
Places to stay near Buffalo Museum of Science
Book unique holiday rentals, homes and more on Airbnb
Top-rated holiday rentals near Buffalo Museum of Science
Guests agree: these stays are highly rated for location, cleanliness and more.

The 2D Spot!
Buffalo's 1st official 2D Airbnb; all hand painted by local Artists. With ideal proximity to DT Buffalo, Elmwood Village & Allentown, you'll find yourself at the heart of the city's culture. Also just a 25 minute drive to the iconic Niagara Falls. Whether you're a first time visitor to Buffalo or a local seeking a unique escape, The2DSpot invites you to step inside the pages of a comic book. Immerse yourself in a world of imagination & book your stay today! Experience Buffalo like never before.

Fireplace Luxury King Bed Rooftop Gym Basketball
This luxury lot offers a truly unique & romantic experience with its open concept design, soaring 16' ceiling, high-end finishes, abundant natural light. Enjoy an evening in front of the custom gas fireplace, while eating dinner/ watching movies on the 65" tv. Located in an architecturally significant building in Elmwood Village & nearby Allentown. Close to Niagara Falls, NHL & NFL venues. Larger families can be accommodated with additional bedrooms and bathrooms. Please inquire when booking.

The Italianate: Historic Home w/ Sauna and Firepit
This beautifully restored late-1800s Victorian Italianate home offers a relaxing, centrally located retreat in Buffalo, NY, complete with a private, fenced yard containing a dry heat sauna and fire pit with complimentary firewood. Historic architectural details blend seamlessly with modern updates, including a fully stocked kitchen (coffee included). Located in the heart of Allentown, it’s an ideal stay for luxury family trips and wedding parties seeking comfort, space, and a refined home base.

Modern Full Home: Hot Tub, Updated Kitchen & Bath
**This is an entire home listing. There is no one else that will be at the house.** Enjoy a stylish experience at this centrally-located single family home. With an updated kitchen, a/c downstairs master BR, guest BR and attic (may-sept). Ultra modern bathroom has a walk-in shower with 2 rain shower heads, 1 extra deep bathtub, heated floor, marble counter tops & bidet Outside you will have a large back porch which includes a hot tub & string lights to enjoy during the cool Buffalo evening.

Cozy Carriage House on Elmwood
Beautiful Airbnb inside a historic carriage house. Located directly on Elmwood Avenue but tucked back & secluded for a peaceful stay. Cozy interior with coffee bar included. The cottage’s prime location is within walking distance to many restaurants, bars, cafes, boutique shops, Delaware Park, the AKG and Birchfield Penney art museums, and more. Off-street parking allows easy access to adventure outside of the village with Niagara Falls & the Bills Stadium just a 20-30 min. drive/Uber away!

Peaceful Walkable 1 Queen Upper+parking+laundry
Enjoy this bright & peaceful One bedroom upper apartment located in Buffalo’s happening Westside. Great for long stays! Perfect spot for traveling professionals or couples. The apartment is a 5 min drive to downtown & Buff Gen & 10 min walk to Allen & Elmwood. The Neighborhood is pocketed with many cafes & shops and is one of Buffalo’s Garden Walk highlights. Soak in the historic architecture enjoy & delicious sourdough sandwich made by Breadhive-just a block away! LGBTQ+ POC welcome

Five Points Hideaway
Welcome to 5 Points! Offering a private, hotel room style- 1 bedroom/1 bathroom guest suite attached to a historic home in the heart of the Five Points neighborhood on Buffalo’s Westside. Private entrance. This cozy spot is perfect for an overnight or weekend visit. Mini fridge, microwave and Keurig provided. Just 8 minutes from Downtown and 25 minutes from Niagara Falls. Walking distance to great restaurants and bars. Close to Buff State, AKG, Medical Campus, Convention Center & Arena.

Cozy Apartment in LarkinVille (Unit 2)
If this listing is not available please check out my other listings This 1st floor apartment features an open concept kitchen & living room with stove, refrigerator & microwave. A queen sleeper sofa & 54" smart TV are in the living room. The bedroom has a queen bed & dresser. The space features a In unit washer & dryer soaker jacuzzi tub and A/C mini split to help cool down the space. This is a mix use property with periment tenants as well as other guest. Noise is typically low

Five Points Apartment- Upper Unit
Updated Upper Unit Apartment. Great City Location! Walking Distance to Five Points, and Lower West Side Restaurants and Shops. Off Street Parking (when available). In Unit Laundry. WiFi. Pets Allowed ($50 pet fee). Queen Bed and Fold Down Futon. Blocks from D’Youville University and minutes from Buffalo State University! Close to Kleinhans Music Hall, Elmwood Village and Allentown! 10 Min Drive To KeyBank Center - 20 Min Drive To Highmark Stadium - 20 Min Drive To Niagara Falls

Cozy & Spacious Getaway! Centrally located.
Enjoy this quaint and spacious getaway located in the Elmwood Village! Walkable to shops, restaurants, museums and parks! Close to Buffalo’s best features such as Niagara Falls, Lake Erie, AGK Art Museum, Buffalo Bills and so much more! This fully renovated fourth unit is located on the third floor and offers you two bedrooms, one bath, large full kitchen, spacious living room and can sleep up to 6! This property is locally owned and maintained in pristine condition.

Clean 2-Bedroom Apt (11 min to DT, 12 to stadium)
Keep it simple yet cozy in our comfortable, centrally-located apartment! This quiet, dead end street is nestled in the center of a vibrant, up and coming part of town. All amenities included - free street parking, WiFi, central heating, and everything you may need to make your stay a good one. We are only 11 minutes from the city, 5 minutes from the thru way, and within walking distance to many restaurants, shops and markets, parks, and a golf course!

The Byrnebury Studio
Important: A few bad apples spoiled it for the bunch. Please read our house rules before booking and share them with your travel companions. This self-contained, cozy little studio is located on the second floor (need to climb stairs) of a grand home in the Parkside neighborhood. Private entrance, bath (5' x 5'), and kitchenette (6' x 8'), this studio is the perfect space for short visit to our beautiful region. (bedroom area is 12' x 12')
Popular amenities for holiday rentals near Buffalo Museum of Science
Apartment rentals with wifi

Elmwood 1 King 1 Queen 1.5 bath Garage EV Charger

Lovely Niagara Falls Vacation Home

The Eugene

Entire Condo Minutes from Niagara Falls (USA)

Quiet nice and clean apartment downtown Buffalo

NEW, Luxurious 2BR Condo - Niagara Falls

An Artists Designed_Condo Suite (Canadian Side)

*Central location*Clean*Parking*2BDRM*A/C
Family-friendly house rentals

Bright, Beautiful Lakefront @ Historical Fort Erie

Historic Allentown home in Elmwood Village

Comfortable updated home near all Buffalo sights

Beautiful Cozy House in Buffalo

Modern Kenmore Getaway | Renovated Home in Buffalo

West Side Retreat Steps from Allentown & Downtown

MODERN SPACIOUS 2-BR BEST LOCATION IN ALLENTOWN

Timber-frame home on 12 wooded acres
Apartment rentals with air conditioning

Space, comfort and hospitality!

Chic and Charming Apt in Downtown Allentown 2B2B

Suite Studio ❤️️ (Free Parking, Elmwood Village!)

Historic Apartment Steps Away from Allentown Area

Cozy & Walkable Elmwood Village Charmer

Cozy 2 Bedroom Apt Close 2 Everything

Clean, Cozy, Historic, Stylish, Convenient

Cozy S. Buffalo Retreat - 10 mins to Bills Stadium
Other great holiday rentals near Buffalo Museum of Science

A Castle in the Heart of Buffalo

Spacious! Game Rm, Lounge, Arcade, Jungle Rm!

Charming 2 bedroom cottage on the EA golf course

2bdrm single family home. Medical area

Luxury Romantic Glamping Dome near Niagara Falls

Private 3-bedroom cottage at St. Patrick's Friary

Hidden Parkside Carriage House near everything.

Sunlit Serenity on Pearl: 2-BR in Downtown Buffalo
Destinations to explore
- Letchworth State Park
- Holiday Valley Ski Resort
- Six Flags Darien Lake
- Niagara Falls State Park
- Niagara Falls
- Buffalo RiverWorks
- Casino Niagara
- Fallsview Indoor Waterpark
- Brock University
- Jackson-Triggs Niagara Estate
- Knox Farm State Park
- Seneca Niagara Resort & Casino
- University at Buffalo North Campus
- Keybank Center
- 13th Street Winery
- Vineland Estates Winery
- Kissing Bridge
- Buffalo Zoo
- Wayne Gretzky Estates
- Lakeside Park Carousel
- MarineLand
- Legends on the Niagara Golf Course
- Highmark Stadium
- Balls Falls Conservation Area





