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Holiday rentals in Santa Clara, Panama City

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Top-rated holiday rentals in Santa Clara, Panama City

Guests agree: these stays are highly rated for location, cleanliness and more.

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Guest favourite
Flat in Panamá
4.93 out of 5 average rating, 130 reviews

Apto 4 min from Tocumen Airport | 24-hr check-in

Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

Guest favourite
Flat in Parque Lefevre
4.95 out of 5 average rating, 42 reviews

5MINUTOSCOSTADELESTEwifi6-tvstreaming

BIENVENID@! disfruta de la sencillez de este alojamiento tranquilo y céntrico. El apartaestudio es ideal para esas personas que quieren conocer la ciudad y también para el que viene por trabajo,ya que tiene su escritorio y su comodidad,esta cerca de plaza de comidas,supermercados,gym,etc. queda cerca a algunos lugares turísticos,como costa del este centro de negocios,malecón,Panamá Viejo.. te puedo horientar para sitios turísticos si necesitas carro en alquiler también tenemos esa opción 😇

Guest favourite
A comfortable sleeping area is presented with a spacious bed covered in a soft, patterned blanket. Lively artwork featuring tulips adorns the wall above, while bedside tables with lamps provide gentle illumination. Dark curtains frame the window, and air conditioning is installed overhead.
Loft in Panama
4.95 out of 5 average rating, 60 reviews

Entire Apartment #4, 20 minutes from the airport

Comfortable and cozy apartment on Av. la Pulida, 8 minutes from the Cincuentenario metro station. For business travelers and couples, this apartment features a bedroom with a full bed, a TV in the room, a full bathroom with hot water, a fully equipped kitchen, a living-dining room, a Smart TV, air conditioning, a laundry room, and a closet. It's just 8 minutes from the metro station and offers easy access to any point in the city. Centrally located, yet quiet. Enjoy a perfect stay!

Top guest favourite
Flat in San Felipe
5 out of 5 average rating, 14 reviews

Luxury Balcony Stays + Pool Casco Viejo

Wake up overlooking one of the last historic bastions of Casco Viejo, sip your morning cofee on a private balcony, and step directly into Panama City most vibrant and wakable neighboorhood. Surrounded by colonial architecture, charming plazas, and a vibrant culinary scene, this space invites you to experience Panama with style and tranquility. Ideal for those seeking an exclusive, walkable, and characterful environment in one of the city's most iconic areas.

Top guest favourite
A spacious living area features a combination of modern and vintage furnishings. A large turquoise sofa and a floral chaise lounge are complemented by a round coffee table and a green wooden chair. Exposed stone walls and large windows with blue accents create a warm ambiance.
Flat in San Felipe
4.98 out of 5 average rating, 180 reviews

The apartment of a legendary Panamanian footballer

Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Guest favourite
The kitchen features modern cabinetry and a granite countertop, equipped with stainless steel appliances. A dining table with stylish chairs is set elegantly with plates and glasses. Fresh flowers are placed in a vase, adding a touch of color to the dining area.
Flat in Costa del Este
5 out of 5 average rating, 30 reviews

Luxury 2BR Suite with Pool & Views

Live a Luxury Experience in the Heart of Panama City 🏙️✨ Welcome to your home away from home: a modern and elegant apartment designed to offer you the highest level of comfort, style, and functionality. Perfect for tourists, business travelers, or remote workers, every space has been thoughtfully designed to ensure an unforgettable stay. We look forward to welcoming you and offering you a luxurious and comfortable experience.

Superhost
Guest house in Panama City
4.88 out of 5 average rating, 254 reviews

Boho Studio - Private Terrace 9 km from the airport

Perfecto para 1–2 huéspedes, Wifi, Terraza tranquila, cuarto independiente, cuenta con A/C , y su baño pequeño. Ubicado cerca del Aeropuerto Internacional de Tocumen, de 10 a 13 minutos en auto. El Studio está Cerca de 2 Centros Comerciales, Metromall y Los Pueblos OUTLET. La zona residencial es segura al caminar, calles organizadas y limpias. Tenemos la estación del Metro de Cerro Viento afuera en Metromall.

Guest favourite
A spacious balcony offers a panoramic view of Panama City's skyline, with a backdrop of dramatic clouds and sunlight illuminating the scene. A modern swing chair sits alongside a potted plant, inviting relaxation among the urban landscape.
Serviced apartment in Parque Lefevre
4.92 out of 5 average rating, 38 reviews

Luxury Suite 18th View Coco del Mar Panama

Immerse yourself in the elegance and comfort of this beautiful apartment located in the heart of Panama. With stunning views of the ocean and the city, it is designed to provide you with a unique experience. Equipped with top-notch amenities such as a pool, gym and social areas, this space guarantees a stay full of tranquility, luxury in this haven of tranquility and exclusivity. Your home away from home!

Superhost
The living area features a light blue accent wall and a cozy gray sectional sofa accompanied by a round ottoman. A large window with striped awnings allows natural light to fill the space. Wall art and a small shelf with a clock add functional decor.
Flat in Distrito de Panamá
4.79 out of 5 average rating, 24 reviews

Hippodrome Suites

Hippodrome Suites is located in a safe gated community in the suburbs of Panama City, just a short drive 🚘 from the Tocumen International Airport (✈️PTY), Santa Maria and Costa del Este Budiness District. City views, 24-hours security and covered parking. It is ideal for resting and working, business trips or layover nights. This condo offers a perfect mix of comfort, convenience, and tranquility.

Guest favourite
The kitchen area features a black dining table with four chairs, complementing a modern microwave and refrigerator. Warm decorative elements, including wall art and a candle, add character to the space, which is equipped with essential appliances and a clean countertop.
Home in Panamá
4.94 out of 5 average rating, 407 reviews

Private Studio 10 Min from the Airport!

Entire apartment 10 minutes from the airport! The apartment is fully furnished including appliances and kitchen items, toiletries, dining room, work table and more. Just a few minutes walk from the SAN ANTONIO METRO Station, restaurants, shopping malls, laundries, supermarkets and pharmacies. We offer tours to San Blas to make the most of your trip. Our house is your house in Panama 🇵🇦

Top guest favourite
A spacious living area is highlighted by large windows that offer views of urban high-rises and the distant ocean. A soft, rounded sectional sofa and a plush armchair provide comfort, while a dark area rug anchors the space beneath a sleek coffee table.
Flat in Costa del Este
5 out of 5 average rating, 31 reviews

Elegant Apt in Costa del Este. Premium Amenities

Enjoy a luxurious stay in our modern design apartment located in the exclusive Costa del Este area. It has a room with a private bathroom, a cozy living room, and a fully-equipped kitchen. Building facilities include a state-of-the-art gym, swimming pool, and co-working space ideal for remote work. Perfect for extended stays, combining comfort and convenience in the heart of Panama.

Guest favourite
A private balcony features woven chairs and a glass-topped table. Green ferns are visible hanging from the wall, while the tiled roof of nearby buildings adds a traditional touch to the view.
Loft in San Felipe
4.88 out of 5 average rating, 208 reviews

Corcho rooms #1 - queen rom with a balcony

Enjoy charming “Corcho rooms” in the heart of touristic Casco Viejo district of Panama City. We carefully restored old colonial building and converted it to the restaurant and apartments upstairs. “Corcho” is luckily situated in the central, restored part of Casco. Most of the buildings around are restored and the neighborhood is safe.

Popular amenities for Santa Clara, Panama City holiday rentals

  1. Airbnb
  2. Panama
  3. Panamá Province
  4. San Miguelito
  5. Santa Clara