Villa holiday rentals in Los Santos Province

Find and book unique villas on Airbnb

Top-rated villa rentals in Los Santos Province

Guests agree: these villas are highly rated for location, cleanliness and more.

%{current} / %{total}1 / 1

Superhost

An aerial view of a modern, three-bedroom villa nestled among dense green foliage. The structure features a light-colored exterior with a metal roof. A pool area is visible at the back, framed by lush trees, creating a sense of privacy and connection to nature.

Villa in Las Escobas del Venado

5 out of 5 average rating, 3 reviews

El Nido, Jungle Villa with Pool at Venao

Escape to El Nido, a stunning 3-bedroom, 3-bathroom jungle villa offering the perfect blend of tranquility and modern comfort. Nestled in Playa Venao, Panama, this boho-chic home features vibrant interiors, breathtaking ocean views, and a private pool. Ideal for families, groups, or remote workers, El Nido is just 2 minutes from the beach and Venao’s lively center, where you’ll find top dining, activities, and local charm. With high-speed Wi-Fi, a fully equipped kitchen, and spacious living area

Guest favourite

A serene sunset casts soft hues of orange and pink across a calm ocean surface. Gentle waves reflect the sky's colors, while distant hills create a subtle silhouette along the horizon.

Villa in Las Escobas del Venado

5 out of 5 average rating, 13 reviews

Villa Tortugas 16, Playa Venao / Beachfront Club

Enjoy a spectacular Villa, just a short 3-minute walk to the beach in the most exclusive gated community, with security guards, surveillance & parking. There are 2 bedrooms, each with a private bathroom and an extra bathroom for guests, full kitchen, living room, and a beautiful terrace to rest with friends and family. The house has a 65" Samsung Smart TV/Apple TV, 130MB Wi-Fi internet in each room, & air conditioning. Our facilities at the oceanfront clubhouse & restaurant are exquisite.

A spacious living area is presented with large glass doors, offering a panoramic view of the ocean and palm trees. Natural wood accents enhance the warm atmosphere, while comfortable seating is arranged around a coffee table. The dining area is visible in the background, creating an inviting and open space.

Villa in Playa Venao

5 out of 5 average rating, 5 reviews

Playa Laska – Oceanfront Escape with Infinity Pool

Welcome to Playa Laska, a luxury beachfront villa where tropical elegance meets modern comfort. With three beautifully designed bedrooms, a private infinity pool, and open-air decks surrounded by lush greenery, every corner invites you to unwind, connect, and savor the ocean breeze. Start your mornings with the sound of waves, relax by the pool or stroll along the shore, and let evenings unfold with dining under the stars. Every corner is thoughtfully crafted for a seamless and relaxing stay.

Villa in Las Escobas del Venado

4.25 out of 5 average rating, 4 reviews

Villa Paradise - Blue Venao 3BR

Villa Paradise is a modern beach apartment in the most luxarious resort in Playa Venao - 'Blue'. Only 2 minute walking distance from the beach and an exclusive beach club where you will have access to a stunning beachfront infinity pool, delicious restarunt, and a spacious relaxation area. The Blue community is a relaxed, central and secure gated community where you will always be just a few minutes walking distance from the best restaurant, surfing spots, parties and of course - the beach!

Superhost

A shaded patio area features comfortable seating arrangements with dark wicker chairs and a matching table. An oceanfront saltwater pool is visible with loungers arranged beside it. Lush palm trees sway gently in the background against a clear blue sky.

Villa in Cambutal

4.86 out of 5 average rating, 7 reviews

Casa Almendra

A 3-bedroom luxury villa located on the pristine beaches of Cambutal, Panama. This beachfront paradise offers everything you need for a truly unforgettable stay... A spacious and elegantly designed living area, an open-concept kitchen, fully equipped with top-of-the-line appliances and breathtaking ocean views, and an oceanfront saltwater pool surrounded by comfortable loungers. Entirely off-grid with a state-of-the-art solar power system, your stay is not only luxurious but eco-friendly.

Guest favourite

The inviting living space features a plush white sofa adorned with textured cushions. A modern kitchen with sleek stainless steel appliances and bar seating is visible in the background. Pendant lights provide soft illumination, creating a cozy atmosphere.

Villa in Playa Venao

4.93 out of 5 average rating, 44 reviews

Villa La Piragua: 3BR Surfside Retreat: 5-7G

Welcome to Villa La Piragua, an enchanting sanctuary in Blue Playa Venao. Let yourself go in this tropical paradise with pristine beaches. This beautiful villa offers 3 comfortable bedrooms and 3 well appointed baths. Two bedrooms have dreamy queen beds, while the third features a bunk bed with a pullout and an additional twin bed. All bedrooms have smart TV's and WiFi. Enjoy a serene spacious atmosphere in the living area, kitchen, and terrace, ensuring a memorable family getaway.

A modern kitchen showcases sleek cabinetry and a spacious island with a gas cooktop. Pendant lights hang above the island, illuminating the open space. A wooden dining table is visible, accompanied by decorative elements that enhance the minimalist design.

Villa in Pedasi

4.5 out of 5 average rating, 44 reviews

Elegant Villa Cascada in Pedasi, 5 bdrm sleeps 11

You may never want to leave this beautiful Pedasi 2 story villa in the gated community of Andromeda. There is 5 professionally decorated bedrooms with 4 full bathrooms and one 1/2 balf. This home will sleep up to 10 people. There are covered patios upstairs and downstairs for you to enjoy the beautiful Pedasi sunrise and sunsets. The neighborhood boasts one of the most stunning infinity pools in the azuero peninsula! This community pool is available for you to use for a daily fee.

A modern kitchen area features a large island with four stylish chairs. Stainless steel appliances, including a refrigerator and oven, are positioned against a light-colored backsplash. Natural light floods the space through expansive windows, creating a bright and inviting atmosphere.

Villa in Playa Venao

4.53 out of 5 average rating, 15 reviews

Cozy & Comfy 2BR Villa 7 at Playa Venao

Welcome to Villa-7! This beautiful Villa is located in BlueVenao on the Azuero Peninsula, a unique beachfront community and tropical paradise with miles of beautiful beaches. Just a quick walk and you’ll be on the beach, ready for new adventures! Our spacious and bright Villa-7 has 2 bedrooms, one w/Queen bed and ensuite bathroom, and the other w/Twin over full bunk bed. There's also a sofa bed in the Living. The open kitchen and terrace are fully equipped for your tropical getaway.

Guest favourite

A tranquil infinity pool is visible, surrounded by lush greenery and palm trees. The crystal-clear water reflects the sky, with the ocean seen in the background. The deck area includes shaded seating and natural landscaping, creating an inviting space for relaxation.

Villa in Playa Venao

4.91 out of 5 average rating, 22 reviews

Best Located Villa in Blue | With Private Pool

Vivienda en Playa Venao; con todo lo necesario para pasar unas excelentes vacaciones con familiares o amigos. 7 personas incluyendo bebés y niños. Se pueden adicionar personas con costo extra. La vivienda es parte de un proyecto privado con garita de seguridad y estacionamiento gratuito. Disfruta de Playa Venao, con sus magníficas olas, disfrutar de un tour a Isla Iguana, hacer yoga, comer delicioso, disfrutar de la vida nocturna y de la naturaleza... todo en este paraíso tropical.

Guest favourite

A tranquil outdoor space is highlighted by lounge chairs positioned beside a Salt Water Infinity pool. The expansive view of the Pacific Ocean is visible in the background, with lush landscaping contributing to the serene atmosphere during dusk.

Villa in Punta Mala

5 out of 5 average rating, 6 reviews

3-BR Villa with Infinity Pool

Experience luxury at our 3-bedroom waterfront retreat, just steps from the beach. This gated community home features panoramic Pacific Ocean views, a Salt Water Infinity pool, and spacious interiors fully furnished with high-end amenities. Each bedroom includes ensuite bathrooms, with the master suite offering a king-sized bed and walk-in closet. Enjoy a gourmet kitchen, outdoor gazebo with BBQ, Sonos speakers, and high-speed Wi-Fi throughout. Perfect for families and groups.

A spacious living area features a modern gray sofa paired with a wooden coffee table, accented by a woven rug. Bright light floods in through large sliding glass doors, which offer a view of the lush garden outside. Bar stools surround a kitchen island in the background.

Villa in Playa Venao

5 out of 5 average rating, 3 reviews

Playa Venao Blue 12 | Luxury Beach Escape Villa

A 3 bedroom villa centrally located at Blue, A gated community in Playa Venao with everything at your doorstep. Just a few minutes walk to the beach, local shops, restaurant and grocery store. Access to an oceanfront beach club that hosts an infinity pool, restaurant and casual sitting area. Enjoy the best of Playa Venao a great surf spot for beginners and experienced surfers. Local tours, yoga and fitness, restaurants and music. Playa Venao offers something for everyone.

A pair of comfortable chairs is positioned under a wooden pergola surrounded by lush green foliage and blooming flowers. The tranquil pool reflects the clear sky, inviting guests to relax in this serene outdoor space.

Villa in Pedasí

4.84 out of 5 average rating, 32 reviews

Villa del Sol Panama-Private Paradise

Set in Los Destiladeros, 7 km from Pedasì, Villa del Sol B&B Boutique boasts an outdoor pool and barbecue. Free WiFi is featured throughout the property and free private parking is available on site. Every room at this bed and breakfast is air conditioned and is equipped with a flat-screen TV with satellite channels. Safety Box. You will find a kettle and a fridge in the room. Rooms are fitted with a private little garden with hammoc.