Pool & Spa

Built in 1928, yet fully remodeled and professionally decorated, this Spanish Colonial Revival masterpiece on an idyllic palm-lined avenue adjacent to Encanto Park is the ideal getaway. Stroll the surrounding storybook lanes, cool off in the private pool, soak in the hot tub, lounge by the fire pit, or sleep late in one of 3 luxuriously appointed King bedrooms, including a main floor primary with en-suite bath. 2-car off-street parking and super-fast wifi make this the ideal home base.

Guest favourite
The image captures a modern pool area at dusk, featuring a sparkling saltwater pool and a heated hot tub. Surrounding greenery adds to the atmosphere, while the backdrop showcases the Midtown skyline. Soft lighting illuminates the outdoor seating area, enhancing the inviting space.
Home in Encanto
4.87 out of 5 average rating, 134 reviews

Modern Midtown Oasis with Pool, Spa, & Roof Deck

Featured in Phoenix Home & Garden, this designer-renovated 1920s home blends timeless elegance with modern luxury. Enjoy a 3BR/2BA main house, stylish pool house, chef’s kitchen, saltwater pool and spa, moody lounge with wet bar, and refined indoor-outdoor living—all in the heart of Midtown Phoenix. Walking distance to the LightRail, Restaurants, Bars, The Heard Museum, Phoenix Theater & Phoenix Art Museum! Easy train access to/from SkyHarbor Airport and everything Phoenix offers!

Guest favourite
Apartment in Encanto
4.89 out of 5 average rating, 195 reviews

The Beverly Bungalow | Stylish Stay Near Downtown

Relax & unwind at our mid-century bungalow in the heart of Phoenix. This 1BR/1BA condo will comfortably sleep 2. Our condo is complete with a full kitchen, cozy living room & dedicated work space for the WFH professional. Also included is a shared pool/hot tub to cool off on those hot summer days. Located in Midtown center to museums, unique bar & restaurant concepts, Chase Field, The Footprint Center - the list goes on. We hope you enjoy all AZ has to offer!

Guest favourite
Home in Phoenix
4.94 out of 5 average rating, 516 reviews

Uptown Historic Home | Resort Style Outdoor Space

Experience Monarch House in a Phoenix Historic District—your spa-like retreat with unique artistic touches. The well-designed interior features a dining room and a fully equipped kitchen, perfect for memorable meals. Located in Uptown Phoenix, enjoy trendy restaurants, local boutiques, and vibrant nightlife just minutes away. Seamlessly switch between two private outdoor spaces and a shared courtyard, featuring an outdoor dining room and cozy fire pit.

Top guest favourite
A spacious living area contains a light grey loveseat and a small wooden desk paired with a chair. A decorative lamp provides soft lighting beside the couch. Artwork is displayed on the wall above the desk, and large windows allow natural light to fill the room.
Guest house in Encanto
5 out of 5 average rating, 249 reviews

Adorable Willo Cottage in Historic Central Phoenix

Peaceful one bedroom cottage in unbeatable location within Central Phoenix. Walking/ biking distance from light rail, restaurants, Heard Museum and Phoenix Art Museum. Enclosed backyard with a shared washer/dryer on property. The cottage has a queen bed, mini kitchen and private patio. Property is cleaned and sanitized according to the Airbnb cleaning procedures. 15 minutes from Sky Harbor Airport. 5 minutes from Encanto Park (Golf Course)

Top guest favourite
A light-filled living area features a marble dining table set with a bowl of fruit. Cozy seating includes a dark sofa accented with blue pillows, complemented by warm wood floors and light curtains. The adjacent kitchen is visible, showcasing modern appliances.
Home in Encanto
4.94 out of 5 average rating, 127 reviews

Cozy Casa in the heart of PHX w/ private patio

This newly restored 1930's home is loaded with charm and amenities. Situated on a quiet cul-de-sac in the upscale Willo neighborhood, our Granada Casitas are just a walk or short light rail ride from the heart of downtown Phoenix. From this unique location you can enjoy it all in true Phoenician style - food, drinks, arts, culture, music and sports! Plus easy access to Scottsdale, Tempe, hiking, golf, shopping and airport in <10 mile radius.

Popular amenities for Osborn Medical Center, Phoenix holiday rentals