Holiday rentals in Santee River

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Top-rated holiday rentals in Santee River

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Top guest favourite
An elegantly decorated sitting area is presented with a detailed mural ceiling and rich purple drapes. A plush loveseat and two accent chairs surround a circular rug in the center. Windows allow natural light to fill the space, highlighting the ornate moldings.
Flat in North Charleston
4.96 out of 5 average rating, 146 reviews

Bridgerton inspired fantasy 2 min from park circle

Live out your Bridgerton fantasy in this stunning historic space. The apartment features antique furnishings/art, a private entrance and patio with lounge and a hot tub (The hot tub is available Apr through Nov). Off street parking. A sumptuous bathroom with an oversized soaking tub and a kitchenette. There is also a 55 inch frame tv in the bedroom including WiFi. Available for photo shoots upon request rates may differ please contact host prior. Bridal pics by Olivia Allain Permit#2026-0414

Top guest favourite
Home in Moncks Corner
5 out of 5 average rating, 11 reviews

All the Amenities of Home!

Welcome to our beautifully renovated home, conveniently located in the western area of the town limits near Berkeley High School. This charming residence offers easy access to area attractions, venues, local lakes and rivers, and is a short drive to both downtown Summerville (17.3 miles) and downtown Charleston (33 miles), including their beaches and offerings. Enjoy a large backyard with a fenced area attached to a large patio, providing a safe area for children to play while adults relax.

Top guest favourite
The exterior of a two-story house is nestled among tall trees, showcasing a deck with steps leading to the ground. Screened-in porches on both levels provide ample outdoor space and views of the surrounding greenery.
Home in Georgetown
4.98 out of 5 average rating, 184 reviews

Black River Refuge on the Water

The first guest comment I hear is "Wow - pictures don't do this place justice - the house is incredible and the views are spectacular! The next comment is "I thought we were way out in the country but it's only 20 minutes to the waterfront town of Georgetown, with shops, dining, museums and more. Looking to get away? This place is truly a retreat- a 3 bedroom house on the beautiful Black River in Georgetown. Four kayaks provided, swim or fish off the dock just a few steps from the house.

Guest favourite
A serene sunset casts warm hues over the water, with a houseboat moored alongside a covered dock. Silhouetted against the sky, fishing rods stand tall, and tall grasses frame the scene, enhancing the tranquility of this riverside setting.
Home in Georgetown
4.89 out of 5 average rating, 160 reviews

Maggie Jo’s paradise on the river !

Reconnect with nature at this unforgettable escape. Maggie jo is a 1970 completely restore houseboat. She has got a full size refrigerator , gas range ,microwave and toaster oven. Out on the back deck she has a gas grill. The aft berth has 2 full beds that are extremely comfortable. Galley dinette make into bed and the couch in the saloon pulls out also. While on the decks you will see eagles, dolphins , gator or fishing jumping out of the water. I also have 2 tandem kayaks for your use.

Top guest favourite
A cozy seating area features a soft armchair and a tufted ottoman, positioned near a stone fireplace. Built-in shelves display decorative items and books. Expansive glass doors provide natural light and a view of the outdoor space, enhancing the inviting ambiance.
Guest house in Summerville
4.98 out of 5 average rating, 58 reviews

Cottage 1 king bed, 1 set bunk beds, heated pool

Escape to a cozy, beautifully furnished cottage nestled in historic Summerville, just a stroll away from the heart of the town. Whether you're a couple seeking a romantic getaway or a small family looking for a peaceful home base, this cottage offers the perfect blend of comfort, character, and convenience. The patio is ideal for relaxing mornings or evening meals under the stars. With easy access and free parking, it's perfect for day trips to the beach, Charleston, or a walk into town.

Superhost
An antique tugboat is anchored on calm waters, showcasing its sleek black hull and bright white cabin. Large windows provide an unobstructed view, while nearby flags flutter gently in the breeze. The surrounding area features a mix of greenery and docks.
Boat in Georgetown
4.74 out of 5 average rating, 34 reviews

Antique Tugboat on the Harborwalk

Welcome aboard this lovingly restored antique tugboat, moored just steps from the storied streets of Georgetown. Once a proud workhorse of American waterways, this vessel now offers a rare opportunity to experience life as it was in 1907—without sacrificing comfort. Let the scent of old pine and briny air greet you each morning as the harbor stirs to life. Cradle a warm mug of coffee as the sun lifts above the horizon, painting the masts and marshes in amber light. Your voyage awaits.

Top guest favourite
The living area showcases two gray sofas, a blue accent chair, and a dark wooden coffee table. Natural light filters through sheer curtains, with vibrant yellow decor accents on one sofa. A welcoming entry door with a circular window is positioned to the left.
Home in Andrews
4.89 out of 5 average rating, 46 reviews

Graceful Comfort

Discover the charm and comfort of our cozy country Airbnb, nestled in the heart of Andrews, SC. Perfect for a relaxing family getaway. Start your mornings with a cup of coffee on the screened-in porch, listening to the sounds of nature and soaking in the fresh country air. Inside, you'll find a warm and inviting atmosphere with comfortable furnishings, a fully equipped kitchen, and plenty of room for family and friends . Book your stay today and experience the charm of country living .

Top guest favourite
A newly renovated cabin is nestled among tall trees during twilight, featuring warm lighting on a spacious deck. The cabin's dark exterior contrasts with the natural surroundings, while a gravel area leads to the entrance. The peaceful setting offers an inviting retreat.
Farm stay in Georgetown
4.99 out of 5 average rating, 67 reviews

Lo & Billy’s Place a Historic 1940s Newlywed Cabin

This romantic cabin located on our small farm just outside of town in the country offers a history all its own. Lo was Billy’s nickname for Lorene Ella. Lo & Billy got married in the 1950s and lived here. Renovated after meeting Lo and hearing her stories. We pay homage to the rich history of Georgetown and the Southerners that have called Lo & Billy’s Place home. Heavy on coziness & design. Full kitchen; good coffee; & comfy queen bed w/high end linens. The perfect escape.

Top guest favourite
A living area is arranged with floral-patterned seating and a wooden coffee table. Soft light from a nearby window illuminates the space, which features a circular braided rug and a lamp beside a comfortable armchair.
Home in Moncks Corner
4.98 out of 5 average rating, 85 reviews

The Brown Trailer

Welcome to The Brown Trailer in Pinopolis. It's a peaceful 3 bedroom, 2 bathroom older trailer that’s been well taken care of, sleeps up to 9 (7 in beds) with views of a pasture, use of a large backyard, and parking. Bring your boat as lake accesses to Moultrie start a 1/4 mile away with Cooper River accesses near by. Somerset, Wampee, Pineland Place, 108 W Main, Santee Canal as well as MC Regional Complex are minutes away, Summerville is 20’, and Downtown Chas is 45’. Come enjoy!

Top guest favourite
The exterior of the villa is shown, featuring a light-colored stucco façade contrasted by large windows. Surrounding landscaped areas include planters with vibrant greenery and flowers. A gravel pathway leads to the entrance, framed by the natural beauty of trees in the background.
Home in Summerville
4.92 out of 5 average rating, 170 reviews

Guest House/Villa

Enjoy your stay at this immaculately designed new build Villa. Located on a family property surrounded by 2 acres of trees, in a quiet rural neighborhood. Lots of privacy, peace and quiet, yet only 5 minutes from restaurants and stores. 15 minutes from Downtown Summerville, 40 minutes from Charleston and various coastal attractions. The villa is separate from main house and has no shared space other than the driveway. NO smoking, No pets. Laundry service available for long stays.

Top guest favourite
Farm stay in Hemingway
4.96 out of 5 average rating, 238 reviews

Quiet farmhouse near the beach

The best memories are made on the farm. Life is just better away from the hustle and bustle of city lights and busy schedules. Come stay in this recently renovated fourth generation 1950s farmhouse on an 80 acre working farm. Unwind on the porch, walk trails, find millions of years old sharks teeth, build a bonfire, pick blackberries, swim in the ponds, collect walnuts, or just relax while you’re here but don’t forget to wish on a dandelion or a shooting star before you leave.

Top guest favourite
A field of blooming yellow flowers is displayed in the foreground, with delicate petals and green stems. In the background, a white farmhouse is visible, providing a serene country setting. The scene captures the tranquility of the flower field adjacent to the cottage.
Tiny home in Moncks Corner
4.95 out of 5 average rating, 162 reviews

The Goose Cottage at Wild Goose Flower Farm

Located next to the family farmhouse at Wild Goose Flower Farm, The Goose Cottage was designed to immerse guests in our calm and peaceful country life. We are located 15 minutes from the hearts of Cane Bay, Nexton and Exit 194 on I-26, and 45 minutes from Downtown Charleston. Two can sleep in the queen size bed but the sofa also extends into a queen-sized sleeper. Please reach out with further questions or if you would like to inquire about an extended stay.

Popular amenities for Santee River holiday rentals