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Villa holiday rentals in Los Santos Province

Find and book unique villas on Airbnb

Top-rated villa rentals in Los Santos Province

Guests agree: these villas are highly rated for location, cleanliness and more.

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Villa in Los Santos Province
4.89 out of 5 average rating, 27 reviews

Esplendorosa | Luxury Villa with Included Services

This magnificent private villa is located in the beautiful coastal community of Azueros; at Destiladeros, Pedasí. It's just a few steps away from beautiful white sand beaches and waves for surfing. Villa Esplendorosa offers a luxurious retreat with impeccable service provided by dedicated house staff. Your reservation includes daily housekeeping and laundry service, as well as a private chef who prepares breakfast each morning. Please note that groceries and ingredients are provided by the gue

Guest favourite
A serene outdoor area features a rectangular pool surrounded by well-maintained grass. Colorful flora, including pink and yellow blooms, adorns the edges, complementing the scenic view of the ocean and rolling hills in the distance.
Villa in Playa Venao
5 out of 5 average rating, 6 reviews

Luxurious Villa Bella Vista

Nestled on a hill in a peaceful neighborhood, our amazing house offers relaxation for the entire family. You’ll feel home the moment you enter this well-equipped villa. While spending time on the terazza and near the pool, it will be hard to turn your eyes away from the breathtaking overview of the famous Venao Beach – also well known as a great surfer beach! Enjoy great barbecue evenings using our stainless Weber grill. Need to work: Top notch redundant office w/internet, monitors - great view!

Superhost
An aerial view of a modern, three-bedroom villa nestled among dense green foliage. The structure features a light-colored exterior with a metal roof. A pool area is visible at the back, framed by lush trees, creating a sense of privacy and connection to nature.
Villa in Las Escobas del Venado
4.8 out of 5 average rating, 5 reviews

El Nido, Jungle Villa with Pool at Venao

Escape to El Nido, a stunning 3-bedroom, 3-bathroom jungle villa offering the perfect blend of tranquility and modern comfort. Nestled in Playa Venao, Panama, this boho-chic home features vibrant interiors, breathtaking ocean views, and a private pool. Ideal for families, groups, or remote workers, El Nido is just 2 minutes from the beach and Venao’s lively center, where you’ll find top dining, activities, and local charm. With high-speed Wi-Fi, a fully equipped kitchen, and spacious living area

Guest favourite
A serene sunset casts soft hues of orange and pink across a calm ocean surface. Gentle waves reflect the sky's colors, while distant hills create a subtle silhouette along the horizon.
Villa in Las Escobas del Venado
5 out of 5 average rating, 15 reviews

Villa Tortugas 16, Venao Beach / Beachfront Club

Enjoy a spectacular Villa, just a short 3-minute walk to the beach in the most exclusive gated community, with security guards, surveillance & parking. There are 2 bedrooms, each with a private bathroom and an extra bathroom for guests, full kitchen, living room, and a beautiful terrace to rest with friends and family. The house has a 65" Samsung Smart TV/Apple TV, 130MB Wi-Fi internet in each room, & air conditioning. Our facilities at the oceanfront clubhouse & restaurant are exquisite.

Guest favourite
A spacious living area is presented with large glass doors, offering a panoramic view of the ocean and palm trees. Natural wood accents enhance the warm atmosphere, while comfortable seating is arranged around a coffee table. The dining area is visible in the background, creating an inviting and open space.
Villa in Playa Venao
5 out of 5 average rating, 6 reviews

Playa Laska – Oceanfront Escape with Infinity Pool

Welcome to Playa Laska, a luxury beachfront villa where tropical elegance meets modern comfort. With three beautifully designed bedrooms, a private infinity pool, and open-air decks surrounded by lush greenery, every corner invites you to unwind, connect, and savor the ocean breeze. Start your mornings with the sound of waves, relax by the pool or stroll along the shore, and let evenings unfold with dining under the stars. Every corner is thoughtfully crafted for a seamless and relaxing stay.

A shaded patio area features comfortable seating arrangements with dark wicker chairs and a matching table. An oceanfront saltwater pool is visible with loungers arranged beside it. Lush palm trees sway gently in the background against a clear blue sky.
Villa in Cambutal
4.62 out of 5 average rating, 13 reviews

Casa Almendra

A 3-bedroom luxury villa located on the pristine beaches of Cambutal, Panama. This beachfront paradise offers everything you need for a truly unforgettable stay... A spacious and elegantly designed living area, an open-concept kitchen, fully equipped with top-of-the-line appliances and breathtaking ocean views, and an oceanfront saltwater pool surrounded by comfortable loungers. Entirely off-grid with a state-of-the-art solar power system, your stay is not only luxurious but eco-friendly.

Guest favourite
A modern living area features a sectional sofa adorned with textured cushions, accompanied by a stylish armchair. A sleek fire feature is mounted on the wall, providing warmth. Natural light flows through large windows, with greenery visible outside, enhancing the space's freshness.
Villa in Las Escobas del Venado
4.9 out of 5 average rating, 10 reviews

Villa Sirena - Blue Venao

Villa Sirena is a modern beach apartment in the most luxarious resort in Playa Venao - 'Blue'. Only 2 minute walking distance from the beach and an exclusive beach club where you will have access to a stunning beachfront infinity pool, delicious restarunt, and a spacious relaxation area. The Blue community is a relaxed, central and secure gated community where you will always be just a few minutes walking distance from the best restaurant, surfing spots, parties and of course - the beach!

Villa in Pedasi
4.67 out of 5 average rating, 94 reviews

Super Private Beachfront 3BR Villa & Infinity Pool

Sky above, sand below, peace within ~ Welcome to la Dolce Vita! Located in Andromeda, an oceanfront gated community on the Azuero Peninsula. Andromeda villas offer amazing and unparalleled ocean views where you can be with the sights and sounds of nature at its most beautiful. Our sun-filled and stunning Villa is 3 bed / 3 bath for up to 4 adults and 3 kids Features a spectacular view, private pool and direct beach access. Fully equipped so you can feel at home and enjoy your getaway!

Guest favourite
The inviting living space features a plush white sofa adorned with textured cushions. A modern kitchen with sleek stainless steel appliances and bar seating is visible in the background. Pendant lights provide soft illumination, creating a cozy atmosphere.
Villa in Playa Venao
4.93 out of 5 average rating, 45 reviews

Villa La Piragua: 3BR Surfside Retreat: 5-7G

Welcome to Villa La Piragua, an enchanting sanctuary in Blue Playa Venao. Let yourself go in this tropical paradise with pristine beaches. This beautiful villa offers 3 comfortable bedrooms and 3 well appointed baths. Two bedrooms have dreamy queen beds, while the third features a bunk bed with a pullout and an additional twin bed. All bedrooms have smart TV's and WiFi. Enjoy a serene spacious atmosphere in the living area, kitchen, and terrace, ensuring a memorable family getaway.

A spacious bedroom features a wooden bed frame with a light-colored bedding set. Natural light enters through a nearby door leading to a balcony, complemented by a hammock and decorative curtains. A small plant sits on a wooden nightstand, adding a touch of greenery.
Villa in Cambutal
4.56 out of 5 average rating, 25 reviews

Pacific Escape

Pacific Escape looks out over an expanse of pacific ocean and protected reef. The 2 bedroom, 2 full-bath home has panoramic views of the ocean, mountains, and reef. Yet, it is close to the beach, restaurants and dining, and family-friendly activities. You’ll love the expansive oceanside porch, high ceilings, the ocean views from bedrooms and living room, and the ambiance. The villa is great for couples and families (with kids) because it sits at the top of a private gated road.

Guest favourite
A tranquil outdoor space is highlighted by lounge chairs positioned beside a Salt Water Infinity pool. The expansive view of the Pacific Ocean is visible in the background, with lush landscaping contributing to the serene atmosphere during dusk.
Villa in Punta Mala
5 out of 5 average rating, 6 reviews

3-BR Villa with Infinity Pool

Experience luxury at our 3-bedroom waterfront retreat, just steps from the beach. This gated community home features panoramic Pacific Ocean views, a Salt Water Infinity pool, and spacious interiors fully furnished with high-end amenities. Each bedroom includes ensuite bathrooms, with the master suite offering a king-sized bed and walk-in closet. Enjoy a gourmet kitchen, outdoor gazebo with BBQ, Sonos speakers, and high-speed Wi-Fi throughout. Perfect for families and groups.

Superhost
A spacious living area features a modern gray sofa paired with a wooden coffee table, accented by a woven rug. Bright light floods in through large sliding glass doors, which offer a view of the lush garden outside. Bar stools surround a kitchen island in the background.
Villa in Playa Venao
5 out of 5 average rating, 4 reviews

Playa Venao Blue 12 | Luxury Beach Escape Villa

A 3 bedroom villa centrally located at Blue, A gated community in Playa Venao with everything at your doorstep. Just a few minutes walk to the beach, local shops, restaurant and grocery store. Access to an oceanfront beach club that hosts an infinity pool, restaurant and casual sitting area. Enjoy the best of Playa Venao a great surf spot for beginners and experienced surfers. Local tours, yoga and fitness, restaurants and music. Playa Venao offers something for everyone.

Popular amenities for villa rentals in Los Santos Province