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Holiday rentals in Santa Clara, Panama City

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Top-rated holiday rentals in Santa Clara, Panama City

Guests agree: these stays are highly rated for location, cleanliness and more.

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Guest favourite
Flat in Panamá
4.93 out of 5 average rating, 131 reviews

Apto 4 min from Tocumen Airport | 24-hr check-in

Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

Top guest favourite
A modern living area features a light-colored sofa adorned with colorful cushions. A round coffee table sits on a textured rug, while a dining table for six is visible in the background. Large windows present striking views of the city skyline.
Flat in Panama City
5 out of 5 average rating, 66 reviews

Luxury apt in Panama City 2 Rooms 3 Baths

El edificio Wanders by yoo esta ubicado en el corazón de la ciudad, es un proyecto fuera de serie donde cada rincón tiene una historia que contar. Recepción 24/7, muchas areas de esparcimiento, estación de hidratación. En las afueras del lobby tenemos la Cafetería cafe con teclas y un restaurante de Carnes Popino. En el area social servicio de barra en la piscinas, parque de niños, sala de juegos con pantallas en e l techo baños, salon de eventos, cocina para eventos, gym full equipado y más

Guest favourite
A spacious outdoor area features wooden dining tables surrounded by potted plants. The space includes a plunge pool, comfortable seating, and a hammock for relaxation, with views of the nearby structures and the sky above.
Flat in Panamá
4.87 out of 5 average rating, 390 reviews

Casco Viejo 360° View Old Tower Penthouse

Located in one of the oldest buildings in Panama and set over 3 stories with unrivaled panoramic views over the historical Casco Viejo, the skyline of Panama City and views of the causeway, our gorgeous penthouse is the ideal space to take in the local sights, sounds, art, culture, socialize with your friends and family, or simply relax in a cozy love nest! Top speed wifi, excellent location, and fully equipped with all the home comforts, the penthouse is the perfect spot to explore Panama.

Guest favourite
A stone pathway leads through lush tropical foliage toward a welcoming entrance. Tall trees and vibrant greenery frame the path, creating a serene approach to the property, which is partially visible in the background, surrounded by nature's tranquility.
Home in Panama City
4.97 out of 5 average rating, 75 reviews

Mountain Retreat

Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

Guest favourite
A comfortable sleeping area is presented with a spacious bed covered in a soft, patterned blanket. Lively artwork featuring tulips adorns the wall above, while bedside tables with lamps provide gentle illumination. Dark curtains frame the window, and air conditioning is installed overhead.
Loft in Panama
4.95 out of 5 average rating, 60 reviews

Entire Apartment #4, 20 minutes from the airport

Comfortable and cozy apartment on Av. la Pulida, 8 minutes from the Cincuentenario metro station. For business travelers and couples, this apartment features a bedroom with a full bed, a TV in the room, a full bathroom with hot water, a fully equipped kitchen, a living-dining room, a Smart TV, air conditioning, a laundry room, and a closet. It's just 8 minutes from the metro station and offers easy access to any point in the city. Centrally located, yet quiet. Enjoy a perfect stay!

Top guest favourite
A balcony is visible with colorful tiled tables and black wrought iron chairs. Lush potted greenery adds a natural touch, while surrounding buildings with terracotta roofs can be seen in the background. The scene is illuminated by daylight, enhancing the vibrant colors.
Loft in Panama
4.99 out of 5 average rating, 172 reviews

Patty’s Casco 2BR Loft | Balcony & Personal Touch

“Feel at home in Casco Viejo—personally welcomed by your hosts, Patty & Rudy.” Stay in the Heart of Casco Viejo with Patty’s Casitas! Prime Casco Viejo Location | Quiet, Convenient & Charming Stay steps from restaurants, cafés, bars, and plazas—right by the El Rey boutique supermarket and the waterfront promenade. This peaceful spot is rare in Casco, tucked away from rooftop noise and perfectly located at the entrance of the neighborhood for easy in & out access!

Top guest favourite
Flat in Panamá
5 out of 5 average rating, 15 reviews

Luxury Balcony Stays + Pool Casco Viejo

Wake up overlooking one of the last historic bastions of Casco Viejo, sip your morning cofee on a private balcony, and step directly into Panama City most vibrant and wakable neighboorhood. Surrounded by colonial architecture, charming plazas, and a vibrant culinary scene, this space invites you to experience Panama with style and tranquility. Ideal for those seeking an exclusive, walkable, and characterful environment in one of the city's most iconic areas.

Top guest favourite
A spacious living area features a combination of modern and vintage furnishings. A large turquoise sofa and a floral chaise lounge are complemented by a round coffee table and a green wooden chair. Exposed stone walls and large windows with blue accents create a warm ambiance.
Flat in Panamá
4.98 out of 5 average rating, 180 reviews

The apartment of a legendary Panamanian footballer

Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Superhost
A spacious bed is presented with a neatly arranged white bedspread, complemented by light wooden nightstands on either side. Each nightstand features a lamp providing soft illumination, enhancing the calming atmosphere of the room.
Flat in Panamá
4.78 out of 5 average rating, 27 reviews

chanis-apto-wifi-kitchen-tv-streaming-panamaviejo

Hello 😇 I want you to feel at home! This accommodation is cozy, quiet and centrally located. Its prime location will allow you to explore the city with ease. Its location in downtown Chanis, the accommodation offers peace and quiet. Ideal for three people looking for a pleasant stay. Relax in a cozy and comfortable atmosphere. with easy access to large shopping areas, it is 5 minutes away from the east coast (tourist) and also the ruins of Panama

Guest favourite
Guest suite in Panamá
4.93 out of 5 average rating, 69 reviews

Studio- Stay for 2 near PTY Tocumen Airport

✈️ Perfect for layovers, late or early flights and short stays Stay just 10 minutes from Tocumen Airport and recharge comfortably before your next flight. • Easy Check-in 🛏️ Private studio for up to 2 guests ❄️ Air conditioning 📶 Fast WiFi 🚿 Hot shower 🍳 Equipped kitchen 🔒 Safe residential community 🚗 Airport shuttle available (pre-book) 🕒 Flexible self check-in after 3pm Ideal for travelers in transit, couples, or short stays without hassle.

Superhost
Guest house in Panama City
4.88 out of 5 average rating, 254 reviews

Boho Studio - Private Terrace 9 km from the airport

Perfecto para 1–2 huéspedes, Wifi, Terraza tranquila, cuarto independiente, cuenta con A/C , y su baño pequeño. Ubicado cerca del Aeropuerto Internacional de Tocumen, de 10 a 13 minutos en auto. El Studio está Cerca de 2 Centros Comerciales, Metromall y Los Pueblos OUTLET. La zona residencial es segura al caminar, calles organizadas y limpias. Tenemos la estación del Metro de Cerro Viento afuera en Metromall.

Guest favourite
The kitchen area features a black dining table with four chairs, complementing a modern microwave and refrigerator. Warm decorative elements, including wall art and a candle, add character to the space, which is equipped with essential appliances and a clean countertop.
Home in Panamá
4.94 out of 5 average rating, 407 reviews

Private Studio 10 Min from the Airport!

Entire apartment 10 minutes from the airport! The apartment is fully furnished including appliances and kitchen items, toiletries, dining room, work table and more. Just a few minutes walk from the SAN ANTONIO METRO Station, restaurants, shopping malls, laundries, supermarkets and pharmacies. We offer tours to San Blas to make the most of your trip. Our house is your house in Panama 🇵🇦

Popular amenities for Santa Clara, Panama City holiday rentals

  1. Airbnb
  2. Panama
  3. Panamá Province
  4. San Miguelito
  5. Santa Clara