Holiday rentals in Rochester

4.93 out of 5 average rating, 162 reviews

Woodland Retreat, Full private walkout lower level

Peaceful retreat down gravel driveway 15 min from Mayo Clinic. Enjoy your own apartment with private backyard walkout entrance to the lower level of our home. You will have a bedroom, living area, kitchenette with mini fridge, microwave and toaster oven (no conventional stove/oven), bathroom w/ tub & shower, pingpong table, laundry, and patio with fire ring. You may hear piano music weekday afternoons, since I give lessons (usually 3-6 pm; a bit earlier in summer) NEW HEATED FLOORS w/thermostat

4.85 out of 5 average rating, 240 reviews

St. Augustine’s Flat @ St. Marys Mayo Clinic!

St Augustine Flat is the best place in town to stay. Unmatched location and space, save $$. Located in the prestigious “Pill Hill” walking distance to all of downtown Rochester, 1 block from St. Marys Hospital (in the background of pic). From St Marys catch the free Mayo Shuttle to other Mayo locations. Beautiful hardwood floors, 1 bedroom with walk-in closet, full bath, Kitchen, Fast WiFi, Smart Tv. The space is upstairs. The stairs are steep with narrow tread! I look forward to hosting you!

4.94 out of 5 average rating, 32 reviews

Lux 3BR Cozy Nook I Mins to Mayo & Dwtwn I Pets

Cozy Nook is a thoughtfully designed 3-bedroom, 1.5-bath 1971 sqft home just minutes from Mayo Clinic and downtown Rochester. Blending modern amenities with timeless charm, this cozy space is perfect for Mayo visits, family getaways, or business trips. Guests love the cozy warm atmosphere, pristine cleanliness, and functional design. With restful bedrooms, a fully equipped kitchen, and 2 inviting living spaces, The Cozy Nook offers the comfort and convenience you need for a comfortable stay.

5 out of 5 average rating, 45 reviews

New! MN Comforts The Heart 4Bd/2Bth, 12min to Mayo

Welcome to MN Comforts The Heart! Are you here for work or leisure, or want to feel comforted after a Mayo appts? 12 min to Mayo Clinic, Wifi, work-station, ROKU/Smart TVs, and a fireplace in the family room. We offer a 2nd home feel. Near stores. Split-level, chill, and quiet, thoughtfully designed to cater to your needs, ensuring a comfortable, enjoyable stay. A blend of traditional & modern styling in a tranquil home, with fun opportunities for family & friends. Partially fenced backyard.

4.73 out of 5 average rating, 155 reviews

Relaxing, main floor apartment in 4plex, #2.

This is a quiet main floor apartment (491 sq. ft.) in a 4-plex located 1 mile from Mayo. It has a all of the cooking necessities needed to make your own meals. There is a full size bed in the bedroom. This unit is in an older house with radiator heat and a big front porch. The floors are squeaky in a few places. Since it is a 4plex you will hear some sounds from other guests but it is generally quiet. There is parking behind the house and a washer and dryer in the basement available to guests.

4.93 out of 5 average rating, 160 reviews

Home for the Traveler, a walk to St. Mary's

This place is located near the heart of Rochester, within blocks of St. Mary's hospital, very peaceful, cozy and private. A lower-level unit in an older home, plenty of windows and light, and includes a gorgeous bedroom with a fireplace, a full kitchen, a reading room, and a clean, updated bathroom. This home is also close to the Apache mall, the Canadian Honker and other local restaurants, coffee shops, and the walking/biking trail system. There is also Wi-Fi, laundry, and parking on-site.

4.98 out of 5 average rating, 98 reviews

Pine Cove Cottage under 5 miles to Mayo

Sun filled one room cottage w/everything you need for your short or long stay. Wether it’s a get away or a visit to Mayo Clinic. We have two cottages side by side for you to enjoy. One is the main cottage with everything you need, sleeps 2. The other is a bunkhouse for sleeping. There is no bath or kitchen in the bunkhouse. It has two recliners, a tv, and a daybed. The property is 40 acres of trees, walking paths, post & beam pavilion, 2 fishing ponds all enjoyed on your own private deck.

4.87 out of 5 average rating, 341 reviews

Mayo Downtown's Prairie Home Retreat

Nestled in a serene corner, this home offers a perfect blend of tranquility and accessibility; being near the Mayo campus and Rochester's key attractions. Enjoy comfortable beds, a well-appointed kitchen, and a fenced yard with patio gardens. It's an excellent spot for family bonding, featuring three smart TVs, rapid Wi-Fi, and a variety of indoor and outdoor entertainment options. We strive to accommodate flexible check-in/check-out arrangements whenever feasible. Rollator accessible.

4.97 out of 5 average rating, 242 reviews

Restful sanctuary close to Mayo Clinic

This cozy space has private, self-entrance with off-street parking at no cost...a mere 2.5 miles or 10 minute drive to the Mayo Clinic downtown. Located in a quiet neighborhood in northwest Rochester. Easy access to highways, grocery store, coffee shop, Target, restaurants and biking/walking trail. Completely furnished with linens, hair-dryer, Netflix and Hulu, Smart TV and Wi-fi....and a Keurig Coffee maker with enough coffee pods to get you started. Truly, a home away from home!

4.97 out of 5 average rating, 226 reviews

Guest house in Rochester

Hygge House | A Cozy Guesthouse

The Hygge (pronounced hyoo·guh) House is a tiny taste of Scandinavia in Southeastern Minnesota. What is Hygge? In short, it's a Scandinavian way of living that focuses on hunkering down and creating a safe, comforting and warm place to while away. My husband and I hand built the Hygge House with your comfort in mind. We love being cozy and having space to spend together so when the opportunity arose to renovate our studio, we wanted to share it!

Tiny home in Downtown Rochester

4.96 out of 5 average rating, 49 reviews

Lovely Tiny Home | 5 Blocks From Mayo | No Stairs!

Welcome to our Downtown Cottages, Rochester’s First "Tiny Homes" : 3 min drive/10-15 min walk to the Mayo Clinic Campus. Experience our four charming cottages- Enjoy zero-entry, slab-on-grade living with NO stairs!! Elegantly furnished and fully stocked, each unit also includes off-street parking. Located just 5 blocks from the downtown Mayo Clinic Campus, our cottages offer the perfect blend of comfort and convenience. Book your stay today!

4.87 out of 5 average rating, 223 reviews

SALE: Remodeled retreat near Mayo Clinic

• Enhanced cleaning protocols due to COVID • Fully renovated apartment in summer 2018 • 650 square feet • Upstairs apartment in quiet 4plex • Free off-street parking • 5 blocks north of Mayo Clinic • Walk-in tiled shower • Queen bed • Full kitchen with gas stove (new 5/16/19) • Reclining leather loveseat • 43" Smart TV with DirecTV/cable • High-speed WiFI — 300 MBPS • Shared laundry in the basement • Huge windows for tons of natural light

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Popular amenities for Rochester holiday rentals

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Other great holiday rentals in Rochester

4.95 out of 5 average rating, 415 reviews

Magical Nest

MicheleRating, 5 stars1 week ago

We love staying at the Magical Nest. It is beautiful, peaceful and comfortable. Greg and Yvonne are perfect hosts.

4.77 out of 5 average rating, 56 reviews

upstairs #1 spacious pretty bedroom

MarkRating, 5 stars1 month ago

Nice spot. Noise from others walking around and closing/slamming doors in the house.

4.96 out of 5 average rating, 155 reviews

You’re home! St.Augustine MAYO CLINIC garage!

DanielRating, 5 stars2 weeks ago

We enjoyed our stay in Rochester. The house was clean and in a safe neighborhood. Our toddler loved the toys and the park nearby.

4.76 out of 5 average rating, 25 reviews

Cute Rochester House

Mary JaneRating, 5 stars3 days ago

Perfect place to stay for my very short time in Rochester. Great value, safe surroundings Super clean and comfy Thank You

4.97 out of 5 average rating, 110 reviews

St. Augustine’s Mint Mayo Clinic WALK GARAGE!

SavannahRating, 5 stars1 month ago

Denise & Hilda are amazing! Thank you SO much for all you both do! We’re blessed to have the st Augustine air bnbs during the next month of radiation treatments for my son! Thank you!!

4.83 out of 5 average rating, 23 reviews

4 bed 3 bath relaxing lake home near Mayo Clinic

ColeRating, 5 stars2 weeks ago

Loved the house and the location! Derek was incredibly friendly and made everything easy.