Skip to content
Sign up
Log in
Vacation rentals in Santa Cruz

Vacation rentals in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

Punta Barco Home near Playa Teta with Cental A/C
SUPERHOSTEntire house · 8 guests · 4 beds · 2.5 bathrooms
Punta Barco Home near Playa Teta with Cental A/C

New house in one of the best beaches in Panama, Playa Teta, Punta Barco. Near grocery stores, restaurants, and hospital. House has central air conditioning, fully equipped kitchen, pool, and grill.

What guests are saying:

“We absolutely LOVED our stay at Carlo's place. The entire house, backyard and pool were very clean and inviting. The central a/c worked great. The house was quite stylish and had an inviting, calm and relaxing vibe. The huge flat screen tv with cable channels was nice for kicking back and relaxing. The pool was the perfect size for hanging out. The beds were very comfortable and the bedrooms were large. Carlo was very pleasant to talk to and quick to respond to any questions we had. He also suggested some good eats in the area. Overall we had an excellent experience and would definitely come back again!”

Casa Di Pietra
SUPERHOSTPrivate room · 3 guests · 1 bed · 1.5 bathrooms
Casa Di Pietra

Casa Di Pietra is located in the lush, calm and relaxing Valle de Antón, about 1 hour and 30 minutes from Panama City. We are a family operated B&B since 2010 and offer 6 rooms each with private bathroom, breakfast, parking space and much more.

What guests are saying:

“This is an absolutely lovely place in such a peaceful town - a highlight of our time in Panama! Alfredo is so welcoming and friendly and we felt right at home immediately. Our top floor room had windows on two sides and a comfortable balcony. The winds in this area are truly something to experience and this was the perfect place for it. The house is centrally located but felt private and far away from the hustle and bustle of Panama City. The breakfasts were wonderful and we would absolutely stay here again on another trip to El Valle!!!”

Experience Panama @ Villa Bowes
SUPERHOSTEntire villa · 2 guests · 1 bed · 1 bathroom
Experience Panama @ Villa Bowes

come live in Paradise, if only for a brief stay, relax, take in awesome views of Mountains, Valleys and the Pacific Ocean, from the wraparound Terrace. excellent hiking trails, and natural Mountain swimming hole. Close to several Beaches, and neighbouring Mountain Community of el Valle.

What guests are saying:

“Fabulous! A private, quiet mountain getaway with a nice cool wind and gorgeous views from the front and back! The cozy cottage is decorated beautifully and the bed is unbelievably comfortable with the best linens, softest blanket and down pillows! Great hosts! Brian replied within minutes to every message and Jeanette can give you more info on Panama than you would ever need! A trip to the waterfall & swimming hole is a must! Highly recommend!!”

Holiday rentals for every style

Get the amount of space that is right for you.

  • Homes
  • Hotels
  • Unique stays

Popular amenities for Santa Cruz holiday rentals

  • Kitchen
  • Wifi
  • Pool
  • Free parking on premises
  • Air conditioning

Other great holiday rentals in Santa Cruz

Dreamy Beachfront Condo in Paradise (Palmar beach)
SUPERHOSTEntire apartment
Dreamy Beachfront Condo in Paradise (Palmar beach)
Price:$ 38 SGD / night
Perfect for birdwatchers, nature lovers
Ecolodge
SUPERHOSTEntire flat
Perfect for birdwatchers, nature lovers Ecolodge
Price:$ 95 SGD / night
Privat Casa INDIA DORMIDA by Hiking Trail
SUPERHOSTEntire bungalow
Privat Casa INDIA DORMIDA by Hiking Trail
Price:$ 88 SGD / night
Chic Coronado Beach House
SUPERHOSTEntire villa
Chic Coronado Beach House
Price:$ 258 SGD / night
Birders and nature lovers enjoy Cabanas Potosi
SUPERHOSTPrivate room
Birders and nature lovers enjoy Cabanas Potosi
Price:$ 79 SGD / night
Rio Mar Surf Platforms in the Trees.
SUPERHOSTEntire bungalow
Rio Mar Surf Platforms in the Trees.
Price:$ 106 SGD / night
Casa de Playa en Costa esmeralda
SUPERHOSTEntire cottage
Casa de Playa en Costa esmeralda
Price:$ 360 SGD / night
Amazing SMART House in Coronado Beach
Private Pool
SUPERHOSTEntire house
Amazing SMART House in Coronado Beach Private Pool
Price:$ 185 SGD / night
Luxurious designer beach house with private pool
SUPERHOSTEntire house
Luxurious designer beach house with private pool
Price:$ 595 SGD / night
Modern House in Altos del Maria, Panama
SUPERHOSTEntire house
Modern House in Altos del Maria, Panama
Price:$ 363 SGD / night
Amazing Beach Condo Rio Mar, Panama
SUPERHOSTEntire flat
Amazing Beach Condo Rio Mar, Panama
Price:$ 161 SGD / night
Cabaña Victoria
Private room
Cabaña Victoria
Price:$ 75 SGD / night
Show all