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Holiday rentals in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

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Guest favourite
A modern living area is displayed, featuring a comfortable sofa and a green accent pouf. A dining table is situated nearby. Floor-to-ceiling windows offer a view of the greenery outside, allowing natural light to fill the space. The kitchen is equipped with sleek appliances.
Flat in Santa Cruz de la Sierra
4.91 out of 5 average rating, 154 reviews

Studio 518 - Luxury near Everything

Automatic access, 2 Air Conditioners, Washing Machine, Kitchen, Sofa and TV perfect for working all day with a green view from an 8th floor apartment in the most sought-after neighborhood in the city, Equipetrol. If you get bored you can use the pool at no cost, social areas, BBQ. If you get bored, you'll be 2 minutes away from supermarkets, pharmacies, blocks from Equipetrol's main square with renowned restaurants, 5 minutes from the Central Plaza or 5 minutes from Bolivia's largest shopping mall, Ventura Mall.

Guest favourite
Flat in Santa Cruz de la Sierra
4.92 out of 5 average rating, 111 reviews

Cozy & modern · Fully equipped studio

You'll wake up in a fully equipped Studio that combines home comfort and comfort. You will enter a sophisticated lifestyle; every detail has been carefully designed to meet high expectations. You'll have all amenities. Relax? Immerse yourself in the pool. Exercise? There is Gym! Work? You will be able to continue your routine in the multiple social zones that offer the perfect setting.Have fun? You will be able to play billiard and use the common room ¡Book and discover this Studio!

Top guest favourite
A modern interior is presented, featuring a cozy seating area with a dark sofa, complemented by a circular coffee table. A wooden divider offers separation from the sleeping area, where a spacious bed with neutral bedding is visible. Natural light fills the space from the nearby window.
Flat in Santa Cruz de la Sierra
4.98 out of 5 average rating, 43 reviews

SkyLuxia New Equipetrol Apartment - Safe & Luxurious

Enjoy and relax in this new, quiet and elegant space for two people. Located in Equipetrol, the best area of Santa Cruz, close to restaurants and shopping centers. It offers comfort, convenience and safety. You'll find: WiFi, 55” Smart TV, Cable TV, Air Conditioning, Washer + Dryer. ✔ Large swimming pool and sauna ✔ Gym ✔ Meeting room ✔ 24/7 Reception Fully equipped with towels, shampoo, conditioner, soap, toilet paper, tea, coffee, sugar, salt and oil.

Guest favourite
A contemporary entryway featuring sleek, metallic walls and smooth marble flooring. A minimalist reception desk with soft ambient lighting displays the name 'NUU.' A large potted plant adds a touch of greenery, while well-placed lighting creates a bright atmosphere.
Flat in Santa Cruz de la Sierra
4.94 out of 5 average rating, 72 reviews

apartment with an excellent view

Apartment located in the Equipetrol area. Located on the 13th floor, you'll enjoy stunning views in a comfortable and elegant atmosphere. This apartment has two bedrooms and two bathrooms, ideal for families or groups. It's fully equipped to make you feel at home. Among the building's amenities, you will find a cinema, a swimming pool, a barbecue area, an equipped gym, a playground, and parking for visitors. Easy access to restaurants, shops, and attractions.

Top guest favourite
Flat in Santa Cruz de la Sierra
5.0 out of 5 average rating, 14 reviews

Comfortable apartment in Luxe Suites, Equipetrol

This charming apartment is located in the prestigious Equipetrol neighborhood, one of the most privileged areas of the city. The place has a double bed and a sofa bed, ideal for accommodating up to 3 people. Private balcony with a view where you can enjoy the outdoors, 1 modern bathroom, with everything you need for your comfort. Bright space with modern-style decor. A fully equipped kitchen for you to enjoy your meals as if you were in your own home.

Superhost
Flat in Santa Cruz de la Sierra
4.6 out of 5 average rating, 5 reviews

Balcony on the 17th Floor / Desk / Pool / Gym

Meters from the 2nd ring, Equipetrol area, many restaurants, shops, supermarkets, gyms among others. With a balcony and a view of the 17th floor, pool, work area, gym and others in the social areas. Apartment with: -WiFi 100Mbps - Kitchen - Washing machine -Smart TV - Fully equipped bathroom - Bed - Sofa bed - WiFi 100 Mb In the building you will have: -swimming-pool - Gym - Sauna - Work area - Games area Live the Experience and book ya!

Top guest favourite
Cottage in Samaipata
5.0 out of 5 average rating, 21 reviews

EcoHouse · Pool · Nature · Tranquility · Samaipata

A Living Earth Sanctuary on Samaipata Mountain Handcrafted with natural materials and a Bolivian soul. Welcome to CASA CACTUS — fully equipped and personalized for a stay surrounded by natural luxuries. 🏊 Pool · 🛜 Starlink · 🌿 Nature · Weekly and monthly DEALS *see below or contact us*. A place to really rest. To write. For slow cooking. To work online and offline. To look at the mountains without rushing.

Top guest favourite
Flat in Santa Cruz de la Sierra
5.0 out of 5 average rating, 37 reviews

Green Tower* 27th Floor Stunning views & Luxury

Truly the highest floor in the building, this modern luxury retreat soars above the city with breathtaking panoramic views. Sleek finishes, stylish decor, and plush comforts create a refined, high-end ambiance. Whether you’re sipping wine at sunset or waking up in the clouds, this stunning high-rise sanctuary delivers an unforgettable, elevated stay.

Top guest favourite
Flat in Santa Cruz de la Sierra
5.0 out of 5 average rating, 17 reviews

Luxury apartment across from the Hotel Yotaú

Enjoy a unique stay in the heart of Equipetrol, the best area of the city. Located on the 13th floor, this modern apartment offers a wonderful view and a private balcony for relaxing. Fully equipped for short or long stays, designed for your maximum comfort. Plus, enjoy exclusive luxury social areas that will make your experience even more special.

Top guest favourite
A modern living space is shown, featuring a round dining table surrounded by four chairs. A dark sofa with colorful cushions is positioned against a wall. The kitchen appliances and cabinetry are visible in the background, complemented by bright decor elements on the wall.
Flat in Santa Cruz de la Sierra
4.99 out of 5 average rating, 70 reviews

Comfortable and modern apartment

Guests can enjoy a pleasant stay in an excellent location, the apartment's design, furniture and equipment suitable for a unique experience. It has a double bed and a sofa bed, A/C in the master bedroom and living room, a bathroom with a washing machine and all the amenities, and a kitchen equipped with everything you need. Internet speed: 35 Mbps

Guest favourite
Apartment in Santa Cruz de la Sierra
4.94 out of 5 average rating, 31 reviews

Modern Fully Equipped Studio – 5th Floor

Your ideal city retreat ✨ Cozy apartment on the 5th floor of the luxurious Skyluxia building, located in Equipetrol. Queen bed 🛏️ Hot water bathroom 🚿 Fully equipped kitchen 🍳 Wi-Fi 💻 45” TV 📺 A/C ❄️ Natural light ☀️ Enjoy... Swimming pool 🏊‍♂️ Gym 🏋️ Sauna ♨️ Cinema room 🎬 Panoramic views 🌇 Comfort, style, and the perfect location! ❤️

Guest favourite
Flat in Santa Cruz de la Sierra
5.0 out of 5 average rating, 48 reviews

POX | Green Tower 15 Th Floor | Luxury and confort

Enjoy a unique experience in Bolivia's most exclusive and luxurious building: the iconic Green Tower! Let yourself be surprised with an unbeatable view, in an apartment of 80 m2, technological and luxurious. No further explanation is needed—see for yourself what it's like to live under the purest sky in America. Rest, Enjoy, Come Back

Popular amenities for Santa Cruz holiday rentals