
House holiday rentals in Panama City
Find and book unique houses on Airbnb
Top-rated house rentals in Panama City
Guests agree: these houses are highly rated for location, cleanliness and more.

On the beach, entire apartment, panoramic terrace and more
For those who love: Sea, Sun, Tropical, Tranquility, Freedom, Comfort. This exclusive apartment, directly on the beach, offers a unique view of the Gulf. Enjoy sunsets, sunrises, and walks. - On the large panoramic terrace, a sea-view bathtub. Sofa. Unique emotions. - 360° panoramic view with palm-leaf roof. - Queen bed, sofa, bathroom with shower, kitchen. * In the beachfront social area: - Hammock, barbecue, sofas, gazebo, kitchen, pool. Dcent of Paradise Pure Life Suitable for long stays.

3BR Home in Ancon Hill - Urban Oasis
Discover our home at Ancon Hill in Panama City, steps from Supreme Court. The hill offers scenic hiking trails to the top with city views, lush greenery, and wildlife. 5 min to Albrook Mall. 10 min to Casco Viejo (UNESCO site, restaurants, museums, nightlife), Amador Causeway, Cinta Costera, Metropolitan Park, Panama Convention Center, and Albrook Airport. 20 min to Panama Canal Miraflores Locks and Veracruz beach (across Bridge of Americas, gateway to countryside). 35 min to Tocumen Airport.

Mountain Retreat
Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

Designer Canal Home - Med or Longterm
Welcome to our little oasis in Panama City's historic Canal Zone! Our home has recently undergone a spectacular renovation with features that set it apart from other canal homes: luxury stone floors, tall ceilings, and an open, modern kitchen. It's the perfect retreat for someone who wants to be in the city but still surrounded by parks and wildlife. Note that we are ideally looking for guests who will stay for a month or more and would consider longer term tenancies if the fit were right.

Large Private Residence in an Excellent Area
House in the best area of the country. Very quiet street, central, close to restaurants, pharmacies, mall among others. Large comfortable residence for groups or families. Private parking for up to 2 cars 4 spacious bedrooms, 2 comfortable studios, living room, breakfast room, large terrace. *Kosher Option Available* House in one of the best areas of the country. Very quiet street, central, close to restaurants, pharmacies, mall, and more. Large, comfortable residence for groups.

Charming House in Casco Viejo
This recently renovated house is an absolute treasure. It blends history, charm, and modern comfort. Archeologists uncovered artifacts dating to the seventeenth century. Tastefully furnished with modern comforts and antiques, it's steps away from the Panama Canal Museum and in the heart of Casco Viejo, perfect for guests looking to immerse themselves in the cultural and culinary delights before retreating to the comfort and tranquility of their temporary home.

A Charming Colonial House in Casco Antiguo
Welcome to Casa Arango, a beautifully restored 19th-century gem in the heart of Casco Antiguo. Located on a quiet, picturesque street, this colonial house blends historic charm with modern comforts. Casa Arango offers three elegant rooms with private bathrooms, a front balcony, and a spacious patio with a barbecue and private bar. Perfect for families or groups of up to 8, the property also includes two private parking spaces—an exclusive luxury in the area.

Beautiful spacious full apartment near Albrook
Spacious and cozy apartment in a very quiet area surrounded by nature. The apartment is complete, everything is ready to welcome you. All services are included. Close to the Miraflores locks, Ciudad del Saber, the Metropolitan National Park, Cerro Ancón, and Albrook Terminal. Close to the Los Ríos pool. Accessibility for buses and taxis. For security reasons, cameras in the main entrance, terrace and patio. There are no cameras in indoor spaces.

Wonderful nature
Enjoy a family retreat in the heart of nature, where tranquility envelops you. This cozy accommodation, surrounded by a beautiful garden in the Metropolitan Natural Park, offers you a unique escape just 3 minutes from Albrook Mall and 5 minutes from downtown. Wake up to birdsong and a visit from the ñeques (agoutis), while relaxing in an exclusive and lively atmosphere. The perfect getaway to disconnect and enjoy nature with all the amenities!

Spacious Panama House in the 'heart of the city'
You couldn't ask for a better place to stay while you visit Panama. This location is perfect, while other properties might advertise similar amenities; not one of them can boast a combination of space and amazing location quite like this one. This is very private & secure property in a fantastic, & very safe area right in the heart of the city & close to everything! An oasis in the middle of the city with AC IN EVERY ROOM AND DININING ROOM.

Unique 4 room house - direct access to the beach
Welcome to Casa Playa, your haven in the heart of Casco Viejo! This elegant property blends the historic charm of the area with modern comfort and style. It features 4 cozy bedrooms, 3 bathroom, a fully equipped kitchen, living and dining areas, and an in-unit laundry center. Perfect for groups of up to 8 guests to share in an exclusive and comfortable setting. Enjoy an unforgettable stay in a warm, spacious, and fully equipped space.

Exceptional three-story building with sea view
This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.
Popular amenities for house rentals in Panama City
House rentals with a pool

Luxury Home with Pool in the Best Neighborhood

A beautiful apartment with a swimming pool, BBQ area, and gym

Nice duplex house with a swimming pool.

Villa Helena 3 Bedrooms Los Altos de Cerro Azul

House with Private Pool and two parking spaces

House of the waterfalls

Airbnb - Vacation

Carmen's House
Weekly house rentals

Modern house with a/c 10 mins from airport

Cozy house with a garden

2 bedroom apartment in the heart of Panama

Your Little House in Linda Vista

Casco Viejo 02, Luxury Condo, Panama Bay.

Comfortable house in the nature of Panama Pacifico

The Bird's Nest - Cerro Azul

Luxury house in Cerro Azul
Private house rentals

House near the airport

Country house in Altos de Cerro Azul

Modern and minimalist Altos de Cerro Azul

2 bedroom house, 2 bathrooms, kitchen, dining room, in Ancon

House with spectacular city and ocean views

LovelyviewPty House 15 minutes away from the airport

Oceanfront views/access w/ Pool, Privacy & Space

Cabin in Cerro Azul with Forest View
Quick stats about house rentals in Panama City

Total holiday rentals
Explore 470 holiday rentals in Panama City

Verified guest reviews
Over 7,710 verified reviews to help you choose

Family-friendly holiday rentals
180 properties offer extra space & child-friendly amenities

Pet-friendly holiday rentals
Find 160 rentals that welcome pets

Holiday rentals with a pool
90 properties feature pools

Rentals with dedicated workspaces
230 properties have a dedicated workspace

Wifi availability
430 of Panama City holiday rentals include wifi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Panama City rentals

4.7 Average rating
Panama City stays receive an average rating of 4.7 out of 5 from guests

Nearby attractions
Panama City’s top spots include Miraflores Locks, Museo de Arte Contemporáneo and Santo Tomas (Panama Metro)
Destinations to explore
- Cartagena Holiday rentals
- San Andrés Holiday rentals
- Puerto Viejo de Talamanca Holiday rentals
- Uvita Holiday rentals
- Boquete Holiday rentals
- Playa Blanca Holiday rentals
- Coveñas Holiday rentals
- Ancón Holiday rentals
- Valle de Antón Holiday rentals
- Bahía Ballena Holiday rentals
- Limon Holiday rentals
- Playa Venao Holiday rentals
- Rentals with a sauna Panama City
- Serviced apartment rentals Panama City
- Fitness-friendly rentals Panama City
- Rentals with a firepit Panama City
- Rentals with a hot tub Panama City
- Bed and breakfasts Panama City
- Loft rentals Panama City
- Rentals with a washing machine and dryer Panama City
- Waterfront rentals Panama City
- Flat rentals Panama City
- Beachfront rentals Panama City
- Townhouse rentals Panama City
- Rentals with lake access Panama City
- Rentals with an EV charger Panama City
- Pet-friendly rentals Panama City
- Rentals with a cinema Panama City
- Rentals with beach access Panama City
- Private suite rentals Panama City
- Hotel rooms Panama City
- Rentals with a patio Panama City
- Boutique hotels Panama City
- Guest house rentals Panama City
- Cabin rentals Panama City
- Rentals with breakfast Panama City
- Villa rentals Panama City
- Family-friendly rentals Panama City
- Rentals with a fireplace Panama City
- Rentals with outdoor seating Panama City
- Rentals with an accessible-height bed Panama City
- Smoking-friendly rentals Panama City
- Rentals with pools Panama City
- Hostel rentals Panama City
- Apartment rentals Panama City
- House rentals Panama
- Things to do Panama City
- Sightseeing Panama City
- Tours Panama City
- Food and drink Panama City
- Art and culture Panama City
- Sports activities Panama City
- Nature and outdoors Panama City
- Things to do Panama
- Food and drink Panama
- Sightseeing Panama
- Art and culture Panama
- Tours Panama
- Entertainment Panama
- Sports activities Panama
- Nature and outdoors Panama




