
Hotel holiday rentals in Mission Bay
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Top-rated hotel rentals in Mission Bay
Guests agree: these hotel rentals are highly rated for location, cleanliness and more.
Holiday rentals for every style
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Popular amenities for hotel rentals in Mission Bay
Family-friendly hotel rentals

Stylish San Diego downtown Suite

2 Pet-friendly Rooms—Minutes to Mission Bay Beach

Cozy Twin Room w/ Ensuite Bath, Desk & A/C in SD

Pet-friendly Hotel with Free Breakfast and Pool!

Equipped with the essentials

Clean 1 Bedroom San Diego-Poway

Hit the Trails in La Mesa + Free Breakfast & Pool

Hotel Marisol Coronado - King Room
Hotel rentals with a pool

1-Bedroom Hotel Suite - 2 beds

Recently reno’d escape near the Gaslamp Quarter

Iconic Resort in San Diego

Soothing neutrals & killer coastline location

Beachside La Jolla Stay | 1 Unit | Near Shores

Playful escape near games & concerts at Petco Park

Idyllic beachside escape with outdoor pool

Spacious King Bed|Pool|Free Parking
Hotel rentals with a patio

Modern King Room | Luxe Stay in Little Italy

Club Wyndham Harbour Lights

Queen Studio in Central Little Italy (Patio)

Comic-Con 2026: Spacious King Suite + Sofa Bed

ITH Mission Beach Backpacker Hostel Mixed Dorm

2 bd/2 bth Resort Style Hotel

Worldmark Studio Sleeps 4

WorldMark San Diego Mission Valley Two Bedroom
Destinations to explore
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