
Hotel holiday rentals in Mission Bay
Find and book unique hotel rentals on Airbnb
Top-rated hotel rentals in Mission Bay
Guests agree: these hotel rentals are highly rated for location, cleanliness and more.
Holiday rentals for every style
Get the amount of space that is right for you
Popular amenities for hotel rentals in Mission Bay
Family-friendly hotel rentals

Stylish San Diego downtown Suite

Ocean Beach - Bed in 6-Bed Female Dorm

Soothing neutrals & killer coastline location

Stylish South Bay Home

Pet-friendly Hotel with Free Breakfast and Pool!

Equipped with the essentials

Ocean Beach - Bed in 6-Bed Mixed Room

3BR Suite w/ Event Space & Resort Amenities Sleep8
Hotel rentals with a pool

Recently reno’d escape near the Gaslamp Quarter

Convenient Base Near San Diego Zoo & Balboa Park

Marriott At San Diego - Studio

Iconic Resort in San Diego

San Diego Stay w/ Pool + Free Airport Shuttle

Playful escape near games & concerts at Petco Park

1-Bedroom Hotel Suite - 2 beds

Free B’fast & Parking – Minutes to Pacific Beach
Hotel rentals with a patio

Coronado Beach Resort July 6-13

Modern King Room | Luxe Stay in Little Italy

WorldMark Inn at the Park

Club Wyndham Harbour Lights

Queen Studio in Central Little Italy (Patio)

San Diego 2 Queen Suite City View w/ Breakfast

Charming 1 bedroom resort steps away from beach

Comic-Con 2026: Spacious King Suite + Sofa Bed
Destinations to explore
- Southern California Holiday rentals
- Los Angeles Holiday rentals
- Stanton Holiday rentals
- Las Vegas Holiday rentals
- Channel Islands of California Holiday rentals
- San Diego Holiday rentals
- Palm Springs Holiday rentals
- San Fernando Valley Holiday rentals
- Henderson Holiday rentals
- Las Vegas Strip Holiday rentals
- Anaheim Holiday rentals
- Santa Monica Holiday rentals
- Rentals with beach access Mission Bay
- Rentals with a fireplace Mission Bay
- Apartment rentals Mission Bay
- Flat rentals Mission Bay
- Cottage rentals Mission Bay
- Waterfront rentals Mission Bay
- Rentals with outdoor seating Mission Bay
- Rentals with pools Mission Bay
- Pet-friendly rentals Mission Bay
- Rentals with a sauna Mission Bay
- Rentals with a patio Mission Bay
- Rentals with a beach view Mission Bay
- Beachfront rentals Mission Bay
- Family-friendly rentals Mission Bay
- Rentals with a washing machine and dryer Mission Bay
- Rentals with a hot tub Mission Bay
- House rentals Mission Bay
- Fitness-friendly rentals Mission Bay
- Rentals with a firepit Mission Bay
- Townhouse rentals Mission Bay
- Rentals with an EV charger Mission Bay
- Hotel rentals San Diego
- Hotel rentals San Diego County
- Hotel rentals California
- Hotel rentals United States
- Rosarito Beach
- Oceanside City Beach
- Torrey Pines State Beach
- Pacific Beach
- Tijuana Beach
- Coronado Beach
- SeaWorld San Diego
- San Clemente State Beach
- LEGOLAND California
- University of California San Diego
- San Diego Zoo Safari Park
- San Onofre Beach
- Balboa Park
- Oceanside Harbor
- Coronado Shores Beach
- Black's Beach
- Pechanga Resort Casino
- Belmont Park
- Trestles Beach
- Surf Beach
- Sesame Place San Diego
- Moonlight Beach
- Liberty Station
- Law Street Beach