House holiday rentals in Los Santos Province
Find and book unique houses on Airbnb
Top-rated house rentals in Los Santos Province
Guests agree: these houses are highly rated for location, cleanliness and more.
Holiday rentals for every style
Get the amount of space that is right for you
Popular amenities for house rentals in Los Santos Province
House rentals with a pool
Home in Cambutal
4.6 out of 5 average rating, 5 reviewsCasa Gerard
21–28 Jul
Home in Pedasi
Casa Del Amor in Pedasi Panama
4–11 Jul
Home in PA
4.83 out of 5 average rating, 42 reviewsCozy and quiet beach house- pool
23–30 Aug
Home in Pedasí
5.0 out of 5 average rating, 25 reviewsBeautiful Home, Birds, Monkeys, Pool, Trail
18–25 Feb
Home in Playa Venao
5.0 out of 5 average rating, 6 reviewsCasa Pelicano - Tropical house w pool and seaview
12–19 Jul
Home in Pedasi
5.0 out of 5 average rating, 8 reviewsLittle Bit of Heaven
17–24 Jan
Home in Pedasi
4.64 out of 5 average rating, 70 reviewsSuper Private Beachfront 3BR Villa + Infinity Pool
11–18 Aug
Home in Cañas
4.94 out of 5 average rating, 17 reviewsLa Hacienda Ojo de Agua * Full Summer Here *
8–15 Apr
Weekly house rentals
Home in Cambutal
5.0 out of 5 average rating, 5 reviewsCasa Concha and Luna Negra
7–14 Jan
Home in Tonosí
4.94 out of 5 average rating, 16 reviewsBeachfront Home w/key to empty beach
15–22 Sep
Home in Chitre
4.53 out of 5 average rating, 15 reviewsHermosa Casa en Chitre
22–29 Aug
Home in San Juan Bautista
5.0 out of 5 average rating, 11 reviewsNew house in Chitre located in a very central location
27 Jan – 3 Feb
Home in La Villa de los Santos
4.67 out of 5 average rating, 3 reviewsHouse in La Villa de Los Santos
1–8 Oct
Home in El Ciruelo
4.88 out of 5 average rating, 49 reviewsView of the Sea , Ocean view El Ciruelo
11–18 Jun
Home in Pedasi
4.88 out of 5 average rating, 26 reviewsCasa Luna 2 bdrm 2 bath walk to square!
16–23 Jul
Home in Chitré
4.88 out of 5 average rating, 8 reviewsMinimalist House In Chitre
30 Aug – 6 Sep
Private house rentals
Home in Pedasí
5.0 out of 5 average rating, 6 reviewsAdorable Pedasi 2 bdrm fenced home; Walk to Square
29 Sep – 6 Oct
Home in Las Tablas
4.52 out of 5 average rating, 25 reviewsEntire House "Las Marias"
8–15 Nov
Home in Pedasí
4.73 out of 5 average rating, 30 reviewsVillage House #1 - 2BR Beautiful Towny Pedasi Home
7–14 Jun
Home in Chitré
4.62 out of 5 average rating, 13 reviewsGrandpa's Casita Two Blocks From Downtown Chitré
21–28 Sep
Home in Las Tablas
4.67 out of 5 average rating, 3 reviewsVilla Carola, Las Tablas
27 Aug – 3 Sep
Home in Los Ángeles
5.0 out of 5 average rating, 3 reviewsLa casa de Campo de guelo Nino
6–13 Jul
Home in Chitre
4.67 out of 5 average rating, 3 reviewsCasa Abuela Aurelia
9–16 Aug
Home in Chitré
4.63 out of 5 average rating, 8 reviewsCozy country house.
31 May – 7 Jun
Destinations to explore
- Townhouse rentals Panama
- Beach house rentals Panama
- Guest house rentals Panama
- Treehouse rentals Panama
- House rentals Panama
- Tiny house rentals Panama
- Townhouse rentals Panama
- Beach house rentals Panama
- Guest house rentals Panama
- Treehouse rentals Panama
- House rentals Panama
- Tiny house rentals Panama
- House rentals Playa Coronado
- House rentals Altos del Maria
- Rentals with a hot tub Los Santos Province
- Rentals with pools Los Santos Province
- Apartment rentals Los Santos Province
- Smoking-friendly rentals Los Santos Province
- Rentals with outdoor seating Los Santos Province
- Rentals with a patio Los Santos Province
- Hotel rentals Los Santos Province
- Family-friendly rentals Los Santos Province
- Monthly Rentals Los Santos Province
- Rentals with beach access Los Santos Province
- Beachfront rentals Los Santos Province
- Waterfront rentals Los Santos Province
- Pet-friendly rentals Los Santos Province
- Villa rentals Los Santos Province
- Rentals with a firepit Los Santos Province
- Rentals with a washing machine and dryer Los Santos Province
- Flat rentals Los Santos Province
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom