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Holiday rentals in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top guest favourite
Flat in Santa María La Ribera
4.91 out of 5 average rating, 563 reviews

Independent apartment on 3 levels and 2 bathrooms.

New apartment on three levels with splendid views of a beautiful Mexican-Andalusian garden. Two large beds, two full bathrooms, equipped kitchen, dining room and a comfortable living room. Very quiet, with four leafy trees in the garden muting sounds from the outside world. The Santa María caters to young people's tastes, has a big range of cuisines and features 'colonial style' architecture given that it is in the town's Historic Center; it is just a 10 minute walk to the San Cosme Metro, with Zócalo just four stops down the line.

Guest favourite
A spacious living area is framed by large windows that overlook a lush garden. A curved sectional sofa adorned with decorative cushions invites relaxation, while a round coffee table displays small art objects and fresh flowers. Light filters through, highlighting the vibrant wall colors.
Apartment in Roma Norte
4.96 out of 5 average rating, 160 reviews

Breathtaking duplex in the heart of the Roma

With an unbeatable location in the heart of the Roma Norte neighborhood, is steps away from great cafes, restaurants and galleries. Thoughtfully newly decorated by a recognized European interior designer based in Mexico, the apartment is full of magical touches -art. The dining area will make you live an unforgettable experience. In the terrace you can relax and dine al fresco in complete peace and privacy. Unique apartment! King bedroom on the second floor, loft-style with a semi-open layout.

Guest favourite
A sunlit corner features large floor-to-ceiling windows offering views of greenery outside. A dark wooden table is accompanied by two cushioned seats, while a cozy seating area with a collection of books and decorative items is situated nearby, contributing to a serene environment.
Flat in Hipódromo
4.88 out of 5 average rating, 127 reviews

Kaya Kalpa-Organic Designer Apartment in Condesa

After a year-long remodeling project, I’m thrilled to present this personal residence Kaya Kalpa. Every inch of the property has been thoughtfully remodeled. Ideal place for artists, wanderers, all walks of life practitioners to come reset, reflect, and create.  The space is located on Amsterdam street in Condesa, one block from Parque Mexico. You’ll find all nice restaurants, cafes, and stores downstairs. Big supermarket, local Mercado, metro station…all within 5 minutes walking distance.

Guest favourite
A bright open space features a dining table with two wooden chairs and a wall of exposed brick. Potted plants add greenery, and a workspace is visible in the background. The kitchen area includes modern appliances, complementing the unique patterned flooring.
Loft in Mexico City
4.88 out of 5 average rating, 484 reviews

Our praceful place, perfect oasis in the city.

Discover the City from this small and cozy oasis. A space full of light and with details that will make you feel in Mexico. The place is very quiet and the apartment lovingly decorated. As a host we can support you with whatever you need, do not hesitate to ask and if it is in our hands we will gladly do so. High ceilings, wooden beams and traditional pasta floors. A loft with a lot of character. The kitchen is fully equipped and the bathroom and its tub is an ideal way to end the day.

Top guest favourite
Flat in Mexico City
5 out of 5 average rating, 13 reviews

Architect-Designed Duplex · Roma Norte

A duplex residence conceived by a recognized architecture studio and furnished by one of Mexico City’s leading design firms. Every material, finish, and object was selected with intention — nothing is accidental. Steps from Roma Norte’s best restaurants, cafés, and galleries. Everything you need is walkable; everything inside is intentional. Full kitchen, premium linens, fast Wi-Fi, and a host committed to one standard: every guest leaves wishing they’d stayed longer.

Top guest favourite
Townhouse in Roma Norte
4.97 out of 5 average rating, 132 reviews

Hidden 2BR Gem with Rooftop Terrace & Greenery

Welcome to Casa Chaya! At Casa Chaya, we have a unique obsession with plants, so you'll find lush greenery all around, creating a truly refreshing atmosphere. Your comfort, enjoyment, and connection with nature are our top priorities during your stay. We want you to experience and love this place as much as we do, so we are here to make your time a memorable one. We can't wait to host you and ensure you have a wonderful experience!

Superhost
A spacious open layout is shown, featuring a comfortable sleeping area and a work desk. A hammock is suspended in the center, while plants add greenery. The concrete ceiling is complemented by warm wooden accents, and shelves hold various books in the background.
Loft in Santa Catarina
4.88 out of 5 average rating, 219 reviews

Casa Mavi's loft in Coyoacán

Welcome to Coyoacán! Great 120 m2 loft located just a 5-minute walk from downtown Coyoacán. Experience this quiet and bright open space, ideal for resting or working and decorated with objects full of stories. The loft is located on the third floor of Casa Mavi, an old factory that was remodeled to create a place full of charm that makes it unique. It has shared terraces. With option for a third guest. 200 megabyte Wi-Fi.

Top guest favourite
A wrought iron fence encloses a lush garden featuring tropical plants, with various green leaves providing a vibrant backdrop. The stone facade of the building is partially visible, highlighting arched windows and a welcoming entrance. Soft lighting enhances the serene atmosphere.
Flat in Colonia Juárez
4.94 out of 5 average rating, 347 reviews

EXCLUSIVE SUITE IN CASA DE 1905. GREAT LOCATION

cozy suite of 60 m2 located in a unique set of houses built in 1905 in havre, one of the most exclusive streets and with the best gastronomic offer of the Juarez colony. the house was completely restored adding contemporary elements to its typically Porfirian architecture. the space has been furnished with original pieces in the modern mid-century style and other finds of our searches by the antique dealers of the city.

Superhost
Flat in Mexico City
5 out of 5 average rating, 3 reviews

Stylish Apartment with Balcony Steps from Café

- Experience a stylish 2-bedroom suite in vibrant Roma Norte, a dynamic neighborhood - Enjoy a private balcony perfect for morning coffee or evening relaxation - Relax in the cozy living room with a Smart TV and high-speed WiFi for remote work - Fully equipped kitchen for easy meal prep, with modern appliances and cookware - Book now and discover the perfect blend of comfort, style, and location

Guest favourite
A private terrace is equipped with a wooden dining table and a hammock, inviting relaxation. An outdoor kitchen area features wooden cabinetry and counter space, all under a slatted canopy that offers shade while allowing light to filter through.
Loft in Santa Catarina
4.94 out of 5 average rating, 634 reviews

ECO-ROOF with terrace in the heart of Coyoacán

Nice and cozy room with a private balcony in the heart of Coyoacán, one of the most picturesque and traditional neighborhoods in Mexico City. Located a 5-minute walk from downtown Coyoacan, traditional restaurants, cafes, craft bazaars, and museums.

Top guest favourite
The exterior of a two-story house is surrounded by lush greenery and vibrant planters. A small terrace features a white umbrella, where a person is seated, enjoying the garden view. A paved pathway leads to the entrance, enhancing the welcoming atmosphere.
Loft in Del Carmen
4.95 out of 5 average rating, 245 reviews

Loft Coyoacan Viveros (Bow)

A super special and very cozy place in the heart of Coyoacán! right next to Coyoacán nurseries, on Melchor Ocampo street Ideal for a couple with or without children who want to enjoy a pleasant stay or a good walk through the wonders of Coyoacán :)

Top guest favourite
An open living space features a dining area with a round table surrounded by chairs, overlooking a cozy lounging area with a spacious bed. Plants are placed throughout, with large windows allowing natural light to illuminate the room. Wooden beams add a rustic touch to the modern design.
Flat in Roma Norte
5 out of 5 average rating, 59 reviews

A little house

Una Casita is located on a quiet street in the heart of Condesa. It is surrounded by delicious restaurants, fantastic coffee, and leafy walks. Hosted by a Bosnio-Mexican couple that is madly in love with this beautiful city.

Popular amenities for Santa Cruz holiday rentals

  1. Airbnb
  2. Mexico
  3. Santa Cruz