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House holiday rentals in Santa Cruz County

Find and book unique houses on Airbnb

Top-rated house rentals in Santa Cruz County

Guests agree: these houses are highly rated for location, cleanliness and more.

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Top guest favourite
A well-maintained yard features mature trees providing shading, with a spacious lawn that stretches towards the hacienda. The structure's exterior is characterized by a traditional design, complemented by a covered porch area. Clouds drift in the sky, hinting at a serene atmosphere.
Home in Arivaca
4.85 out of 5 average rating, 117 reviews

Private Getaway: Pandora Ranch House in Arivaca

Pandora is a private remote hacienda located on 20 acres in the high grasslands of the Sonoran Desert with 6 bedrooms, 6 bathrooms, a fully equipped kitchen, a dining room, living room. A well maintained yard with mature trees and charcoal BBQ grills invites to enjoy time outside. Minutes away from the quaint town of Arivaca, Buenos Aires Wildlife Refuge, Arivaca Lake and the Coronado National Forest Pandora offers easy access to hiking, boating,fishing, bird watching and off road exploration.

Top guest favourite
The spacious ranch house is situated on a gravel driveway, surrounded by green grass and gently rolling hills. A clear blue sky with wispy clouds serves as a backdrop, highlighting the peaceful rural setting and bringing attention to the home's exterior features.
Home in Sonoita
4.94 out of 5 average rating, 102 reviews

McFitz Guest Ranch

McFitz Ranch House is fully remodeled and available. Its a 3000 sqft 4 bedroom 3 bathroom w/ two master suites, and game room on 5 acres of beautiful horse property. Close to many attractions such as several wineries, brewery, the Sonoita rodeo grounds, Parker Canyon and Patagonia Lake, La Cienega Preserve and more. This location is ideal for Wedding Parties, Wine vacations, Rodeo, Kentucky Derby Fans, bird watching the Santa Cruz County Fair, hunting seasons or family weekends to the lake

Top guest favourite
A serene landscape features rolling mountains bathed in warm light from a setting sun. The view encompasses lush greenery and a dirt path leading to a guest house nestled among the hills, highlighting a peaceful rural retreat.
Home in Patagonia
5 out of 5 average rating, 35 reviews

Serenity, Starlink and waking up with bird songs

Wake up to nothing but bird sounds, enjoy morning coffee and the bright stars in dark nights on the covered patio. Contemporary furnished, spacious guest house with beautiful Mountain Views, in rural location, but close vicinity to the towns of Patagonia and Sonoita. Open kitchen - dining area floor plan. The house is set up with all amenities needed by seasonal visitors and remote working professionals. No pets. A small dog may be ok. 1 month or longer preferred. Shorter stays on request.

Superhost
A single-story home is presented, featuring a neutral-colored exterior with a pitched roof. A spacious driveway leads to a double garage, while a wrought iron gate enhances the entrance. Desert landscaping with native plants surrounds the property, complemented by a clear blue sky above.
Home in Rio Rico
4.88 out of 5 average rating, 8 reviews

Desert Oasis Retreat

Relax with the whole family at this beautiful home. Our home has 3 bedrooms. Master suite with large walk-in closet, TV in room. Double sink vanity and a large soaking tub/shower. Second bedroom has a double size bed and walk-in closet, TV in room. Third bedroom has trundle bed (basically two twin beds and large closet. Beautiful living room, comfy family room and all appliances kitchen. Dining area seats 6. Located in the quiet hills of Rio Rico. Valley scenery to enjoy in the evening.

Guest favourite
A southwestern-style ranch home is nestled on expansive land, surrounded by rolling plains. The structure features a white exterior with traditional architectural elements. Majestic mountains are visible in the distance under a clear sky, enhancing the serene rural landscape.
Home in Elgin
4.93 out of 5 average rating, 165 reviews

Peaceful SW-style ranch home in wine country

Welcome to our southwestern style ranch home in Sonoita/Elgin, Arizona wine country! Our home is 2,600 square feet and sits on 40 acres with unobstructed views of the beautiful Santa Rita Mountains. Our entire home is available for a wine country getaway. With three bedrooms, two full bathrooms with dual vanities, a half bath, an amazing kitchen, dining, two living spaces, and high-speed Internet, our home is ideal for two or three couples, or a family getaway (crib available for use).

Top guest favourite
A dining area features a long wooden table surrounded by six dark chairs. A large chandelier shaped like a star hangs above the table, casting intricate patterns on the walls. A decorative centerpiece of fresh fruits adds a touch of color.
Home in Tubac
5 out of 5 average rating, 142 reviews

A Tubac Getaway

Amazing luxury vacation rental in beautiful, historic Tubac, Arizona. Located in The Sanctuary neighborhood, this home is within walking distance of either The Village of Tubac or the Tubac Golf Resort. Plenty of nearby activities including hiking, golf, birdwatching, or day trips to southern Arizona. Visit unique shops in The Village of Tubac or the Resort for furnishings, jewelry, or great food at a variety of restaurants. Come see everything that southern Arizona has to offer!

Guest favourite
A spacious living area features a light-colored sofa with colorful accent pillows and a glass coffee table. Artwork adorns the walls, while natural light filters in through a window. A dining area with chairs and a modern workspace is visible in the background.
Home in Patagonia
4.94 out of 5 average rating, 109 reviews

Cottage on Santa Rita | Sundrenched 2 bd/1 bth

Nestled against the hill, this private, sun-filled home is located in the heart of Patagonia, a few quick steps to local businesses. Expansive patios and a cactus garden provide a hidden oasis behind the cottage - an ideal base for exploring the region's wineries, historic towns, gravel cycling, and forests. The home is fully updated, with a generously equipped kitchen, large master bedroom, washer/dryer, flexible second sleeping space, and tasteful minimalist southwest decor.

Guest favourite
Home in Patagonia
5 out of 5 average rating, 6 reviews

Peaceful Family Friendly + Fire Pit + Volleyball

Escape to this peaceful desert retreat nestled against the hills of Patagonia. With two bedrooms, a bonus office with daybed, and a spacious living area with pull out bed, the home comfortably hosts families or small groups looking to relax, explore, and enjoy the quiet beauty of Southern Arizona. Spend evenings under the twinkle lights around the fire pit, wake up to views of the hills, or enjoy a friendly match on the volleyball court.

Top guest favourite
A green casita is situated in an open landscape, surrounded by a rustic fence. A gravel driveway leads towards the entrance, with an American flag waving gently overhead. Lush grass and a few scattered trees enhance the rural setting under a clear blue sky.
Home in Sonoita
4.98 out of 5 average rating, 285 reviews

Sky Island Retreat Sonoita, AZ.

Sky Island Retreat is a quiet and peaceful hilltop retreat in which you can relax and enjoy the natural beauty of this historic area. The casita is the original but updated ranch house built in the late 60’s. We have kept much of its original charm while upgrading to modern comfort and conveniences. We are located on a privately gated property just minutes from the heart of Sonoita and Southern AZ’s growing wine country.

Guest favourite
Home in Sonoita
5 out of 5 average rating, 5 reviews

Vino & Vibes | 3BR | Hot Tub + Views + Game Room

Escape to Sonoita wine country at this stylish 3BR retreat just minutes from wineries. Soak in the hot tub under star-filled skies, enjoy unparalleled desert views, and unwind in a fun game room with billiards + darts. Thoughtfully designed for couples, friends, or small groups, with cozy beds, a fully stocked kitchen, and a complimentary bottle of wine on arrival. Relax, connect, and make unforgettable memories.

Guest favourite
A well-appointed living area features a navy blue sectional sofa, complemented by two bright yellow chairs. A sleek black coffee table sits in the center, while a mounted flat-screen TV and framed artwork enhance the modern ambiance. A ceiling fan is visible above.
Home in Nogales
4.94 out of 5 average rating, 16 reviews

Vince’s Townhome

Stylish 3-Bedroom Stay—Steps from Dining, Shopping & More Enjoy the comfort of a well-equipped home with three cozy bedrooms—all with queen beds —plus a dedicated desk for remote work, a relaxing living area, and in-unit washer/dryer. Located just minutes from popular restaurants, shopping centers, movie theaters, and a nearby medical clinic, this spot offers convenience for every kind of traveler.

Top guest favourite
A modern kitchen area features wooden cabinetry and stainless steel appliances, including a stove and refrigerator. Natural light fills the space through the window, and a cozy dining table is set nearby. Decorative elements, such as wall art, enhance the inviting design.
Home in Sonoita
4.99 out of 5 average rating, 347 reviews

Winemaker's Casita in the heart of Wine Country

The perfect casita for your wine tasting getaway! Our cozy space is full of local charm and minutes away from Elgin and Sonoita's many wineries. Centrally located near the Sonoita Crossroads, the Winemaker's Casita is walking distance from local restaurants, including Copper Brothel Brewery and Tia 'Nita's Cantina. Owned + operated by the proprietors of Rune Wines.

Popular amenities for house rentals in Santa Cruz County