Boutique hotel holiday rentals in Missouri

Find and book unique boutique hotel rentals on Airbnb

Top-rated boutique hotel rentals in Missouri

Guests agree: these boutique hotel rentals are highly rated for location, cleanliness and more.

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Guest favourite

Hotel room in Washington

4.95 out of 5 average rating, 111 reviews

River Sirens Hotel Deluxe Suite

11 Room Boutique Hotel in beautiful Downtown Washington. Each room has: Private Entrance Guest Access - Key Pad, Free Parking, King Size bed, TV, Wifi, Hair Dryer, Individual A/C & Heat. Guests can enjoy a shower room featuring a changing area with separate vanity and water closet spaces. Every room as a very large balcony with river views. Each room is also equipped with a full kitchen featuring large refrigerators w/ ice dispensers, induction stove top, microwave, toaster, and coffee station.

Guest favourite

Hotel room in Osceola

4.92 out of 5 average rating, 87 reviews

Historic Commercial Hotel(1868),Sally Rand Suite

The Historic Commercial Hotel (Est.1868) on the Downtown square in beautiful Osceola,Missouri. Old world feel with modernized accommodations. The Historic Commercial Hotel has numerous themed rooms which are designed and named after past historical guests. This specific room is "The Sally Rand Suite". Named after past historical guest Sally Rand ( 1904 – 1979) who was an American burlesque dancer and Silver Screen star, most noted for her ostrich feather fan dance and balloon bubble dance.

Guest favourite

Hotel room in Springfield

4.95 out of 5 average rating, 186 reviews

“Camp Rockwood”at Rockwood Motor Court on Route 66

Rockwood Motor Court, on historic Route 66, was built in 1929. Each room is themed and furnished to the era of Route 66. Camp Rockwood pays homage to the important history of motor courts along the road. It is decorated with historic photos of Rockwood and other courts and motels. Newly renovated in 2019, you’ll enjoy clean and comfortable room amenities while experiencing authentic motor court lodging. Need more space? We have larger rooms or can package multiple rooms for your group.

Guest favourite

Hotel room in Springfield

4.98 out of 5 average rating, 42 reviews

Culture Boutique Hotel: Casablanca Suite

We're located on Historic C-Street, home to artisan shops, Askinosie, a farmer’s market, yoga studios, wedding venues + more. Downstairs from our hotel is our very own coffee shop! Our loft-like suites feature furniture made from reclaimed materials from our building, a converted mattress factory. Each suite is inspired by a city in Eurasia. The rooms boast high ceilings, a 39in tv, a refrigerator, microwave and a V60, Electric Kettle, + complimentary coffee from Eurasia Coffee & Tea.

Superhost

Hotel room in Pacific

4.92 out of 5 average rating, 13 reviews

Captain two room for two with pool

Individual room bookings are allowed to 6 months in advance. For information about booking the hotel privately for an event. Please contact us. Cozy queen bedroom with a full bath in a boutique hotel. You have access to the kitchen, dining and all community area within the hotel. Only 1 med. to large dog in this size room. If traveling with smaller dogs please inquire. This room is located on the first floor in the community area. There may be a potential for noise due to this.

Guest favourite

Hotel room in Hannibal

4.95 out of 5 average rating, 108 reviews

The Woodsman Suite

A third floor suite, facing the river with the train tracks only a couple blocks away. It took 2 months to do the ceiling. Carefully polished and placed the old lath in a specific design, the ceiling is a work of art. Eighty percent of the material used in this room is from re purposed lumber, either from this building or from a childhood barn built in the late 1800's. It will take you a while to notice every detail down to the toilet paper holder which is from an old barn post.

Guest favourite

Hotel room in Eldon

5 out of 5 average rating, 30 reviews

#10 A 1930’s motor court, Historic Randles Court

Family owned and operated! Built in the early 1930s, our recently restored rooms will take you back to simple times. The days of bus & railway rest stops, road-trips in the family car, and the quintessential motor court. Our town is alive with new and old businesses alike - places to eat, shop, and play for everyone in the family! We’re centrally located in downtown Eldon-just 15 minutes from the Lake of the Ozarks and 30 minutes from Jefferson City.

Guest favourite

Hotel room in Perryville

5 out of 5 average rating, 5 reviews

The Atrium - A Boutique Hotel - Suite 17

The Atrium is a historic building located in downtown Perryville, MO that has recently been beautifully rehabbed. Each room is a new experience. Spend your time resting and recharging in your private room, playing pool/socializing in the community lounge, or getting some fresh air in the outdoor courtyard. *DIsclaimer* The Atrium is located right next to the local downtown night life, so you may hear noise between the hours of 10:30pm-1:30am.

Guest favourite

Hotel room in Seneca

4.86 out of 5 average rating, 14 reviews

The Den Suite

Cozy, country, and charming in the open floor plan of The Den. Guests will be able to enjoy the comforts of Small Town America; while, being minutes away from local attractions. Queen Log Bed sleeps 2 guest, kitchenette (stocked with dishes, coffee maker, and microwave), and includes such amenities as guest-controlled A/C and Heat, Wi-Fi access, Smart TV, and more!

Superhost

Hotel room in Washington

4.87 out of 5 average rating, 141 reviews

430 West Front: Balcony Riverfront View

This room is located on the second floor over our quaint wine bar with a private balcony overlooking the Missouri River. Enjoy a cup of coffee or glass of wine from our wine bar on your private balcony. Just steps from our Historic downtown riverfront community with plenty of bars, restaurants, and charming shops to explore.

Guest favourite

Hotel room in Saint Louis

4.87 out of 5 average rating, 604 reviews

Evergreen Room Queen Bed at BnB in CWE

This is one of the available rooms we have at our BnB in the Central West End - a 125 year old house in one of St. Louis' most historic neighborhoods. It has one Queen sized bed, a kitchen space and bathroom shared with two other guest rooms on the floor. Within a short walk of the basilica and many bars and restaurants!

Superhost

Hotel room in Louisiana

5 out of 5 average rating, 5 reviews

The Eagles Nest Inn

The Eagles Nest Inn is a family-run Inn tucked away in historic downtown Louisiana, Missouri. Our lovingly restored historic building features comfortable and inviting guest rooms, each with its own unique character. You'll experience our quaint town like a local, thanks to our helpful tips and recommendations.