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House holiday rentals in Panama City

Find and book unique houses on Airbnb

Top-rated house rentals in Panama City

Guests agree: these houses are highly rated for location, cleanliness and more.

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Guest favourite
The exterior of a two-story residence is shown, featuring a classic design with a stone façade and wooden accents. Lush greenery surrounds the entrance, where steps lead to the upper level. Two friendly dogs can be seen in the foreground, adding a welcoming touch to the scene.
Home in Panamá
4.88 out of 5 average rating, 102 reviews

Central|Confort|surrounded by nature|Wifi|parking

Conectar con la ciudad y la maravillosa naturaleza al mismo tiempo. Descansar en una hamaca en el balcón lo hace único. Te quedará genial si deseas visitarnos de placer, trabajo (WiFi de alta velocidad); en familia o en grupos de amigos. Casa de la Antigua Zona del Canal, Primer Alto; desde aquí para explorar lugares turísticos y restaurantes. (Cerca Terminal de Buses, Metro Tren, Albrook Mall, parque Metropolitano, Aeropuerto Marcos Gelabert, Casco Antiguo, Coast Way de Amador, Canal de 🇵🇦)

Top guest favourite
The image showcases the exterior of a two-story house, framed by lush greenery. Sunlight filters through trees, highlighting the white façade and green shutters. A covered area is visible at the front, along with a gated fence that adds security to the property.
Home in Cerro Ancón
4.89 out of 5 average rating, 103 reviews

3BR Home in Ancon Hill - Urban Oasis

Discover our home at Ancon Hill in Panama City, steps from Supreme Court. The hill offers scenic hiking trails to the top with city views, lush greenery, and wildlife. 5 min to Albrook Mall. 10 min to Casco Viejo (UNESCO site, restaurants, museums, nightlife), Amador Causeway, Cinta Costera, Metropolitan Park, Panama Convention Center, and Albrook Airport. 20 min to Panama Canal Miraflores Locks and Veracruz beach (across Bridge of Americas, gateway to countryside). 35 min to Tocumen Airport.

Guest favourite
A stone pathway leads through lush tropical foliage toward a welcoming entrance. Tall trees and vibrant greenery frame the path, creating a serene approach to the property, which is partially visible in the background, surrounded by nature's tranquility.
Home in Panama City
4.97 out of 5 average rating, 78 reviews

Mountain Retreat

Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

Guest favourite
A spacious living room features a bright yellow sofa and a flat-screen TV. An open-concept layout leads to a dining area with a table and chairs, alongside a well-equipped kitchen visible in the background. Large windows provide natural light and views of the lush surroundings.
Home in Panamá
4.87 out of 5 average rating, 15 reviews

Family-Friendly Panama Canal Home with Fenced Yard

Welcome to our 3-bedroom vacation rental in Cardenas, Panama Canal area! Perfect for families, this home boasts a kitchen with quality appliances, including a 6-burner gas stove and a large fridge. Relax in stylish bedrooms, featuring a king suite with a private bath, and enjoy the lush surroundings filled with wildlife. Located next to a park with sports courts, this kid-friendly neighborhood offers outdoor fun. Experience the unique blend of comfort and nature right at your doorstep!

Guest favourite
A two-story residence features a light-colored facade with large windows allowing ample natural light. A spacious garage with a multi-car door is prominently displayed in front. The surrounding area is neatly paved, with a tranquil atmosphere suggested by the absence of heavy traffic.
Home in Punta Paitilla
4.77 out of 5 average rating, 114 reviews

Large Private Residence in an Excellent Area

House in the best area of the country. Very quiet street, central, close to restaurants, pharmacies, mall among others. Large comfortable residence for groups or families. Private parking for up to 2 cars 4 spacious bedrooms, 2 comfortable studios, living room, breakfast room, large terrace. *Kosher Option Available* House in one of the best areas of the country. Very quiet street, central, close to restaurants, pharmacies, mall, and more. Large, comfortable residence for groups.

Guest favourite
A spacious bedroom is highlighted by a large bed featuring neutral bedding. Natural light flows through expansive windows that provide views of the surrounding greenery. Two bedside lamps and a seating area with a chair add functionality to the space, creating a serene retreat.
Home in Panamá
4.92 out of 5 average rating, 12 reviews

House of the waterfalls

Your ideal escape: A hidden refuge in the Panamanian capital. Harmony between waterfalls and urban comfort. Rest in a natural environment, minutes away from everything. Wake up to birdsong and the relaxing sound of water. To make your stay more pleasant, we offer a swimming pool, pool table, board games, campfire area, spacious and equipped kitchen, three cozy rooms with private bathrooms. Enjoy a country experience to contemplate, share, or simply disconnect.

Superhost
Home in Panamá
4.76 out of 5 average rating, 29 reviews

Charming House in Casco Viejo

This recently renovated house is an absolute treasure. It blends history, charm, and modern comfort. Archeologists uncovered artifacts dating to the seventeenth century. Tastefully furnished with modern comforts and antiques, it's steps away from the Panama Canal Museum and in the heart of Casco Viejo, perfect for guests looking to immerse themselves in the cultural and culinary delights before retreating to the comfort and tranquility of their temporary home.

Top guest favourite
A spacious living and dining area is depicted, featuring a blue sectional sofa with yellow accent pillows. A glass dining table with yellow placemats and black chairs is shown. Natural light enters through windows, revealing a glimpse of greenery outside.
Home in Panama City
4.83 out of 5 average rating, 123 reviews

Spacious Panama House in the 'heart of the city'

You couldn't ask for a better place to stay while you visit Panama. This location is perfect, while other properties might advertise similar amenities; not one of them can boast a combination of space and amazing location quite like this one. This is very private & secure property in a fantastic, & very safe area right in the heart of the city & close to everything! An oasis in the middle of the city with AC IN EVERY ROOM AND DININING ROOM.

Guest favourite
The kitchen area features a black dining table with four chairs, complementing a modern microwave and refrigerator. Warm decorative elements, including wall art and a candle, add character to the space, which is equipped with essential appliances and a clean countertop.
Home in Panamá
4.94 out of 5 average rating, 407 reviews

Private Studio 10 Min from the Airport!

Apartamento Entero a 10 MINUTOS del Aeropuerto! El apartamento está completamente amueblado incluyendo electrodomésticos y artículos de cocina , productos de aseo , sala comedor ,mesa de trabajo y demás. A sólo minutos caminando de la Estacion de METRO SAN ANTONIO y METROMALL. Ofrecemos Tours a San Blas -Tours a Monkey Island y el Canal de Panamá para que aproveches al maximo tu viaje. Nuestra casa es Tu casa en Panamá 🇵🇦

Superhost
A charming facade displays three balcony areas adorned with greenery, enhancing the welcoming appearance of the building. The entrance features decorative signage alongside floral accents, while the muted color palette and architectural details of the windows contribute to the overall harmonious design.
Home in Panamá
4.86 out of 5 average rating, 28 reviews

Comfortable and luxurious apartment

Enjoy a stylish experience in our accommodation in the Old Town, take advantage of the location close to art galleries, restaurants, crafts, etc. Our house has three bedrooms each with a balcony, bathroom and closet, with a nice contemporary equipped kitchen; a large living and dining room, work area. You have a total area of 326 m² The whole house is surrounded by balconies where you can enjoy panoramic views.

Guest favourite
A private rooftop terrace offers expansive views of the ocean and skyline. Comfortable seating arrangements include a coffee table and lounge chairs beneath a shaded umbrella. Decorative plants enhance the outdoor space, while string lights provide a warm ambiance during evenings.
Home in Panamá
4.92 out of 5 average rating, 161 reviews

Exceptional three-story building with sea view

This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Guest favourite
Home in Panama City
5 out of 5 average rating, 22 reviews

Casa del Lago 2025

New lakefront house in Cerro Azul, decorated by a D&G architect with furniture brought from Bali. It has 3 bedrooms, 3 bathrooms and 4 double beds, equipped kitchen, BBQ, air conditioning and hot water. Cook a delicious BBQ with your friends in front of the lake and enjoy the sunsets from an unparalleled view with direct access and kayak included.

Popular amenities for house rentals in Panama City

Quick stats about house rentals in Panama City

  • Total holiday rentals

    Explore 490 holiday rentals in Panama City

  • Verified guest reviews

    Over 7,960 verified reviews to help you choose

  • Family-friendly holiday rentals

    200 properties offer extra space & child-friendly amenities

  • Pet-friendly holiday rentals

    Find 170 rentals that welcome pets

  • Holiday rentals with a pool

    90 properties feature pools

  • Rentals with dedicated workspaces

    230 properties have a dedicated workspace

  • Wifi availability

    460 of Panama City holiday rentals include wifi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi and Pool across Panama City rentals

  • 4.7 Average rating

    Panama City stays receive an average rating of 4.7 out of 5 from guests

  • Nearby attractions

    Panama City’s top spots include Miraflores Locks, Museo de Arte Contemporáneo and Santo Tomas (Panama Metro)

Destinations to explore

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  2. Panama
  3. Panamá Province
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