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Holiday rentals in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top guest favourite
Flat in Santa María La Ribera
4.91 out of 5 average rating, 563 reviews

Independent apartment on 3 levels and 2 bathrooms.

New apartment on three levels with splendid views of a beautiful Mexican-Andalusian garden. Two large beds, two full bathrooms, equipped kitchen, dining room and a comfortable living room. Very quiet, with four leafy trees in the garden muting sounds from the outside world. The Santa María caters to young people's tastes, has a big range of cuisines and features 'colonial style' architecture given that it is in the town's Historic Center; it is just a 10 minute walk to the San Cosme Metro, with Zócalo just four stops down the line.

Guest favourite
A modern living area features a curved black sectional sofa adorned with decorative pillows. Large floor-to-ceiling windows provide views of a lush patio with tropical plants. A wooden coffee table complements the relaxed atmosphere, while colorful wall art adds interest to the room.
Apartment in Roma Norte
4.96 out of 5 average rating, 161 reviews

Breathtaking duplex in the heart of the Roma

With an unbeatable location in the heart of the Roma Norte neighborhood, is steps away from great cafes, restaurants and galleries. Thoughtfully newly decorated by a recognized European interior designer based in Mexico, the apartment is full of magical touches -art. The dining area will make you live an unforgettable experience. In the terrace you can relax and dine al fresco in complete peace and privacy. Unique apartment! King bedroom on the second floor, loft-style with a semi-open layout.

Top guest favourite
A private roof garden is depicted, featuring a seating area with two armchairs and a small table. A glass of beverage sits on the table, surrounded by urban views and evening lights. A glass railing provides unobstructed sightlines of the cityscape.
Flat in Iztacalco
4.96 out of 5 average rating, 106 reviews

Next to the Autodromo with parking

You have everything in the same place. We are located next to the Autódromo Hermanos Rodríguez (Formula 1), the Foro Sol, and the Harp Helu Stadium. 5 minutes from the airport, shopping centers, 25 minutes from the capital's main square and the IPN academic unit of UPIICSA. With a sports field next door, a gym on the premises, and a private roof garden. Peace and quiet inside the apartment and excellent views of the volcanoes that shelter the city.

Top guest favourite
Apartment in Ignacio Zaragoza
4.93 out of 5 average rating, 181 reviews

Large penthouse near Foro Sol GNP Airport

A LARGE APARTMENT 5 MINUTES FROM MEXICO CITY INTERNATIONAL AIRPORT 15 MINUTES FROM THE CITY CENTER ONE BLOCK FROM THE SOL FORUM TWO FLOORS 145 M2 WITH PRIVATE ROOF GARDEN AREA TWO FULL BATHROOMS VERY SOFT BEDS VERY WELL CONNECTED METRO 5 MINUTES SAFE QUIET STREET FULLY EQUIPPED EVERYTHING FIRST CLASS TO SPEND A COMFORTABLE AND PEACEFUL STAY CAN ACCOMMODATE 5 PEOPLE COMFORTABLY ALL SERVICES ARE TOTALLY WELCOME FROM ANYWHERE IN THE WORLD.

Superhost
Loft in Tlalpan
4.87 out of 5 average rating, 915 reviews

Punto Lofts Periférico Sur (South Peripheral Point Lofts)

Punto Lofts Periférico Sur is a modern concept with 18 fully equipped lofts, ideal for short or long stays. Each loft accommodates up to 3 people and has a queen size bed and sofa bed, offering comfort and rest. Enjoy 24/7 reception, digital key access, and high standards of cleanliness and safety. Located on Periférico Sur, opposite the Azteca Stadium, with easy access to hospitals, restaurants and shopping centers.

Guest favourite
A charming mini cabin is displayed, featuring a brick exterior and a welcoming porch. Two red Adirondack chairs are positioned on the manicured lawn, surrounded by greenery. The clear blue sky and sunlight enhance the tranquil setting of this inviting retreat.
Cabin in 012
4.95 out of 5 average rating, 119 reviews

cozy tiny house, adorable casa!

Relájate en pareja o con toda la familia en este alojamiento donde la tranquilidad se respira, adorable mini cabaña ubicada en zona boscosa, rodeada de cedros, un lugar ideal para descansar, hacer una carne asada, picnic o realizar home office. Pero no por eso dejar de disfrutar de tus series o películas favoritas en Netflix, Prime Video, Disney y/o partidos de futbol

Top guest favourite
Flat in Condesa
4.85 out of 5 average rating, 1,705 reviews

Cool Apt w/Rooftop in La Roma | Gym+Work Lounge

This stylish apartment in Roma Norte offers the perfect setup for digital nomads—ultra-fast Wi-Fi, a sleek workspace, and steps from Condesa’s trendiest cafés, restaurants, and nightlife. Enjoy top-tier amenities: a business center, a full gym, a game room, and a rooftop with stunning views. Stay productive, stay inspired, and experience CDMX like a local.

Top guest favourite
A charming outdoor patio is surrounded by vibrant greenery and a blue-walled house. A round glass table is complemented by six white metal chairs, creating an inviting space for dining or gathering. Potted plants and flowers add color to the serene environment.
Home in Coyoacán
4.97 out of 5 average rating, 103 reviews

Casa Omac | Colonial house with two patios

Typical colonial house, located in the most picturesque and emblematic street of Coyoacán. The style is reminiscent of Frida Kahlo's Blue House, which is a few minutes' walk away. Organized around a large internal patio, the house has 5 double rooms and can host up to 10 people, making it ideal for groups and families.

Guest favourite
Home in Roma Norte
4.88 out of 5 average rating, 156 reviews

New Casa Rosa in the heart of Roma neighborhood

A beautiful and newly remodeled pink house in the heart of Roma neighborhood. A home away from home to spend a few days or a long season near historic sites, shops, and local restaurants in a neighborhood with attitude. All the amenities in a house with personality and impeccable architecture and interior design.

Guest favourite
Home in Del Carmen
4.82 out of 5 average rating, 100 reviews

Spacious Home in Trendy Coyoacán

Undoubtedly a house to enjoy with the family and be part of the historical memory of this city. Our interior design team took advantage of this emblematic property in the center of Coyoacan to transform it into a modern, comfortable town house with a lot of personality.

Guest favourite
Loft in Coyoacán
4.94 out of 5 average rating, 634 reviews

ECO-ROOF with terrace in the heart of Coyoacán

Nice and cozy room with a private balcony in the heart of Coyoacán, one of the most picturesque and traditional neighborhoods in Mexico City. Located a 5-minute walk from downtown Coyoacan, traditional restaurants, cafes, craft bazaars, and museums.

Top guest favourite
The exterior of a two-story house is surrounded by lush greenery and vibrant planters. A small terrace features a white umbrella, where a person is seated, enjoying the garden view. A paved pathway leads to the entrance, enhancing the welcoming atmosphere.
Loft in Del Carmen
4.95 out of 5 average rating, 246 reviews

Loft Coyoacan Viveros (Bow)

A super special and very cozy place in the heart of Coyoacán! right next to Coyoacán nurseries, on Melchor Ocampo street Ideal for a couple with or without children who want to enjoy a pleasant stay or a good walk through the wonders of Coyoacán :)

Popular amenities for Santa Cruz holiday rentals

  1. Airbnb
  2. Mexico
  3. Santa Cruz