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House holiday rentals in Los Santos Province

Find and book unique houses on Airbnb

Top-rated house rentals in Los Santos Province

Guests agree: these houses are highly rated for location, cleanliness and more.

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Superhost
Home in Pedasi
4.91 out of 5 average rating, 78 reviews

2/2 Private Oasis Pedasi's best location & rental!

You wont find a better rental in Pedasi! Every aspect of the unit is upgraded and designed as if it was your home! Private pool with sound system, private outdoor kitchen, generator, 2 identical master suites with king beds, extra blow up queen mattress. Private laundry. Minutes walk from CooCoo Crazy or Jungle, two of the best restaurants in town. The beach a small jaunt away. Toiletries & basics included. ELECTRICITY IS CHARGED AT 10 A DAY. PROPERTY FOR SALE WITH DIRECT OWNER FINANCING

Guest favourite
A private pool is framed by a stone patio, surrounded by lush greenery and tropical plants. A shaded area features outdoor seating and a grill, while the enclosed space provides a sense of tranquility. The home is visible in the background, set against a clear blue sky.
Home in Pedasí
4.92 out of 5 average rating, 192 reviews

3 min to Pedasi, 5 min to the Beach, Private Pool!

Your family will be close to everything when you stay at this centrally-located place. Outfitted with room to sleep 6 and a fenced yard for your dog, Casa Catch and Relax has it all! Look us up online, Casa Catch and Relax You'll Love - Beach access a short drive or walk away (3 min drive, 10 min walk) - Central to town and local restaurants - Private, fenced outdoor space with pool - Cool days and nights with A/C in every room - Fully equipped kitchen and tons of sleeping space - Wifi

Guest favourite
A beachfront house features a thatched roof and is elevated on stilts, surrounded by lush greenery and palm trees. The structure showcases a spacious porch with wooden railings, offering a shaded area for relaxation and enjoying the natural landscape.
Home in Cambutal
5 out of 5 average rating, 27 reviews

Beachfront Gem w/ Ocean Views & Prime Surf Access

Welcome to your slice of beachfront paradise! Our home sits right on Cambutal's beautiful shoreline. Gorgeous ocean views greet you from every window, while the gentle rhythm of waves creates the perfect soundtrack for your stay. We've equipped the house with Starlink WiFi and a large dining table that doubles as an ideal workspace, making this a perfect retreat for both vacationers and remote workers. The house feels like a real home – comfortable, clean, and ready for your beach memories.

Superhost
A welcoming entrance is framed by vibrant tropical plants, with a pathway leading to a covered porch. The structure features a tiled roof and red steps, providing an inviting transition from the outdoors to the interior space.
Home in Pedasi
4.81 out of 5 average rating, 16 reviews

Peaceful Pedasi

Peaceful Pedasi. Get completely away from the city and forget the rest of the world exists. Pedasí is a town and corregimiento situated on the south-eastern tip of the Azuero Peninsula on Panama’s Pacific coast. And although remote enough to feel protected from the stresses of life, Pedasi offers wonderful dining and shopping. Our home offers a full functioning kitchen, large dining space, 5 Bedrooms, 4 Bathrooms, 2 car garage, private pool, and cabana with your own view of the ocean.

Top guest favourite
A bright living area features high wooden ceilings and large windows that invite natural light. A comfortable sofa is arranged beside a coffee table, with a television visible across the room. A dining area is highlighted by stylish lighting above the wooden counter.
Home in Cambutal
5 out of 5 average rating, 13 reviews

2 Bed/2 Bath Beachfront House in prime location

Welcome to Casa Marea! We invite you to relax with the whole family at our beautiful beachfront house. The location can’t be beat. Our spacious 2 bed/2 bath house is located on Playa Cambutal, with easy access to the surf break, fishing, and snorkeling right out front. The house is walking distance to restaurants, hotels, and the Local Market. Enjoy a relaxing night's sleep with AC and fans in the bedrooms and the sounds of the ocean in the background. We welcome you to beautiful Cambutal!

Superhost
The house exterior features a warm peach-colored facade with a large white-framed window. Tropical palm trees and vibrant flowering shrubs border the front, providing a refreshing touch to the entrance.
Home in Chitre
4.81 out of 5 average rating, 78 reviews

NinaHouse, spacious and cool house in Chitré.

House just for you, now with a water tank! Up to 7 people, spacious and in one of the best areas of Chitré, quiet and family-friendly, access to the pool in the social area, parks and courts, close to everything: supermarkets, casino, bus; come to Chitre and enjoy typical meals, crafts; plan your walks and visit the best beaches: Pedasi, Venao, Isla Iguana, you can work from NinaHouse with fast internet. We now have air conditioning in the living room for your comfort.

Guest favourite
The interior living space features large windows providing a view of lush greenery. A comfortable seating area with a cozy throw and cushions is complemented by a small coffee table. A dining area with wooden stools and a fully equipped kitchen is visible, enhancing the inviting ambiance.
Home in Playa Venao
4.96 out of 5 average rating, 27 reviews

Beachfront Tropical Chalet

Imagine waking up in oasis - a Tropical Chalet in a paradise full of flora and overlooking the turquoise blue Pacific Ocean and your own white sandy beach; hearing and seeing different species of monkeys and colorful birds. This brand new comfortable eco 2-bedroom 1-bath house is fully air conditioned, and has ocean views, fully equipped kitchen. 3 min. walk to the beach and hotel La Playita and 5 min. drive or 15 min walk from the famous Playa Venao surfing beach.

Top guest favourite
The exterior of Casa Serena showcases a spacious two-story structure with a warm, inviting facade featuring wooden accents. A wooden deck surrounds a private pool, and comfortable lounge chairs are positioned beside it. Umbrellas provide shade, while lush greenery complements the peaceful setting.
Home in Playa Los Destiladeros
5 out of 5 average rating, 25 reviews

Pedasí, Los Destiladeros Beach / Casa Serena

❤ Welcome to Casa Serena, escape to our stunning 3-bedroom ocean view house, perfectly located in Playa Los Destiladeros, an area of ​​beautiful beaches in Pedasí. This unique retreat offers a blend of modern luxury and coastal charm, ensuring an unforgettable vacation experience for you and your loved ones. Book your stay today and experience the magic of Casa Serena. Create lasting memories with your family and friends in this perfect ocean view escape.

Guest favourite
A modern tropical home is set amid lush greenery, featuring an expansive deck that connects to a serene pool. Large glass doors provide a view of the inviting interior and allow natural light to fill the space. Mountains and trees frame the backdrop.
Home in Playa Venao
4.97 out of 5 average rating, 69 reviews

Casa Samambaia - sea view tropical paradise w pool

With a modern tropical design, this home features a cozy living room and a stylish kitchen at the center of the social area. Open the glass doors to immerse yourself in open-concept living, seamlessly blending the indoors with the main terrace and the pool, all oriented towards the ocean view. With two en-suite bedrooms with AC and fans, the house is immersed in nature, green mountains, and a lovely garden, everything 5 minutes from the beach center.

Guest favourite
The modern house is surrounded by lush greenery, featuring a spacious wooden deck with lounge chairs and a private pool. Sliding glass doors enhance the connection with nature, while a covered terrace provides shaded seating areas for relaxation.
Home in Playa Venao
4.91 out of 5 average rating, 68 reviews

Casa Pelicano - Tropical house w pool and seaview

Welcome to Casa Pelicano! Indulge yourself in a retreat with breathtaking views of the ocean and mountains from every corner. Unwind in the private refreshing pool, where the turquoise waters seem to blend seamlessly with the horizon. The stylish interior features open-plan living spaces, perfect for entertaining or relaxing. Whether you're soaking up the sun or gazing at the moonlit ocean under the stars, this home is your ultimate escape.

Superhost
A colorful hammock hangs between two posts on a wooden terrace, overlooking a vast landscape. The sun sets in the distance, casting a warm glow over the scene, framed by lush greenery and bamboo fencing that adds privacy.
Home in Provincia de Los Santos
4.93 out of 5 average rating, 14 reviews

Casa Inito - Romantic Getaway

Indulge in the charm of Casa Inito, a thoughtfully crafted haven that invites you to experience a one-bedroom retreat like no other. This well-designed space seamlessly blends modern comfort with an intimate setting, creating the perfect atmosphere for your getaway. The Villa is located just 7 minutes from Playa Venao Beach (by car). ****(Vehicle a MUST, preferably SUV due to steep paved access road)****

Top guest favourite
The two-story house is framed by lush greenery, featuring large glass doors that open to a spacious patio. Comfortable seating areas are provided, accompanied by tropical plants. Warm outdoor lighting hangs above, enhancing the inviting ambiance, while views of the sea are visible through the glass.
Home in Cambutal
5 out of 5 average rating, 32 reviews

Beach side stay at Casa Blanca

This beautiful two bedroom, double-storey house sits in one of the best locations around, nestled amongst the trees and overlooking a stunning swimming bay in the tropical paradise of Cambutal. Perfectly situated, you will have the warm Pacific Ocean literally on your doorstep, as well as easy access to the highlights of a beach holiday - surfing, swimming, sunsets and more.

Popular amenities for house rentals in Los Santos Province