
Holiday rentals in Panamá Province
Find and book unique accommodation on Airbnb
Top-rated holiday rentals in Panamá Province
Guests agree: these stays are highly rated for location, cleanliness and more.

CASA SAEMA -PRESTIGIOUS DUPLEX PENTHOUSE WITH TERRACES
Spectacular duplex penthouse in Panama's Casco Antiguo, 265 m2 with balconies, private outdoor terraces, an indoor garden lounge, a dining room, 3 bedrooms (+ sofa bed in the studio), recently renovated with a loft concept, exclusive, unique, and comfortable design, in the best area of the Casco Viejo, perfect for relaxing and unwinding, kitchen, dishwasher, living room with washing machine, shared pool, elevator, 24/7 doorman, children who cannot swim are not allowed, wide variety of leisure activities in the area.

Best Location – Spacious Luxury Apartment for 8
Welcome to our spacious and elegant apartment, designed to comfortably host up to 8 guests in the heart of Casco Viejo. Located directly in front of one of the most beautiful and lively plazas in the historic district, you’ll be surrounded by top restaurants, cafés, and vibrant city life. The building also features an elevator for your convenience and access to a rooftop, perfect for relaxing after a day exploring the city. Its prime location allows you to easily discover the best attractions

Apartment with unique views to remember
Pasarás una Experiencia con estilo, alojamiento céntrico. acceso a líneas de buses y el Metro, restaurante , grocery store 24 horas, y una vida nocturna genial, casinos, cinta costera, iglesia del Carmen. casco antiguo a minutos en uber. compras. Soho Mall, Multi Plaza Mall y Albrook Mall. Piscina para adultos y niños. Bar, restaurante, rooftop vistas panorámicas, coworking, gym. Una habitación Con cama queen y un sofá cama en la sala para huéspedes extras (costo xtra 15.00 pp x noche)

Casco Viejo 360° View Old Tower Penthouse
Located in one of the oldest buildings in Panama and set over 3 stories with unrivaled panoramic views over the historical Casco Viejo, the skyline of Panama City and views of the causeway, our gorgeous penthouse is the ideal space to take in the local sights, sounds, art, culture, socialize with your friends and family, or simply relax in a cozy love nest! Top speed wifi, excellent location, and fully equipped with all the home comforts, the penthouse is the perfect spot to explore Panama.

Luxury Mid-Century Apartment In Casco Viejo
Luxury mid-century one bedroom Boutiqe 72 m2 apartment. Step into the elegant, functional and comfortable place that we offer with love. The apartment located within a beautiful two-floors antique building in the heart of Casco Viejo. The apartment includes a well equipped brand new kitchen, a dining area and a spacious living room, also a balcony with a view of the lively streets below. The tranquil bedroom has an ensuite bathroom and a walking closet that fitting perfectly to your needs.

Patty’s Casco 2BR Loft | Balcony & Personal Touch
“Feel at home in Casco Viejo—personally welcomed by your hosts, Patty & Rudy.” Stay in the Heart of Casco Viejo with Patty’s Casitas! Prime Casco Viejo Location | Quiet, Convenient & Charming Stay steps from restaurants, cafés, bars, and plazas—right by the El Rey boutique supermarket and the waterfront promenade. This peaceful spot is rare in Casco, tucked away from rooftop noise and perfectly located at the entrance of the neighborhood for easy in & out access!

Luxury Balcony Stays + Pool Casco Viejo
Wake up overlooking one of the last historic bastions of Casco Viejo, sip your morning cofee on a private balcony, and step directly into Panama City most vibrant and wakable neighboorhood. Surrounded by colonial architecture, charming plazas, and a vibrant culinary scene, this space invites you to experience Panama with style and tranquility. Ideal for those seeking an exclusive, walkable, and characterful environment in one of the city's most iconic areas.

The apartment of a legendary Panamanian footballer
Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Amazing loft with an iconic view of Casco Viejo
Enjoy a unique experience, in this elegant and centrally-located loft. Fully remodeled 1 bedroom apartment, in a central location in Casco Viejo (the old city). You will be just steps away from many restaurants, cafes, museums, and the existing night life casco has to offer. Located in “Jeronimo,” this restored- colonial building was built in the year 1850, and features unique crafted wall décor, as well as some of the original "calicanto" walls.

Loft 3b Old Town Best! It's 150 m2 (492 feet)
Immerse yourself in the historic charm and modern elegance of our 3-bedroom, 150 m2 loft in the heart of the Old Town. With wooden floors that radiate warmth and a modern open-plan kitchen ideal for sharing, this space guarantees a memorable vacation. Located on Avenida A, you'll find yourself just a few steps away from exquisite restaurants, museums, colonial churches, and the Casco's coveted rooftops, making every day an adventure.

The best view of the Old Town
Welcome to this charming accommodation in the heart of the Casco Viejo, located on the third floor facing one of Panama's most iconic squares, Plaza Catedral! Thanks to its prime location, you will enjoy a unique view of the square and the imposing Cathedral Church. Right in this lively square, you will have a wide variety of restaurants and shops at your disposal where you can buy souvenirs of this wonderful trip.

Full apartment in Panama
This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.
Popular amenities for Panamá Province holiday rentals
Other great holiday rentals in Panamá Province

Most Beautiful Loft in the Heart of Casco Viejo

1B • 5 Bedroom Apt • 4 Baths • Great for Groups

Centric - 2BDR Apt - Old Town

Casco Antiguo Apartment with Balcony & Stone Wall

w* | Luxury 2BR in Old Town

Casa Condal - Your Private Nature Eco-Retreat

Amazing loft with Casco charm in the best location

Peaceful Stay in the Heart of Casco
Destinations to explore
- Pet-friendly rentals Panamá Province
- Private suite rentals Panamá Province
- Rentals with an EV charger Panamá Province
- Loft rentals Panamá Province
- Waterfront rentals Panamá Province
- Fitness-friendly rentals Panamá Province
- Boat rentals Panamá Province
- Townhouse rentals Panamá Province
- Apartment rentals Panamá Province
- Rentals with a firepit Panamá Province
- Rentals with an accessible-height bed Panamá Province
- Boutique hotels Panamá Province
- Rentals with a patio Panamá Province
- Serviced apartment rentals Panamá Province
- Hostel rentals Panamá Province
- Cabin rentals Panamá Province
- Rentals with a cinema Panamá Province
- Rentals with lake access Panamá Province
- Nature eco lodge rentals Panamá Province
- Rentals with a hot tub Panamá Province
- Tiny house rentals Panamá Province
- Family-friendly rentals Panamá Province
- Bed and breakfasts Panamá Province
- Villa rentals Panamá Province
- House rentals Panamá Province
- Rentals with a kayak Panamá Province
- Rentals with a sauna Panamá Province
- Flat rentals Panamá Province
- Hotel rooms Panamá Province
- Rentals with outdoor seating Panamá Province
- Rentals with pools Panamá Province
- Beachfront rentals Panamá Province
- Smoking-friendly rentals Panamá Province
- Rentals with a fireplace Panamá Province
- Holiday home rentals Panamá Province
- Rentals with a washing machine and dryer Panamá Province
- Rentals with beach access Panamá Province
- Guest house rentals Panamá Province
- Rentals with breakfast Panamá Province
- Things to do Panamá Province
- Art and culture Panamá Province
- Food and drink Panamá Province
- Sightseeing Panamá Province
- Tours Panamá Province
- Nature and outdoors Panamá Province
- Things to do Panama
- Sightseeing Panama
- Entertainment Panama
- Nature and outdoors Panama
- Food and drink Panama
- Tours Panama
- Art and culture Panama





