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Holiday rentals in Isthmus of Panama

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Top-rated holiday rentals in Isthmus of Panama

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top guest favourite
Flat in Panamá
4.97 out of 5 average rating, 234 reviews

In the heart of Casco, refurbished and with parking

Escape and discover the old town in this remodeled, comfortable and central accommodation in the heart of Casco Viejo. Our location is the best, it will make you come back. Close to restaurants, bars, impressive churches, and museums. The property dates back to the 17th century (1756) history and good atmosphere. You can explore the area on foot, fully equipped kitchen, European king bed, you will feel right at home, surrounded by the famous calicanto walls. -A large living room -Fully-equiped kitchen

Top guest favourite
The rustic wooden cabaña is nestled among trees, featuring a sloped roof and a cozy porch illuminated by warm lights. A vibrant hammock is draped beneath the porch, surrounded by lush greenery and a gravel path, showcasing a tranquil outdoor atmosphere.
Cabin in Cambutal
4.94 out of 5 average rating, 68 reviews

Charming Cabaña on the beach

If you're looking for a place to relax and experience the magic of Cambutal with its lush jungle and stunning beaches, look no further. Nestled amongst the trees and overlooking one of the best swimming bays around, this rustic wooden cabaña has everything you need to make your stay unforgettable. Wake up to the sounds of the ocean on your doorstep, spend your days swimming in the warm ocean, or try other exciting activities, such as horse riding, hiking, yoga, surfing, diving and snorkelling.

Top guest favourite
A spacious living area features a comfortable sofa and two accent chairs surrounding a striped area rug. Floor-to-ceiling windows offer panoramic views of the ocean and surrounding islands, while a flat-screen TV is positioned on a low console for easy viewing.
Villa in Boca Chica
4.96 out of 5 average rating, 103 reviews

Sand Dollar Villa by the sea at Boca Chica Panama

Sand Dollar Villa by the sea This beautiful, very private retreat boasts panoramic views and direct access to a beautiful beach and sheltered bay. Located in Boca Chica, it is only 45 minutes from Panama’s second largest city, David. From your doorstep, you can enjoy island hopping in an archipelago of unexplored islands, or you can choose to soak in the sun on your very own private beach. Sand Dollar Villa offers the perfect décor for gracious living and entertaining in a magical setting!

Guest favourite
An aerial view captures a charming retreat nestled in lush greenery. The red-tiled roof of the cabin stands prominently surrounded by colorful gardens and fruit trees. A winding path leads to the property, with a vehicle parked nearby, highlighting the spacious natural surroundings.
Tiny home in Cocle
4.93 out of 5 average rating, 134 reviews

Cozy 2 Bedrooms, el Cope/ Retreat at the Mountains

Hermosa cabaña de dos habitaciones y dos baños , den panorámico ubicada a unos 50 minutos de Penonome, Provincia de Cocle, en el Area del Parque Nacional Omar Torrijos Herrera , temperaturas entre 22 y 25 grados C a orillas del turístico Chorro de las Yayas en la comunidad de Barrigon del Cope, distrito de La Pintada. Agradable ambiente rodeado de árboles frutales y hermosas cascadas. Ideal para disfrutar de la naturaleza y relajarse. Cuenta con internet satelital de rápida velocidad .

Top guest favourite
A tranquil outdoor area is depicted, featuring a small private pool surrounded by lush greenery. The charming cottage stands nearby, characterized by large windows and a covered porch that offers ample natural light.
Guest house in Panamá Oeste
4.8 out of 5 average rating, 170 reviews

Mountain cabin with private pool in Panama

Enjoy peace and nature in this cozy and equipped cabin, perfect for disconnecting and relaxing. Surrounded by forests and spectacular views, here you can breathe fresh air and gaze at the stars. ✔️ Ideal for couples, families or adventurers. ✔️ Trails, rivers and viewpoints nearby. ✔️ Comfortable and equipped spaces for your comfort. - Sleeps 4 people. - Discount for two nights or more. Close to: Laguna de San Carlos, Valle de Antón, beaches of the Panamanian Pacific.

Guest favourite
A tranquil dipping pool is framed by lush greenery, featuring white loungers and a large umbrella for shade. The pool area exudes a serene vibe with vibrant bougainvillea in the background, enhancing the inviting outdoor space.
Home in Taboga Island
4.95 out of 5 average rating, 206 reviews

Casa Rosie - Dream Home on Tabogá Island

Casa Rosie is a gorgeous villa on Taboga island with an intimate vibe and spectacular views of the ocean. The perfect place for couples, small groups, and families to unwind and make magical memories! . With great wifi, fully equipped kitchen, 3 inviting bedrooms, and a spacious yet personal feel… Casa Rosie is your home away from home. Included in every stay is free pick up and drop off to the ferry terminal - please let us know the details of your arrival.

Guest favourite
A cozy bedroom features a spacious bed with yellow pillows, draped with a patterned blanket. Sheer curtains frame the view of the waterfront, while a hammock is positioned nearby. A large window allows natural light to illuminate the space, enhancing the connection to the surroundings.
Hut in Cristóbal Island
4.94 out of 5 average rating, 175 reviews

Cocovivo Bioluminescent Coconut

Strategically placed to catch the sunset, this airy waterfront cabin is designed for ultimate relaxation. Perfect for sun bathing, sunset gazing and when night falls, strong bioluminescent waters makes this cabin seem like it's out of a fairy tale. A coral reef aligns the whole property for world-class snorkeling, kayak or SUP expeditions! Jetsons-meet-Flintstones" is the vibe here. Please read the “Other things to note” section so you know what to expect!

Top guest favourite
Camper van/Motorhome in El Valle de Antón
4.99 out of 5 average rating, 251 reviews

Armadillo Shelter & Garden Valle de Anton

It is a unique and special accommodation that we have designed for you to experience the Anton Valley in a more conscious and natural way. It's a remodeled RV or trailer, to make it cozy>functional and comfortable>tiny house style. The space has a small and complete kitchen, hot water, Wi-Fi, coffee and tea. It is surrounded by a nice garden. With a separate entrance and an area to park the car. Ideal for 1-2 people.

Guest favourite
A private deck features two modern chairs with a small table between them, positioned on a textured area rug. A custom-built jacuzzi is visible in the background, surrounded by a wooden railing. Natural light floods the indoor living area through expansive glass doors.
Cabin in Boquete
5 out of 5 average rating, 5 reviews

New World Casita @ Finca Panda

Mundo Novo is one of our new, one-room casitas and has one of the most incredible views on the property. Perfect for couples, singles or family with a small child, Geisha sleeps 2 people comfortably in one king bed (maximum 3 guests when using sofa). Geisha was designed with every amenity needed to have a perfect and relaxing stay. Custom-built jacuzzi, fire-pit, kitchen, incredible shower, high-speed WiFi and more

Superhost
A serene indoor space features a spacious bed with decorative pillows, natural wooden accents, and plants adding a touch of nature. A gourmet table is set nearby, while a jacuzzi is positioned against a glass wall, allowing for views of the lush greenery outside.
Bungalow in Puerto Viejo de Talamanca
4.92 out of 5 average rating, 156 reviews

Pura Bali- Casa Blanca (100 meters from the beach)

Welcome to Pura Bali, Just 100 meters from the most beautiful beach in the Caribbean. A place where you can enjoy the exuberance of nature in a luxurious and art-filled environment. In our private tropical gardens you will find a safe and quiet space to disconnect from the stress of the city. In the midst of birdsong, you can relax in the jacuzzi and enjoy a unique and unforgettable experience.

Guest favourite
Farm stay in Santa Fe
4.9 out of 5 average rating, 313 reviews

Cabaña del Sol en Finca Namuiki by the River

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Superhost
A house with a broad, green roof is situated over clear blue waters, surrounded by the Caribbean Sea. A long wooden dock extends towards the structure, enhancing the serene tropical setting. Soft clouds drift above, reflecting the tranquil nature of the environment.
Home in Bocas del Toro Province
4.86 out of 5 average rating, 132 reviews

Casa Clearwater... Your Caribbean Dream

Located in the tropical archipelago of Bocas Del Toro, Casa Clearwater calmly sits in the serene, crystal clear, blue waters of the Caribbean Sea. Built in 2014, the 4500 sq. foot tropical/modern design lies over a pristine reef on a private 9 acre property.......a unique & special place to spend a relaxing holiday.

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