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Apartment holiday rentals in Panama City

Find and book unique apartments on Airbnb

Top-rated apartment rentals in Panama City

Guests agree: these apartments are highly rated for location, cleanliness and more.

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Top guest favourite
Flat in Panamá
4.98 out of 5 average rating, 221 reviews

In the heart of Casco, refurbished and with parking

Escape and discover the old town in this remodeled, comfortable and central accommodation in the heart of Casco Viejo. Our location is the best, it will make you come back. Close to restaurants, bars, impressive churches, and museums. The property dates back to the 17th century (1756) history and good atmosphere. You can explore the area on foot, fully equipped kitchen, European king bed, you will feel right at home, surrounded by the famous calicanto walls. -A large living room -Fully-equiped kitchen

Guest favourite
Flat in Panamá
4.94 out of 5 average rating, 16 reviews

SeaView Balcony •Rooftop Pool• San Francisco

➤ Ocean View, warmly decorated Apartment with sea-view Balcony in Prime Panama City! ★ Walk 5-10 mins to Restaurants, Supermarkets, Multiplaza Mall & Cafes ★ Perfect for Remote Workers, desktop, 750 MB internet speed, 100 Up. ➤ Urban Escape - Building Highlights: ★ Breathtaking City Views from the Rooftop Pool ★ Washer/dryer, Equipped kitchen ★ Gym, 2 Co-Workings Space, 500 MB internet speed ➤ Cozy 1BR Balcony Retreat | Rooftop Pool & Ocean Views | Central San Francisco | Uber-Friendly

Top guest favourite
Flat in Obarrio
4.96 out of 5 average rating, 26 reviews

Modern apartment in the heart of Obarrio

This apartment stands out for its prime location in Obarrio, with a modern and cozy design. Located on the 14th floor, it offers a spectacular view, its decoration in neutral tones conveys serenity. The comfort of having two bathrooms makes it unique. Ideal for travelers looking for tranquility and functionality. Located within walking distance of Calle 50 and the iconic El Tornillo building. You're surrounded by casinos, hotels, and restaurants. Safe area to walk and enjoy the city.

Top guest favourite
A spacious living room features a comfortable brown sofa and an armchair beside a decorative coffee table. Natural light enters through large glass doors draped with sheer curtains, illuminating the warm wood floors and elegant decor.
Flat in Panama City
5 out of 5 average rating, 87 reviews

Luxury Mid-Century Apartment In Casco Viejo

Luxury mid-century one bedroom Boutiqe 72 m2 apartment. Step into the elegant, functional and comfortable place that we offer with love. The apartment located within a beautiful two-floors antique building in the heart of Casco Viejo. The apartment includes a well equipped brand new kitchen, a dining area and a spacious living room, also a balcony with a view of the lively streets below. The tranquil bedroom has an ensuite bathroom and a walking closet that fitting perfectly to your needs.

Guest favourite
An infinity pool stretches along the edge of the property, offering panoramic views of the city skyline and waterway. Lounge chairs in bright colors are positioned around the pool area, with vast glass windows reflecting the serene landscape.
Flat in Panamá
4.83 out of 5 average rating, 181 reviews

private ocean view studio apto.

The Sand Avenida Balboa cuenta con apartamentos tipo estudio de 24 metros, amueblado y con acabados, cada apartamento cuenta con una pequeña cocina, baño privado, armario y muebles cómodos; incluyen ventanas de piso a techo. The Sand Avenida Balboa está idealmente ubicado en el corazón de la ciudad de Panamá, Avenida Balboa con fácil acceso al centro, al Casco Antiguo y a menos de 5 minutos de Causeway y el BiomuseoDisfruta de una experiencia con estilo en este alojamiento céntrico.

Top guest favourite
Flat in Panama City
4.97 out of 5 average rating, 94 reviews

Amazing loft with an iconic view of Casco Viejo

Enjoy a unique experience, in this elegant and centrally-located loft. Fully remodeled 1 bedroom apartment, in a central location in Casco Viejo (the old city). You will be just steps away from many restaurants, cafes, museums, and the existing night life casco has to offer. Located in “Jeronimo,” this restored- colonial building was built in the year 1850, and features unique crafted wall décor, as well as some of the original "calicanto" walls.

Top guest favourite
Flat in Panamá
5 out of 5 average rating, 11 reviews

Private parking & rooftop | Studio Casco Center

This beautiful restored studio from the 1870s blends history with modern design. Enjoy a private rooftop terrace with seating and BBQ, plus private PARKING—ideal after exploring Casco's best restaurants, galleries, and nightlife steps away. ✨ Highlights: - Historic Charm: Original tile floors and exposed colonial stone walls. - Comfort: King bed, living room, and full kitchen. - Amenities: Private rooftop & private PARKING. - Great location

Guest favourite
The living area features a comfortable sofa facing a large wall-mounted TV, with natural light filtering through expansive glass doors that lead to a balcony. The stylish floor tiles showcase a geometric pattern, enhanced by the antique calicanto walls that add character.
Flat in Panamá
4.9 out of 5 average rating, 107 reviews

Comfortable Apartment in the Heart of Casco Viejo

Experience the charm of Casco Viejo in a beautifully appointed apartment with antique calicanto walls. Conveniently located near dining, shopping, and attractions, this apartment boasts a queen-sized bed, air conditioning, Wi-Fi, cable TV, fully equipped kitchen, and in-unit washing/drying. Relax on the balcony overlooking the street. Please treat the apartment with the care and respect you would give your own. Enjoy your stay!

Superhost
Flat in Panamá
5 out of 5 average rating, 4 reviews

Cozy Studio in Cinta Costera with Home Vibes

✨ Live the "Cinta Costera Vibes" experience 🌴 from this modern studio apartment with a panoramic view of the Bay and the vibrant Balboa Avenue. Perfect for travelers looking for comfort, style, and a premium location. Enjoy the pool, restaurant, gym, and rooftop with the best sunset in Panama 🌅. Ideal for short or long stays — your home with home warmth and a 5⭐ touch. Save it as a favorite and live the Host Up experience!

Guest favourite
A modern dining area features a white table set for four, surrounded by stylish chairs. Large windows allow natural light to fill the space, revealing views of the city skyline. A sleek kitchen is visible in the background, showcasing a gas stove and granite countertops.
Flat in Panamá
4.94 out of 5 average rating, 110 reviews

k*| Delightful 1 BR w/King Bed in Calle 50

Calle 50 es el Times Square de la Ciudad de Panamá. Esta emblemática calle resguarda a la concurrida Area Bancaria. La ubicación del apartamento es excepcional y céntrica, cercana a: ->Estación Iglesia del Carmen [Línea 1 del Metro de Panamá] ->Cinta Costera ->Parque Urracá ->Supermercado Rey ->F&F Tower (Edificio del "Tornillo") ->Nightlife en Calle Uruguay Desde el piso 19 se ofrecen vistas a la ciudad y a la selva.

Guest favourite
Flat in Panamá
4.99 out of 5 average rating, 135 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Superhost
A private terrace features a jacuzzi surrounded by lush greenery against an exposed stone wall. Wooden decking creates a warm ambiance, complemented by two lounge chairs designed for relaxation, offering an inviting outdoor space for guests.
Flat in Panama City
4.89 out of 5 average rating, 161 reviews

Jacuzzi in colonial ruins in beautiful apartment

Welcome to Casa Marquez Portazgo! This cozy apartment in the heart of Panama City offers comfort and convenience, ideal for your stay. With one bedroom and capacity for two people, you'll enjoy a relaxing atmosphere in 70 m². Located in the San Felipe neighborhood, just steps from the entrance to the Casco Antiguo, it offers a unique experience. You can also unwind in the jacuzzi.

Popular amenities for Panama City apartment rentals

Quick stats about flat rentals in Panama City

  • Total holiday rentals

    Explore 2,890 holiday rentals in Panama City

  • Nightly prices starting at

    Panama City holiday rentals start at $13 SGD per night before taxes and fees

  • Verified guest reviews

    Over 79,200 verified reviews to help you choose

  • Family-friendly holiday rentals

    900 properties offer extra space & child-friendly amenities

  • Pet-friendly holiday rentals

    Find 1,090 rentals that welcome pets

  • Holiday rentals with a pool

    1,840 properties feature pools

  • Rentals with dedicated workspaces

    1,770 properties have a dedicated workspace

  • Wifi availability

    2,760 of Panama City holiday rentals include wifi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi and Pool across Panama City rentals

  • 4.7 Average rating

    Panama City stays receive an average rating of 4.7 out of 5 from guests

  • Nearby attractions

    Panama City’s top spots include Miraflores Locks, Museo de Arte Contemporáneo and Santo Tomas (Panama Metro)

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