Holiday rentals in Depew

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Top-rated holiday rentals in Depew

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top guest favourite
A living area is furnished with a light gray sectional sofa adorned with patterned pillows. A dark armchair complements the space, which is brightened by natural light from large windows. A woven basket holds decorative items, and a subtle area rug adds texture to the floor.
Home in Lancaster
4.98 out of 5 average rating, 58 reviews

eye pleaser

Enjoy a stylish experience at this centrally-located home. Many guests come for the Buffalo Bills games. 25 minute ride to Highmark Stadium. 7 minutes from airport. 20 minutes to downtown Buffalo. Walking distance to the village of lancaster. The village offers restaurants, bars, shopping, coffee shop, barber shop etc. around the corner from the home offers a grocery store, liquor store, consumer beverages, and a gym. Enjoy our out door patio with grill, fire pit, as well as covered side patio.

Top guest favourite
A living room is depicted featuring a white brick fireplace as a focal point, with a dark television mounted above. Grey sofas are positioned around a small wooden table, and bright plants add a touch of greenery. A large window allows light to fill the space.
Home in Lancaster
5 out of 5 average rating, 22 reviews

Mid-Century Modern Upper Unit

Experience the small-town charm in this centrally located Village of Lancaster property. Lancaster’s up-and-coming vibrant downtown offers access to local taproom and bodega, ample restaurant choices, and boutique shopping – all within walking distance! Looking for something to do outside the Village? This property is perfectly situated close to all of Buffalo’s Best Attractions: Bill’s Stadium - 21 mins; Airport - 12 mins; Buffalo Outer Harbor/Downtown - 22 mins; Chestnut Ridge Park - 25 mins

Top guest favourite
The living room features a flat-screen television mounted on the wall, with a modern black entertainment center and a small side table. Natural light enters through a window adorned with light curtains, while a patterned rug and various furnishings add to the space.
Flat in Cheektowaga
5 out of 5 average rating, 37 reviews

Convenient cozy two bedroom apartment

Convenient newly furnished 2 bedroom apartment near Buffalo Airport, Centrally located near Buffalo and Niagara Falls. Close to University at Buffalo. Five minutes to Buffalo International Airport. Enjoy this private 2 bedroom apt. steps from a walking park & playground. Enjoy Buffalo cuisine from many local restaurants. Come cheer on the Bills or Sabres or attend one of the many festivals and music events Buffalo has to offer. The Galleria Mall is minutes away as well as supermarkets.

Top guest favourite
A comfortable living area features a cozy fireplace set within a brick accent wall, providing a focal point. A large TV is positioned nearby, while a soft leather sofa and a vibrant orange chair offer ample seating. Natural light enters through the windows, enhancing the inviting ambiance.
Flat in Clarence
4.99 out of 5 average rating, 163 reviews

Meticulous Main St. Ranch 2 Bd Lux Apt. Rear Unit

This well-appointed, recently renovated, 1200 sq. ft. ranch duplex apt. is located on Main St in the heart of charming & historic Clarence, NY. The community is a beautiful, safe, and family friendly suburb of Buffalo, NY. The entire apt. is on one level, with four parking spaces next to the entrance. The beautiful open concept floor plan provides an abundance of natural lighting, creating a comfortable airy feeling, that is perfect for small gatherings, business travelers, and entertaining.

Top guest favourite
A single-story bungalow is showcased with a well-maintained lawn. The brick exterior is complemented by large windows that allow natural light. Neatly trimmed bushes and shrubs frame the entrance, while a pathway leads to the front door. A lamp post stands to the right, adding subtle illumination.
Home in Cheektowaga
4.94 out of 5 average rating, 105 reviews

Bungalow near BuffaloNiagara International Airport

Relax and unwind at this peaceful bungalow in suburban Buffalo. Comfortable 3-bedroom house located 2 miles from airport, 13.4 miles from Bills Stadium, 24 miles from Niagara Falls and only 15-minute drive from downtown Buffalo, NY. Two of the bedrooms are equipped with a queen-sized bed and the 3rd bedroom has a full sized bed. With plenty of storage space in the dressers and closets. Full kitchen/dining area. Laundry is available on site with a washer and dryer located in the basement.

Top guest favourite
Home in Cheektowaga
5 out of 5 average rating, 8 reviews

Cozy & Modern House in a Peaceful Neighborhood

Welcome to your home away from home. This beautifully maintained ranch-style residence offers the perfect balance of comfort, space, and modern convenience—ideal for both short getaways and extended stays. Located in a quiet, welcoming neighborhood, this single-family home features 1,327 sq. ft. Open-concept living space. The home includes three well-appointed bedrooms—one with a king bed and two with queen beds—making it a comfortable choice for families, groups, or business travelers.

Guest favourite
A living area features a wall-mounted television above a rustic wooden table. A small ladder shelf stands to the left, adorned with decorative items. The kitchen area is visible in the background, showcasing wooden cabinets and coffee-making equipment.
Flat in Depew
4.8 out of 5 average rating, 427 reviews

The Shecave - 2 Bedroom Apt

This is perfect for your staycation or for a cozy pit stop. If you’re looking for a short term, no frills, respite, or workplace area, this is the place for you. This is not intended as a party house. Plenty of take out, pick up, or delivery of food. We PRIDE ourselves on the CLEANLINESS of our spaces. Great for a visit to Niagara Falls. Close to Galleria Mall. Quiet and safe neighborhood. **Please be at least 25 book.** **Photo ID will be required from you after booking.**

Superhost
A living room area features a light-colored sofa set arranged around a circular glass-top table. A dark-patterned area rug is positioned beneath the furniture. A flat-screen television rests on a simple stand against the wall, while warm light emanates from a lamp on a side table.
Flat in Depew
4.83 out of 5 average rating, 24 reviews

Sharun’s Vacation House Near Niargafalls/Buffalo

Spacious 3-bedroom home in a prime location! Just 30 mins to Niagara Falls, 20 mins to Highmark Stadium, and within 5 mins walking distance to shops, restaurants, and all amenities. Perfect for families, groups, or long-term stays, this home offers a full kitchen, cozy living and dining areas, WiFi, smart TV, free parking, and a relaxing porch with outdoor space. Enjoy comfort and convenience while exploring all that Western New York has to offer.

Guest favourite
A comfortable living area showcases two armchairs and a spacious sofa, all adorned with decorative pillows. A circular coffee table anchors the space, while a patterned rug adds warmth. Natural light filters through sheer curtains, softly illuminating the neutral-toned walls and accent artwork.
Flat in Buffalo
4.88 out of 5 average rating, 138 reviews

Lovely 2-bedroom unit w/game room & free parking

Enjoy a stylish experience at this centrally-located place. Close to everything Buffalo has to offer. Be to the airport, Highmark stadium, down town Buffalo or Galleria mall in minutes. 2 bed 1 bath. One off street parking spot. House is located on a dead end street in a nice quiet neighborhood. Game room in the basement for the kids or adults, along with access to free washer and dryer. Free WiFi. Only a 28 minute drive to Niagara Falls.

Superhost
Flat in Bowmansville
4.74 out of 5 average rating, 161 reviews

Garden House Apartment

This lovely apartment has an open layout that includes a full kitchen and comfortable living space complete with a sofa-bed and large-screen TV . There is a private bedroom with a queen size bed. The decor is an eclectic collection of color, comfort and class. This decor was chosen with the intention that you, our guests will have a cozy experience when you choose The Garden House Apartment at Old Orchard Estate.

Guest favourite
A modern living area features a dark sofa adorned with decorative cushions. A large television is mounted on a media console, while two abstract art pieces hang on the wall. Natural light enters through the nearby doorway, highlighting the warm wood flooring.
Flat in Depew
4.85 out of 5 average rating, 79 reviews

Modern 2-bedroom upper apartment with free parking

Enjoy a stay in our updated, modern apartment! This is the perfect place for professionals on business or for couples or families visiting the area. Conveniently located within 10 minutes of the Buffalo Airport and the Galleria Mall and within 20 minutes of KeyBank Center and Highmark Stadium. You're guaranteed a great stay in our cozy modern space! Apartment comfortably sleeps four.

Superhost
The living room features a grey sofa and a brown leather couch, complemented by a wooden coffee table with decorative items. A framed artwork is displayed on the wall, and light streams through the windows with wooden trim, enhancing the cozy atmosphere of the space.
Home in Depew
4.86 out of 5 average rating, 43 reviews

Home sweet home away

Welcome to this newly remodeled bright gem in the village of Depew. Perfect for anyone who wishes to be close to most of what Buffalo has to offer! Spacious enough for a family and not too overwhelming for the traveling professional. This house has everything you need to feel like you are at home.

Popular amenities for Depew holiday rentals

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