
Lake house holiday rentals in Santee
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Top-rated lake house rentals in Santee
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Lakefront home with boat ramp and game room
This beautiful home is perfect for your Marion Lake family vacation! With four bedrooms and two living rooms, there is plenty of space! Our home is kid friendly, and includes toys, books, board games, arcade games, foosball, and puzzles. Outside you will find plenty of seating and dining areas, a large yard, a fire pit, a grill, beach along the waterfront, a private dock and a private boat ramp. Perfect for swimming, fishing, and boating! Kayaks are available.

Lake Murray Paradise~2 BR, 1 Bth, Kit/Living area.
Enjoy the full lake adventure with 4 kayaks included. Our property is a lake front paradise w/ about 1 acre on Lake Murray near the dam on the Lexington side of the lake. Close to Columbia, USC and Ft. Jackson. 3 Decks, 1 dock, hot tub & fire pit w/ wood. Private upper deck to the 2 Bedroom, 1 Bath suite with Open Kitchen, Living & Game Area w/ large flat screen TVs, Pool, Ping Pong & Foosball table. The entire upstairs is your private area w/ views of the lake. We offer boat tours. Fees apply.

Lakefront w/ dock at Mill Creek
Nestled between Santee & Eutawville, Vance is less than an hour from Downtown Charleston. Experience lake life w/ a front row seat to live music, dancing & karaoke at the Mill Creek Marina! Float over to grab a bite or drink at the Barefoot Lakeside Bar & Mill Creek Food & Spirits! Community hosts golf cart parades, Halloween bash, & a spectacular 4th of July fireworks show. Launch your pontoon a few doors down, tie up at your dock & conveniently fuel up at the marina. Campground store on site!

KING Beds - Bungalow Downtown Cola
* KING Beds in both bedrooms * PET FRIENDLY * EV CHARGER PLUG (4 Prong outlet ONLY, no cord or adapter) * TVs in both bedrooms and living room * 1.4 miles from PRISMA Hospital (4-minute drive) * BLACKOUT CURTAINS in all the bedrooms * 15 minutes to Fort Jackson * 7 minutes to Riverbanks Zoo * 5 minutes to the Columbia Museum of Art and Soda City Market * HUGE Deck with table and small covered area ***Primary booker must be 21 years of age and 30 to waive a security deposit of $250***

Luxurious Lakefront Log Home W/Pool & hot tub
Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Santee lakefront home, big water right off I-95
Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Lakefront w pool, dock and pool table, sleeps12
Location, location, location! 10 minutes to Lexington, 15 minutes to Chapin, 15 minutes to downtown Columbia, 8 minutes to Harbison shopping. Boat parking at the dock. No need to pay high docking fees. Gorgeous sunsets, calm cove. Swim in the lake or relax by the pool. The massive deck is great for family fun or unforgettable events with your friends. Close to Liberty’s /Lake Murray marina on the lake, and Cat Fish Johnnys/rusty anchor marina. Not your typical Lake Murray Airbnb!

Perfect Family Retreat at Lake Marion
Great water front family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. We purchased our home is 2006 and began a complete interior and exterior renovation. In 2023 we installed solar panels and an electric vehicle charging station, yet we also have access to the grid for cloudy days and when power demand exceeds what our panels generate. We use a deep well for water. Bring your family for an off-the-grid vacation in our lake home!

Nanny’s Lake Retreat
3 BR, 2 BA. Located in a quiet, dead end community. Enjoy the lake sounds from the spacious screened in porch. The porch has a swing, rocking chairs, and table with chairs. The den boasts a beautiful gas log fireplace and has two futons and a loveseat. The house is located in a golf cart community on a cove. Sandy beaches are just minutes away depending on the lake levels. Whether you’re looking for a vacation destination or fishing/hunting trip you will love this home.

Cheerful 3 bedroom home on the lake
Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Sunset Serenity Pool/Swim Spa
Experience next-level lakefront luxury in this brand-new 5BR/3BA custom home featuring a massive open-concept layout, chef’s kitchen, two master suites, and resort-style amenities like 20x40 infinity pool, swim spa, and fire pit. Enjoy a private dock, multiple lounge spaces, dual laundry sets, paddleboard/kayaks, and designer finishes throughout. Every detail of Sunset Serenity was designed for comfort, beauty, and unforgettable moments on Lake Marion.

Lake House at Lake Marion
Beautiful lakefront 3 Bedrooms/2 full baths with million dollar view of Lake Marion. -2 Queen beds/2 twins/1 futon -Private Dock so you can fish in “big water” -Canoe and Kayak -Firepit -Includes linens and beach towels and more! -Fully Furnished + grill and covered parking -One level open concept -75” Roku TV and WiFi -great safe neighborhood for walking and bike riding -public boat landing and county park with playground within 2 blocks.
Popular amenities for Santee lake house rentals
Waterfront lakehouse rentals

Old Man’s Fishing Hole (Lake Front-Lake Marion)

Lakefront Cabin Off i95, Bells Marina & Resort

The Cypress House

Lakefront Fishing + Grilling | Home Sweet Home!

Lakefront Farmhouse Retreat+Pool

Lake House Getaway

Lake Marion Cottage

Lakeview Leisure-Face to the Sun
Pet-friendly lake house rentals

Jewel on the Lake

Tie One On! at 4 Bdr Waterfront Lake Marion

The Heron Lake House

Almost Heaven on Lake Marion, SC

Fisherman's Dream at Low Falls Landing-Lake Marion

Stanley's Lake House

Lakefront Lookout

Big’s Place
Private lake house rentals

The Fishnet

Lovin’ Lake Life

Blue Heron Lake House w/Kayak

Charleston-themed House for 10!

Lakefront retreat with boat ramp and dock

1930's Cape Cod Style Home On Pond

Beautiful Lake Murray Retreat

Lake Retreat
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- Lakehouse rentals South Carolina
- Lakehouse rentals United States
- Riverbanks Zoo and Garden
- University of South Carolina
- Middleton Place
- Congaree National Park
- Magnolia Plantation & Gardens
- South Carolina State House
- North Charleston Coliseum & Performing Arts Center
- Columbia Museum of Art
- Cypress Gardens
- South Carolina State Museum
- Colonial Life Arena
- West Columbia Riverwalk Park and Amphitheater
- Columbia Metropolitan Convention Center
- Williams Brice Stadium
- Charleston Southern University
- Edventure
- Riverfront Park
- Sesquicentennial State Park
- Soda City Market
- Wannamaker County Park




