Kid-friendly holiday rentals in Cape Girardeau

Guest house in Cape Girardeau

4.92 out of 5 average rating, 112 reviews

Cozy 1-BR guest house w/free parking on premises

Enjoy a cozy experience at this centrally, located place. Literally, a 1-4 minute walk to Mercy Hospital(formerly Southeast Hospital), less than 1 mile to Southeast University Campus, along with downtown(river). A street over is Broadway with many restaurants. Walmart Market and Dollar General are also conveniently located nearby. The kitchen is fully furnished with cooking utensils, clean towels, pots and pans for those who prefer eating in. Please no animals and no smoking in the apartment.

4.98 out of 5 average rating, 415 reviews

Beautiful Historic Boulevard District Apartment

This beautiful, private upstairs apartment is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. Recently remodeled for laundry, spacious rooms offer private bedroom spaces and a cozy den for watching movies or reading. The kitchen is fully equipped with amenities. This quiet neighborhood setting even has a front porch swing and sitting area where you can enjoy your morning coffee.

4.82 out of 5 average rating, 113 reviews

Home in Cape Girardeau

Herman's Corner Cottage.

Tucked in historic Cape Girardeau, this charming cottage offers comfort and convenience. Enjoy the cozy back deck with a privacy fence—perfect for relaxing or grilling. With ample off-street parking, your stay is stress-free. The home is equipped with essentials for a smooth, hassle-free visit. Book the entire house for added privacy, providing a peaceful retreat for you and your guests. Experience the perfect blend of comfort, affordability, and convenience during your Cape Girardeau getaway.

Guest suite in Cape Girardeau

4.97 out of 5 average rating, 151 reviews

MAINSTAY CAPE [downtown]

Nestled in the heart of the Downtown Historic District, this suite is centrally located as a prime destination for any and all travelers alike. With parking available, this space offers a unique & trendy “midwest boho” vibe. ~WALKABLE~ Our studio is 1 block from the bustling Southeast Missouri State University, 1 block from the gorgeous Capaha Park, and 2 blocks from Mercy Hospital. If you are interested in night life, this space is simply a 5-10 minute walk to all DT bars and restaurants.

4.95 out of 5 average rating, 246 reviews

Brand new 2 bedroom unit right in downtown Cape.

This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .

4.86 out of 5 average rating, 609 reviews

Unique Design | Walk Downtown/River | .5 mile SEMO

At our Adventurous 2 Bedroom Suite you’ll first arrive at a Brightly decorated Space with Artsy Walls and Bold Decor. Designed with its History in mind & a twist of Creativity, you will Immerse Yourself within your Stay; from our Stocked Kitchen, Reading Area with Indoor Swing to Themed & Cozy Bedrooms. Enjoy being near Downtown/the River with a short Bike Ride or Walk and when you are ready to Tuck in at night, Sink into our 10” Memory Foam mattress with Plush Pillows and feel at Ease.

Treehouse in Cape Girardeau

4.99 out of 5 average rating, 141 reviews

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

4.85 out of 5 average rating, 124 reviews

Home in Cape Girardeau

5 Bed Home in Great Neighborhood - Sleeps 10

Looking for a comfortable and spacious Airbnb in Cape Girardeau? 🏡✨ This 3 bedroom, 2 bathroom home in a great neighborhood is the perfect spot for your next group stay. This home features great living areas to relax and unwind including a living room with a large sectional and 70 inch TV. The game room features an air hockey table, dart board, and other board games. It will sleep 10 comfortably. Make this your destination for your next girls trip, sports tournament, or SEMO event.

4.96 out of 5 average rating, 196 reviews

Barn in Cape Girardeau

Under the Stars - Farmhouse

Enjoy the tranquility of this modern farmhouse charmer! Custom built minutes from downtown Cape. Relax outside around the fire pit, roast marshmallows and watch the sunset. Finish the night with a long soak in the hot tub. Start the morning on the front porch rocking chairs and take in a sunrise. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Near Trail of Tears and walking distance to classic dive bar/burger joint

Guest house in Cape Girardeau

4.93 out of 5 average rating, 516 reviews

Downtown Guesthouse- Romantic Getaway

The guesthouse seamlessly blends modern amenities with historic charm in a cozy, compact space. The antique claw foot tub/shower combo offers a charming, yet snug, spot for a relaxing soak—true to its historic roots, the bathroom could be best described as a quaint water closet. After a day of exploring unwind in the patio. Play a favorite record, and savor your coffee while daydreaming about new experiences. Despite its small size, it provides all the modern comforts you need.

4.88 out of 5 average rating, 100 reviews

Visit the "Gone Girl" neighborhood

Living rm/bedrm, full kitchen, ADA bath, and walk in closet. Fully equipped with dishes,linens, refig, micro,stove, keurig, dishwasher and welcome home snacks. Double Murphy bed, queen hide a bed couch convert the living room to bedroom. Space is good for up to 3 adults, 2 adults and 2 children or a single guest. We accept well mannered dogs up to 50 pounds. We do not accept CATS. Like cats but they cause additional clean up. See pets section for dog guest guidelines.

4.77 out of 5 average rating, 100 reviews

Home in Cape Girardeau

Historic Blvd District Home in Cape Girardeau

This beautiful, private home is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. With large bedrooms, spacious living room and separate dining room you will have all the room you need! The kitchen is fully equipped with amenities. This quiet neighborhood setting with a big front porch sitting area where you can enjoy your morning coffee.

Holiday rentals for every style

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Convenient locations with everyday essentials

Cabins

Kick off your hiking boots at these rustic lodgings

Popular amenities for Cape Girardeau family-friendly rentals

Kitchen

Wifi

Pool

Free parking on premises

Air conditioning

Kid-friendly house rentals

4.99 out of 5 average rating, 126 reviews

Home in Alto Pass

The Farmhouse in Rhine Valley

EydieRating, 5 stars3 weeks ago

We are returning visitors to the Farmhouse. Jessica is an excellent hostess and provides a lovely place to stay. We highly recommend staying there.

4.97 out of 5 average rating, 156 reviews

Home in Dongola

Spacious Home in Country Setting

Mari AnaRating, 5 stars5 days ago

Rhoda’s place was perfect yet again for our families trip to the area. The house is always spotless. Rhoda’s welcome snack is always appreciated by my kids.

4.99 out of 5 average rating, 141 reviews

Home in Ste. Genevieve

Silo Farm Haus

KirkRating, 5 stars3 months ago

We had a great, relaxing time celebrating our 15 year anniversary at the Silo Haus! The property was very peaceful and quiet. We enjoyed visiting some of the local wineries (even though some have closed down there are still plenty to visit close-by) and the nearby Tiger Sanctuary!

4.92 out of 5 average rating, 332 reviews

Home in Carterville

Newly Updated Family Home in Carterville

RonaldRating, 5 stars3 weeks ago

This was our 3rd or 4th stay at Jared's spacious and well equipped place, so that says a lot right there! They are always quickly responsive and accomodating hosts ahead of time and their house ( that is a whole house in a nice neighborhood not next to the hosts) and they always leave us lots of sweet and savory snacks, sweets, and fruit. We highly recommend Jared's place and plan to return again whenever visiting family in the area.

4.92 out of 5 average rating, 136 reviews

Home in New Grand Chain

Cozy and charming modern vintage style home

LukasRating, 5 stars1 month ago

Jennifer’s place was perfect for what we needed, especially close to the hiking spots we were looking forward to along the Cache River. The house was clean and had lots of local recommendations, snacks, it was much bigger than we expected and Jennifer even reached out about what to do in the event of severe weather when the forecast looked not so great. Highly recommend!

4.96 out of 5 average rating, 233 reviews

Home in Carbondale

Cozy 2 Bedroom Garden Oasis Home

SamanthaRating, 5 stars5 days ago

Good spot to experience southern IL for a weekend! Quiet neighborhood and easy to get around to other towns. Lia was very responsive and helpful in planning and while on site. Two bedrooms on the same level with a shared bathroom was convenient for our little family!

4.83 out of 5 average rating, 173 reviews

Home in Makanda

Ranch style home in country setting, near SIU-C

AnthonyRating, 5 stars1 month ago

Beautiful location and so close to town! very roomy and everything I needed for a weekend getaway. A great stay!

4.99 out of 5 average rating, 145 reviews

Home in Carterville

Sweet Peas Bungalow

CarolRating, 5 stars1 week ago

We enjoyed staying in Mary Ann's home that once belong to her grandparents. Everything was right where we needed it to be. We were on a bicycle tour in Carterville and took advantage of having a nap on the screened in front porch wicker furniture. We were able to cook most of our meals and do laundry before we left for the next location. We would stay there again if we are in the area. Thanks.

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Family-friendly apartment rentals

4.83 out of 5 average rating, 6 reviews

Flat in Jackson

Cozy & Comfortable 1 Bedroom Suite

SierraRating, 5 stars2 months ago

This apartment was so cute and cozy 😁

4.95 out of 5 average rating, 44 reviews

Downtown Condo on the River

RogerRating, 5 stars1 day ago

Place was very nice very clean. Definitely say there again.

5 out of 5 average rating, 32 reviews

Flat in Old Appleton

Apple Creek Loft

JeremyRating, 5 stars3 weeks ago

This place was way more than enough space for three of us, in fact at the price point it’s a great deal for the size. There is a beautiful waterfall right by the entryway, I kept my bedroom window open all night so I could hear it. Everything was really clean and we were able to use the kitchen to cook breakfast. I would definitely stay here again. They have some older TVs that are CRT based, so if you have an old NES with Duck Hunt bring it!!! Duck Hunt won’t work on new HDTVs. We were on motorcycles so we parked out front. The back parking lot is gravel and there’s a little bit of a rough entryway if you’re on bikes. Laundry room is big and works great. I wish we had more time to spend around the area. It was nice and quiet and very clean.

4.86 out of 5 average rating, 22 reviews

Downtown Loft 1 on Main

GinaRating, 5 stars3 months ago

We loved our stay! It’s in a perfect location If you want to hang out downtown! We walked to hot shots to meet friends and it was very enjoyable!

4.93 out of 5 average rating, 41 reviews

Downtown 4BR with 2 King Beds! Off-street parking

MarcusRating, 5 stars1 month ago

Beautiful place. Great location. Plenty of amenities. I would stay there anytime I'm in town.

4.78 out of 5 average rating, 23 reviews

Modern Luxe 2 KBR Apt w/ Electric Fireplace

AllynRating, 5 stars2 months ago

Grace’s place is clean, elegant, thoughtfully and tastefully furnished. The old exposed brick exudes warmth. I would stay here again — and I plan to.

4.83 out of 5 average rating, 6 reviews

2Bdrm Stay in Downtown Cape | Walkable, Laundry

MalloryRating, 5 stars1 month ago

We came to Cape for a quick getaway weekend from STL. Lindsey’s place was perfect for the 2 of us. Kitchen was well stocked with cooking gear but we did not use them! Beds were super comfortable!! My only real complaint is how loud the noise from the street is. Might have just been situational as I heard from many people that the college kids were all having their last hurrah but there were many many cars revving engines and squealing tires right outside the building until about 2AM. Lindsey was a fab host and we will book with her again if we ever come back to Cape!