
House holiday rentals in Los Santos Province
Find and book unique houses on Airbnb
Top-rated house rentals in Los Santos Province
Guests agree: these houses are highly rated for location, cleanliness and more.

3 min to Pedasi, 5 min to the Beach, Private Pool!
Your family will be close to everything when you stay at this centrally-located place. Outfitted with room to sleep 6 and a fenced yard for your dog, Casa Catch and Relax has it all! Look us up online, Casa Catch and Relax You'll Love - Beach access a short drive or walk away (3 min drive, 10 min walk) - Central to town and local restaurants - Private, fenced outdoor space with pool - Cool days and nights with A/C in every room - Fully equipped kitchen and tons of sleeping space - Wifi

Beachfront Gem w/ Ocean Views & Prime Surf Access
Welcome to your slice of beachfront paradise! Our home sits right on Cambutal's beautiful shoreline. Gorgeous ocean views greet you from every window, while the gentle rhythm of waves creates the perfect soundtrack for your stay. We've equipped the house with Starlink WiFi and a large dining table that doubles as an ideal workspace, making this a perfect retreat for both vacationers and remote workers. The house feels like a real home – comfortable, clean, and ready for your beach memories.

Peaceful Pedasi
Peaceful Pedasi. Get completely away from the city and forget the rest of the world exists. Pedasí is a town and corregimiento situated on the south-eastern tip of the Azuero Peninsula on Panama’s Pacific coast. And although remote enough to feel protected from the stresses of life, Pedasi offers wonderful dining and shopping. Our home offers a full functioning kitchen, large dining space, 5 Bedrooms, 4 Bathrooms, 2 car garage, private pool, and cabana with your own view of the ocean.

Casa Gerard
A stylish, modern beach house perched above the Pacific ocean and a large stylish pool. Ample space with 3 bedrooms with en-suite bathrooms, large open living space with a fully equipped kitchen, giving onto a large wooden deck. Una casa playera con piscina en un estilo moderno ubicada en la colina dando vistas espectaculares al mar Pacifico. Tiene 3 recamaras, cada una con su bano. Cuenta con un espacio abierta de sala y cocina bien equipada. Cuenta con un deck grande para disfrutar.

NinaHouse, casa amplia y fresca en Chitré.
Casa solo para ti, ahora con tanque de agua!hasta 7 p, amplia y en una de las mejores zonas de Chitré, tranquila y familiar, acceso a la piscina del area social, parques y canchas, cerca de todo: supermercados, casino, bus; ven a Chitre y disfrutar de comidas típicas, artesanía; planifica tus paseos y visita las mejores playas: Pedasi, Venao, Isla Iguana, podrás trabajar desde NinaHouse contando con un rápido internet. Ahora contamos con aire acondicionado en la sala para tu confort.

Casa Ola – Steps from the Beach | Pool & BBQ Oasis
Just a 2-minute walk from Playa Venao’s magical beach and top surf spots, Casa Ola is your own tropical hideaway. This modern, stylish home blends lush nature with laid-back comfort. Inside, you’ll find two cozy bedrooms, a fully equipped kitchen, and a relaxed living area with smart TV. Step outside to your pool, tropical garden, and BBQ. Perfect for sunny days and breezy evenings. Playa Venao’s best restaurants, surf schools, and ocean views are just a short stroll along the sand.

Steps from Ocean: Couple's Getaway Private Villa
Escape to Villa 37! A romantic casita in Blue Playa Venao, 1 min walk from the ocean. This charming 1 bedroom is perfect for two. Enjoy an ensuite bathroom, fully equipped kitchen, cozy living space, WiFi, A/C, dreamy bedding, laundry closet, toiletries, and a comfortable terrace. You will have full access to the Blue oceanfront pool, beach club and restaurant, the perfect spot to enjoy a cold beverage and an unforgettable sunset. Villa 37 is your perfect Playa Venao getaway!

Nuestro Lugar Feliz
Relájate con toda la familia en este tranquilo lugar para quedarse. Es una residencia unifamiliar, en la recámara principal mantenemos una cama Queen (1.50 m x 1.90 m) en la segunda habitación mantenemos 2 camas Twin (90 m x 1.90 m). En la residencia mantenemos disponibilidad para 4 personas cómodamente, sin embargo mantenemos un sillón cama y una cama tipo Pee disponible para 2 personas adicionales. Consulta el pequeño costo adicional por las personas adicionales.

Casa Samambaia - sea view tropical paradise w pool
With a modern tropical design, this home features a cozy living room and a stylish kitchen at the center of the social area. Open the glass doors to immerse yourself in open-concept living, seamlessly blending the indoors with the main terrace and the pool, all oriented towards the ocean view. With two en-suite bedrooms with AC and fans, the house is immersed in nature, green mountains, and a lovely garden, everything 5 minutes from the beach center.

Casa Pelicano - Tropical house w pool and seaview
Welcome to Casa Pelicano! Indulge yourself in a retreat with breathtaking views of the ocean and mountains from every corner. Unwind in the private refreshing pool, where the turquoise waters seem to blend seamlessly with the horizon. The stylish interior features open-plan living spaces, perfect for entertaining or relaxing. Whether you're soaking up the sun or gazing at the moonlit ocean under the stars, this home is your ultimate escape.

Country House Like in the City / La Casita
Casa fresca, con árboles, naturaleza y portales p/ descansar, cámaras de seguridad afuera Ubicación céntrica, cerca de malls, restaurantes, buses y ciclovía. Entrada privada, estacionamientos, cocina completa, mobiliario completo, baño, TV HD con cable, AC en recámara, agua caliente y Wi-Fi. ENG, PORT, FRAN and ITA Spoken! Contamos con un pozo de agua y sistema de purificación de agua por ósmosis inversa: agua segura, potable y purificada!

A minimalist Casita in Pedasi
Imagine a peaceful casita with ocean views and a nearby pool house boasting an edgeless pool overlooking the ocean. Plus, you have your own private beach. Inside, you will find an open-concept living space adorned with simple yet stylish furnishings, designed for relaxation and comfort. It's the perfect blend of tranquility, peaceful seclusion and breathtaking natural beauty. Gated community, 24 hour security
Popular amenities for house rentals in Los Santos Province
House rentals with a pool

Chitré Oasis: Modern Home with Private Pool & BBQ

Vista del Mar , Ocean view El Ciruelo

Yellowfin Casa 3

Beachfront home on Playa Venao + private pool

Casa Del Amor - Main Floor - on the beach.

Oceanfront Loft with Private Beach & Pool

Tropical Oasis, Full House, Private Pool,

Pedasí :Andromeda Boroda 4-6 p. Beach, swimm. pool
Weekly house rentals

Montana y Mar

Breathtaking Views: Sleeps 13, Walk to Beach!

Apartamento en Chitré

Casa en el centro de Las Tablas

Casa Almar · Beachfront | La Cuchilla, Cambutal

Casa en Plaza Praga - Las Tablas

El Refugio: Nature Escape in Chitré

Tropical Cozy Cabin / Playa venao
Private house rentals

Casa para grupos/Perfecta para Fiestas Locales

La Hacienda Ojo de Agua * Family & Friends Getaway

Pedasí, Earth House Casa Alegre / 3BR

Elegancia y comodidad en un solo lugar

Casa acogedora disponible para alquiler-Las tablas

2 Bed/2 Bath Beachfront House in prime location

Encantador Alojamiento en Las Tablas

Casa Blu · 3BR · Private Parking · Azuero Base
Destinations to explore
- Family-friendly rentals Los Santos Province
- Rentals with a patio Los Santos Province
- Rentals with outdoor seating Los Santos Province
- Pet-friendly rentals Los Santos Province
- Bed and breakfasts Los Santos Province
- Flat rentals Los Santos Province
- Guest house rentals Los Santos Province
- Smoking-friendly rentals Los Santos Province
- Rentals with pools Los Santos Province
- Rentals with beach access Los Santos Province
- Rentals with a washing machine and dryer Los Santos Province
- Rentals with a firepit Los Santos Province
- Hotel rooms Los Santos Province
- Apartment rentals Los Santos Province
- Boutique hotels Los Santos Province
- Beachfront rentals Los Santos Province
- Rentals with a hot tub Los Santos Province
- Waterfront rentals Los Santos Province
- Rentals with an accessible-height bed Los Santos Province
- Villa rentals Los Santos Province
- House rentals Panama





