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House holiday rentals in Santa Cruz

Find and book unique houses on Airbnb

Top-rated house rentals in Santa Cruz

Guests agree: these houses are highly rated for location, cleanliness and more.

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Top guest favourite
Home in Santa Cruz de la Sierra
4.95 out of 5 average rating, 22 reviews

Casa indep y Moderna con Churrásquera +Garaje Priv

💎 Casa Centrica Moderna e Independiente en la mejor y más segura zona de SC, ideal para Reuniones 🥳. A solo Pasos de supermercados 24hrs, Mall, hospitales y farmacias. Cuenta con 3 dormitorios ( 1 en Suit ), 4 baños completos, sala y comedor amplio, cocina equipada y churrasquera en patio privado. Ideal para familias o Amigos 🫂 que buscan confort y Privacidad, con ubicación estratégica para disfrutar lo mejor de la ciudad con total comodidad, estilo y seguridad. Parqueo Priv para un vehículo

Superhost
A tranquil area is featured, showcasing a large, shimmering lagoon with palm trees lining the shore. Colorful, casual seating is visible on the sandy ground, providing spots for relaxation. The clear blue sky is dotted with a few clouds, enhancing the serene environment.
Home in Santa Cruz de la Sierra
4.87 out of 5 average rating, 23 reviews

Davezies House, A Unique Experience, Inland Sea

​¡Descubra un refugio sublime y cautivador! Una joya con 2 suites, incluyendo una imponente Máster Suite. Disfrute de ambientes amplios y distinguidos en el living comedor y una cocina gourmet integrada. Relájese en la piscina o el parrillero, ideales para forjar momentos memorables con familia y amigos. Aire Acondicionado, TV y WiFi veloz; el confort está garantizado. Acceso a áreas de élite: playa, restaurante, tiki bar, áreas infantiles y más Te esperamos ¡Reserva ahora y asegura tus fechas!

Guest favourite
Home in Samaipata
5 out of 5 average rating, 19 reviews

“Casita Lagunita” at Casa Samai Boutique Hotel

This sweet casita ‘Lagunita’ is a unique private guest room with a private bath at the edge of our pond, part of Casa Samai Boutique Hotel in Samaipata. Included is a gourmet buffet breakfast served in the main house. ‘Lagunita’ has a queen bed, with views of the pond and surrounding landscape. It includes a kitchenette with stove, an electric kettle and fridge. A front and back patio offer privacy at the pond’s edge and the fruit orchard, a small slice of the hotel’s 2 hectares of paradise.

Guest favourite
An open living space features a light-colored sofa, coffee table, and accent chairs, complemented by an area rug. The dining area includes a table with high-backed chairs, while the kitchen is visible in the background, showcasing a well-lit and functional layout.
Home in Santa Cruz de la Sierra
4.96 out of 5 average rating, 97 reviews

Nice 2 bedroom house, the best rest.

Charming 2-bedroom house, equipped and decorated with timeless style. Located in a quiet and ultra-safe condominium, just 10 minutes from Viru Viru Airport and 30 minutes from downtown. Enjoy the condo's amenities: Swimming pool with slides Supermarket and ATM within walking distance Gym, saunas and jacuzzi to relax Walking circuits and tennis and soccer courts to stay active. Great for: Relaxing away from the hustle and bustle A stop after a flight Families and groups of friends.

Guest favourite
A bright living area is presented with two light-colored sofas adorned with colorful pillows. A wooden coffee table is centered between the sofas, while two stylish chairs are positioned nearby. Large windows allow natural light to fill the space, showcasing indoor plants.
Home in Santa Cruz de la Sierra
5 out of 5 average rating, 5 reviews

Beautiful house, private condominium

Hermosa casa de 320 m² construidos, ubicada en la Av. Milton Parra, esquina prolongación Av. Beni. Ideal para familias, cuenta con 2 dormitorios, una oficina y 1.5 baños. Dispone de un comedor espacioso y confortable, así como una cocina grande y bien equipada. Esta propiedad se encuentra en un condominio privado que ofrece áreas verdes y zonas de entretenimiento, tales como: - Piscina - Gimnasio - Cancha de fútbol de césped sintético - Cancha de baloncesto - Salón de eventos

Guest favourite
The exterior of the house features a unique slanted roof made of terracotta tiles. Large windows reflect the surrounding greenery, while a small patio area with white chairs invites relaxation. Lush plants and flowers enhance the inviting garden setting.
Home in Samaipata
4.9 out of 5 average rating, 72 reviews

BEAUTIFUL HOUSE IN SAMAIPATA

Beautiful and cozy house in Samaipata with a wonderful view! Located in a very safe area with ample parking. On a plot of almost 4 hectares surrounded by nature typical of the place and beautiful gardens that can be seen even from the interior through its large windows! The house has all the necessary amenities; barbecue, clay oven and structure for cooking the traditional 'chancho al palo' (pork on a stick). Ideal for recharging positive energies and breathing fresh air.

Guest favourite
A spacious living area features a large white sectional sofa adorned with decorative pillows. A dark coffee table sits at the center, surrounded by a plush area rug. A pendant light hangs above, illuminating the space, while a piece of wall art adds a touch of color.
Home in Santa Cruz de la Sierra
4.94 out of 5 average rating, 34 reviews

Centrally located and spacious house 50 meters from 2nd Ring

One-story house with an unbeatable location and well-lit spaces. It has 4 spacious bedrooms (2 en suite). Fully furnished and very well decorated to make you feel at home. Located 50 meters from the 2nd Ring between Av. Alemana and Beni avenues, a safe and easily accessible residential area. Assisted by supermarkets, restaurants, such as the traditional “Casa del Camba” and others. Spacious social areas, living room, dining room, and barbecue. A fully-equipped kitchen.

Guest favourite
Home in Samaipata
4.88 out of 5 average rating, 16 reviews

Spacious & Modern Duplex-Style House Central Area

Modern, spacious duplex right in front of the Main Plaza, in the heart of Samaipata! Unbeatable location: surrounded by cafes, art, restaurants (veggie options), and bars. 🏠 Apartment-style interior featuring 2 bedrooms, 2 baths, and a large, fully equipped open-plan living-dining-kitchen. Perfect for relaxing after hiking El Fuerte. Strategic & safe area: transport, market, gym, pharmacy, and tours just steps away. The perfect balance of comfort and adventure! 🌄

Superhost
Home in Santa Cruz de la Sierra
5 out of 5 average rating, 3 reviews

Suite para 5 con balcón y hamaca | Zona top

Suite privada amplia ubicada en el segundo piso de una casa, ideal para 5 personas. Cuenta con dormitorio con dos camas de dos plazas y sofá cama, baño privado, vestidor, comedor privado y balcón con hamaca. Incluye Smart TV 43”, WiFi, microondas, frigobar y utensilios. Además, la propiedad ofrece áreas comunes compartidas como cocina equipada con horno, lavadora, salas, churrasquera, patio, parqueo y espacios recreativos (ping pong y futbolín).

Superhost
The serene pool area is highlighted by clear blue waters, surrounded by lush palm trees and tropical vegetation. Sunlight reflects off the water's surface, offering a calm and inviting atmosphere for relaxation. The space provides access to nearby facilities and is designed for leisure.
Home in Santa Cruz de la Sierra
4.92 out of 5 average rating, 24 reviews

Condominium house near Fexpocruz for 8

New house, cozy, ideal for a large family, one floor with four bedrooms and four bathrooms, garden, gallery and barbecue to enjoy the outdoors. Enjoy the security of a beautiful condominium with multi-functional courts, a children's playground, a large swimming pool, barbecues with a cabin, a micro market, and private streets with 24-hour security. Located very close to Fexpocruz, a few minutes from downtown and Equipetrol.

Superhost
A spacious room is featured, showcasing a large bed with light-colored bedding. A wooden frame holds a large mirror above the bed. A television sits on a wooden dresser, and a small table with a chair is positioned nearby. Light fixtures provide ample illumination.
Home in Santa Cruz de la Sierra
4.73 out of 5 average rating, 30 reviews

Cozy House, WIFI, A/C, Washing Machine

Are you passing through Santa Cruz or do you plan to stay several days in the city? Then enjoy the simplicity of this quiet and central accommodation. Located 2 blocks from the Expocruz fair and minutes from any important point in the city, here you can rest quietly to start the next day with all your energy. We have 2 bedrooms, a kitchen with all amenities, laundry and parking for your vehicle.

Guest favourite
The image captures a relaxing jacuzzi surrounded by lush greenery. Sunlight filters through the trees, illuminating the bubbling water. A tranquil atmosphere is created by the natural setting, offering a peaceful retreat for guests.
Home in Buena Vista
4.91 out of 5 average rating, 11 reviews

Capibara House

Bienvenidos a tu Refugio en Buena Vista! Una encantadora casa céntrica a solo 3 cuadras de la plaza, con una vista impresionante al Parque Amboró. Relájate en el hidromasaje, descansa en la suite con baño privado o en el acogedor cuarto de 2 camas. También cuenta con la elegante sala con sofá cama, cocina equipada y parrillero hacen de este hogar único tu escapada perfecta.

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