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Holiday rentals in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

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Guest favourite
A tranquil beachfront scene features several hammocks strung between palm trees on soft sand. Blue lounge chairs are positioned alongside the water, with gentle waves lapping at the shore under a clear sky.
Villa in Chame District
4.85 out of 5 average rating, 249 reviews

Surf Relax Play Pacific Ocean View Villa

White sand, surf-able waves, or just a comfortable chill vibe to enjoy the tropical weather of Panama. Playa Caracol is about an hour and 10 minutes drive from the city. This spacious, 2 bedroom, 2 bath villa with it's Pacific Ocean front location is the perfect place for you to enjoy an unforgettable family vacation. Walk out to the beach just steps from the villa, swim in the pool next to this villa or enjoy the resort pools and amenities. Or hike the nearby mountains with a local guide. PET

Guest favourite
A spacious outdoor area features an inviting parking space beside a well-lit terrace. Comfortable seating arrangements are visible under the covered porch, surrounded by greenery and decorative potted plants. The design promotes relaxation and social gatherings in a welcoming environment.
Home in Chame District
4.77 out of 5 average rating, 62 reviews

Residencia 3 habitaciones cerca de playas y ríos

Residencia amplia cerca de playas y ríos. Con amplia terraza, Asador. Tres habitaciones capacidad 7 personas. Dos camas king otra doble o fuul y sofá cama. Muy cerca variedad de restaurantes, supermercados, tiendas. Cocina amplia equipada. Aire Acondicionado en todos los espacios. Agua caliente. Asador, estacionamiento. Ubicada en el Celaje de Chame detrás de la policía del transito calle 11 de octubre bajar directo Octava Casa muro verde portón corredizo chocolate. WiFi-9192

Top guest favourite
A welcoming outdoor area features a stone pathway leading to a cozy seating arrangement with two pink chairs and a small table. Lush greenery surrounds potted plants and hanging decorations, while a patterned rug adds comfort underfoot.
Cottage in Las Lajas Coronado
4.95 out of 5 average rating, 79 reviews

House in Playa Coronado near the beach

Blocks from the beach in Playa Coronado, Panamá. This cottage/casita comes with private master bedroom, small living room that can also be used as a second bedroom, a bathroom with hot water, A/C, TV, and WiFi. You'll also have a fully equipped private kitchen with stove, refrigerator, microwave, air fryer, ice maker, etc. and huge outdoor living/sitting area with hammocks. You will also have access to a laundry room and a pool. Secure parking available under carport. Quiet neighborhood.

Superhost
A private swimming pool is set against a backdrop of vibrant sunset colors. Water features provide gentle splashes, and green plants outline the pool area. The modern house with large windows is visible in the background, blending with the natural surroundings.
Cottage in Panamá Oeste
4.82 out of 5 average rating, 188 reviews

Santa Fe de Lajas Chame, Panamá.

Santa Fe de Lajas en Chame, Provincia de Panamá oeste una casa vacacional, que te permite conectarte con la naturaleza y pasar ratos de esparcimiento solo o en familia. La casa tiene una capacidad para 10 personas. Cuenta con tres habitaciones, cada una con su baño privado. Cocina, sala, comedor, una habitacion para trabajar, piscina, terraza techadas, jardín al aire libre y área de BBQ. Servicios de Wifi y televisión. Accesibilidad a las playas del área, centros comerciales, montañas etc.

Top guest favourite
The exterior of the cabin is depicted, featuring a stone wall and a metal roof. A manicured grass area surrounds the structure, with pine trees in the background against a bright blue sky, creating a serene environment.
Cabin in Chicá
4.94 out of 5 average rating, 291 reviews

Cabaña Horizonte by Casa Amaya

Relájate en esta escapada única y tranquila en Cabaña Horizonte. Casa Amaya es un complejo de 6 cabañas ubicado en Chicá de Chame, clima fresco entre 18 y 24 grados, donde podrás contactarte con la naturaleza y relajarte con tu pareja, amigos o familia. https://www.airbnb.com/h/miradorbycasamaya https://www.airbnb.com/h/lospinosbycasaamaya https://www.airbnb.com/h/buenavistabycasaamaya https://www.airbnb.com/h/panoramabycasaamaya Contamos con generador eléctrico en caso de apagón.

Top guest favourite
The exterior of the three-story beach house is showcased, featuring terracotta roofs and lush landscaping. Palm trees and colorful flowers enhance the vibrant surroundings, while the ocean is visible in the background, complementing the peaceful neighborhood setting.
Home in San Carlos
4.94 out of 5 average rating, 145 reviews

OceanView-Rooftop Jacuzzi&Pool | Concierge Service

Unique 3-story beach house – one of a kind. 7 bedrooms, 13 beds, 8.5 baths. hot water. Every room with full bath -AC’s and ceiling fans in all rooms, separate laundry -Rooftop area pool, Jacuzzi, bar, BBQ(charcoal & gas) with amazing ocean view -High ceilings, large open kitchen and living area. -Spacious balcony for dining or relaxing. - 5 min. walk to the beach. -Parking for up to 7 cars - Base rate covers up to 4 guests, with a $40 charge per additional person, per night.

Top guest favourite
A light-filled living area features a comfortable sofa and two accent chairs around a wooden coffee table. Large glass doors provide stunning views of nearby mountains and allow access to the balcony. A practical TV unit is mounted on the wall, completing the space.
Apartment in Nueva Gorgona
4.94 out of 5 average rating, 54 reviews

Gorgeous Beachfront Condo w/ Amazing Views 1413

As close as you can get to the beach! Welcome to Gorgona’s newest beachfront condo project, Royal Palm. Located just 50 minutes from Panama City and minutes to Coronado. This 2 bedroom is fully furnished, located on the 14th floor and offers stunning Pacific ocean and mountain views. Take a dip in any of the 4 pools or put your feet in the sand and swim in the ocean. DISCLAIMER: if looking to book a stay more than 90 days out, please contact Beth directly.

Top guest favourite
Flat in Chame, Panama
5 out of 5 average rating, 8 reviews

24 horas vista al Mar en Coronado

Relájate en este espacio tan tranquilo y elegante. Puedes caminar y llegar a la playa , caminas y puedes ir a comer rica cena o almuerzo con restaurantes muy cercanos, si deseas ir al gym tenemos todos los implementos, ir y disfrutar de la piscina , encantadora y grande para nadar, tenemos mesas de pipon,mesa de billar ,un área de recreación, y tienes espacio de trabajo, y vista refrescante al mar. contamos una habitación con cama Queen y un sofá cama .

Guest favourite
Tiny home in Altos del Maria
4.83 out of 5 average rating, 178 reviews

Casa Arcón

This earth-sheltered studio home offers a unique and romantic escape in the mountain of Altos del Maria. Cozy space surrounded by a lush green environment, ideal for those seeking a peaceful getaway, or an affordable stay to explore the gated community's amenities. This bunker home provides an inviting haven to unwind and disconnect from the hustle of city life.

Guest favourite
A modern kitchen is equipped with stainless steel appliances and an island with four white chairs. Natural light enters through the window, highlighting the white cabinetry and stylish decor. A wall-mounted TV and decorative hanging light fixture enhance the functional yet inviting space.
Villa in Chame
4.78 out of 5 average rating, 41 reviews

Sea Breeze (C12-1D) 2 bed, 2 bat

Beachfront ground-floor villa with ocean and pool views at Playa Caracol. This stylish 2-bed, 2-bath unit features a private patio, full kitchen, and elegant furnishings. Master bedroom includes a TV; guest room has bunk beds and extra sleeping space. Enjoy modern comforts, mountain views, and 1km of beautiful beach just steps away—your perfect coastal getaway!

Guest favourite
Home in San José
5 out of 5 average rating, 11 reviews

Family Paradise | Pool, Jacuzzi & Garden

Escápate a esta exclusiva villa en Punta Barco, dentro de una urbanización privada. Disfruta piscina y jacuzzi privados, amplias terrazas, un enorme jardin y 4 elegantes recámaras. Perfecta para familias o grupos que buscan lujo, privacidad y cercanía a la playa. El terreno de esta villa es totalmente cercado.

Top guest favourite
A spacious bed is dressed in a colorful quilt, complementing an inviting orange pillow. Large glass doors offer a panoramic view of the surrounding mountains and lead to a private outdoor space with a swimming pool.
Tiny home in Panamá
4.97 out of 5 average rating, 232 reviews

Cabaña de montaña en Altos del María

La cabaña en Altos del María, está ubicada en el corazón de la montaña, con hermosos paisajes, árboles, animales, monos, pájaros, a solo minutos de zonas de picnic, juegos al aire libre , río, cascada, senderos y miradores. Escápate a la naturaleza! Cerca de todo, lejos de la rutina!

Popular amenities for Santa Cruz holiday rentals

  1. Airbnb
  2. Panama
  3. Panamá Oeste
  4. Santa Cruz