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House holiday rentals in Panama City

Find and book unique houses on Airbnb

Top-rated house rentals in Panama City

Guests agree: these houses are highly rated for location, cleanliness and more.

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Superhost
Home in Veracruz
4.67 out of 5 average rating, 6 reviews

On the beach, entire apartment, panoramic terrace and more

For those who love: Sea, Sun, Tropical, Tranquility, Freedom, Comfort. This exclusive apartment, directly on the beach, offers a unique view of the Gulf. Enjoy sunsets, sunrises, and walks. - On the large panoramic terrace, a sea-view bathtub. Sofa. Unique emotions. - 360° panoramic view with palm-leaf roof. - Queen bed, sofa, bathroom with shower, kitchen. * In the beachfront social area: - Hammock, barbecue, sofas, gazebo, kitchen, pool. Dcent of Paradise Pure Life Suitable for long stays.

Top guest favourite
The image showcases the exterior of a two-story house, framed by lush greenery. Sunlight filters through trees, highlighting the white façade and green shutters. A covered area is visible at the front, along with a gated fence that adds security to the property.
Home in Panamá
4.88 out of 5 average rating, 95 reviews

3BR Home in Ancon Hill - Urban Oasis

Discover our home at Ancon Hill in Panama City, steps from Supreme Court. The hill offers scenic hiking trails to the top with city views, lush greenery, and wildlife. 5 min to Albrook Mall. 10 min to Casco Viejo (UNESCO site, restaurants, museums, nightlife), Amador Causeway, Cinta Costera, Metropolitan Park, Panama Convention Center, and Albrook Airport. 20 min to Panama Canal Miraflores Locks and Veracruz beach (across Bridge of Americas, gateway to countryside). 35 min to Tocumen Airport.

Guest favourite
A stone pathway leads through lush tropical foliage toward a welcoming entrance. Tall trees and vibrant greenery frame the path, creating a serene approach to the property, which is partially visible in the background, surrounded by nature's tranquility.
Home in Panama City
4.98 out of 5 average rating, 63 reviews

Mountain Retreat

Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

Superhost
An inviting entryway leads into a spacious dining area with a large table surrounded by upholstered chairs. Natural light floods in from windows, illuminating the light-colored stone floors and emphasizing the open design of the modern kitchen visible in the background.
Home in Panamá
5 out of 5 average rating, 4 reviews

Designer Canal Home - Med or Longterm

Welcome to our little oasis in Panama City's historic Canal Zone! Our home has recently undergone a spectacular renovation with features that set it apart from other canal homes: luxury stone floors, tall ceilings, and an open, modern kitchen. It's the perfect retreat for someone who wants to be in the city but still surrounded by parks and wildlife. Note that we are ideally looking for guests who will stay for a month or more and would consider longer term tenancies if the fit were right.

Guest favourite
A two-story residence features a light-colored facade with large windows allowing ample natural light. A spacious garage with a multi-car door is prominently displayed in front. The surrounding area is neatly paved, with a tranquil atmosphere suggested by the absence of heavy traffic.
Home in Punta Paitilla
4.76 out of 5 average rating, 107 reviews

Large Private Residence in an Excellent Area

House in the best area of the country. Very quiet street, central, close to restaurants, pharmacies, mall among others. Large comfortable residence for groups or families. Private parking for up to 2 cars 4 spacious bedrooms, 2 comfortable studios, living room, breakfast room, large terrace. *Kosher Option Available* House in one of the best areas of the country. Very quiet street, central, close to restaurants, pharmacies, mall, and more. Large, comfortable residence for groups.

Guest favourite
Home in Panamá
4.86 out of 5 average rating, 22 reviews

Charming House in Casco Viejo

This recently renovated house is an absolute treasure. It blends history, charm, and modern comfort. Archeologists uncovered artifacts dating to the seventeenth century. Tastefully furnished with modern comforts and antiques, it's steps away from the Panama Canal Museum and in the heart of Casco Viejo, perfect for guests looking to immerse themselves in the cultural and culinary delights before retreating to the comfort and tranquility of their temporary home.

Top guest favourite
Home in Panama City
4.94 out of 5 average rating, 17 reviews

A Charming Colonial House in Casco Antiguo

Welcome to Casa Arango, a beautifully restored 19th-century gem in the heart of Casco Antiguo. Located on a quiet, picturesque street, this colonial house blends historic charm with modern comforts. Casa Arango offers three elegant rooms with private bathrooms, a front balcony, and a spacious patio with a barbecue and private bar. Perfect for families or groups of up to 8, the property also includes two private parking spaces—an exclusive luxury in the area.

Superhost
A bright bedroom features a spacious bed with a neutral gray quilt and two matching pillows. Natural light enters through multiple windows, which are flanked by light curtains. An air conditioning unit is mounted on the wall, adding comfort to the space.
Home in Panamá
4.64 out of 5 average rating, 33 reviews

Beautiful spacious full apartment near Albrook

Spacious and cozy apartment in a very quiet area surrounded by nature. The apartment is complete, everything is ready to welcome you. All services are included. Close to the Miraflores locks, Ciudad del Saber, the Metropolitan National Park, Cerro Ancón, and Albrook Terminal. Close to the Los Ríos pool. Accessibility for buses and taxis. For security reasons, cameras in the main entrance, terrace and patio. There are no cameras in indoor spaces.

Superhost
A lush green lawn showcases well-maintained grass, framed by tropical plants with vibrant yellow leaves. In the background, a spacious outdoor area is visible, featuring a covered seating area. Hammocks are gently swaying, inviting relaxation amidst the natural surroundings.
Home in Panamá
4.8 out of 5 average rating, 46 reviews

Wonderful nature

Enjoy a family retreat in the heart of nature, where tranquility envelops you. This cozy accommodation, surrounded by a beautiful garden in the Metropolitan Natural Park, offers you a unique escape just 3 minutes from Albrook Mall and 5 minutes from downtown. Wake up to birdsong and a visit from the ñeques (agoutis), while relaxing in an exclusive and lively atmosphere. The perfect getaway to disconnect and enjoy nature with all the amenities!

Top guest favourite
A spacious living and dining area is depicted, featuring a blue sectional sofa with yellow accent pillows. A glass dining table with yellow placemats and black chairs is shown. Natural light enters through windows, revealing a glimpse of greenery outside.
Home in Panama City
4.82 out of 5 average rating, 115 reviews

Spacious Panama House in the 'heart of the city'

You couldn't ask for a better place to stay while you visit Panama. This location is perfect, while other properties might advertise similar amenities; not one of them can boast a combination of space and amazing location quite like this one. This is very private & secure property in a fantastic, & very safe area right in the heart of the city & close to everything! An oasis in the middle of the city with AC IN EVERY ROOM AND DININING ROOM.

Superhost
A bright living room features two gray sofas positioned around a wooden coffee table on a jute rug. Large windows allow natural light to fill the space, framed by sheer white curtains. A wall-mounted Smart TV offers streaming options, enhancing relaxation.
Home in Panamá
4.86 out of 5 average rating, 76 reviews

Unique 4 room house - direct access to the beach

Welcome to Casa Playa, your haven in the heart of Casco Viejo! This elegant property blends the historic charm of the area with modern comfort and style. It features 4 cozy bedrooms, 3 bathroom, a fully equipped kitchen, living and dining areas, and an in-unit laundry center. Perfect for groups of up to 8 guests to share in an exclusive and comfortable setting. Enjoy an unforgettable stay in a warm, spacious, and fully equipped space.

Guest favourite
A private rooftop terrace offers expansive views of the ocean and skyline. Comfortable seating arrangements include a coffee table and lounge chairs beneath a shaded umbrella. Decorative plants enhance the outdoor space, while string lights provide a warm ambiance during evenings.
Home in Panamá
4.92 out of 5 average rating, 142 reviews

Exceptional three-story building with sea view

This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Popular amenities for house rentals in Panama City

Quick stats about house rentals in Panama City

  • Total holiday rentals

    Explore 470 holiday rentals in Panama City

  • Verified guest reviews

    Over 7,710 verified reviews to help you choose

  • Family-friendly holiday rentals

    180 properties offer extra space & child-friendly amenities

  • Pet-friendly holiday rentals

    Find 160 rentals that welcome pets

  • Holiday rentals with a pool

    90 properties feature pools

  • Rentals with dedicated workspaces

    230 properties have a dedicated workspace

  • Wifi availability

    430 of Panama City holiday rentals include wifi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi and Pool across Panama City rentals

  • 4.7 Average rating

    Panama City stays receive an average rating of 4.7 out of 5 from guests

  • Nearby attractions

    Panama City’s top spots include Miraflores Locks, Museo de Arte Contemporáneo and Santo Tomas (Panama Metro)

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