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Holiday rentals in Santa María

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Top-rated holiday rentals in Santa María

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top guest favourite
An aerial view showcases a serene saltwater pool framed by lush greenery. Red umbrellas provide shade for outdoor seating areas. The open kitchen and dining space are visible, along with comfortable hammocks situated nearby, offering a relaxed atmosphere for guests.
Home in Costa Esmeralda
4.98 out of 5 average rating, 197 reviews

Beach House-Amazing Pool & Jacuzzi - Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

Guest favourite
A single-story house is nestled beneath a large tree, featuring a tiled roof and a covered parking area. Surrounding greenery includes bushes and ornamental plants, enhancing the natural setting. The house is positioned to provide a sense of privacy and tranquility.
Home in Chitre
4.87 out of 5 average rating, 62 reviews

Country House Like in the City / La Casita

Casa fresca, con árboles y naturaleza. Áreas amplias para descansar. Ubicación céntrica, cerca de malls, restaurantes, estación de buses y ciclovía. Entrada privada, estacionamientos, cocina completa, mobiliario completo, baño, TV HD con cable, AC en recámara, agua caliente y Wi-Fi. ENG, PORT, FRAN and ITA Spoken! Ahora, Chitré, tiene un problema con el agua: no está potable; tenemos 50% de lo habitual, a veces estamos sin agua por algunas horas. Por favor, consulten antes de reserar.

Guest favourite
An aerial view reveals a stretch of coastline featuring sandy beaches with a mix of dark volcanic sand and vibrant turquoise water. Lush greenery lines the shore, complemented by residential areas visible in the background, creating a serene and inviting landscape.
Tiny home in San Carlos
4.8 out of 5 average rating, 127 reviews

Cozy beach cabin at Costa Esmeralda.

Cozy private community cabin on a triple space for up to three people located in Costa Esmeralda beach, over the Pacific ocean. Very quiet area with a 2,200 Square meter patio with trees and vegetation. Relax enjoying of the tropical sun, warm temperatures all year long and the ocean breeze. Only 8 minutes away by walk from the closest beach with warm waters and volcanic black sand. 10 minute drive to Coronado (Grocery Stores, restaurants, bakeries, movie theater, malls and much more)...

Guest favourite
A scenic view of rolling hills under a colorful sky at sunset. Shades of orange, pink, and purple blend, creating a vibrant horizon. Lush trees are scattered across the landscape, adding a touch of greenery to the terrain.
Cottage in Olá
4.92 out of 5 average rating, 24 reviews

Country House in Olá, rivers, waterfalls, Los Picachos

Finca La Terapia lives up to its name, it is located among the mountains of the picturesque village of Olá de Penonomé, where you can disconnect from the busy day to day of the city. It has 42 private hectares to explore nature. The Olá district is characterized by having the most beautiful natural landscapes, among which we can mention Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, among others, just a few minutes from the property.

Guest favourite
Home in Canto del Llano
4.92 out of 5 average rating, 12 reviews

Peaceful home w/ spacious living & office area

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Guest favourite
A terrace space is defined by outdoor seating arranged around a table. Lush greenery frames the scene, with soft sunlight illuminating the horizon where the sun rises over a tranquil landscape.
Flat in Rio Hato
4.94 out of 5 average rating, 139 reviews

Amazing! A paradise 5 minutes away from the sea

Discover our charming apartment just 5 minutes from the beach, where every morning will give you a spectacular view. Wake up to the beauty of a beautiful sunrise from the comfort of your room. Enjoy tranquility and serenity as you gaze at the warm colors painting the sky over the sea. Our apartment has been designed with you and your family in mind. Enjoy a cozy and functional space to create unforgettable memories.

Guest favourite
A cozy sleeping area features a spacious bed with neutral bedding. Soft lighting is provided by bedside lamps, and a ceiling fixture adds warmth. Two framed art pieces adorn the walls, offering a subtle contrast to the light decor.
Tiny home in Penonome
4.85 out of 5 average rating, 60 reviews

Fenced and Pet-Friendly Cottage in Penonomé

Cozy private cottage, fully fenced — perfect for relaxing, remote work, or traveling with your pet. Enjoy the garden surrounded by greenery, rest in the covered hammocks, or do some birdwatching. Equipped kitchen, air conditioning, high-speed WiFi, and secure on-site parking. Just minutes from the Interamerican Highway, with easy access to cafés, shops, and more. Ideal for a peaceful getaway or productive stay.

Guest favourite
Farm stay in Santa Fe
4.9 out of 5 average rating, 306 reviews

Cabaña del Sol en Finca Namuiki by the River

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Guest favourite
Cottage in Santa Fe
5 out of 5 average rating, 6 reviews

k* Casa Matilde | 2BR Santa Fe Retreat by River

Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.

Top guest favourite
A comfortable porch area features two colorful hammocks suspended from the walls. The polished tile flooring reflects soft light, and a pair of large wooden doors stands closed in the background. A vehicle is parked nearby, adding to the casual ambiance.
Home in Penonome
4.92 out of 5 average rating, 132 reviews

Comfortable, fenced and safe house.

Enjoy the simplicity of this spacious, quiet and centrally located place at Casa las Hamacas. You can enjoy the pleasant Penonomeño climate. A place close to everything, shopping malls, schools, hospital, mountains, rivers and beaches. Both rooms feature A/C to ensure your rest. A few minutes away from the Pan-American Highway.

Guest favourite
A bright bedroom is displayed, featuring a spacious bed covered with a textured white blanket. A television is mounted on the wall opposite the bed. Natural light floods through large windows, accompanied by sheer curtains. A cozy orange chair and potted plant add a touch of warmth.
Tiny home in Playa El Jobo
4.96 out of 5 average rating, 23 reviews

Little home near to the beach -Las Tablas

10 min drive- Las Tablas Get away from it all when you stay under the stars. A room very close to the sea, with an open kitchen that will allow you to disconnect and enjoy the view and nature in Las Tablas. You can plan to visit nearby beaches or take a walk through Pedasí, 30 minutes from Las Tablas.

Guest favourite
Home in La Villa de los Santos
4.94 out of 5 average rating, 104 reviews

Spacious house in Villa de los Santos

Comfortable family accommodation in La Villa de Los Santos, with Wi-Fi, A/C, equipped kitchen, patio and parking. Located near supermarkets and plazas. Only 15 minutes from El Rompió and Monagre, 45 minutes from Isla Iguana and 1h 30 minutes from Playa Venao.

Popular amenities for Santa María holiday rentals

  1. Airbnb
  2. Panama
  3. Herrera
  4. Santa María