
Apartment holiday rentals in Panama City
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Top-rated apartment rentals in Panama City
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Apto 4 min from Tocumen Airport | 24-hr check-in
Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

Apartment in the Causeway Amador
Olvídate de las preocupaciones en este gran alojamiento ¡es un oasis de tranquilidad! Donde podrás disfrutar de las vistas al canal de Panamá y ver los barcos que por ahí transitan,un espacio lleno de comodidades con una ubicación perfecta, puedes caminar por las calles del Causeway, visitar el museo de la Biodiversidad, restaurantes de diversas especialidades, parque de diversiones, paseos en bici etc, todo combina para hacer de estas vacaciones una experiencia inolvidable para toda tu familia

Casco Viejo 360° View Old Tower Penthouse
Located in one of the oldest buildings in Panama and set over 3 stories with unrivaled panoramic views over the historical Casco Viejo, the skyline of Panama City and views of the causeway, our gorgeous penthouse is the ideal space to take in the local sights, sounds, art, culture, socialize with your friends and family, or simply relax in a cozy love nest! Top speed wifi, excellent location, and fully equipped with all the home comforts, the penthouse is the perfect spot to explore Panama.

Lovely Spacious 3BR in Casco Viejo w/Balcony
Welcome to Casa Bandera, your retreat in the heart of Casco Viejo! Located in Panama's iconic Casco Antiguo, this elegant apartment combines the area's historic charm with modern comfort. It features three cozy bedrooms, each with a private bathroom; an in-house laundry center, a fully equipped kitchen, a living room, and a dining room, perfect for sharing in an exclusive setting. Perfect for up to six people. Enjoy an unforgettable stay in a cozy and fully equipped environment.

Cozy 2 Bedroom w/ Splash Pool
Our place is a 3-story apartment located on the quiet side of Casco Viejo. It has a very private feel to it, which allows for an incredible afternoon of sunbathing or bbqing on our private rooftop. The splash pool allows for a refresh and fits 2 people at a time. This place has so much character from with original exposed stone walls, to the sweeping view of the Arto Chato ruins. It also has a great work space, all the necessities to stay in and cook, watch a movie, etc.

The apartment of a legendary Panamanian footballer
Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Amazing loft with an iconic view of Casco Viejo
Enjoy a unique experience, in this elegant and centrally-located loft. Fully remodeled 1 bedroom apartment, in a central location in Casco Viejo (the old city). You will be just steps away from many restaurants, cafes, museums, and the existing night life casco has to offer. Located in “Jeronimo,” this restored- colonial building was built in the year 1850, and features unique crafted wall décor, as well as some of the original "calicanto" walls.

Studio apartment in the heart of Casco
Welcome to Casa Pérez, your retreat in the heart of the Old Town! Enjoy a prime location and the best views from a spectacular private balcony facing the most iconic square in the Casco. Ideal for 3 people, this cozy and bright one-bedroom apartment includes Wi-Fi, air conditioning, living room, dining room, equipped kitchen, washing machine and elevator for your comfort. Enjoy an unforgettable stay in a warm and fully equipped atmosphere.

Best location - Spacious and Fancy Apt
Welcome to our spacious apartment that comfortably accommodates up to 8 guests, complete with an elevator for your convenience. Located right in front of one of the best plazas in Casco Antiguo, you’ll be surrounded by renowned restaurants and vibrant city life. Its prime location offers easy access to all the major attractions, making it the perfect base for exploring. With high security standards, you can feel at ease during your stay.

The best view of the Old Town
Welcome to this charming accommodation located in the heart of Casco Viejo, in front of one of the most emblematic squares in Panama, Plaza Catedral! Thanks to its privileged location, you will enjoy a unique view of the square and the imposing Cathedral Church. Right in this lively square, you will have at your disposal a wide variety of restaurants and shops where you can buy souvenirs of this wonderful trip.

Full apartment in Panama
This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Jacuzzi in colonial ruins in beautiful apartment
Welcome to Casa Marquez Portazgo! This cozy apartment in the heart of Panama City offers comfort and convenience, ideal for your stay. With one bedroom and capacity for two people, you'll enjoy a relaxing atmosphere in 70 m². Located in the San Felipe neighborhood, just steps from the entrance to the Casco Antiguo, it offers a unique experience. You can also unwind in the jacuzzi.
Popular amenities for Panama City apartment rentals
Weekly apartment rentals

New apartment in the heart of Panama

Cozy Studio in Cinta Costera with Home Vibes

Apartamento Privado en Poin, Vista al Mar.

2BR King Suite Ocean View, Casco, Canal 500MB WIFI

Large Apartment in La Cuadra - Casco | By Alura

Panoramic Casco Viejo Lookout in The Sands

Sea View in Panama City: BrisaMarina

24o Penthouse, Unique Design, 2 Balconies, Ocean View
Private apartment rentals

Most Beautiful Loft in the Heart of Casco Viejo

Luxury apartment in the heart of Panama

w* | Luxury 2BR in Old Town

Modern City Escape Nice Views & Great Location!

Amazing experience in Casco Viejo historical site3

Modern Suite in the Heart of the City

City center apartment with pool and ocean view

Modern apartment in the Historic Center
Apartment rentals with a hot tub

3 bedroom penthouse with spectacular views!

Luxury 2BR Suite with Pool & Views

Apartment between ocean and jungle

New Flat with Ocean + City Views

Panoramic Ocean View Studio Retreat in Panama City

Tropical Paradise at Playa Bonita

Panama Dream View Escape

On the beach. Entire floor with oceanfront terrace
Quick stats about flat rentals in Panama City

Total holiday rentals
Explore 2,890 holiday rentals in Panama City

Nightly prices starting at
Panama City holiday rentals start at $13 SGD per night before taxes and fees

Verified guest reviews
Over 79,200 verified reviews to help you choose

Family-friendly holiday rentals
900 properties offer extra space & child-friendly amenities

Pet-friendly holiday rentals
Find 1,090 rentals that welcome pets

Holiday rentals with a pool
1,840 properties feature pools

Rentals with dedicated workspaces
1,770 properties have a dedicated workspace

Wifi availability
2,760 of Panama City holiday rentals include wifi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Panama City rentals

4.7 Average rating
Panama City stays receive an average rating of 4.7 out of 5 from guests

Nearby attractions
Panama City’s top spots include Miraflores Locks, Museo de Arte Contemporáneo and Santo Tomas (Panama Metro)
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