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Apartment holiday rentals in Panama City

Find and book unique apartments on Airbnb

Top-rated apartment rentals in Panama City

Guests agree: these apartments are highly rated for location, cleanliness and more.

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Top guest favourite
A cozy living area with a large window offering a panoramic view of the city lights at night. A comfortable sofa is positioned to face a television, creating a relaxed space. The room's walls are softly illuminated, enhancing the viewing experience.
Flat in Panamá
4.97 out of 5 average rating, 118 reviews

The Spot Panama - Comfy, great view & much more

Ideally located in Panama City Panama 🇵🇦 we're just 15-20 minutes from Tocumen Airport 🛩 . Approximately 10 minutes from Albrook Mall, SoHo Mall, Alta Plaza, Multiplaza and much more! Enjoy easy access to supermarkets and restaurants!. Experience peace of mind with 24/7 security and outstanding facilities: pool, gym, and free parking! More than a stay, it's a chance to shop, unwind, and soak in Panama City views. Don't hesitate- Book instantly or contact us if you have any questions.

Guest favourite
A cozy living area features a comfortable blue sofa against an original brick wall, complemented by a round mirror. A small kitchen area with white cabinetry and modern appliances is visible. A decorative coffee table and elegant chairs complete the inviting space.
Flat in Panamá
4.81 out of 5 average rating, 161 reviews

The Penthouse Annex

Inspired by Panama's rich history with France and located in one of the oldest watch towers in Panama, this chic apartment combines original features of this historically important building with the elegance and style of Europe. Perfectly situated to indulge in the restaurants, cafes, museums and boutique stores of Casco Viejo, and equipped with everything you expect from a home-from-home base, the annex is the perfect combination of comfort and style for couples and small groups of friends.

Top guest favourite
A balcony features two red chairs on a patterned tile floor, overlooking the vibrant Main Plaza. The wrought-iron railing provides a classic touch, while trees and buildings can be seen in the background, under a partly cloudy sky.
Flat in Panamá
4.93 out of 5 average rating, 133 reviews

Elegant Apt - View to Main Plaza of Casco Viejo

Experience the charm of Casco Viejo with this beautiful apartment, located in the heart of the historic neighborhood - close to many dining options, cafes, supermarkets and attractions. Enjoy the stunning views of the Main Plaza from the comfort of your balcony or rest easy inside with the soundproof doors and strong WIFI connection. We provide a water biden throughout your stay for hydration and Panamanian coffee renowned as one of the best in the world, at the moment of check in.

Guest favourite
An open living space features a large gray sectional sofa paired with a round wooden coffee table. A patterned rug lies beneath, complementing the light wooden flooring. The kitchen area is visible in the background, showcasing modern appliances and a breakfast bar with stools.
Flat in Panamá
4.94 out of 5 average rating, 155 reviews

Cozy 2 Bedroom w/ Splash Pool

Our place is a 3-story apartment located on the quiet side of Casco Viejo. It has a very private feel to it, which allows for an incredible afternoon of sunbathing or bbqing on our private rooftop. The splash pool allows for a refresh and fits 2 people at a time. This place has so much character from with original exposed stone walls, to the sweeping view of the Arto Chato ruins. It also has a great work space, all the necessities to stay in and cook, watch a movie, etc.

Guest favourite
A clear blue swimming pool is seen, reflecting sunlight under a bright sky. Surrounding greenery provides privacy, while a modern building stands nearby, featuring large balconies. The pool area is designed for relaxation and leisure.
Flat in Panamá
4.92 out of 5 average rating, 203 reviews

Cozy apartment near Casco Viejo

Enjoy a stay in one of the most exclusive areas in the center of Panama, few minutes from Casco Viejo the Cozy Apartment City Center offers free WiFi, air conditioning and stunning views amidst skyscrapers. The apartment has one bedroom with a queen-size bed, a bath and shower, a sofa bed, two smart TV, a fully equipped kitchen, a washer and dryer, and a half bath. On the property there is a work area, a gymnasium, a community pool, and a barbeque area FREE PARKING

Guest favourite
A balcony view overlooks a vibrant plaza adorned with greenery and historic structures. Taxicabs and pedestrians are visible on the streets below, while a gazebo stands in the square, surrounded by colorful buildings and a bright blue sky with scattered clouds.
Flat in Panamá
4.82 out of 5 average rating, 156 reviews

Studio apartment in the heart of Casco

Welcome to Casa Pérez, your refuge in the heart of the Old Town! Enjoy a privileged location and the best views from a spectacular private balcony facing the most emblematic square of the Old Town. Ideal for 3 people, this cozy and bright one-bedroom apartment includes Wi-Fi, air conditioning, living room, dining room, equipped kitchen, laundry center, and elevator for your convenience. Enjoy an unforgettable stay in a warm and fully equipped environment.

Top guest favourite
A spacious living area features a combination of modern and vintage furnishings. A large turquoise sofa and a floral chaise lounge are complemented by a round coffee table and a green wooden chair. Exposed stone walls and large windows with blue accents create a warm ambiance.
Flat in Panamá
4.98 out of 5 average rating, 152 reviews

Escape to the Heart of Casco with a Private Balcony

Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Top guest favourite
An inviting living area is featured, showcasing a modern grey sofa accented with decorative pillows. A round glass dining table is surrounded by chairs, and artistic wall frames complement the space. Natural light is filtered through elegantly layered window shades.
Flat in Panamá
4.96 out of 5 average rating, 122 reviews

Luxury apartment in downtown Panama, banking area

We have a strategic location right on the main road of Panama (Calle 50) Bella Vista. You will find yourself located in the heart of the banking area. Whether you're coming for work or vacation, this is the ideal place. You'll find all kinds of restaurants, shops, and shopping malls nearby. You'll have the Cinta Costera just a 10-minute walk away where you can walk or exercise. Fun and enjoyment within walking distance

Guest favourite
A modern dining area features a white table set for four, surrounded by stylish chairs. Large windows allow natural light to fill the space, revealing views of the city skyline. A sleek kitchen is visible in the background, showcasing a gas stove and granite countertops.
Flat in Panamá
4.93 out of 5 average rating, 103 reviews

k*| Delightful 1 BR w/King Bed in Calle 50

Calle 50 es el Times Square de la Ciudad de Panamá. Esta emblemática calle resguarda a la concurrida Area Bancaria. La ubicación del apartamento es excepcional y céntrica, cercana a: ->Estación Iglesia del Carmen [Línea 1 del Metro de Panamá] ->Cinta Costera ->Parque Urracá ->Supermercado Rey ->F&F Tower (Edificio del "Tornillo") ->Nightlife en Calle Uruguay Desde el piso 19 se ofrecen vistas a la ciudad y a la selva.

Guest favourite
Flat in Panamá
4.98 out of 5 average rating, 124 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Guest favourite
A private terrace features a jacuzzi surrounded by lush greenery against an exposed stone wall. Wooden decking creates a warm ambiance, complemented by two lounge chairs designed for relaxation, offering an inviting outdoor space for guests.
Flat in Panama City
4.9 out of 5 average rating, 155 reviews

Jacuzzi in colonial ruins in beautiful apartment

Welcome to Casa Marquez Portazgo! This cozy apartment in the heart of Panama City offers comfort and convenience, ideal for your stay. With one bedroom and capacity for two people, you'll enjoy a relaxing atmosphere in 70 m². Located in the San Felipe neighborhood, just steps from the entrance to the Casco Antiguo, it offers a unique experience. You can also unwind in the jacuzzi.

Guest favourite
An inviting lobby area features modern furniture with plush white chairs arranged around a circular table. The wall is adorned with a text sign that reads 'La Cuadra.' Decorative plants add a touch of greenery to the stylish space, complemented by patterned flooring.
Flat in Panamá
4.87 out of 5 average rating, 111 reviews

Beautiful apartment in Casco Viejo

Located in the heart of Casco Viejo, you can enjoy the sunset with views of the city, the sea and the canal, from its rooftop. The building's ground floor is home to La Cuadra Market where there are a variety of renowned restaurants with different styles of food, as well as a bar. Close to everything, you can walk around everything and enjoy every place it offers you.

Popular amenities for Panama City apartment rentals

Quick stats about flat rentals in Panama City

  • Total holiday rentals

    Explore 2,770 holiday rentals in Panama City

  • Nightly prices starting at

    Panama City holiday rentals start at $13 SGD per night before taxes and fees

  • Verified guest reviews

    Over 71,040 verified reviews to help you choose

  • Family-friendly holiday rentals

    850 properties offer extra space & child-friendly amenities

  • Pet-friendly holiday rentals

    Find 990 rentals that welcome pets

  • Holiday rentals with a pool

    1,730 properties feature pools

  • Rentals with dedicated workspaces

    1,720 properties have a dedicated workspace

  • Wifi availability

    2,640 of Panama City holiday rentals include wifi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi and Pool across Panama City rentals

  • 4.7 Average rating

    Panama City stays receive an average rating of 4.7 out of 5 from guests

  • Nearby attractions

    Panama City’s top spots include Miraflores Locks, Museo de Arte Contemporáneo and Santo Tomas (Panama Metro)

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