
House holiday rentals in Santo Domingo
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Top-rated house rentals in Santo Domingo
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El Refugio: Nature Escape in Chitré
El Refugio at Playa El Agallito, Chitré: Nature Escape: Just 7 minutes from downtown Chitré, El Refugio is a fully equipped countryside home, perfect for disconnecting in a natural setting. Surrounded by mangroves and accommodating up to 8 guests, it offers a unique experience for couples, families or digital nomads. Enjoy bird watching, the peaceful surroundings, and the comfort of our large gazebo. Ideal for those seeking simple relaxation and a close connection to nature. A unique experience

Nearly Oceanfront: Blue 3 Bedroom Spacious Villa
Villa-33, your exquisite retreat nestled within Blue Playa Venao. Discover a tropical paradise of stunning beaches. Embark on endless adventures just a short walk away. This beautiful Villa offers 3 bedrooms and 3 baths. Two of the bedrooms feature queen beds, while the third bedroom has 2 twin beds, ensuring a restful night's sleep for everyone. The living area, kitchen, and terrace are thoughtfully equipped with everything you need to make yourself at home during your fun family getaway.

3 min to Pedasi, 5 min to the Beach, Private Pool!
Your family will be close to everything when you stay at this centrally-located place. Outfitted with room to sleep 6 and a fenced yard for your dog, Casa Catch and Relax has it all! Look us up online, Casa Catch and Relax You'll Love - Beach access a short drive or walk away (3 min drive, 10 min walk) - Central to town and local restaurants - Private, fenced outdoor space with pool - Cool days and nights with A/C in every room - Fully equipped kitchen and tons of sleeping space - Wifi

Peaceful Pedasi
Peaceful Pedasi. Get completely away from the city and forget the rest of the world exists. Pedasí is a town and corregimiento situated on the south-eastern tip of the Azuero Peninsula on Panama’s Pacific coast. And although remote enough to feel protected from the stresses of life, Pedasi offers wonderful dining and shopping. Our home offers a full functioning kitchen, large dining space, 5 Bedrooms, 4 Bathrooms, 2 car garage, private pool, and cabana with your own view of the ocean.

NinaHouse, casa amplia y fresca en Chitré.
Casa solo para ti, ahora con tanque de agua!hasta 7 p, amplia y en una de las mejores zonas de Chitré, tranquila y familiar, acceso a la piscina del area social, parques y canchas, cerca de todo: supermercados, casino, bus; ven a Chitre y disfrutar de comidas típicas, artesanía; planifica tus paseos y visita las mejores playas: Pedasi, Venao, Isla Iguana, podrás trabajar desde NinaHouse contando con un rápido internet. Ahora contamos con aire acondicionado en la sala para tu confort.

Costa Pedasi, Casa Calma / 3BR
❤ Welcome to Casa Calma, enjoy this beautiful house ideal for groups of up to 6 people. With 3 comfortable and bright rooms, each equipped to guarantee your rest and comfort. The jewel of the house is its direct access to the sea, perfect for cooling off at any time of the day. In addition, you will have access to a private pool with a large terrace where you can enjoy spectacular sunrises and relax to the sound of the waves. Embark on this unique new adventure! ✿

Casa Samambaia - sea view tropical paradise w pool
With a modern tropical design, this home features a cozy living room and a stylish kitchen at the center of the social area. Open the glass doors to immerse yourself in open-concept living, seamlessly blending the indoors with the main terrace and the pool, all oriented towards the ocean view. With two en-suite bedrooms with AC and fans, the house is immersed in nature, green mountains, and a lovely garden, everything 5 minutes from the beach center.

Casa Pelicano - Tropical house w pool and seaview
Welcome to Casa Pelicano! Indulge yourself in a retreat with breathtaking views of the ocean and mountains from every corner. Unwind in the private refreshing pool, where the turquoise waters seem to blend seamlessly with the horizon. The stylish interior features open-plan living spaces, perfect for entertaining or relaxing. Whether you're soaking up the sun or gazing at the moonlit ocean under the stars, this home is your ultimate escape.

Country House Like in the City / La Casita
Casa fresca, con árboles, naturaleza y portales p/ descansar, cámaras de seguridad afuera Ubicación céntrica, cerca de malls, restaurantes, buses y ciclovía. Entrada privada, estacionamientos, cocina completa, mobiliario completo, baño, TV HD con cable, AC en recámara, agua caliente y Wi-Fi. ENG, PORT, FRAN and ITA Spoken! Contamos con un pozo de agua y sistema de purificación de agua por ósmosis inversa: agua segura, potable y purificada!

Villa La Jungla featuring a New Pool
Escape to this serene, private retreat just minutes from Pedasí, Playa Venao, and stunning beaches. Perfect for 4–8 guests, the home features spacious en-suite bedrooms with quality linens, a fully equipped kitchen, and a newly resurfaced infinity pool. Enjoy total privacy, comfort, and easy access to local adventures. Whether you're here to surf, explore, or relax, this is your ideal home base for a peaceful and memorable stay.

A minimalist Casita in Pedasi
Imagine a peaceful casita with ocean views and a nearby pool house boasting an edgeless pool overlooking the ocean. Plus, you have your own private beach. Inside, you will find an open-concept living space adorned with simple yet stylish furnishings, designed for relaxation and comfort. It's the perfect blend of tranquility, peaceful seclusion and breathtaking natural beauty. Gated community, 24 hour security

Casa Inito - Romantic Getaway
Indulge in the charm of Casa Inito, a thoughtfully crafted haven that invites you to experience a one-bedroom retreat like no other. This well-designed space seamlessly blends modern comfort with an intimate setting, creating the perfect atmosphere for your getaway. The Villa is located just 7 minutes from Playa Venao Beach (by car). ****(Vehicle a MUST, preferably SUV due to steep paved access road)****
Popular amenities for house rentals in Santo Domingo
House rentals with a pool

Chitré Oasis: Modern Home with Private Pool & BBQ

Beachfront home on Playa Venao + private pool

Casa en Las Tablas, con piscina y acceso a playa

Casa Del Amor in Pedasi Panama Oceanfront paradise

Pedasí :Andromeda Boroda 4-6 p. Beach, swimm. pool

Casa - Domaine De La Rose

Vila Sueño Azul - Blue Venao 3BR

Casa Carolina: Spacious 3 Bedroom at Blue Venao
Weekly house rentals

Casa Amarilla-Cozy 2Bed/ 1Bath/ Pocri, Las Tablas

Vista del Mar , Ocean view El Ciruelo

Yellowfin Casa 3

Pedasí, Earth House Casa Alegre / 3BR

Lugar tranquilo familiar y acogedor

Casa entera -7 min de Las Tablas

Casa Maitri: Panoramic Ocean View, Pool, Near Surf

Casa familiar, amplia, céntrica para vacacionar
Private house rentals

Finca Dorado Retreat in Cañas

CASA ROSA 49’ - Playa Venao Beach

Yayo's Place

Alquilo Hermosa Casa en Chitré Centro

Casa completa en Herrera

La Casa de Rosa

Elegancia y comodidad en un solo lugar

La Casita 29 de las Villas de San José
Destinations to explore
- Panama City Holiday rentals
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- Boquete Holiday rentals
- Quepos Holiday rentals
- Playa Blanca Holiday rentals
- Valle de Antón Holiday rentals
- Ancón Holiday rentals
- Bahía Ballena Holiday rentals
- Limon Holiday rentals
- David Holiday rentals
- Playa Venao Holiday rentals





