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Holiday rentals in Isthmus of Panama

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Top-rated holiday rentals in Isthmus of Panama

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Top guest favourite
The exterior of the three-story beach house is showcased, featuring terracotta roofs and lush landscaping. Palm trees and colorful flowers enhance the vibrant surroundings, while the ocean is visible in the background, complementing the peaceful neighborhood setting.
Home in San Carlos
4.94 out of 5 average rating, 145 reviews

OceanView-Rooftop Jacuzzi&Pool | Concierge Service

Unique 3-story beach house – one of a kind. 7 bedrooms, 13 beds, 8.5 baths. hot water. Every room with full bath -AC’s and ceiling fans in all rooms, separate laundry -Rooftop area pool, Jacuzzi, bar, BBQ(charcoal & gas) with amazing ocean view -High ceilings, large open kitchen and living area. -Spacious balcony for dining or relaxing. - 5 min. walk to the beach. -Parking for up to 7 cars - Base rate covers up to 4 guests, with a $40 charge per additional person, per night.

Top guest favourite
The exterior of the cabin is showcased amidst lush greenery, featuring a sloped roof and large glass windows. A wooden staircase leads up to the entrance, while a stone pathway meanders through the garden, enhancing the natural surroundings.
Cabin in Penonome
4.98 out of 5 average rating, 125 reviews

Aqeel cabin in the nature

Relax at this unique and tranquil getaway surrounded by nature. If you're lucky, you may wake up to see white-faced capuchins from your bedroom window and spot an abundance of birds, such as the crested oropendola or a toucan. The property offers river access with a sandy, beach-like area, and there is a 1 km walking trail alongside the river. With satellite high-speed internet access, you'll stay connected, though the river and sandy area may not be accessible during rainy days.

Top guest favourite
An inviting infinity pool overlooks a stunning coastal view. A spacious seating area, featuring colorful cushions, complements the serene atmosphere. Natural light fills the space, enhancing the connection to the outdoors, while the blue waters of the pool blend seamlessly with the distant ocean.
Villa in Cacique
4.98 out of 5 average rating, 54 reviews

FACING THE SEA Cacique (Portobello Park)

A house! A real glass island in the heart of the jungle! In the middle of the Portobello National Park (access only by 4x4 AWD) nestled at the top of the hill, between sky/sea, away from all eyes, a transparent house where glass embraces nature on all sides creating a unique connection between the inside and the outside, ideal for resting, disconnecting, comfortable, spacious, cool (central air conditioning), exclusive. It is the witness of a grandiose spectacle that awaits you!

Top guest favourite
A tranquil outdoor area is depicted, featuring a small private pool surrounded by lush greenery. The charming cottage stands nearby, characterized by large windows and a covered porch that offers ample natural light.
Guest house in Panamá Oeste
4.8 out of 5 average rating, 170 reviews

Mountain cabin with private pool in Panama

Enjoy peace and nature in this cozy and equipped cabin, perfect for disconnecting and relaxing. Surrounded by forests and spectacular views, here you can breathe fresh air and gaze at the stars. ✔️ Ideal for couples, families or adventurers. ✔️ Trails, rivers and viewpoints nearby. ✔️ Comfortable and equipped spaces for your comfort. - Sleeps 4 people. - Discount for two nights or more. Close to: Laguna de San Carlos, Valle de Antón, beaches of the Panamanian Pacific.

Guest favourite
A serene swimming pool is depicted surrounded by lush palm trees, with the tranquil sea visible in the background. The water's clear blue tiles reflect the sky and nearby greenery, while the gentle curvature of the pool edge invites relaxation.
Villa in Portobelo
4.97 out of 5 average rating, 79 reviews

Entire Villa with pool in front of beach!

Beautiful spacious 4 bedroom villa right in front of the sea. Enjoy the swimming pool with your family, then take a dip into the sea only steps away. Very pet friendly! Take a boat trip for the day with a local certified tour guide from portobelo town. Every room has full AC, including the living room - but please be conscious of the environment when using ACs. Excellent WiFi ! Open Kitchen, with breakfast included. We can also arrange for lunch - fresh lobster!

Guest favourite
A tranquil dipping pool is framed by lush greenery, featuring white loungers and a large umbrella for shade. The pool area exudes a serene vibe with vibrant bougainvillea in the background, enhancing the inviting outdoor space.
Home in Taboga Island
4.95 out of 5 average rating, 206 reviews

Casa Rosie - Dream Home on Tabogá Island

Casa Rosie is a gorgeous villa on Taboga island with an intimate vibe and spectacular views of the ocean. The perfect place for couples, small groups, and families to unwind and make magical memories! . With great wifi, fully equipped kitchen, 3 inviting bedrooms, and a spacious yet personal feel… Casa Rosie is your home away from home. Included in every stay is free pick up and drop off to the ferry terminal - please let us know the details of your arrival.

Top guest favourite
An aerial view captures the lush greenery surrounding the treehouse, which extends over tranquil waters. The vibrant blue and green hues of the lagoon contrast with the shoreline, showcasing the natural beauty of the area. Mangroves frame the water's edge, emphasizing the secluded environment.
Treehouse in Provincia de Bocas del Toro
4.93 out of 5 average rating, 248 reviews

Cocovivo Mangrove Tree house

This secluded loft-style treehouse sits on stilts above the water, 30 feet from our colorful coral reef. Transparent and airy but bug proof walls let you enjoy the fresh ocean breeze and views while keeping you safe and cozy. When a sloth comes to visit, no need to leave the house to see him! Blend in with the surroundings of mangrove, lagoon and jungle, and enjoy water and reef access from your own deck. Bright and airy, 100% eco-conscious.

Top guest favourite
A charming wooden house is surrounded by lush greenery, featuring a wraparound porch with a wooden railing. Large windows and double doors provide ample natural light, while a surfboard leans against the porch steps, indicative of nearby ocean activities.
Cottage in Bocas del Toro Province
4.97 out of 5 average rating, 290 reviews

Rustic cottage-Ocean views/walk to surfing/Jungle

Casa Palmera is located in the quieter north/west side of Isla Carenero. Relax and watch the sunsets. Only a few minutes walk to the Carenero Surf Breaks . Restaurants are within walking distance, hike around the island, or use the kayaks and see the beauty. We are 5 minute boat taxi away from the main town of Bocas, but everything you need to make your vacation unforgettable is on this island! Drinking water included.A/C in bedrooms

Superhost
Home in Altos del Maria
5 out of 5 average rating, 3 reviews

Three Bedroom Luxurious Mountain Home with Jacuzzi

Marte is a spacious, luxurious mountain home designed to accommodate up to 8 guests. It is an excellent choice for those seeking a quiet and relaxing stay while enjoying the comforts of a brand-new home. This two-story residence features three bedrooms, a large terrace overlooking the impressive Picacho Peak, and a private jacuzzi. With its serene setting and modern amenities, Marte is an outstanding choice in Altos del María.

Top guest favourite
Camper van/Motorhome in El Valle de Antón
4.99 out of 5 average rating, 251 reviews

Armadillo Shelter & Garden Valle de Anton

It is a unique and special accommodation that we have designed for you to experience the Anton Valley in a more conscious and natural way. It's a remodeled RV or trailer, to make it cozy>functional and comfortable>tiny house style. The space has a small and complete kitchen, hot water, Wi-Fi, coffee and tea. It is surrounded by a nice garden. With a separate entrance and an area to park the car. Ideal for 1-2 people.

Guest favourite
Farm stay in Santa Fe
4.9 out of 5 average rating, 313 reviews

Cabaña del Sol en Finca Namuiki by the River

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Top guest favourite
Home in Panama City
5 out of 5 average rating, 14 reviews

Casa del Lago 2025

New lakefront house in Cerro Azul, decorated by a D&G architect with furniture brought from Bali. It has 3 bedrooms, 3 bathrooms and 4 double beds, equipped kitchen, BBQ, air conditioning and hot water. Cook a delicious BBQ with your friends in front of the lake and enjoy the sunsets from an unparalleled view with direct access and kayak included.

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