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Holiday rentals in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top guest favourite
The living area features large glass doors that invite natural light and views of the garden. Indoor plants enhance the space, and a cozy seating arrangement includes a sofa and eclectic chairs. A workspace with a desk and lamp is positioned to the side.
Guest house in El Valle de Antón
4.99 out of 5 average rating, 124 reviews

Spacious Casita with Bamboo View

Walk 20 minutes to the artisan mercado and restaurants on Ruta 71. Cerro Cara Iguana trailhead is walking distance from the casita. High insulated ceilings and 2 ceiling fans for comfort. Private hammock patio for an afternoon nap. Washer/dryer in the casita. Hot water throughout. Kitchen has a 2 burner cooktop, countertop oven, microwave, instant pot, electric skillet, blender and coffee maker. 2 Internet providers and a small workspace available. * No television set * Non smoking property

Guest favourite
Guest house in El Valle de Antón
4.95 out of 5 average rating, 100 reviews

The Retreat in El Valle - Garden House

Welcome to your serene retreat in El Valle, Panama! Nestled amid lush nature, our two-bedroom casitas offer a peaceful escape with breathtaking views, exotic wildlife, and flora. Each casita features a queen bed, choice of king or twin beds in the second room, a small fridge, coffee station, Wi-Fi, and large terrace. Enjoy the shared pool, meditation and healing sessions by appointment, and explore world-class hiking nearby. Just a short walk to restaurants and El Valle’s famous artisan market!

Top guest favourite
Home in Costa Esmeralda
4.98 out of 5 average rating, 211 reviews

Beach House-Amazing Pool & Jacuzzi - Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

Top guest favourite
A swimming pool is positioned in the foreground, surrounded by lounge chairs and shaded by umbrellas. The house features a terracotta roof and a hammock hangs near the entrance, with lush greenery and a twilight sky providing a serene backdrop.
Home in Playa Coronado
5 out of 5 average rating, 39 reviews

The Dream of Playa Coronado

Whether traveling to Playa Coronado to relax, spend time with family, flee the cold weather or scout your retirement destination, this house is perfectly located in the heart of Playa Coronado and features an airy, tropical ambience, a pool with loungers to soak up the sun, two bohios with dining/lounging areas, hammocks to sway your day away and a BBQ to cook fresh fish bought at the local fish market. The house has a water well so no problems with access to water during the Dry Season.

Guest favourite
A private pool area is featured, surrounded by lush greenery. A patio table with six chairs invites dining outdoors, while a lounge chair with colorful stripes offers a spot for relaxation. A large umbrella provides shade by the shimmering blue water.
Place to stay in San José
4.93 out of 5 average rating, 201 reviews

House in Punta Barco - Pool and Nature

Sun, breeze, nature, and tranquility. House 2 minutes away from the sea. Come and relax with all the amenities. We have: - 1 master bedroom (king size bed) with air conditioning, full bathroom - 1 room with queen bed, bunk bed, A/C, and full bathroom - 1 room with queen bed, bunk bed, air conditioning, and full bathroom - 1 room for service personnel: 1 bunk bed, fan and full bathroom. Private pool with sunbed, a practical bench, and a dining table. Large terrace with 3 hammocks.

Guest favourite
A stone paved area features four wooden chairs arranged around a central fire pit, illuminated by soft landscape lighting. In the background, a cabin structure can be seen, bordered by lush greenery and softly lit paths, creating an inviting outdoor space.
Cabin in Provincia de Panamá Oeste
4.89 out of 5 average rating, 294 reviews

Buenavista Cabin by Casa Amaya

Casa Amaya is a cabin complex located one hour from the capital city, in Chicá de Chame, with pleasant temperatures between 18 and 24 degrees, where you can get in touch with nature and relax with your partner, friends or family. Other cabins: https://www.airbnb.com/h/miradorbycasamaya https://www.airbnb.com/h/lospinosbycasaamaya https://www.airbnb.com/h/panoramabycasaamaya https://www.airbnb.com/h/horizontebycasaamaya We have an electric generator in case of outages.

Guest favourite
Home in Altos del Maria
4.76 out of 5 average rating, 147 reviews

Villa Acuario

Relaxation is guaranteed in this one-of-a-kind glass house nestled in the lush mountains of Altos del María. Surrounded by nature and designed with floor-to-ceiling glass walls on all sides— as if you’re living inside a crystal ball. With no direct neighbors, panoramic forest views, it is perfect for a family getaway, a quiet reset, or an extended stay. The home offers light-filled interiors during the day and unforgettable stargazing nights from the rooftop.

Guest favourite
A small pool sits within a wooden deck area, surrounded by lush greenery. Steps lead from the deck to the pool, where a gentle waterfall feature adds a soothing element. Lounge chairs are positioned nearby for relaxation in a tranquil setting.
Guest house in Panamá Oeste
4.84 out of 5 average rating, 143 reviews

Mountain cabin with private pool

Enjoy peace and nature in this cozy and equipped cabin, perfect for disconnecting and relaxing. Surrounded by forests and spectacular views, here you can breathe fresh air and gaze at the stars. ✔️ Ideal for couples, families or adventurers. ✔️ Trails, rivers and viewpoints nearby. ✔️ Comfortable and equipped spaces for your comfort. - Sleeps 4 people. - Possibility of having 1 double bed and 2 single beds or 4 single beds. - Discount for two nights or more.

Guest favourite
An outdoor patio space is presented with wooden chairs and a small table. Lush green grass extends towards the sandy beach, adorned with palm trees and sun loungers under thatched umbrellas, creating a calm coastal view.
Home in Chame
4.85 out of 5 average rating, 104 reviews

P/Caracol Ocean Haven View (C5-PBB) 2 bed, 2 bath

This unique place has a style all its own, steps away from the ocean and fully furnished ground floor unit 2 bed/2 bath apt has an open concept living, dining & kitchen space and an outside pergola area. (4 guests). This is a unique villa apartment over looking the picturesque Playa Caracol coast with ocean front and majestic mountain views and great on-site amenities. 1km of beach to offer you the best beach and surfing experience around.

Top guest favourite
Camper van/Motorhome in El Valle de Antón
4.99 out of 5 average rating, 263 reviews

Armadillo Shelter & Garden Valle de Anton

It is a unique and special accommodation that we have designed for you to experience the Anton Valley in a more conscious and natural way. It's a remodeled RV or trailer, to make it cozy>functional and comfortable>tiny house style. The space has a small and complete kitchen, hot water, Wi-Fi, coffee and tea. It is surrounded by a nice garden. With a separate entrance and an area to park the car. Ideal for 1-2 people.

Top guest favourite
The modern two-story cabin features large glass windows that offer expansive views of the surrounding greenery. A spacious deck with seating is visible, surrounded by lush vegetation and natural stone pathways leading up to the entrance.
Cabin in Panamá Oeste
4.91 out of 5 average rating, 200 reviews

Altos del María Cabin La Loma de Styria

Relax with the whole family at this peaceful place to stay. It is a fantastic, cool and pleasant place where you can do many ecotourism activities, the best option if you want to have one of the best views you can imagine. Great for couples too. We have 2 bedrooms on the 2nd floor and 2 bathrooms. Multiple places to take beautiful photographs

Top guest favourite
A spacious living area features large windows that provide a view of the ocean. Comfortable seating options include a sectional sofa and armchairs. A round coffee table sits on a textured rug, while ceiling fans circulate air in the bright, airy space.
Apartment in Nueva Gorgona
4.95 out of 5 average rating, 222 reviews

Fabulous Beach Apartment-Ph Royal Palm-Gorgona

FIRST LINE TO THE SEA WITH DIRECT ACCESS TO THE BEACH FROM THE PH POOLS. Fabulous BEACH APARTMENT, Beach Front Unit, comfortable, unique and to relax with the family, it has 4 incredible swimming pools, jacuzzi, sauna, sports courts, board games and access to the beach and restaurant service, coming is not wanting to leave ever

Popular amenities for Santa Cruz holiday rentals

  1. Airbnb
  2. Panama
  3. Panamá Oeste
  4. Santa Cruz