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Holiday rentals in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

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Guest favourite
A modern single-story house is displayed with a large front porch and a carport. The exterior features a mix of light and dark materials, with a neatly landscaped yard and a white picket fence. Clear blue skies and scattered clouds complete the setting.
Home in Chame
4.94 out of 5 average rating, 66 reviews

Casa de Veraneo

Lleva a toda la familia a este fantástico lugar con muchas zonas para divertirse. Cerca a todas las amenidades de Coronado, a pocos minutos de playas, laguna de San Carlos y a tan solo una hora y media de la ciudad. El PH cuenta con piscina del PH y una privada, en una zona tranquila y espaciosa. Encontraras 4 supermercados, farmacias, hospital privado (urgencias). Cerca a actividades campestres, playas, montañas, lago. Tiene en un gazebo con todas las comodidades. El lugar es seguro y completo.

Top guest favourite
Home in Playa Costa Esmeralda
4.98 out of 5 average rating, 220 reviews

Beach House-Amazing Pool & Jacuzzi - Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

Top guest favourite
A two-story white house is surrounded by lush greenery, featuring a blue roof and large windows. The spacious lawn showcases a hammock hanging beneath trees, inviting relaxation. Potted plants line the entrance, enhancing the natural setting of the property.
Home in Nueva Gorgona
4.95 out of 5 average rating, 43 reviews

Beachfront Private Family-Friendly House | Nature

Spectacular property with private access to the beach, garden, hammocks and panoramic view of the bay, just over an hour's drive from Panama City. A place with a lot of privacy and nature, it is perfect to relax, have a barbecue with the family, walk on the beach, lie in a hammock and enjoy the beautiful sunset with the sound of the sea. There are two wonderful caretakers in the property who are in charge of security, cleaning, and can answer questions and help you with anything you need.

Guest favourite
A dining area is illuminated by natural light streaming through a large window, offering a clear view of the surrounding mountains. A table is set with plates and utensils, creating a space for shared meals while connecting with the scenic landscape.
Cottage in Chame
4.84 out of 5 average rating, 88 reviews

Cabaña con Piscina Privada en las Montañas

Hospédate en esta casa de campo ubicada a 30 minutos de la carretera panamericana y con vistas a las montañas de Panamá Oeste y Coclé. Esta casa tiene piscina, área social, cancha de fútbol y estacionamientos privados. Tiene capacidad para 10 huéspedes y cuenta con los servicios básicos, cocina bien equipada y asados a gas, además de WiFi, TV y aires acondicionados en las habitaciones. Se ubica pocos minutos de senderos en las montañas de Panamá Oeste y playas del Pacífico Panameño.

Guest favourite
Home in Bejuco
4.85 out of 5 average rating, 20 reviews

Casa de Campo con Piscina / Villas del Maria

Relájate en este espacio tranquilo y elegante. Este alojamiento es perfecto para grupos de personas, viajes en familia o una puerta de entrada romántica. Ubicado en Sora, a 5 minutos de la Interamericana, a 15 minutos de supermercados y lugares para comer en Coronado. Villas del María es un lugar seguro y relajante para pasar el tiempo en familia. Disfruta de un acogedor lugar silencioso con todo lo necesario para la estancia. A ti y a tu familia les encantará este lugar!

Guest favourite
Home in Nueva Gorgona
4.95 out of 5 average rating, 38 reviews

Playa Malibu Beach House.

Wake up to the sound of the waves at this beautiful oceanfront home in Playa Malibu, where the beach is literally your backyard. Step outside and enjoy direct beach access, morning walks on the sand, and unforgettable sunsets over the water. The home features a private pool, BBQ area, and an outdoor dining space perfect for shared meals and long, laid-back evenings. Inside, the house offers a cozy, comfortable, and relaxed vibe, with all the essentials for a stress-free stay.

Superhost
The modern house is set amidst lush greenery, featuring a sleek design with large glass windows. An infinity pool is positioned on a spacious patio that offers unobstructed views of the surrounding hills, creating an inviting outdoor space for relaxation.
Home in Altos del María
4.82 out of 5 average rating, 333 reviews

Modern House with Great Views and Heated Pool

Modern mountain house in Altos del Maria, Panama, a gated comunity at just 1 hour and 30 minutes away from Panama city. The comunity has rivers, bird watching trails, and is only 25 minutes away from the pacific beaches. Its a perfect place to take a break and relax. The house has a modern decor, infinity pool, 2 bedrooms with A/C, wifi, dishwashing machine, washer and dryer and great view of the mountains. Free late checkout is given for rentals checking out on Sundays.

Guest favourite
Home in Altos del María
4.76 out of 5 average rating, 164 reviews

Villa Acuario

Relaxation is guaranteed in this one-of-a-kind glass house nestled in the lush mountains of Altos del María. Surrounded by nature and designed with floor-to-ceiling glass walls on all sides— as if you’re living inside a crystal ball. With no direct neighbors, panoramic forest views, it is perfect for a family getaway, a quiet reset, or an extended stay. The home offers light-filled interiors during the day and unforgettable stargazing nights from the rooftop.

Superhost
Cabin in Sora
5.0 out of 5 average rating, 4 reviews

Blue Sky Suites; clima más frío en Altos del María

Esta cabaña estilo suite de lujo en la montaña ofrece un diseño moderno, acabados de calidad y vistas increíbles de las montañas. Se encuentra en una comunidad cerrada segura, rodeada de un jardín verde, con amplias ventanas de vidrio que favorecen la conexión con la naturaleza. El clima es agradable, con temperaturas entre 18°C y 28°C.

Guest favourite
A pool area is visible with a clear blue pool surrounded by a concrete patio. Two lounge chairs are positioned beside the pool, and greenery from surrounding plants enhances the outdoor space. The area is framed by a shaded overhang, providing a comfortable retreat.
Home in Bejuco Chame
4.87 out of 5 average rating, 47 reviews

Casa de Campo- familiar Bejuco-Chame

Este lugar único tiene su propio estilo. Apropiado para celebrar cumpleaños, proyectos, trabajar, escribir y estar totalmente en tranquilidad .Leer un buen libro, darse una buena terapia de piscina y compartir grandes momentos y eventos en familia o pareja .Además de poder estar en un área de vivencias cultural.

Top guest favourite
A spacious bed is dressed in a colorful quilt, complementing an inviting orange pillow. Large glass doors offer a panoramic view of the surrounding mountains and lead to a private outdoor space with a swimming pool.
Tiny home in Panama City
4.97 out of 5 average rating, 268 reviews

Cabaña de montaña en Altos del María

La cabaña en Altos del María, está ubicada en el corazón de la montaña, con hermosos paisajes, árboles, animales, monos, pájaros, a solo minutos de zonas de picnic, juegos al aire libre , río, cascada, senderos y miradores. Escápate a la naturaleza! Cerca de todo, lejos de la rutina!

Superhost
An outdoor area features modern seating arranged around a central fire pit, surrounded by gravel and stone pathways. Elevated swings are positioned for relaxation, with a backdrop of expansive mountain views. Natural light filters through a structured canopy, enhancing the spacious feel.
Cabin in Chame
4.84 out of 5 average rating, 158 reviews

Paseo por Las Nubes

Relájate en esta escapada unica y tranquila a solo una hora y media de la ciudad. Cada rincón de este lugar mágico fue meticulosamente diseñado para brindar el escape perfecto a las parejas que buscan intimidad, serenidad y momentos inolvidables juntos.

Popular amenities for Santa Cruz holiday rentals