
Holiday rentals in Isthmus of Panama
Find and book unique accommodation on Airbnb
Top-rated holiday rentals in Isthmus of Panama
Guests agree: these stays are highly rated for location, cleanliness and more.
0 of 0 items showing
1 of 3 pages
Holiday rentals for every style
Get the amount of space that is right for you
Popular amenities for Isthmus of Panama holiday rentals
Other great holiday rentals in Isthmus of Panama
Guest favourite

Dome in El Valle de Antón
4.89 out of 5 average rating, 47 reviews5 minutes from Valle I Domo No. 7
SherleyRating, 5 stars2 days ago
Ame ame 100% really is 5 minutes from the valley, the instructions are super easy. The map of google maps gives the exact location asique was everything 10/10 and the Communication with Nestor was also excellent. I recommend it with my eyes closed, quality/price. Spectacular.
Superhost

Guest house in Panamá Oeste
4.76 out of 5 average rating, 122 reviewsMountain house with pool in Panama
AnaRating, 5 stars2 weeks ago
Jose’s property is so beautiful. We enjoyed exploring this property and I would love to host a wedding or event here.
Superhost

Home in Chame
4.78 out of 5 average rating, 55 reviewsP/Caracol Ocean Haven View (C5-PBB) 2 bed, 2 bath
AlexanderRating, 5 stars1 month ago
Great stay. The place was as described and the view was just amazing! Live right on the beach - great. Nearby are some restaurants (e.g. Surf Shack) with top dishes, cocktails and absolutely friendly staff. It was a wonderful stay and the reliable and extremely friendly communication with the host also contributed to this. We will be happy to come back!
Superhost

Place to stay in Altos del Maria
4.77 out of 5 average rating, 238 reviewsMountain Nature and Architectural Paradise Loft
MarissaRating, 5 stars1 week ago
We absolutely loved this mountain retreat. The open concept & jacuzzi let us enjoy all the incredible nature that surrounded us. Comfortable & modern furnishings in a remote setting, exactly what we wanted!
Guest favourite

Home in San José
5 out of 5 average rating, 5 reviews25% OFF Casa Lirios Mini Resort House @Punta Barco
MicahRating, 5 stars1 week ago
The place was great, and incredible for the price. It was just the perfect escape close to the beach.
Guest favourite

Villa in Rio Hato
4.93 out of 5 average rating, 91 reviewsBeach Front Paradise!
JoyceRating, 5 stars2 months ago
This place was a wonderful place to relax, enjoy the fresh ocean air and go for quiet walks on the beach. Very quiet, secluded. The host is wonderful and will help with any questions - and went out of his way to help our son who received a jellyfish sting.
Top guest favourite

Bungalow in Jaramillo
5 out of 5 average rating, 26 reviewsPanoramic Views Pacific to Baru, Boquete District
ChrisRating, 5 stars2 weeks ago
If you are looking for a modern, clean, functional casita in an absolutely tranquil and relaxing spot…..This is it! Wake up to the sounds of beautiful birds every morning. Open the curtains to see the lush flora and fauna of the stunning property. Enjoy a cup of local coffee (provided by the host) on the lower patio for views of the Pacific Ocean, Vulcan Baru and the town of Boquete below. Nothing more peaceful than the serene air of the cloud forest. All or your worries and woes will melt away. Although you might not want to leave the property, you are only a short drive from all that Boquete has to offer. The host, Sherry and Troy are wonderful. They are very helpful and informative. Anything you may need they will assist. This is a five star experience. Highly recommend by my wife and I. We cannot stop thinking about it since we have arrived back home.
Top guest favourite

Place to stay in Rio Hato
5 out of 5 average rating, 11 reviewsParadise from ocean to jungle. Bohío cottage
EnriqueRating, 5 stars5 days ago
The place is very nice and the hosts are very friendly, they welcomed us with great affection. The room is very well located, close to the beach and restaurants, the place is very safe and quiet.
Destinations to explore
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom