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Holiday rentals in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top guest favourite
Flat in Santa María La Ribera
4.91 out of 5 average rating, 563 reviews

Independent apartment on 3 levels and 2 bathrooms.

New apartment on three levels with splendid views of a beautiful Mexican-Andalusian garden. Two large beds, two full bathrooms, equipped kitchen, dining room and a comfortable living room. Very quiet, with four leafy trees in the garden muting sounds from the outside world. The Santa María caters to young people's tastes, has a big range of cuisines and features 'colonial style' architecture given that it is in the town's Historic Center; it is just a 10 minute walk to the San Cosme Metro, with Zócalo just four stops down the line.

Guest favourite
A spacious living area is framed by large windows that overlook a lush garden. A curved sectional sofa adorned with decorative cushions invites relaxation, while a round coffee table displays small art objects and fresh flowers. Light filters through, highlighting the vibrant wall colors.
Apartment in Roma Norte
4.96 out of 5 average rating, 161 reviews

Breathtaking duplex in the heart of the Roma

With an unbeatable location in the heart of the Roma Norte neighborhood, is steps away from great cafes, restaurants and galleries. Thoughtfully newly decorated by a recognized European interior designer based in Mexico, the apartment is full of magical touches -art. The dining area will make you live an unforgettable experience. In the terrace you can relax and dine al fresco in complete peace and privacy. Unique apartment! King bedroom on the second floor, loft-style with a semi-open layout.

Guest favourite
A sunlit corner features large floor-to-ceiling windows offering views of greenery outside. A dark wooden table is accompanied by two cushioned seats, while a cozy seating area with a collection of books and decorative items is situated nearby, contributing to a serene environment.
Flat in Condesa
4.88 out of 5 average rating, 128 reviews

Kaya Kalpa-Organic Designer Apartment in Condesa

After a year-long remodeling project, I’m thrilled to present this personal residence Kaya Kalpa. Every inch of the property has been thoughtfully remodeled. Ideal place for artists, wanderers, all walks of life practitioners to come reset, reflect, and create.  The space is located on Amsterdam street in Condesa, one block from Parque Mexico. You’ll find all nice restaurants, cafes, and stores downstairs. Big supermarket, local Mercado, metro station…all within 5 minutes walking distance.

Top guest favourite
Loft in Roma Norte
5 out of 5 average rating, 13 reviews

Designer double-height loft · Roma Norte

KAAN KIN is a double-height loft with soaring ceilings, warm interiors and natural light. Thoughtfully designed with curated furniture, hotel-quality bedding, a fully equipped kitchen, 75” TV and Sonos system. Fast Wi-Fi for remote work. Steps from Roma Norte’s best restaurants, cafés and parks. Seamless self check-in, responsive host and a space prepared to hotel standards before every stay. A private residence with boutique hotel care — designed for guests who notice the details.

Guest favourite
A spacious bedroom incorporates natural elements with wood accents and soft, neutral tones. Large sliding doors lead to a comfortable living area, showcasing a cozy seating arrangement. A stylish glass shower is visible, complementing the overall modern yet serene ambiance.
Loft in Álvaro Obregón
4.92 out of 5 average rating, 506 reviews

Entire apartment, Japanese style in San Angel.

House with one bedroom, with a beautiful Japanese garden. Exclusively for couples or people looking to rest (not a location for events, videos, or thirst for photographs) Ground floor industrial style, first and second level Japanese design. Brand new, fully equipped, with luxury finishes. The place is completely for you. We have parking outside the accommodation (street). A unique experience in the heart of San Angel. Three blocks from San Angelin Restaurant.

Top guest favourite
Townhouse in Roma Norte
4.97 out of 5 average rating, 134 reviews

Hidden 2BR Gem with Rooftop Terrace & Greenery

Welcome to Casa Chaya! At Casa Chaya, we have a unique obsession with plants, so you'll find lush greenery all around, creating a truly refreshing atmosphere. Your comfort, enjoyment, and connection with nature are our top priorities during your stay. We want you to experience and love this place as much as we do, so we are here to make your time a memorable one. We can't wait to host you and ensure you have a wonderful experience!

Guest favourite
An arched corridor is lined with potted plants, creating a serene atmosphere. Two woven chairs are positioned near a small table, inviting relaxation. Natural light filters through the open screen door at the far end, illuminating the textured walls and rustic tile flooring.
Home in Del Carmen
4.94 out of 5 average rating, 177 reviews

Casa de Barro. Beautiful Old Mexican House

Beautiful old traditional mexican house with corridor and patio, located in one of the most traditional neighborhoods in the city, close to Coyoacan’s center and two blocks away from Frida Kahlo’s and Leon Trotsky’s museums. Near by you can also find stores, restaurants, museums, parks, market places, bakeries. If you love to walk or exercise eight blocks away you can find the beautiful tree nursery, viveros de Coyoacan.

Superhost
Loft in Tlalpan
4.87 out of 5 average rating, 915 reviews

Punto Lofts Periférico Sur (South Peripheral Point Lofts)

Punto Lofts Periférico Sur is a modern concept with 18 fully equipped lofts, ideal for short or long stays. Each loft accommodates up to 3 people and has a queen size bed and sofa bed, offering comfort and rest. Enjoy 24/7 reception, digital key access, and high standards of cleanliness and safety. Located on Periférico Sur, opposite the Azteca Stadium, with easy access to hospitals, restaurants and shopping centers.

Top guest favourite
Loft in Ayapango de Gabriel Ramos M.
5 out of 5 average rating, 16 reviews

Beautiful apartment with garden and volcano view

Escape to a dreamy retreat on the volcano route. Perfect for romantic getaways or family gatherings. Enjoy Stunning views of the volcanoes from your private garden, barbecue area and stone oven bring out the chef in you. Spacious and cozy space to relax and enjoy. Located in a picturesque village near Iztapopo National Park, this oasis is the ideal place to disconnect and reconnect with nature and your loved ones.

Superhost
Flat in Condesa
4.84 out of 5 average rating, 1,729 reviews

Chic & Equipped Apt | Rooftop+Gym+B/Center+Lounge

This stylish apartment in the heart Roma Norte and Condesa offers the perfect setup for digital nomads—ultra-fast Wi-Fi, a sleek workspace, and steps from the trendiest cafés, restaurants, and nightlife. Enjoy top-tier amenities: a business center, a full gym, a game room, and a rooftop with stunning views. Stay productive, stay inspired, and experience CDMX like a local.

Guest favourite
A charming mini cabin is displayed, featuring a brick exterior and a welcoming porch. Two red Adirondack chairs are positioned on the manicured lawn, surrounded by greenery. The clear blue sky and sunlight enhance the tranquil setting of this inviting retreat.
Cabin in 012
4.95 out of 5 average rating, 120 reviews

cozy tiny house, adorable casa!

Relájate en pareja o con toda la familia en este alojamiento donde la tranquilidad se respira, adorable mini cabaña ubicada en zona boscosa, rodeada de cedros, un lugar ideal para descansar, hacer una carne asada, picnic o realizar home office. Pero no por eso dejar de disfrutar de tus series o películas favoritas en Netflix, Prime Video, Disney y/o partidos de futbol

Guest favourite
A spacious sleeping area features a large bed with neutral bedding, flanked by two wooden nightstands. A colorful woven rug adds texture to the floor. A full-length mirror is positioned against the wall, reflecting the room's minimalist design, enhanced by natural light.
Home in Roma Norte
4.88 out of 5 average rating, 156 reviews

New Casa Rosa in the heart of Roma neighborhood

A beautiful and newly remodeled pink house in the heart of Roma neighborhood. A home away from home to spend a few days or a long season near historic sites, shops, and local restaurants in a neighborhood with attitude. All the amenities in a house with personality and impeccable architecture and interior design.

Popular amenities for Santa Cruz holiday rentals

  1. Airbnb
  2. Mexico
  3. Santa Cruz