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Holiday rentals in Santa Cruz de la Sierra

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz de la Sierra

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top guest favourite
The living area features a comfortable couch positioned near a large window, allowing natural light to fill the space. A flat-screen television is mounted on a wood-paneled wall, and a small round table is visible nearby. The view showcases the city skyline and nearby greenery.
Apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 26 reviews

Luxury, comfort, ideal location

Bienvenidos a la mejor ubicación de Santa Cruz! En el corazón del centro empresarial, pero en una calle tranquila. Supermercados y mucho más a la vuelta de la esquina. A pocos pasos encontrarás decenas de restaurantes increíbles: parrillada, comida japonesa, italiana o americana. Comida rápida o cenas elegantes. Manzana 40 está a 10 minutos a pie. Ventura Mall está a solo 5 min en auto. Ya sea para trabajo o diversión, este es el lugar ideal! El edificio cuenta con personal de seguridad 24/7.

Top guest favourite
Flat in Santa Cruz de la Sierra
5 out of 5 average rating, 21 reviews

GREEN TOWER SC Luxury Apartment 22nd Floor

Suite de lujo en Green Tower – Santa Cruz Piso 22. Vive en el edificio más alto y exclusivo de la ciudad, en el piso 22, con vistas panorámicas a Manzana 40, el cordón ecológico y el Urubó. Disfruta de gastronomía de primer nivel en el mismo edificio, en Jardines de Asia, Caudilla, Palosanto y el impresionante Sky bar, además acceso libre a la piscina, sauna, churrasqueras. Cuenta con gimnasio Sport Motion. Un departamento nuevo! amoblado con piezas de alta gama, incluyendo sofá cama grande.

Top guest favourite
Flat in Santa Cruz de la Sierra
5 out of 5 average rating, 18 reviews

Modern Studio in Los Cusis

Discover your ideal retreat in Los Cusis, a peaceful and elegant space designed for your comfort, featuring a balcony with a beautiful green view. Its Central Location places you close to shops, restaurants, and green areas—perfect for making the most of the city. The apartment includes a fully equipped kitchen, Smart TV, AC and Wi-Fi. The building offers free laundry facilities. It’s ideal for working, relaxing, or socializing. Enjoy a comfortable, modern, and stylish stay. Welcome!

Guest favourite
A studio space is presented with a modern aesthetic. A spacious bed is complemented by a sleek couch. The kitchen area features stylish bar stools and dark cabinetry, while a large TV is positioned for easy viewing. Soft lighting enhances the overall ambiance.
Flat in Santa Cruz de la Sierra
4.91 out of 5 average rating, 104 reviews

Cozy & modern · Fully equipped studio

Despertarás en un Studio totalmente equipado que combina comodidad hogareña y confort. Entrarás a un estilo de vida sofisticado; cada detalle ha sido cuidadosamente diseñado para satisfacer altas expectativas. Tendrás todas las comodidades. ¿Relajarse? Sumérgete en la piscina. ¿Ejercicio? ¡Hay Gym! ¿Trabajo? Podrás continuar tu rutina en las múltiples zonas sociales que ofrecen el escenario perfecto.¿Divertirte? Podrás jugar billar y usar la sala común ¡Reserva y descubre este Studio!

Top guest favourite
Green Tower, one of the tallest buildings in Bolivia, showcases modern architecture with its glass facade reflecting the surrounding cityscape. The image captures the building's contemporary design, set against a backdrop of Santa Cruz, featuring both urban and natural elements.
Serviced apartment in Santa Cruz de la Sierra
5 out of 5 average rating, 38 reviews

Green Tower 26th Floor, Luxury, Panoramic Views

Enjoy your stay in the highest Airbnb in Santa Cruz, and in the best building in the city. In the facilities you can enjoy a swimming pool, steam sauna, spectacular views from the 26th floor towards the beautiful Manzana 40 building, the nature of the ecological cordon and the urubo. A few steps from supermarket, restaurants, mall, business center, banks, spa. The tallest and most beautiful restaurants in Santa Cruz, Cielo Skay Bar and Jardin de Asia, are in the same building.

Guest favourite
Flat in Santa Cruz de la Sierra
4.8 out of 5 average rating, 10 reviews

Elegant Studio in Equipetrol | Rooftop Pool · Gym

Welcome to your stylish and comfortable studio located in Santa Cruz’s most exclusive area: Equipetrol Norte — just steps from Ventura Mall, Green Tower, and Manzana 40. This studio is perfect for solo travelers, couples, business guests or even small families (up to 3 adults or 2 adults + 2 kids). Inside you’ll find: A double bed and sofa-bed, divided by a sleek glass-block partition for privacy A fully equipped kitchen with oven, cooktop, microwave, and cookware

Top guest favourite
A well-appointed living space features a modern kitchen with wooden cabinetry and stainless steel appliances, including a refrigerator. A cozy seating area with a light gray sofa is arranged beside a spacious bed, while natural light filters through large windows.
Flat in Santa Cruz de la Sierra
5 out of 5 average rating, 50 reviews

Smart Studio in Equipetrol

Welcome to this great Smart Apartment in the best residential and business area of Equipetrol. You're half a block from Av. San Martin and a short walk from restaurants, shops, bars, and more. The apartment is fully furnished with everything you need for a comfortable stay, including a fully equipped kitchen, air conditioning, Wi-Fi, and a large flat-screen TV. It has a swimming pool, barbecue, co-work rooms and washing machines on the terrace and common areas

Guest favourite
Flat in Santa Cruz de la Sierra
5 out of 5 average rating, 14 reviews

Spacious studio perfect for you with a desk

Brand-new bright studio in Equipetrol: 5-minute walk to Hotel Los Tajibos and under 100 m from Fidalga Mall. Queen bed, fiber-optic Wi-Fi, full kitchen, balcony and self check-in. Private washer, A/C and smart TV for comfort. Enjoy the rooftop terrace with panoramic pool, gym, barbecue area and coworking space. Minimarkets and cafés within two blocks. Perfect for executives, couples or digital nomads who value style and security. Book now and be amazed!

Guest favourite
An outdoor terrace features sleek wooden decking, complemented by low seating arrangements and lush greenery. A tranquil water feature runs along one side, reflecting the surrounding cityscape. Modern buildings rise in the background under a clear, blue sky.
Flat in Santa Cruz de la Sierra
4.96 out of 5 average rating, 47 reviews

Elegant family apartment in Equipetrol

Have fun with the family in this new, central, and stylish accommodation. Beautiful and modern apartment located in the best area of Santa Cruz. Just a few steps away from the city's best restaurants, pharmacies, supermarkets, cafes, nightclubs, and shopping malls. Ideal for families, a group of friends, or two couples. You can have all the comforts of a luxury apartment for a cozy and pleasant stay. The building's common areas are a dream!

Guest favourite
A comfortable sleeping area features a spacious bed adorned with soft pillows and a decorative throw. Warm bedside lamps illuminate the space, while large windows offer views of the surrounding cityscape and allow natural light to brighten the room.
Flat in Santa Cruz de la Sierra
4.98 out of 5 average rating, 124 reviews

13° SmartLife - Luxury Equipetrol

Welcome to your sanctuary of sophistication and elegance at the top. This exceptionally cozy and stylish studio on the 13th floor invites you to experience luxury and comfort at their finest. Ready to experience the perfect combination of sophistication, comfort, and technology? Don't miss out on this unique opportunity. Book your stay at "13° SmartLife" and be seduced by the charm of this incomparable space! Your urban retreat awaits.

Top guest favourite
An outdoor swimming pool is set against a skyline backdrop, featuring clear water and a sleek dark stone structure nearby. Two lounge chairs are positioned beside the pool, offering a space for relaxation while enjoying the view of the city.
Flat in Santa Cruz de la Sierra
5 out of 5 average rating, 17 reviews

New & Equipped Studio | Prime Location

Brand-new, fully equipped studio in an unbeatable location. Perfect for both work and relaxation. Enjoy fast WiFi, an integrated kitchen, and a modern space designed for your comfort. Situated in the city’s best area, close to restaurants, cafés, and top attractions. You’ll also have access to the condominium pool. Ideal for guests seeking comfort, convenience, and a cozy atmosphere, with 24/7 security and a peaceful environment.

Guest favourite
Flat in Santa Cruz de la Sierra
5 out of 5 average rating, 6 reviews

Top Luxury Executive Dept. | Equipetrol

Descubrí el equilibrio perfecto entre comodidad, estilo y ubicación. Este moderno departamento está completamente equipado y ubicado en Equipetrol, la zona más exclusiva de Santa Cruz. Ideal para parejas, viajeros de negocios o escapadas de fin de semana. Disfrutá de increíbles áreas sociales como: 🏊 Piscina 💪 Gimnasio completo 🎯 Sala de juegos 📍 Cerca de los mejores restaurantes, cafés y centros comerciales.

Popular amenities for Santa Cruz de la Sierra holiday rentals

Frequently Asked Questions

  • What are the best places to stay in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra has stays in lively neighborhoods like Equipetrol, known for dining and nightlife, and around the city center near plazas and shops. Guests often appreciate areas with leafy streets, local cafes, and easy access to cultural sites.

  • What are the best things to do in Santa Cruz de la Sierra with kids?

    Families can explore city parks, interactive museums, and local zoos featuring native wildlife. Playgrounds and green spaces in residential neighborhoods add opportunities for outdoor fun.

  • What are some of the best things to do in Santa Cruz de la Sierra?

    Discover central plazas, explore Museo de Historia Natural Noel Kempff Mercado, and wander bustling traditional markets. The city also has botanical gardens, art spaces, and vibrant street life.

  • How is the weather in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra generally has warm, humid conditions year-round, with wetter spells in certain months and a tropical atmosphere. Lightweight clothing and sun protection are often suggested, especially for daytime outings.

  • What are the best places to visit in Santa Cruz de la Sierra?

    Explore Plaza 24 de Septiembre, admire local art at Museo de Arte Contemporáneo, and stroll the city’s botanical gardens. Markets and lively pedestrian zones add extra color to the experience.

  • What are some hiking trails in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra has nature reserves and eco-parks where visitors can follow shaded trails amidst tropical plants and birds. Urban green spaces and parks also provide pathways for relaxed walks.

  • What are some family activities we can do in Santa Cruz de la Sierra?

    Families frequently explore city zoos, botanical gardens, interactive museums, and open-air playgrounds. Participating in local craft workshops or tasting fresh fruit at traditional markets brings a sense of discovery.

  • What are some of the best day trip ideas from Santa Cruz de la Sierra?

    Day trips often include exploring nature reserves, visiting Jesuit mission towns, or discovering small communities with locally rooted traditions. Eco-parks around the city provide hiking, birdwatching, and opportunities to connect with regional culture.

  • Are there any pet friendly accommodations available in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra has pet-friendly vacation rentals in neighborhoods like Equipetrol, Urbarí, and around the city center. Many stays include access to green spaces and parks for walks with your pet.

  • What are some local tips for visiting Santa Cruz de la Sierra?

    Locals appreciate lightweight clothes for the heat, insect repellent, and comfortable shoes for exploring urban sights. Trying locally grown fruits at traditional markets is frequently suggested, and learning some Spanish phrases adds ease to your experience.

  • What is Santa Cruz de la Sierra known for?

    Santa Cruz de la Sierra is known for its lively main plaza, tropical botanical gardens, and dynamic blend of Indigenous and European traditions. The city’s vibrant markets, local cuisine, and arts scene are frequently highlighted.

  • What are the best hidden gems to explore in Santa Cruz de la Sierra?

    Around Santa Cruz de la Sierra, visitors often discover small artisan shops, tranquil eco-parks, and street murals tucked in residential neighborhoods. Community-run cafés and weekend craft markets add unique flavor.

  • What are the best foods to try in Santa Cruz de la Sierra?

    Local favorites include salteñas, sonso de yuca, and traditional dishes made from corn, plantain, and tropical fruits. Refreshing drinks such as mocochinchi and locally roasted coffee are often recommended.

  • What should I bring for a trip to Santa Cruz de la Sierra?

    Pack lightweight clothing, sun protection, insect repellent, and comfortable shoes for walking. Bringing a reusable water bottle and rain jacket can add convenience, especially if you plan outdoor excursions.

  • What is the nightlife in Santa Cruz de la Sierra like?

    Santa Cruz de la Sierra has lively nightlife, with bars and clubs frequently suggested around the Equipetrol neighborhood. In the city center, you can explore relaxed venues featuring live music, local cocktails, and outdoor patios.

  • What are the most popular events or festivals in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra has celebrated cultural festivals, Carnaval, and regional fairs throughout the year. Music, dance, and food events are frequently suggested, especially around holidays and community celebrations.

  • Are there family friendly vacation rentals in Santa Cruz de la Sierra?

    Family-friendly vacation rentals can be found in Equipetrol, Urbarí, and the city center, many with spacious layouts and access to parks or play areas. Hosts often provide amenities for children to make visits comfortable.

  • When is the best time to visit Santa Cruz de la Sierra?

    Visitors often prefer the drier months for outdoor activities and exploring city sights, while some enjoy the lush greenery during wet seasons. Popular festivals and pleasant evenings draw many travelers throughout the year.

Quick stats about holiday rentals in Santa Cruz de la Sierra

  • Total holiday rentals

    Explore 4,570 holiday rentals in Santa Cruz de la Sierra

  • Nightly prices starting at

    Santa Cruz de la Sierra holiday rentals start at $13 SGD per night before taxes and fees

  • Verified guest reviews

    Over 55,490 verified reviews to help you choose

  • Family-friendly holiday rentals

    1,260 properties offer extra space & child-friendly amenities

  • Pet-friendly holiday rentals

    Find 1,180 rentals that welcome pets

  • Holiday rentals with a pool

    3,160 properties feature pools

  • Rentals with dedicated workspaces

    2,590 properties have a dedicated workspace

  • Wifi availability

    4,240 of Santa Cruz de la Sierra holiday rentals include wifi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi and Pool across Santa Cruz de la Sierra rentals

  • 4.7 Average rating

    Santa Cruz de la Sierra stays receive an average rating of 4.7 out of 5 from guests

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