
Holiday rentals in Santee River
Find and book unique accommodation on Airbnb
Top-rated holiday rentals in Santee River
Guests agree: these stays are highly rated for location, cleanliness and more.

★Delightful guest house near historic plantations★
Nestled in the Historic Plantation District between Summerville & Charleston, our timberframe "bunkhouse" offers privacy, comfort & convenience. This 850+ sq ft retreat includes full kitchen & bath, 2 dbl beds, twin bed & plenty of living space. There's a private entrance, so come & go as you please (we're right next door if you need us). Minutes from Middleton Place, Drayton Hall & Magnolia Gardens, an easy drive to dntn Charleston, historic S'ville, beaches & golf courses. *Now with WiFi*
4.98 out of 5 average rating, 777 reviews
Pool & Hot Tub Retreat, Arcade, 85" TV, By Airport
Luxury 2,600 sq ft home with sparkling pool, relaxing hot tub, gourmet kitchen, fire pit & gas grill. 5 bedrooms (2 kings, 1 queen, 1 full over twin bunk, 1 crib), 2.5 baths. Master has workspace with dual monitors. Entertainment galore: massive 85" TV, ping pong, foosball, chess/checkers set, Pac-Man arcade, Xbox X, Switch. Stunning Arhaus & Restoration Hardware furnishings throughout. Level 2 EV charger. Minutes to golf, Topgolf, Park Circle, shopping & airport. Beaches & downtown nearby.
4.98 out of 5 average rating, 57 reviews
Your home away from home in Pinopolis
Nestled at the end of a quiet cul-de-sac, this house is close to Lake Moultrie & the Cooper River. It’s also very close to popular wedding venues: Somerset Point, Pineland Village, & Old Santee Canal Park. Moncks Corner Recreational Complex, where many tournaments are hosted, is also about 3 miles away. Pinopolis is less than 20 miles from Summerville & the Volvo area, 40 miles from coastal beaches, and just 45 minutes away from Downtown Charleston. It’s a great location for work or play!
4.98 out of 5 average rating, 181 reviews
Black River Refuge on the Water
The first guest comment I hear is "Wow - pictures don't do this place justice - the house is incredible and the views are spectacular! The next comment is "I thought we were way out in the country but it's only 20 minutes to the waterfront town of Georgetown, with shops, dining, museums and more. Looking to get away? This place is truly a retreat- a 3 bedroom house on the beautiful Black River in Georgetown. Four kayaks provided, swim or fish off the dock just a few steps from the house.
4.98 out of 5 average rating, 190 reviews
Luxury Farm Stay | Hot Tub, Pool & Animals
Welcome to The Days End Farm! Where modern comfort meets country charm 🌾 This home is for quiet stays only — no parties or events are allowed. A thoughtfully designed 700 sq ft farm cabin retreat tucked away on 11 acres of peaceful pastures. Located less than 45 min from downtown Summerville, 40 min from I-20, 1 hr from Downtown Charleston, and 25 min from I-95. We are a livestock property and for the safety of our animals we only allow 1 pet per reservation with a strict leash policy.
4.96 out of 5 average rating, 24 reviews
Fishing, boating, sunrises, peace & quiet, firepit
IMPORTANT NOTE! Do to very low water levels, we have no water in our cove. If you are here to boat and fish, you will have to use one of the boat launches nearby. Fish Tale Cove is a beautiful waterfront home that features a private dock and boat launch, allowing immediate access to the lake. Wake up to the serene sound of the birds chirping while watching our breathtaking sunrises with a fresh cup of joe! The property sits on a half acre of beautiful lake front property.
5.0 out of 5 average rating, 14 reviews
"The Nest" At Maple Hollow
Welcome to our space-age glamping oasis, where you can immerse yourself in nature without sacrificing comfort. Our 400 SF ecological home, designed with advanced technology and sustainable features, offers a unique living experience. Nestled in a tranquil, rural setting, you'll enjoy stunning views of a duck and goose pond, providing a serene escape from the bustling city life. Despite its peaceful surroundings, our intelligent home ensures you stay connected to the world.
4.96 out of 5 average rating, 23 reviews
Lake Moultrie retreat
Relax with the whole family at this peaceful oasis on the water. This home offers a private boat ramp, with 40' dock to tie off multiple boats, kayaks,canoe, paddle board, log & gas fire pits, corn hole boards, hot tub, beautiful 12x28 covered porch to enjoy the water and listen to the birds, swimming for the kiddoes, and plenty of yard space for entertainment and barbecue's for the entire family and friends to enjoy. Inside is beautiful & very accommodating.
5.0 out of 5 average rating, 55 reviews
Quiet Retreat:Secluded & Idyllic
"Quiet Retreat: Idyllic B&B in Rural Seclusion" Gives you that Peaceful Home away from Home Feel. Countryside Comfort. Full Kitchen, Wine Bar, Dining Room for Your Family to Enjoy. 3 Queen BR’s, & 2 Full Size Beds. swimming pool. Large Outdoor Space gives you that Perfect Country Living, Large Front & Back Yard. Swimming Pool -Local Restaurants: MacDaddy's,Swig & Swine, Gilligan's and many more.... Local Beaches: Bonneau Beach Amos Gourdine Boat Landing
4.85 out of 5 average rating, 55 reviews
The Goose Cottage at Wild Goose Flower Farm
Located next to the family farmhouse at Wild Goose Flower Farm, The Goose Cottage was designed to immerse guests in our calm and peaceful country life. We are located 15 minutes from the hearts of Cane Bay, Nexton and Exit 194 on I-26, and 45 minutes from Downtown Charleston. Two can sleep in the queen size bed and one can sleep on the couch. Please reach out with further questions or if you would like to inquire about an extended stay.
4.95 out of 5 average rating, 174 reviews
Lakefront Cabin Compound w Private Dock!
Your ultimate Lake Moultrie adventure starts here! This pet-friendly compound includes two stylishly renovated homes with high-end finishes, lake access via private dock, and plenty of outdoor living space from the wraparound deck to the firepit and fenced yard. Indoors, unwind with cozy furnishings or turn up the fun in the theatre room and full arcade. A rare blend of comfort, adventure, and entertainment for your next getaway.
4.96 out of 5 average rating, 25 reviews
Cutest Cottage on the Lake
Keep it simple at this peaceful and centrally-located cottage on Lake Moultrie in Moncks Corner SC, right outside of Charleston. Bring your boat and launch off of our dock, easy in and out access to the big lake. Our home sleeps 6 on our King bed, 2 twins and a pull out couch. Recently renovated, all the modern luxuries are provided. There is a fire pit to enjoy while you grill on our charcoal grill. Eat outside, enjoy the view!
4.82 out of 5 average rating, 49 reviewsPopular amenities for Santee River holiday rentals
Other great holiday rentals in Santee River

Lake Marion | Chill, Cruise, or Cast a Line for 8!
4.81 out of 5 average rating, 31 reviews
River House Escape
4.86 out of 5 average rating, 37 reviews
Lakefront House | Private Dock + Pet Friendly
4.96 out of 5 average rating, 45 reviews
2 King bed 2 Bath walkable downtown Summerville
5.0 out of 5 average rating, 94 reviews
The Wrenn’s Nest - Quaint National Forest Getaway
5.0 out of 5 average rating, 85 reviews
The Boat Shed
4.93 out of 5 average rating, 27 reviews
Cottage 1 king bed, 1 set bunk beds, heated pool
4.99 out of 5 average rating, 82 reviews
The Condo
4.98 out of 5 average rating, 51 reviewsDestinations to explore
- Atlanta Holiday rentals
- Sevierville Holiday rentals
- Myrtle Beach Holiday rentals
- Gatlinburg Holiday rentals
- Charlotte Holiday rentals
- Pigeon Forge Holiday rentals
- Savannah Holiday rentals
- Charleston Holiday rentals
- Jacksonville Holiday rentals
- Asheville Holiday rentals
- Hilton Head Island Holiday rentals
- North Myrtle Beach Holiday rentals
- Sullivan's Island Beach
- Garden City Beach
- Isle of Palms Beach
- Huntington Beach State Park
- Charleston City Market
- Bulls Island
- James Island County Park
- College of Charleston
- North Charleston Coliseum & Performing Arts Center
- Waterfront Park
- Rainbow Row
- Riverfront Park
- Shem Creek Park
- Caledonia Golf & Fish Club
- Magnolia Plantation & Gardens
- Hampton Park
- The Charleston Museum
- Middleton Place
- White Point Garden
- Murrells Inlet Marsh Walk
- Angel Oak Tree
- Cypress Gardens
- Boone Hall Plantation
- Gibbes Museum of Art





