
House holiday rentals in La Mesa
Find and book unique houses on Airbnb
Top-rated house rentals in La Mesa
Guests agree: these houses are highly rated for location, cleanliness and more.

Entertainers Dream Pool Home
The Lemon Ave Pool Home! Ready for your enjoyment this home has EVERYTHING you need to enjoy a large get-together with beautiful San Diego sunshine! Sparkling pool, relaxing spa, fire pit, kids' playhouse/grass area, decks to view the gorgeous sunsets, and more! The vast open living space has a fully stocked kitchen for any chef's needs! 3 bedrooms, 1 King/1 Queen/2 full/1 twin mattress with 2 queen pullout couches/1 queen &1 twin portable mattress, 2 1/2 bathrooms (2 full showers with bathtubs)

SDSU Beach Cottage
Welcome to our stunning SDSU Beach Cottage. Our home is 10 minutes away from everything amazing in San Diego! Our home is Centrally located in San Diego and in a desirable neighborhood. We are steps away from a Local favorite Eatery, Wine Bar, Beer Pub, Natural-Holistic Market, Pizza shop, Liquor Store, Nail shop, and Einstein's Bagels. Play in San Diego or stay and relax in our tropical yard that is set up to entertain you and your family with outside games and Ping Pong. 25 Yr's of age req'd

Family Fun! Game Garage + Big Yard + Free Parking
Embodying the epitome of cool! This home has the perfect blend of a vintage feel with a modern touch. Stepping inside, you’re greeted by an atmosphere of fun & creativity. A large private serene retreat in the backyard w/abundant seating and fire pit. Huge 3-car garage bonus space with games. Located just minutes from downtown La Mesa, many dining options & conveniences. Everything you need & more! Distance to: San Diego Zoo: 18 min Sea World: 23 min SDSU: 13 min Airport: 19 min Gaslamp: 18 min

XTRA 10% OFF until Nov: Pool, outdoor fire pits, c
Find your family's dream spot in San Diego! Our cozy house sits on a quiet hill, offering privacy and amazing sunset views. Dive into our pool year-round (heating at an additional cost), roast marshmallows by the fire, and cook up fun meals together. With 3 bedrooms and 2 bathrooms, it’s perfect for families, accommodating up to 9 guests. Plus, we're close to all the best attractions. Want a vacation you'll always remember? Send us a message to make it happen! 🌅🏠 We have 3 comfy beds that can

2 Bed Hidden Oasis | Garden, Laundry, Parking
Capture the essence of San Diego in our Hidden King Suite with Garden hosted by Ethos Vacation Homes. The peaceful property features elite comfort for up to 4 guests with beautiful outdoors and garden, off-street parking, A/C and heating, FREE laundry, comfortable king and queen size beds, plenty of sheets and towels, a large HDTV, Netflix, Max, Hulu, Showtime, Disney+, Apple+, and ESPN+. This spacious San Diego vacation rental home has everything you need for your California Dreaming Vacation!

Newly Built Upscale Home with 5 Bedrooms/6 Baths
Experience High End Luxury in our New 5 Bed/6 Bath Home. Located in a Prime area within a 15 minute drive to Downtown Gaslamp/Convention Center, San Diego Zoo, SeaWorld, World Class Pickleball Venues, and Beaches. This Custom Built Home boasts an array of amenities including En-Suite Bathrooms in Each Bedroom, Culinary Chef’s Kitchen, a Cozy Fireplace, and Large Outdoor Entertainment Space. This house is perfect for Families, Groups, or Professionals seeking an unforgettable stay in San Diego.

Sunny & Spacious 3BR Retreat w/ Parking & A/C
Centrally located in La Mesa is this newly refurbished home ideal for business or pleasure with all of life’s little luxuries waiting for you to enjoy. The home features open concept living with a gourmet kitchen, a chic dining space, 3 beautiful bedrooms, 2 modern bathrooms and an expansive yard with an outdoor lounge. Walk 10 mins to Grossman Center with a Target, restaurants, cafes, a cinema & Walmart or drive to the heart of San Diego and all its attractions just 20 mins from your door.

Cottage in the Garden! New! Modern!
COTTAGE IN THE GARDEN - New! Modern! Find beauty and serenity in this special guest house in one of San Diego's most desirable areas! Flowering bushes, plants, olive tree and fruit trees seen from all windows. All amenities: WiFi, Cable, serving dishes and tableware, full coffee bar, Ninja Blender, Flat screen TVs, 100% Egyptian Cotton Sheets or Boll and Branch Sheets (used by 3 Presidents), Japanese Toilette and more. 15 minutes to Downtown San Diego and 20 minutes to the beach!

Zen Retreat: 3-Bedroom Oasis near La Mesa Village
Relax in this charming 3-bedroom, 1-bathroom home located just 1 mile from the heart of Historic Downtown La Mesa Village. Nestled in a quiet, central neighborhood, this cozy retreat offers easy access to major freeways, top-rated restaurants, and the local trolley line making it a breeze to explore the best of San Diego. Within 10 to 15 miles, you’ll find yourself in iconic destinations like Downtown San Diego, Balboa Park, Coronado Island, scenic beaches, and beautiful mountain trails.

SDCannaBnB #2 *420 *parking *dog-friendly *hot tub
Welcome to SDCannaBnB - San Diego's premier cannabis-friendly rental! Our studio is newly remodeled with luxury ammenities. We proudly cater to the cannabis community and non-users alike. Our studio has HEPA air purifiers, is fully ventilated and receives deep cleanings between each guest. This ensures that every guest checks into a clean, fresh-smelling place that feels like home. Our studio is located in our quiet, fully fenced in backyard, close to San Diego's attractions

Mid-Century Style Family House with Spa
Beautiful Mt. Helix mid-century modern family home with incredible views, designed by architect of original Las Vegas, Desert Inn 3/4 acre.Less than 20 minute drive to beaches/Zoo/Sea World/Downtown, . With a swimming pool/hot tub, whole House have AC to. surrounded by California Oak/orange/lemonpomegranate trees and herb garden this home is the epitome of 1950’s luxury. A perfect family oasis, you won’t even want to leave the property. No loud parties please, this is a quite community.

(Relist!) Relax at a Stunning 1931 Historic Tudor!
Come & enjoy our 1931 historic tudor home! Beautifully rebuilt within the last 2 years. This house has a huge front lawn and space to roam. Enjoy the serenity this large property has to offer. Three peaceful patios to enjoy your morning coffee. The kitchen has an 48-inch 1950’s oven for the chef in the family. Bay windows, arched entryways and original light fixtures make this such a charming place to stay. Centrally located to enjoy everything San Diego & La Mesa has to offer.
Popular amenities for house rentals in La Mesa
House rentals with a pool

La Jolla Beach House-Family Focused-3min to Beach

Airbnb Luxe: Designer Pool, Fitness and Office

The Board

University Heights Oasis Getaway

Stunning San Diego Home w/Pool,Spa,Outdoor Oasis

Flamingo Sunset House: Sleeps 10: Pool + Hot Tub

Mid-Century Modern and Contemporary House

Updated TownHome, Great Location, Fantastic Views
Weekly house rentals

Tiny Home with a View

Golden Hill Tree House

Shadow House Mt. Helix

Discover La Mesa: Your Perfect Cozy Base

Helix Haven

Modern, Private, & Stylish Home

Entire house, fenced yard, and driveway

Hilltop Family Retreat | Heated Pool & Ocean Views
Private house rentals

Surreal Serenity Escape wIth Game Room, Pool & Spa

Garden Retreat in North Park.

Cozy quiet getaway, great mattress (1-br)

San Diego's Finest Retreat

25% off •Hot tub•BBQ•Patio•4 min SDSU•CentralSD

Charming Cozy Studio Centrally Located

Serene retreat with valley view!

La Mesa Pool Paradise.
When is the best time to visit La Mesa?
| Month | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Avg. price | $230 SGD | $230 SGD | $244 SGD | $231 SGD | $236 SGD | $275 SGD | $321 SGD | $271 SGD | $237 SGD | $236 SGD | $230 SGD | $248 SGD |
| Avg. temp | 15°C | 15°C | 16°C | 17°C | 18°C | 20°C | 21°C | 22°C | 22°C | 20°C | 17°C | 14°C |
Quick stats about house rentals in La Mesa

Total holiday rentals
Explore 300 holiday rentals in La Mesa

Nightly prices starting at
La Mesa holiday rentals start at $26 SGD per night before taxes and fees

Verified guest reviews
Over 13,300 verified reviews to help you choose

Family-friendly holiday rentals
190 properties offer extra space & child-friendly amenities

Pet-friendly holiday rentals
Find 100 rentals that welcome pets

Holiday rentals with a pool
80 properties feature pools

Rentals with dedicated workspaces
180 properties have a dedicated workspace

Wifi availability
300 of La Mesa holiday rentals include wifi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across La Mesa rentals

4.9 Average rating
La Mesa stays are highly rated by guests – averaging 4.9 out of 5!
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- Rentals with an EV charger La Mesa
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- Pet-friendly rentals La Mesa
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- Rosarito Beach
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- LEGOLAND California
- SeaWorld San Diego
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- University of California-San Diego
- San Diego Zoo Safari Park
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