
Pet-friendly holiday rentals in Cape Girardeau
Find and book unique pet-friendly homes on Airbnb
Top-rated pet-friendly home rentals in Cape Girardeau
Guests agree: these pet-friendly homes are highly rated for location, cleanliness and more.

Downtown Loft Amazing Bath Tub & Shower
Downtown Perryville, MO **DISCLAIMER** you will hear restaurant chatter & music if you do not have a tv/or radio playing between the hours of 10:30am & 1:30am. If you go to bed early I recommend headphones, ear plugs or play nature sounds on Alexa. This is a pet friendly loft apartment so I would not recommend if you are allergic to dogs or cats. This apartment is located above one of the most popular destination restaurant's around "Mary Jane Burgers & Brew" on the Downtown Historic Square.

The Snow Globe*OffGrid DomeGLAMP*Adventurers Only
EXPERIENCE The Dome in the Woods • IMMERSE in complete silence with the absence of electricity: no hum or vibrations from this completely solar/propane fueled geodesic dome. NoAC • GLAMP in this OFF GRID ADVENTURE. 430 sq ft floor plan. 14 ft ceiling. 20 ft bay window with endless nature view at the foot of your bed. Lofted 7ft. • STARGAZE from the deck or fire pit • NESTLE in the romantic wooded nature of southeast MO. S of St Louis.N of Memphis • UNPLUG, UNWIND, RELAX. Adventure seekers only!

A-Frame tiny home in tiny home village
Enjoy nature as you stay in our unique tiny home village. Nestled between Boulder Creek and lovely natural rock formations, we are proud to share our beautiful property. The Mermaid is our bright yellow A-frame with a porch enveloped in nature featuring our Mermaid benches. With two bedrooms (both w/ queen beds), one bathroom and a futon in the living area, the Mermaid sleeps up to 5 people. The unit has a small kitchenette with a larger mini fridge, microwave, hotplate complete with dishes.

Brand new 2 bedroom unit right in downtown Cape.
This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .

The Cottage, Rusted Route Farms
You won’t forget your time in this romantic, memorable place. The Cottage at Rusted Route Farms is a 1 bedroom beautiful suite on an old 10 acre farm history galore. A picturesque pond is settled next to The Market our onsite Restaurant that will be serving food and drinks to be ready on your arrival or for a certain time that you choose. The over 125 year old barn has been renovated to keep the history alive and is located here on site. This retreat is located right outside Cape Girardeau.

Sanctuary Cabin- Hot Tub & Woods
Hi, hello, welcome! We invite you to take it easy at this unique and tranquil getaway. The kitchen is stocked, the hot tub is ready to go, and the local area boasts many wineries, state parks for hiking, and beautiful scenery. This spacious cabin features a comfortable King bed, 55” TV above a gas fireplace, and recently had a top to bottom renovation! The spacious back deck features a large hot tub just steps from the back door, hooks for the provided terry cloth robes, and a Weber grill.

Tiny House of Paul - Center For Lost Arts
Perfect if you're working or spending time exploring Southern Illinois. Great discount for longer stays. Tiny House of Paul house has a cozy & spacious feel. A large west-facing window looks out onto the forest. Windows in the loft open to tree tops & stars. Private inside. Centrally located on the property of Center For Lost Arts near Cobden, Illinois. Wander the trails at the end of a work day, or relax on the deck after hiking or exploring. Enjoy your time in Southernmost Illinois.

Under the Stars - Farmhouse
Enjoy the tranquility of this modern farmhouse charmer! Custom built minutes from downtown Cape. Relax outside around the fire pit, roast marshmallows and watch the sunset. Finish the night with a long soak in the hot tub. Start the morning on the front porch rocking chairs and take in a sunrise. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Near Trail of Tears and walking distance to classic dive bar/burger joint

College town Charm: Minutes from Downtown Cape
EXCELLENT LOCATION near downtown riverfront Cape! Enjoy live music, local dining/coffee, shopping, casino, and seasonal steamboat rides downtown. Less than 5 min. from Southeast Missouri State University & Southeast Hospital. Centrally located near wedding venues: Rusted Route, Deerfield, Watersedge, Sweet Pecan, and Country Club. 2 blocks from scenic Capaha Park. Home to Capaha baseball. This huge park includes play structures, basketball court, disc golf & fishing pond.

Carbondale Pool House - Sauna, Hot Tub, Dogs OK
Rated in “Top 1%” by Airbnb, the Pool House is a separate cottage surrounded by gardens and swimming pool, with retro "Danish Modern" furniture, a gourmet kitchen and plush beds. We have recently added a Finnish Sauna and Japanese Ofuro Soaking Tub. We accept well behaved dogs for a fee of $35 a night. We allow only guests and friends of the Pool House on the grounds, gardens or pool. Hosts are Jane, anthropologist and D. a retired photojournalist for the New York Times.

Romantic Treehouse Retreat w/ Hot Tub
The TreeLoft is a secluded luxury treehouse designed for rest, romance, and reconnection. Nestled in a private forest just 1 hour from St. Louis in Southeast Missouri, it blends upscale comfort with immersive nature. Located 20–35 minutes from hiking, wineries, and dining, this peaceful retreat invites you to unplug, slow down, and reconnect in intentional privacy. Making the TreeLoft perfect for romantic getaways, personal retreats, anniversaries, or creative escapes.

Cedar Lake Retreat A
Enjoy a quiet, peaceful, pet-friendly retreat, less than a mile from Cedar Lake boat ramp/kayak launch and Poplar Camp Beach. This cute and comfy duplex is less than 6 miles from Giant City State Park, located in Shawnee National Forest, and just 4 miles from Southern Illinois University-Carbondale. Enjoy fishing, kayaking, and rock-climbing, or hit the Shawnee Wine Trails. If you’re a nature buff or you’re in town for SIU festivities, this is the place for you.
Popular amenities for Cape Girardeau pet-friendly home rentals
Pet-friendly house rentals

Country Club Road Getaway

Twisted Sister's Retreat

Walk to Weddings-Wineries-Trails, Family Friendly

Home in Perryville

Happy home for traveling professionals

Located near downtown and casino

Shawnee Forest Vacation Lodge

Cottage Near Casino
Pet-friendly home rentals with a pool

Catfish Cabin KK4

Rustic Bass Cabin KK3

Black Bear Cabin K03A

Cozy Country Cabin

Coyote Cabin F09

Greenway Getaway

Racoon Cabin D09
Private, pet-friendly home rentals

Nice living quarters in Pole Barn.

*Unique 7-Sided Retreat • Sauna • 18 Wooded Acres*

Hutchins Creek Cabin -2br- Wine Trail & Wilderness

Cabin in the woods perfect for hiking

[*Charming Cozy Suite*]

All the Amenities of Home

Quiet 2BR w Garage~Dogs OK~Long Stays

*The Hilltop Haven* close to SIU & Wine Trails
When is the best time to visit Cape Girardeau?
| Month | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Avg. price | $154 SGD | $146 SGD | $143 SGD | $143 SGD | $150 SGD | $150 SGD | $154 SGD | $150 SGD | $155 SGD | $152 SGD | $150 SGD | $154 SGD |
| Avg. temp | 1°C | 4°C | 9°C | 14°C | 20°C | 25°C | 26°C | 25°C | 21°C | 15°C | 8°C | 3°C |
Quick stats about holiday rentals that are pet-friendly in Cape Girardeau

Total holiday rentals
Explore 40 holiday rentals in Cape Girardeau

Nightly prices starting at
Cape Girardeau holiday rentals start at $51 SGD per night before taxes and fees

Verified guest reviews
Over 3,530 verified reviews to help you choose

Family-friendly holiday rentals
20 properties offer extra space & child-friendly amenities

Rentals with dedicated workspaces
20 properties have a dedicated workspace

Wifi availability
40 of Cape Girardeau holiday rentals include wifi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Cape Girardeau rentals

4.8 Average rating
Cape Girardeau stays are highly rated by guests – averaging 4.8 out of 5!
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