Guest house holiday rentals in Santa Cruz

Find and book unique guest house rentals on Airbnb

Top-rated guest house rentals in Santa Cruz

Guests agree: these guest house rentals are highly rated for location, cleanliness and more.

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A multi-story building is showcased, featuring a distinctive red facade with decorative archways. Balconies extend from the upper floors, providing outdoor space. The ground level houses various storefronts, while utility poles and street signs are visible, indicating a lively urban environment.

Acogedora casa familiar en Santa Cruz de la Sierra

Casa familiar de 320 mts. cuadrados, en el segundo piso, con todo el menaje y ropa de hogar, maravillosas vistas desde sus 30 mts. de terraza. Ideal para familias que quieran tener una tranquila estancia de cualquier duración en la Ciudad de Santa Cruz de la Sierra. Muy bien comunicada con varias lineas de autobuses que llevan a toda la ciudad y alrededores y muy cercana al Santuario de Cotoca. En los alrededores dispone de toda clase de servicios, desayunos, comidas, mercados, tiendas, etc..

LocationFamilyBathroom

4.36 out of 5 average rating, 14 reviews

Guest favourite

A cozy space features a spacious bed adorned with decorative towels, complemented by patterned curtains and wall accents. A dining table with chairs is positioned near the open kitchen, which includes a stove and sink. Natural light filters in through a window, enhancing the inviting atmosphere.

Guest house in Samaipata

La Casita, Finca La Vispera

La Casita, is a perfect place to spend a couple of days with your partner, it is located inside Finca "La Vispera", we have a Parque Nativo, Café Jardín, Herbolario, great view. You’ll love my place because of the location, the people, the neighborhood, the outdoors space, and the ambiance. My place is good for couples, solo adventurers, families (with kids), big groups, and furry friends (pets). You also will enjoy our vegetable Garden. You can collect the vegetables and enjoy a great meal.

LocationBreakfastCleanliness

5.0 out of 5 average rating, 8 reviews

Guest house in San Miguel de Velasco

Quinta El Retorno: casa cómoda con 2 habitaciones.

Bienvenidos a Quinta El Retorno, un espacio rodeado de naturaleza que brinda tranquilidad y descanso. La casa cuenta con dos habitaciones independientes, cada una con baño privado, ducha con agua caliente, aire acondicionado y ropero empotrado. Tiene capacidad para hasta 5 huéspedes, por lo que es ideal para familias, parejas o grupos pequeños. Además, dispone de estacionamiento techado para dos vehículos, conexión wifi y una amplia galería exterior para disfrutar del aire libre.

LayoutIndoor spacesHospitality

Superhost

Private room in Centro

Habitación en el centro, a dos minutos de todo!

Viví la experiencia de alojarte en el corazón de Santa Cruz, a solo 3 cuadras de la plaza principal. Nuestra habitación luminosa y acogedora te espera en una zona segura y llena de vida: museos, cafés, bares, tiendas y rincones históricos están a pocos pasos. Ideal para quienes buscan comodidad, estilo y una ubicación inmejorable. Con WiFi, detalles pensados para tu descanso y una atención que te hará sentir como en casa.

ValueLocationCleanliness

4.89 out of 5 average rating, 9 reviews

A spacious common area features comfortable seating arrangements with a mix of sofas and chairs. A central table is set with placemats, while a ceiling fan and air conditioning unit contribute to a comfortable environment. Light filters through large windows, enhancing the welcoming feel.

Guest house in Santa Cruz de la Sierra

Casa amplia, con patio y parqueo

Casa de huéspedes, con patio amplio y parrilla (churrasquera), en una zona muy tranquila. Aire acondicionado en todos los ambientes, termotanque (agua caliente), Wi-Fi, amplia sala de estar. Suite con baño privado. Baño común, sofá-cama y sofa amplio en planta baja. (Pueden dormir cómodamente hasta 4 personas) Dirección: km 8, Barrio 14 de Agosto, Calle 3 Entre doble vía la guardia y radial 17 y medio

Superhost

Guest house in Centro

Complete centric apartment with garden and pool

Complete centric apartment with an enormous garden and pool. Private apartment with fully staffed kitchen, private bathroom and a bedroom with a queensized bed. You'll also have access to the big garden and the pool to relax and refresh yourself. By choosing our accommodation, you’re also supporting Ñañope, a local NGO dedicated to empowering household workers in Santa Cruz.

Hospitality

5.0 out of 5 average rating, 3 reviews

A simple sleeping area features a spacious bed with white linens and bright red curtains framing a nearby window. An open shelf housing no items stands against one wall. A doorway leads to a bathroom visible in the reflection of a mirrored door.

Guest house in Ichilo

Ventana Al Parque Amboro

Enjoy a partial view of the Amboro mountains, with birdsong in the morning and the sounds of the small forest at night. Sometimes nocturnal monkeys or early-rising agoutis may appear. Though only 4 blocks from the main square, the place is quiet, away from traffic noise. With advance confirmation, tours to the north side of Amboro National Park can be arranged.

LocationValueQuiet

4.53 out of 5 average rating, 17 reviews

Guest favourite

A cozy bedroom features a spacious bed dressed in neutral linens, accompanied by decorative cushions. Two wooden chairs are positioned beside a round table near a window with light curtains. A wooden nightstand stands beside the bed, contributing to the room's welcoming atmosphere.

Guest house in Centro

Private Apartment In Downtown

Welcome to our cozy guest house in one of the most beautiful and safe areas of the center! Just 6 blocks from Plaza 24 de Septiembre, our historic neighborhood offers you a unique experience.

LocationValueCheck-in

4.89 out of 5 average rating, 140 reviews

Top guest favourite

Private room in Samaipata

Centric, accesible, comfy private room w/bathroom

Peaceful private room with a private bathroom in the heart of Samaipata, 50m from the market, 2 blocks to town plaza. Clean, cozy, simple. Basic amenities, NO Kitchen...

LocationValueGetting around

4.96 out of 5 average rating, 26 reviews