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Holiday rentals in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

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Guest favourite
A modern living area is displayed, featuring a comfortable sofa and a green accent pouf. A dining table is situated nearby. Floor-to-ceiling windows offer a view of the greenery outside, allowing natural light to fill the space. The kitchen is equipped with sleek appliances.
Flat in Santa Cruz de la Sierra
4.91 out of 5 average rating, 156 reviews

Studio 518 - Luxury near Everything

Automatic access, 2 Air Conditioners, Washing Machine, Kitchen, Sofa and TV perfect for working all day with a green view from an 8th floor apartment in the most sought-after neighborhood in the city, Equipetrol. If you get bored you can use the pool at no cost, social areas, BBQ. If you get bored, you'll be 2 minutes away from supermarkets, pharmacies, blocks from Equipetrol's main square with renowned restaurants, 5 minutes from the Central Plaza or 5 minutes from Bolivia's largest shopping mall, Ventura Mall.

Guest favourite
Flat in Santa Cruz de la Sierra
5.0 out of 5 average rating, 6 reviews

Skyline Luxury • Rooftop, Piscina, Billar & Lounge

Designed for discerning guests seeking an experience superior to a 5-star hotel. Located in Equipetrol, the most exclusive and secure area of Santa Cruz, this elegant apartment on the second-to-last floor offers a double balcony with unique views! Premium amenities such as a sky pool, lounge, pool table, barbecue grills, fully equipped gym, and more! Surrounded by the best restaurants, bars, cafes, theaters, shops and business centers. Ideal for executive trips, luxury getaways or unforgettable stays.

Guest favourite
Flat in Santa Cruz de la Sierra
4.9 out of 5 average rating, 21 reviews

Luxury apartment in Equipetrol | SKY Moon

Enjoy a unique stylish experience, steps from Mall Ventura, Mz-40, Green Tower, Camino Real hotel. Elegant studio in SKY MOON, Equipetrol Norte. Furnished studio with a bed, a comfortable sofa, a desk, an equipped kitchen, a private bathroom and a balcony. Great for business trips or rest. Enjoy hotel-like amenities: swimming pool, sauna, gym, coworking, billiards, paddle tennis court and terrace with fireplace in Santa Cruz's best business area. Book and live the experience today

Top guest favourite
The living area features a comfortable couch positioned near a large window, allowing natural light to fill the space. A flat-screen television is mounted on a wood-paneled wall, and a small round table is visible nearby. The view showcases the city skyline and nearby greenery.
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 33 reviews

Luxury, comfort, ideal location

Welcome to the best location in Santa Cruz! In the heart of the business center, but on a quiet street. Supermarkets and much more just around the corner. Within walking distance you will find dozens of amazing restaurants: barbecue, Japanese, Italian or American food. Fast food or elegant dinners. Manzana 40 is a 10-minute walk away. Ventura Mall is just a 5-minute drive away. Whether for work or fun, this is the place to be! The building has 24/7 security staff.

Top guest favourite
Flat in Santa Cruz de la Sierra
5.0 out of 5 average rating, 19 reviews

POX | Green Tower 17th Floor, Luxury in Equipetrol

✨ Live the POX experience of luxury and comfort in the heart of Equipetrol ✨ Located on the 17th floor of the exclusive Green Tower, this POX Glam apartment combines modern design, sophisticated decor and a unique panoramic view of Santa Cruz. Perfect for business travelers, couples, or leisure stays looking for a premium space with all the amenities. At POX we don't just rent apartments: we give you a home away from home. Our team is available 24/7 to help you.

Guest favourite
A contemporary entryway featuring sleek, metallic walls and smooth marble flooring. A minimalist reception desk with soft ambient lighting displays the name 'NUU.' A large potted plant adds a touch of greenery, while well-placed lighting creates a bright atmosphere.
Flat in Santa Cruz de la Sierra
4.92 out of 5 average rating, 76 reviews

apartment with an excellent view

Apartment located in the Equipetrol area. Located on the 13th floor, you'll enjoy stunning views in a comfortable and elegant atmosphere. This apartment has two bedrooms and two bathrooms, ideal for families or groups. It's fully equipped to make you feel at home. Among the building's amenities, you will find a cinema, a swimming pool, a barbecue area, an equipped gym, a playground, and parking for visitors. Easy access to restaurants, shops, and attractions.

Top guest favourite
A comfortable sleeping area features a spacious bed adorned with soft pillows and a decorative throw. Warm bedside lamps illuminate the space, while large windows offer views of the surrounding cityscape and allow natural light to brighten the room.
Flat in Santa Cruz de la Sierra
4.98 out of 5 average rating, 135 reviews

13° SmartLife - Luxury Equipetrol

Welcome to your sanctuary of sophistication and elegance at the top. This exceptionally cozy and stylish studio on the 13th floor invites you to experience luxury and comfort at their finest. Ready to experience the perfect combination of sophistication, comfort, and technology? Don't miss out on this unique opportunity. Book your stay at "13° SmartLife" and be seduced by the charm of this incomparable space! Your urban retreat awaits.

Superhost
Flat in Santa Cruz de la Sierra
4.84 out of 5 average rating, 107 reviews

new and modern apartment

Welcome to your new home in Equipetrol, the best area of Santa Cruz! This new and modern apartment offers you a cozy and comfortable space, ideal for you to enjoy your stay, whether for work or rest. Located in the heart of Equipetrol, you'll be surrounded by everything you need: supermarkets, banks, shops, pharmacies, cafes, restaurants, church and the Ventura Mall. We invite you to enjoy an unforgettable stay.

Superhost
Cottage in Samaipata
4.96 out of 5 average rating, 25 reviews

EcoHouse · Pool · Nature · Tranquility · Samaipata

A Living Earth Sanctuary on Samaipata Mountain Handcrafted with natural materials and a Bolivian soul. Welcome to CASA CACTUS — fully equipped and personalized for a stay surrounded by natural luxuries. 🏊 Pool · 🛜 Starlink · 🌿 Nature · Weekly and monthly DEALS *see below or contact us*. A place to really rest. To write. For slow cooking. To work online and offline. To look at the mountains without rushing.

Guest favourite
Flat in Santa Cruz de la Sierra
5.0 out of 5 average rating, 25 reviews

Work and relax in Equipetrol, accessible and practical

New studio apartment in the heart of Equipetrol. Ideal for 2 people looking for comfort, style and an unbeatable location. It has an equipped kitchen, a desk to work or study, fast Wi-Fi and a giant Smart TV. The building offers a swimming pool, entertainment room with views, air conditioning and automatic check-in. Perfect for digital nomads, tourists or couples who want to enjoy Santa Cruz to the fullest.

Guest favourite
Flat in Santa Cruz de la Sierra
4.87 out of 5 average rating, 38 reviews

Top Luxury Executive Dept. | Equipetrol

Discover the perfect balance between comfort, style, and location. This modern apartment is fully equipped and located in Equipetrol, the most exclusive area of Santa Cruz. Ideal for couples, business travelers, or weekend getaways. Enjoy incredible social areas such as: 🏊 Pool 💪 Full gym 🎯 Game room 📍 Close to the best restaurants, cafes, and shopping malls.

Superhost
A modern bedroom is featured with a spacious bed adorned in neutral tones. Two framed artworks are displayed above the headboard. Natural light enters through large glass doors that open to a private balcony, showcasing views of the surrounding city.
Flat in Santa Cruz de la Sierra
4.93 out of 5 average rating, 120 reviews

Apartment in Equipetrol with Rooftop Pool

✨ Elegant apartment in the vibrant Equipetrol area, ideal for business or leisure. Enjoy a modern design, high-speed Wi-Fi (293 Mbps), Smart TV, and air conditioning. Relax in the rooftop pool with panoramic city views. Perfect for short or long stays, combining comfort and security for an unforgettable experience.

Popular amenities for Santa Cruz holiday rentals