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Guest house holiday rentals in Santa Cruz

Find and book unique guest house rentals on Airbnb

Top-rated guest house rentals in Santa Cruz

Guests agree: these guest house rentals are highly rated for location, cleanliness and more.

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Guest favourite
A cozy space features a spacious bed adorned with decorative towels, complemented by patterned curtains and wall accents. A dining table with chairs is positioned near the open kitchen, which includes a stove and sink. Natural light filters in through a window, enhancing the inviting atmosphere.
Guest house in Samaipata
5.0 out of 5 average rating, 8 reviews

La Casita, Finca La Vispera

La Casita, is a perfect place to spend a couple of days with your partner, it is located inside Finca "La Vispera", we have a Parque Nativo, Café Jardín, Herbolario, great view. You’ll love my place because of the location, the people, the neighborhood, the outdoors space, and the ambiance. My place is good for couples, solo adventurers, families (with kids), big groups, and furry friends (pets). You also will enjoy our vegetable Garden. You can collect the vegetables and enjoy a great meal.

A multi-story building is showcased, featuring a distinctive red facade with decorative archways. Balconies extend from the upper floors, providing outdoor space. The ground level houses various storefronts, while utility poles and street signs are visible, indicating a lively urban environment.
Guest house in Santa Cruz de la Sierra
4.36 out of 5 average rating, 14 reviews

Cozy family home in Santa Cruz de la Sierra

Family house of 320 square meters, on the second floor, with all the household goods and linen, wonderful views from its 30-meter terrace. Ideal for families who want to have a quiet stay of any duration in the City of Santa Cruz de la Sierra. Very well connected with several bus lines that lead to the entire city and surroundings and very close to the Cotoca Sanctuary. Nearby you will find all kinds of services, breakfasts, meals, markets, shops, etc.

Guest house in San Miguel de Velasco

Quinta El Retorno: comfortable house with 2 bedrooms.

Welcome to Quinta El Retorno, a space surrounded by nature that offers peace and relaxation. The house has two separate bedrooms, each with a private bathroom, a shower with hot water, air conditioning, and a built-in closet. It can accommodate up to 5 guests, making it ideal for families, couples, or small groups. In addition, it offers covered parking for two vehicles, Wi-Fi, and a large outdoor gallery for enjoying the outdoors.

A spacious common area features comfortable seating arrangements with a mix of sofas and chairs. A central table is set with placemats, while a ceiling fan and air conditioning unit contribute to a comfortable environment. Light filters through large windows, enhancing the welcoming feel.
Guest house in Santa Cruz de la Sierra

Spacious house with a patio and parking

Guest house, with large patio and grill (churrasquera), in a very quiet area. Air conditioning in all rooms, water heater (hot water), Wi-Fi, spacious living room. Suite with private bathroom. Shared bathroom, sofa bed and large sofa on the ground floor. (Up to 4 people can sleep comfortably) Address: km 8, Barrio 14 de Agosto, Calle 3 Between double track la guardia and radial 17 and a half

Superhost
A charming outdoor patio is framed by lush green trees, providing a shaded area for relaxation. The brick flooring leads to a set of steps ascending to a bright entrance flanked by large windows, allowing natural light to enter the interior space.
Private room in La Guardia
4.69 out of 5 average rating, 16 reviews

Casiopea Eco-Friendly Room

Relax and enjoy a moment with nature, 10 minutes from the municipality of La Guardia and 3 minutes from the tranca al Torno entering through Cañada Seca. Room with air conditioning, 2 1/2 seater bed with option to add 1 or 2 extra mattresses; Grill, electricity, water, wifi, ample space for hiking trails. Fruit trees, easy access with nearby shops to provide food. Owners live on site.

Superhost
Guest house in Centro
5.0 out of 5 average rating, 3 reviews

Complete centric apartment with garden and pool

Complete centric apartment with an enormous garden and pool. Private apartment with fully staffed kitchen, private bathroom and a bedroom with a queensized bed. You'll also have access to the big garden and the pool to relax and refresh yourself. By choosing our accommodation, you’re also supporting Ñañope, a local NGO dedicated to empowering household workers in Santa Cruz.

A simple sleeping area features a spacious bed with white linens and bright red curtains framing a nearby window. An open shelf housing no items stands against one wall. A doorway leads to a bathroom visible in the reflection of a mirrored door.
Guest house in Ichilo
4.5 out of 5 average rating, 16 reviews

Window to Amboro Park

Enjoy a partial view of the Amboro mountains, with birdsong in the morning and the sounds of the small forest at night. Sometimes nocturnal monkeys or early-rising agoutis may appear. Though only 4 blocks from the main square, the place is quiet, away from traffic noise. With advance confirmation, tours to the north side of Amboro National Park can be arranged.

Guest favourite
A cozy bedroom features a spacious bed dressed in neutral linens, accompanied by decorative cushions. Two wooden chairs are positioned beside a round table near a window with light curtains. A wooden nightstand stands beside the bed, contributing to the room's welcoming atmosphere.
Guest house in Centro
4.88 out of 5 average rating, 135 reviews

Private Apartment In Downtown

Welcome to our cozy guest house in one of the most beautiful and safe areas of the center! Just 6 blocks from Plaza 24 de Septiembre, our historic neighborhood offers you a unique experience.

Guest favourite
Private room in Samaipata
4.96 out of 5 average rating, 24 reviews

Centric, accesible, comfy private room w/bathroom

Peaceful private room with a private bathroom in the heart of Samaipata, 50m from the market, 2 blocks to town plaza. Clean, cozy, simple. Basic amenities, NO Kitchen...

Guest house in Santa Cruz de la Sierra

Holistic Portal House # 1

Enjoy this mystical space of tranquility and harmony where your nights will be restored and revitalized with the energy of the Holistic Portal

Guest favourite
Private room in Santa Cruz de la Sierra
4.86 out of 5 average rating, 7 reviews

Posada El Peregrino 7

Enjoy the simplicity of this quiet and centrally-located accommodation.

A cozy sleeping area is furnished with a spacious bed adorned with patterned pillows, complemented by a seating area made of wooden pallets. Textured gray walls provide a simple backdrop, while a small table offers additional surface space. Natural light illuminates the room from the doorway.
Guest house in Santa Cruz de la Sierra

Separate room with private bathroom

Relax in this independent accommodation where tranquility is breathed.

Popular amenities for guest house rentals in Santa Cruz