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Villa holiday rentals in Los Santos Province

Find and book unique villas on Airbnb

Top-rated villa rentals in Los Santos Province

Guests agree: these villas are highly rated for location, cleanliness and more.

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Guest favourite
Villa in Las Escobas del Venado
5 out of 5 average rating, 13 reviews

Villa Tortugas 16, Playa Venao / Beachfront Club

Enjoy a spectacular Villa, just a short 3-minute walk to the beach in the most exclusive gated community, with security guards, surveillance & parking. There are 2 bedrooms, each with a private bathroom and an extra bathroom for guests, full kitchen, living room, and a beautiful terrace to rest with friends and family. The house has a 65" Samsung Smart TV/Apple TV, 130MB Wi-Fi internet in each room, & air conditioning. Our facilities at the oceanfront clubhouse & restaurant are exquisite.

Villa in Playa Venao
5 out of 5 average rating, 3 reviews

Playa Laska – Beachfront Luxury Villa & Pool | A

Welcome to Playa Laska, a luxury beachfront villa where tropical elegance meets modern comfort. With three beautifully designed bedrooms, a private infinity pool, and open-air decks surrounded by lush greenery, every corner invites you to unwind, connect, and savor the ocean breeze. Start your mornings with the sound of waves, relax by the pool or stroll along the shore, and let evenings unfold with dining under the stars. Every corner is thoughtfully crafted for a seamless and relaxing stay.

Guest favourite
Villa in Playa Venao
4.91 out of 5 average rating, 54 reviews

Villa Verde - Luxury & Cozy Villa 1BR #26 BlueVenao

Relax & Calm in a cozy villa with an amazing view of the mountains, located in Playa Venao Beach The villa is fully equipped with 1 Queen size bed and a Sofa bed, High Speed Wi-Fi, Netflix, kitchen cooking tools and appliances like stove, oven, dishwasher, microwave, coffee maker, toaster and blender. Also, you will find a complete laundry with washer and dryer, towels for use inside the Villa, as well as for the pool & beach. Bedrooms come with complete bedding clothes/linens and pillows

Superhost
Villa in Cambutal
4.86 out of 5 average rating, 7 reviews

Casa Almendra

A 3-bedroom luxury villa located on the pristine beaches of Cambutal, Panama. This beachfront paradise offers everything you need for a truly unforgettable stay... A spacious and elegantly designed living area, an open-concept kitchen, fully equipped with top-of-the-line appliances and breathtaking ocean views, and an oceanfront saltwater pool surrounded by comfortable loungers. Entirely off-grid with a state-of-the-art solar power system, your stay is not only luxurious but eco-friendly.

Villa in Las Escobas del Venado
4.57 out of 5 average rating, 14 reviews

Villa Atlantis - Blue Venao 3BR

Villa Atlantis is a modern beach house in the most luxarious resort in Playa Venao - 'Blue'. Only 2 minute walking distance from the beach and an exclusive beach club where you will have access to a stunning beachfront infinity pool, delicious restarunt, and a spacious relaxation area. The Blue community is a relaxed, central and secure gated community where you will always be just a few minutes walking distance from the best restaurant, surfing spots, parties and of course - the beach!

Villa in Pedasi
4.66 out of 5 average rating, 90 reviews

Super Private Beachfront 3BR Villa & Infinity Pool

Sky above, sand below, peace within ~ Welcome to la Dolce Vita! Located in Andromeda, an oceanfront gated community on the Azuero Peninsula. Andromeda villas offer amazing and unparalleled ocean views where you can be with the sights and sounds of nature at its most beautiful. Our sun-filled and stunning Villa is 3 bed / 3 bath for up to 4 adults and 3 kids Features a spectacular view, private pool and direct beach access. Fully equipped so you can feel at home and enjoy your getaway!

Guest favourite
Villa in Playa Venao
4.93 out of 5 average rating, 43 reviews

Villa La Piragua: 3BR Surfside Retreat: 5-7G

Welcome to Villa La Piragua, an enchanting sanctuary in Blue Playa Venao. Let yourself go in this tropical paradise with pristine beaches. This beautiful villa offers 3 comfortable bedrooms and 3 well appointed baths. Two bedrooms have dreamy queen beds, while the third features a bunk bed with a pullout and an additional twin bed. All bedrooms have smart TV's and WiFi. Enjoy a serene spacious atmosphere in the living area, kitchen, and terrace, ensuring a memorable family getaway.

Villa in Pedasi
4.5 out of 5 average rating, 44 reviews

Elegant Villa Cascada in Pedasi, 5 bdrm sleeps 11

You may never want to leave this beautiful Pedasi 2 story villa in the gated community of Andromeda. There is 5 professionally decorated bedrooms with 4 full bathrooms and one 1/2 balf. This home will sleep up to 10 people. There are covered patios upstairs and downstairs for you to enjoy the beautiful Pedasi sunrise and sunsets. The neighborhood boasts one of the most stunning infinity pools in the azuero peninsula! This community pool is available for you to use for a daily fee.

Villa in Cambutal
4.56 out of 5 average rating, 25 reviews

Pacific Escape

Pacific Escape looks out over an expanse of pacific ocean and protected reef. The 2 bedroom, 2 full-bath home has panoramic views of the ocean, mountains, and reef. Yet, it is close to the beach, restaurants and dining, and family-friendly activities. You’ll love the expansive oceanside porch, high ceilings, the ocean views from bedrooms and living room, and the ambiance. The villa is great for couples and families (with kids) because it sits at the top of a private gated road.

Guest favourite
Villa in Punta Mala
5 out of 5 average rating, 6 reviews

3-BR Villa with Infinity Pool

Experience luxury at our 3-bedroom waterfront retreat, just steps from the beach. This gated community home features panoramic Pacific Ocean views, a Salt Water Infinity pool, and spacious interiors fully furnished with high-end amenities. Each bedroom includes ensuite bathrooms, with the master suite offering a king-sized bed and walk-in closet. Enjoy a gourmet kitchen, outdoor gazebo with BBQ, Sonos speakers, and high-speed Wi-Fi throughout. Perfect for families and groups.

Villa in Playa Venao

Playa Venao Blue 12 | Luxury Beach Escape Villa

A 3 bedroom villa centrally located at Blue, A gated community in Playa Venao with everything at your doorstep. Just a few minutes walk to the beach, local shops, restaurant and grocery store. Access to an oceanfront beach club that hosts an infinity pool, restaurant and casual sitting area. Enjoy the best of Playa Venao a great surf spot for beginners and experienced surfers. Local tours, yoga and fitness, restaurants and music. Playa Venao offers something for everyone.

Superhost
Villa in Las Escobas del Venado
4.88 out of 5 average rating, 8 reviews

Villa Ceviche, Surf Villa at the Heart of Venao

Villa Ceviche is a stylish three-bedroom villa in the heart of Playa Venao, just steps from the beach, shops, and restaurants. Guests enjoy full access to Blue Venao’s resort amenities, including the beachfront infinity pool, social areas, and restaurant and bar. The villa is beautifully decorated by its owner, a renowned Panamanian interior designer, giving each space a refined and inviting atmosphere that blends comfort with coastal charm.

Popular amenities for villa rentals in Los Santos Province