Some info has been automatically translated. Show original language

Holiday rentals in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

%{current} / %{total}1 / 1
Guest favourite
A tranquil beachfront scene features several hammocks strung between palm trees on soft sand. Blue lounge chairs are positioned alongside the water, with gentle waves lapping at the shore under a clear sky.
Villa in Chame District
4.85 out of 5 average rating, 249 reviews

Surf Relax Play Pacific Ocean View Villa

White sand, surf-able waves, or just a comfortable chill vibe to enjoy the tropical weather of Panama. Playa Caracol is about an hour and 10 minutes drive from the city. This spacious, 2 bedroom, 2 bath villa with it's Pacific Ocean front location is the perfect place for you to enjoy an unforgettable family vacation. Walk out to the beach just steps from the villa, swim in the pool next to this villa or enjoy the resort pools and amenities. Or hike the nearby mountains with a local guide. PET

Top guest favourite
The exterior of the cabin is depicted, featuring a stone wall and a metal roof. A manicured grass area surrounds the structure, with pine trees in the background against a bright blue sky, creating a serene environment.
Cabin in Chicá
4.94 out of 5 average rating, 291 reviews

Horizonte Cabin by Casa Amaya

Take it easy at this unique and tranquil getaway at Cabaña Horizonte. Casa Amaya is a complex of 6 cabins located in Chicá de Chame, a cool climate between 18 and 24 degrees, where you can connect with nature and relax with your partner, friends or family. https://www.airbnb.com/h/miradorbycasamaya https://www.airbnb.com/h/lospinosbycasaamaya https://www.airbnb.com/h/buenavistabycasaamaya https://www.airbnb.com/h/panoramabycasaamaya We have an electric generator in case of power outages.

Guest favourite
A spacious outdoor area features an inviting parking space beside a well-lit terrace. Comfortable seating arrangements are visible under the covered porch, surrounded by greenery and decorative potted plants. The design promotes relaxation and social gatherings in a welcoming environment.
Home in Chame District
4.77 out of 5 average rating, 62 reviews

3 bedroom residence near beaches and rivers

Residencia amplia cerca de playas y ríos. Con amplia terraza, Asador. Tres habitaciones capacidad 7 personas. Dos camas king otra doble o fuul y sofá cama. Muy cerca variedad de restaurantes, supermercados, tiendas. Cocina amplia equipada. Aire Acondicionado en todos los espacios. Agua caliente. Asador, estacionamiento. Ubicada en el Celaje de Chame detrás de la policía del transito calle 11 de octubre bajar directo Octava Casa muro verde portón corredizo chocolate. WiFi-9192

Top guest favourite
A welcoming outdoor area features a stone pathway leading to a cozy seating arrangement with two pink chairs and a small table. Lush greenery surrounds potted plants and hanging decorations, while a patterned rug adds comfort underfoot.
Cottage in Las Lajas Coronado
4.95 out of 5 average rating, 79 reviews

House in Playa Coronado near the beach

Blocks from the beach in Playa Coronado, Panamá. This cottage/casita comes with private master bedroom, small living room that can also be used as a second bedroom, a bathroom with hot water, A/C, TV, and WiFi. You'll also have a fully equipped private kitchen with stove, refrigerator, microwave, air fryer, ice maker, etc. and huge outdoor living/sitting area with hammocks. You will also have access to a laundry room and a pool. Secure parking available under carport. Quiet neighborhood.

Top guest favourite
The exterior of the three-story beach house is showcased, featuring terracotta roofs and lush landscaping. Palm trees and colorful flowers enhance the vibrant surroundings, while the ocean is visible in the background, complementing the peaceful neighborhood setting.
Home in San Carlos
4.94 out of 5 average rating, 145 reviews

OceanView-Rooftop Jacuzzi&Pool | Concierge Service

Unique 3-story beach house – one of a kind. 7 bedrooms, 13 beds, 8.5 baths. hot water. Every room with full bath -AC’s and ceiling fans in all rooms, separate laundry -Rooftop area pool, Jacuzzi, bar, BBQ(charcoal & gas) with amazing ocean view -High ceilings, large open kitchen and living area. -Spacious balcony for dining or relaxing. - 5 min. walk to the beach. -Parking for up to 7 cars - Base rate covers up to 4 guests, with a $40 charge per additional person, per night.

Top guest favourite
A light-filled living area features a comfortable sofa and two accent chairs around a wooden coffee table. Large glass doors provide stunning views of nearby mountains and allow access to the balcony. A practical TV unit is mounted on the wall, completing the space.
Apartment in Nueva Gorgona
4.94 out of 5 average rating, 54 reviews

Gorgeous Beachfront Condo w/ Amazing Views 1413

As close as you can get to the beach! Welcome to Gorgona’s newest beachfront condo project, Royal Palm. Located just 50 minutes from Panama City and minutes to Coronado. This 2 bedroom is fully furnished, located on the 14th floor and offers stunning Pacific ocean and mountain views. Take a dip in any of the 4 pools or put your feet in the sand and swim in the ocean. DISCLAIMER: if looking to book a stay more than 90 days out, please contact Beth directly.

Superhost
A private swimming pool is set against a backdrop of vibrant sunset colors. Water features provide gentle splashes, and green plants outline the pool area. The modern house with large windows is visible in the background, blending with the natural surroundings.
Cottage in Panamá Oeste
4.82 out of 5 average rating, 188 reviews

Santa Fe de Lajas Chame, Panama.

Santa Fe de Lajas in Chame, Province of West Panama, a vacation home that allows you to connect with nature and spend leisure time alone or with family. The house has a capacity for 10 people. It has three bedrooms, each with its own private bathroom. Kitchen, living room, dining room, a room to work, pool, covered terrace, outdoor garden and BBQ area. Wi-Fi and TV services. Access to the area's beaches, shopping centers, mountains, etc.

Top guest favourite
Flat in Chame, Panama
5 out of 5 average rating, 8 reviews

24-hour ocean view in Coronado

Relax in this quiet and elegant space. You can walk to the beach, and you can go to eat a delicious dinner or lunch at nearby restaurants. If you want to go to the gym, we have all the equipment. Go and enjoy the pool, which is lovely and large for swimming. We have ping-pong tables, a pool table, a recreation area, and you have a workspace, and a refreshing view of the sea. We have a room with a queen size bed and a sofa bed.

Guest favourite
Tiny home in Altos del Maria
4.83 out of 5 average rating, 178 reviews

Arcón House

This earth-sheltered studio home offers a unique and romantic escape in the mountain of Altos del Maria. Cozy space surrounded by a lush green environment, ideal for those seeking a peaceful getaway, or an affordable stay to explore the gated community's amenities. This bunker home provides an inviting haven to unwind and disconnect from the hustle of city life.

Guest favourite
A modern kitchen is equipped with stainless steel appliances and an island with four white chairs. Natural light enters through the window, highlighting the white cabinetry and stylish decor. A wall-mounted TV and decorative hanging light fixture enhance the functional yet inviting space.
Villa in Chame
4.78 out of 5 average rating, 41 reviews

Sea Breeze (C12-1D) 2 bed, 2 bat

Beachfront ground-floor villa with ocean and pool views at Playa Caracol. This stylish 2-bed, 2-bath unit features a private patio, full kitchen, and elegant furnishings. Master bedroom includes a TV; guest room has bunk beds and extra sleeping space. Enjoy modern comforts, mountain views, and 1km of beautiful beach just steps away—your perfect coastal getaway!

Guest favourite
Home in San José
5 out of 5 average rating, 11 reviews

Family Paradise | Pool, Jacuzzi & Garden

Escápate a esta exclusiva villa en Punta Barco, dentro de una urbanización privada. Disfruta piscina y jacuzzi privados, amplias terrazas, un enorme jardin y 4 elegantes recámaras. Perfecta para familias o grupos que buscan lujo, privacidad y cercanía a la playa. El terreno de esta villa es totalmente cercado.

Top guest favourite
A spacious bed is dressed in a colorful quilt, complementing an inviting orange pillow. Large glass doors offer a panoramic view of the surrounding mountains and lead to a private outdoor space with a swimming pool.
Tiny home in Panamá
4.97 out of 5 average rating, 232 reviews

Mountain cabin in Altos del María

The cabin in Altos del María is located in the heart of the mountain, with beautiful landscapes, trees, animals, monkeys, birds, just minutes from picnic areas, outdoor games, river, waterfall, trails and viewpoints. Escape into nature! Close to everything, away from the daily grind!

Popular amenities for Santa Cruz holiday rentals

  1. Airbnb
  2. Panama
  3. Panamá Oeste
  4. Santa Cruz