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Holiday rentals in Santiago

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Top-rated holiday rentals in Santiago

Guests agree: these stays are highly rated for location, cleanliness and more.

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A bright and airy room features two full-size beds with crisp white linens and decorative pillows. A wooden dining table with four chairs is positioned nearby. Fresh towels are neatly arranged on the beds. A small kitchenette is subtly integrated into the space.
Flat in Los Canelos
4.8 out of 5 average rating, 40 reviews

Salamanca Loft

Este hermoso apartamento esta ubicado en el centro de todo Panamá en la hermosa provincia de Herrera, vía interamericana, a pocos minutos de varias ciudades como Chitré, Aguadulce y Santiago. En un ambiente tranquilo, rodeado de árboles. Si corren con suerte podrán observar desde lejos las hermosas iguanas que se pasean por las ramas mas altas. Pueden apreciar al caer la tarde una hermosa puesta del sol. Justo al frente, hay cafetería, también hay pizzerías a domicilio y restaurantes.

Top guest favourite
A simple exterior view of the property is presented, showcasing a small front yard with grass and a stone pathway leading to the entrance. The charming façade features a covered porch supported by white pillars, while a wrought-iron gate and decorative stone wall outline the front garden.
Home in Pocrí
5 out of 5 average rating, 9 reviews

Cozy simple and peaceful space

Discover a cozy, simple, and peaceful space, designed to offer you the rest you deserve. Located in a central area of ​​Aguadulce, you'll be close to everything you need without sacrificing tranquility. It's the perfect place to relax, unwind from daily stress, and enjoy a comfortable and hassle-free stay. Plus, this accommodation is pet-friendly, so you won't have to leave your pets at home: they're welcome here and can also enjoy the warm and relaxed atmosphere.

A spacious studio is presented, featuring a comfortable sofa and a queen bed with an elegant headboard. A flat-screen TV is mounted on the wall opposite. A small table and chairs are arranged near the sofa, providing a cozy seating area within the bright space.
Serviced apartment in Santiago
5 out of 5 average rating, 4 reviews

Studio Hotel Gran David

This studio is located behind the Hotel Gran David, which is located in a very convenient location (Carretera Panamericana). However, this studio is located on a very quiet area at the back part of the hotel. Although the studio has an independent entrance to that of the hotel, you can still use all the amenities of the hotel (swimming pool and gym), and have easy access to the hotel's two restaurants, pool bar and bar.

A cozy corner is shown with a light-toned futon, paired with a small wooden table and two modern chairs. Natural light enters through two windows, complementing the warm wooden paneling on one wall.
Apartment in Panama City
4.66 out of 5 average rating, 29 reviews

Departamento 2E - BEST place in town.

Accessible apartment in the heart of Santiago, located 300m from the Central Bus Station and within walking distance of supermarkets and businesses. With good distribution of space, fresh and illuminated and with all basic services. The apartments provide a harmonious balance in the middle of the rush characteristic of the city, perfect for stays of families, friends, professionals, couples.

Superhost
Home in Santiago
4.22 out of 5 average rating, 9 reviews

Peaceful, Clean, and Conveniently Located House

This house is located in a quiet location on the edge of the city of Santiago about 10 minutes walking distance from the main shopping area of Central Ave. The house is fully furnished with air conditioning throughout the entire house. There is also a spacious kitchen with all the necessary appliances. You can enjoy the private backyard as you lay in the hammock.

Superhost
The two-story colonial house is showcased with a white facade and wooden accents. Decorative balconies with railings are present at the front, along with several potted plants adding color. The street is lined with other buildings, under a clear blue sky dotted with clouds.
Cottage in Parita District
4.78 out of 5 average rating, 41 reviews

Colonial House in Parita

Discover the charm of Parita from a comfortable and spacious home, perfect for large groups. Located in the picturesque and peaceful town of Parita, in the Herrera Province, just 12 minutes from Chitré, this spacious home is the ideal place to immerse yourself in the history and culture of a historic colonial-era town.

Superhost
A small dining area is featured with a round table and two folding chairs. Large windows offer views of lush greenery outside, while sheer white curtains partially filter natural light.
Flat in Santiago
4.88 out of 5 average rating, 8 reviews

d'rosas apartamentos 3PB

Discover the comfort in our cozy home in the heart of Santiago, Veraguas. Just a 5 minute walk from downtown, you'll enjoy a well-equipped space that includes all the necessary amenities for a relaxing stay. Ideal for exploring local culture and resting after a day of adventure. We look forward to seeing you!

Serviced apartment in Santiago
4.83 out of 5 average rating, 6 reviews

Accommodation in Santiago Centro

Enjoy the easy access to everything from this perfectly located accommodation, in the center of Santiago 2 minutes from the cathedral church, park, and the central Ave. Fresh and comfortable on the ground floor of a property a large terrace with access to the patio surrounded by nature.

A modest exterior view features a white building with dark windows and a welcoming black door. Lush greenery surrounds the entrance, and well-maintained stone pathways lead to the door, highlighting the peaceful outdoor setting.
Home in Santiago
4.86 out of 5 average rating, 21 reviews

2 bedroom house in Santiago

centric, well located, walking distance to downtown. Near the Panama Canal Museum, park Juan Demostenes Arosemana, and the Santiago Cathedral Juan Pablo Apostol. A few meters from central avenue.

A softly lit bedroom features a spacious bed covered with a textured grey bedspread. Two pieces of wall art adorn the walls above the bed, with a bedside table holding a small plant. A full-length mirror supports the decor, complemented by light-grey curtains.
Flat in Santiago
4.67 out of 5 average rating, 9 reviews

Apartamento Señorial Urraca

Enjoy the simplicity of this quiet and central accommodation, ideal for you, with everything you need for a pleasant stay.

Guest favourite
A single-story house features an arched entry with decorative windows. The front porch is equipped with seating, surrounded by greenery. A paved driveway leads to the home, providing access for vehicles, while the roof offers ample shade.
Home in Santiago
4.9 out of 5 average rating, 10 reviews

Casa Nuevo San Juan

Easy access from the Panamericana. It is a central area has supermarket, pharmacy, restaurant, hospital availability.

Guest favourite
A dining area is shown with a dark wooden table and matching chairs. A bowl is placed at the center of the table. In the background, a modern kitchen is visible, featuring black cabinetry and stainless steel appliances, with a large window allowing natural light.
Home in Santiago
4.95 out of 5 average rating, 19 reviews

Santiago near hospital ChichoF. ULatinaTarifaxmes

Furnished house, equipped kitchen, amenities included, washer dryer, gardens with set of chairs for rest..

Popular amenities for Santiago holiday rentals

Quick stats about holiday rentals in Santiago

  • Total holiday rentals

    Explore 60 holiday rentals in Santiago

  • Nightly prices starting at

    Santiago holiday rentals start at $13 SGD per night before taxes and fees

  • Verified guest reviews

    Over 530 verified reviews to help you choose

  • Family-friendly holiday rentals

    20 properties offer extra space & child-friendly amenities

  • Pet-friendly holiday rentals

    Find 20 rentals that welcome pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wifi availability

    40 of Santiago holiday rentals include wifi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi and Pool across Santiago rentals

  • 4.7 Average rating

    Santiago stays receive an average rating of 4.7 out of 5 from guests

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