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Apartment holiday rentals in Panama City

Find and book unique apartments on Airbnb

Top-rated apartment rentals in Panama City

Guests agree: these apartments are highly rated for location, cleanliness and more.

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Top guest favourite
Flat in Panamá
5 out of 5 average rating, 82 reviews

New apartment on 50th Street

Enjoy a stylish experience at this centrally-located place. Direct access to bus lines and the Metro. Close to tourist sites and steps away from a variety of restaurants, grocery store, nightlife, casinos and blocks from the coastal strip, Iglesia del Carmen, and Parque Urraca. The old town is just minutes away by Uber. Close to shopping area. Soho Mall, Multi Plaza Mall, and Albrook Mall. Relaxing swimming pool for adults and children. Bar and restaurant, co-working, gym. You'll have a great time.

Top guest favourite
Flat in Panama City
5 out of 5 average rating, 34 reviews

Luxury apt in Panama City 2 Rooms 3 Baths

El edificio Wanders by yoo esta ubicado en el corazón de la ciudad, es un proyecto fuera de serie donde cada rincón tiene una historia que contar. Recepción 24/7, muchas areas de esparcimiento, estación de hidratación. En las afueras del lobby tenemos la Cafetería cafe con teclas y un restaurante de Carnes Popino. En el area social servicio de barra en la piscinas, parque de niños, sala de juegos con pantallas en e l techo baños, salon de eventos, cocina para eventos, gym full equipado y más

Superhost
Flat in Panamá
5 out of 5 average rating, 3 reviews

Incredible Renovated Apartment in Casco Viejo

Disfruta de un loft único en el corazón de Casco Viejo, ubicado en la emblemática Calle 4ta. Este apartamento ha sido totalmente remodelado, combinando a la perfección el encanto histórico de sus muros originales con un diseño moderno y elegante. La doble altura, la pared de piedra restaurada y los detalles artesanales en los pisos crean un ambiente acogedor y sofisticado. Su distribución abierta con sala, comedor y cocina integrada lo convierten en un espacio ideal para relajarse y compartir.

Superhost
Flat in Panamá
4.81 out of 5 average rating, 151 reviews

The Penthouse Annex

Inspired by Panama's rich history with France and located in one of the oldest watch towers in Panama, this chic apartment combines original features of this historically important building with the elegance and style of Europe. Perfectly situated to indulge in the restaurants, cafes, museums and boutique stores of Casco Viejo, and equipped with everything you expect from a home-from-home base, the annex is the perfect combination of comfort and style for couples and small groups of friends.

Guest favourite
Flat in Panama City
5 out of 5 average rating, 14 reviews

Luxury 2BR w/Ocean Views – 27th Fl, Wanders YOO

The name of the Complex comes from the world-renowned architect and interior designer, Marcel Wanders. He had the idea to accentuate the flora and fauna of Panama and bring a relaxed sensation even though the complex is located in the middle of the city. This unit in particular has the most detailed pick on designer furniture from brands such as Herman Miller and Restoration Hardware. The kitchen is also fully equipped with Thermador appliances so you can live the Wanders & Yoo experience.

Guest favourite
Flat in Panamá
4.82 out of 5 average rating, 116 reviews

Ocean View private Studio Apartment

OCEAN VIEW - STUDIO APARTMENT Ocean View Deluxe queen bed, NON - SMOKING Designed for Travelers and corporate executives looking for everything in one place MH PTY by The Sand Apartment & Mall located on Avenida Balboa has PRIVATE STUDIOS APARTMENTS of 24 m2 with ocean views fully furnished, with finishes, floor-to-ceiling windows, private bathroom, kitchenette, closet and a queen size bed MH PTY by The Sand Apartment & Mall is located in the heart of Panama City, Avenida Balboa

Top guest favourite
Flat in Marbella
4.97 out of 5 average rating, 39 reviews

Unique Luxury 3-story Loft at the Yoo

Experience the luxury of a world renowned Philippe Starck designed building. Our 3-bedroom sanctuary is a unique 3-story loft that boasts breathtaking city views, an open-plan kitchen, sleek marble floors, and premium amenities. Steps away from Panama City’s premier attractions, shopping, and dining. Dive into top-tier amenities: a pristine pool, state-of-the-art gym, relaxing spa, and three of the best restaurants in the city! Embrace Panama in unmatched style.

Superhost
Flat in Panamá
4.86 out of 5 average rating, 116 reviews

Apartment in the best area of Panama

A nice apartment in the best area of the city, exclusive, 3 blocks from Balboa Avenue where you can walk and enjoy the ocean view, 4 blocks from the emblematic Tornillo. You will enjoy a space in a new building, with ocean view, fully equipped and with social areas such as a swimming pool, gym, work area, games for children and private parking. Close to restaurants, shops, pharmacies, and transportation such as the subway and others. We also have vehicle rentals.

Guest favourite
Flat in Panamá
4.98 out of 5 average rating, 145 reviews

Escape to the Heart of Casco with a Private Balcony

Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Top guest favourite
Flat in Panamá
4.97 out of 5 average rating, 114 reviews

Luxury apartment in downtown Panama, banking area

We have a strategic location right on the main road of Panama (Calle 50) Bella Vista. You will find yourself located in the heart of the banking area. Whether you're coming for work or vacation, this is the ideal place. You'll find all kinds of restaurants, shops, and shopping malls nearby. You'll have the Cinta Costera just a 10-minute walk away where you can walk or exercise. Fun and enjoyment within walking distance

Guest favourite
Flat in Panamá
5 out of 5 average rating, 114 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Guest favourite
Flat in Panama City
4.9 out of 5 average rating, 151 reviews

Jacuzzi in colonial ruins in beautiful apartment

Welcome to Casa Marquez Portazgo! This cozy apartment in the heart of Panama City offers comfort and convenience, ideal for your stay. With one bedroom and capacity for two people, you'll enjoy a relaxing atmosphere in 70 m². Located in the San Felipe neighborhood, just steps from the entrance to the Casco Antiguo, it offers a unique experience. You can also unwind in the jacuzzi.

Popular amenities for Panama City apartment rentals

Quick stats about flat rentals in Panama City

  • Total rentals

    2.7K properties

  • Nightly prices starting at

    $13 SGD before taxes and fees

  • Total number of reviews

    67K reviews

  • Family-friendly rentals

    870 properties are a good fit for families

  • Pet-friendly rentals

    970 properties allow pets

  • Rentals with a pool

    1.7K properties have a pool

Destinations to explore

  1. Airbnb
  2. Panama
  3. Panamá Province
  4. Panama City
  5. Flat rentals