Guest house holiday rentals in Upstate South Carolina

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Top-rated guest house rentals in Upstate South Carolina

Guests agree: these guest house rentals are highly rated for location, cleanliness and more.

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Top guest favourite
A gravel path meanders through a grassy area, flanked by low shrubs and tall trees, creating a serene and natural environment. Soft sunlight casts a gentle glow over the scene, highlighting the rich green foliage and the open field stretching out in the distance.
Guest house in Abbeville
4.98 out of 5 average rating, 367 reviews

Scenic Loft in the Woods

Come relax for a getaway in our elegant guest loft! Located near the end of a quiet road with lots of wide open fields and beautiful tree lines! Our loft features a cute kitchenette, plenty of closet space, TV(YoutubeTV & Roku), an extremely comfortable bed! The loft is kept very clean and neat and will be stocked with all the essentials. Access to a beautiful 33' above ground pool! We are conveniently located about 5 miles from downtown Abbeville, and only a 10 minute drive to Erskine/Due West!

Top guest favourite
Guest house in Six Mile
4.96 out of 5 average rating, 181 reviews

Your Charming Country Cottage

Whether you need a country getaway or a place to lay your head after a football game, our cottage in the foothills of upstate SC is the perfect spot for both. You’ll find us tucked away just outside the quaint little town of Six Mile, 10 miles north of Clemson University and in close proximity to 3 of the upstate's favorite lakes: Lake Keowee, Lake Jocassee and Lake Hartwell. Here you’ll enjoy the serenity of country life without feeling “too far out" or away from all the upstate has to offer.

Top guest favourite
A living room area is presented with a gray couch and a rustic coffee table. Two lamps offer soft lighting, and a decorative arrangement sits atop the table. Warm wooden floors and light-colored walls contribute to a cozy atmosphere.
Guest house in Clinton
4.98 out of 5 average rating, 117 reviews

Campus Cottage

Upstairs two bedroom apartment located in College View area just a short walk across the street to Presbyterian College. Perfect for campus visits, tours, and sporting events. Short driving distance to local restaurants (less than one mile). Unit has two bedrooms (3 twin mattresses available upon request), one full bath, living room, dining room, and kitchen with full fridge, stove, and microwave. Coffee maker provided with coffee, creamer, and sugar during your stay. Plenty of room to relax!

Superhost
A charming cabin is nestled among towering trees, with a sloped metal roof and rustic log walls. Lush greenery surrounds the property, while vibrant blue hydrangeas bloom in the foreground. A fire pit with seating is positioned to the right, creating an inviting outdoor space.
Guest house in Sunset
4.91 out of 5 average rating, 434 reviews

Mountain Cabin on Creek at Jocassee Gorge.

Welcome to Laurel Valley. A tiny, sleepy neighborhood at the top of a mountain, hidden from the hustle of civilization. This adorable cabin is nestled in beautiful Jocassee Gorge. Minutes away from multiple attractions including Sassafras Mountain and Twin Falls. Property borders thousands of acres of protected land with 5 star trails . This mountain cabin is in a unique setting that time forgot. The rushing creek outside helps you to peel off the world and get a great night's sleep.

Guest favourite
A spacious studio apartment featuring a queen-sized bed with light bedding and two bedside lamps. A cozy gray loveseat is positioned near a wooden coffee table, which is accompanied by a small potted plant. Natural light filters through the window shades, illuminating the inviting interior.
Guest house in Greenville
4.98 out of 5 average rating, 170 reviews

Nishleigh's Nook - West End Downtown Greenville

Welcome to your cozy retreat in the West End of Downtown Greenville! This newly constructed, detached garage studio near the up and coming West End Village, Unity Park, and downtown offers easy access to the city's best entertainment, boutique shops, and vibrant food scene. Enjoy a queen-sized memory foam bed, a fully equipped kitchen, and a dedicated dining area. High-speed Wi-Fi and a smart TV are included. Perfect for a peaceful escape with all the comforts you need for a memorable stay.

Top guest favourite
The serene cottage is surrounded by lush greenery and colorful flowers, with pink azaleas and white dogwoods blooming prominently in the foreground. A charming red barn is nestled among the trees, enhancing the peaceful rural setting.
Guest house in Greenville
4.99 out of 5 average rating, 456 reviews

The Cottage at Old Oaks Farm

Built in the early 1900's, this serene cottage is located approximately one mile from Furman University at the base of Paris Mt. It has been lovingly improved, but the floors are a bit slanted and no corner is exactly square. Located in a neighborhood on a five acre farm, it consists of three large rooms, comfortably furnished and lots of natural light. The cottage is convenient to downtown Greenville(5 miles),Travelers Rest, Furman, and the Swamp Rabbit Trail. No pet fee or cleaning fee.

Top guest favourite
The entrance to the guest house is framed by rich wooden siding and features a charming porch. A small seating area with decorative cushions invites relaxation, while foliage and seasonal plants add natural beauty. The double doors provide a welcoming entry point.
Guest house in Mountain Rest
5 out of 5 average rating, 110 reviews

The Guest House By The River

Our Guest House is a quaint little place perfect for couples getaway. It is located on Chauga River, with a great swimming hole and beach. Perfect location if you are interested in River rafting (Chattooga River rafting is near by). If you enjoy hiking, fishing or just enjoying outdoors this is the place for you. Guest House is located to the right of the main house, but it is private. We would love to have you!! Close to Clemson, Cashiers, Highlands, Chattooga Belle Farms.

Top guest favourite
A charming cottage featuring a brown wooden exterior and a green roof, surrounded by trees. An inviting outdoor deck hosts a picnic table and a lounge chair, with a charcoal grill nearby, offering a serene space for relaxation and enjoyment of nature.
Guest house in Tryon
4.97 out of 5 average rating, 155 reviews

Warrior Hall Cottage 1

Alpine look cottage is at the end of private road. Pretty place to walk and enjoy the outdoors. Several hosting vineyards, hiking and kayaking nearby. Convenient to nearby towns of Tryon, Landrum, Columbus and 1 Saluda. 15 minutes to the Tryon International Equestrian Center and other event venues. Less than an hour to Asheville, Greenville, Spartanburg, BMW Plant, and 3 major airports. A great gateway to western Carolina. Sofa bed and loft add to sleeping space for families.

Top guest favourite
The pool area features a clear, inviting swimming pool surrounded by a paved deck. Umbrellas provide shade over seating areas, while lush greenery and distant mountain views enhance the outdoor space. The scene is framed by tall trees and a bright blue sky.
Guest house in Greenville
4.97 out of 5 average rating, 273 reviews

Greenville With A View!

ONLY 10-15 MINUTE DRIVE TO THE HEART OF BEAUTIFUL DOWNTOWN GREENVILLE! We are only 11 miles to GSP Airport; 6 miles to Greenville Downtown Airport; and 10 minutes to the Swamp Rabbit Trail. We are minutes to Furman University, Bob Jones University, North Greenville University and Clemson University is only 45 minutes away. We are tucked away open top of Paris Mountain. If you want to bike, hike, paddle, swim, boat or just soak it all in, start here!

Guest favourite
The exterior view of the Shou-Sugi-Ban Guest House features a dark wooden facade with a sloped roof. A spacious deck is present, furnished with two orange chairs and a potted plant. Lush greenery surrounds the area, providing a natural feel.
Guest house in Piedmont
4.98 out of 5 average rating, 132 reviews

Shou-Sugi-Ban Retreat on the Saluda River

The Shou-Sugi-Ban Guest House is 5 miles from Greenville city center and West Greenville, yet you'll feel like you've escaped it all with the rush of the river and surrounding trees. This cozy, custom space has a king-size bed, and two sets of French doors leading out to a private deck. No matter where you are in the space, you'll have views of the 700 ft of Saluda river frontage.

Top guest favourite
A charming cottage is set among lush greenery, featuring a spacious deck that extends from the front. Large windows provide natural light, while surrounding trees and plants create a serene atmosphere.
Guest house in Greenville
5 out of 5 average rating, 183 reviews

Sally's Cottage

Couples retreat located 6 miles from downtown Greenville and the Swamp Rabbit Trail in a comfortable country setting. Wake up to a beautiful woods view through a large bay window and wildlife that surrounds the cottage (deer, birds and squirrels). Experience the beauty of the country in the city! Enjoy the eclectic collection of art and design in this cute little cottage.

Top guest favourite
The exterior of the apartment building is visible, featuring a rustic design with wooden elements and a metal roof. A spacious driveway leads to the double garage doors, surrounded by landscaped greenery and blooming flowers. Trees in the background provide a peaceful environment.
Guest house in Hartwell
4.99 out of 5 average rating, 164 reviews

1 bedroom lake front apartment with gorgeous views

Relax in a cozy apartment on Lake Hartwell. The apartment is located in a secluded peaceful, cove near downtown Hartwell and is in close proximity to hiking and numerous outdoor activities in the hill country of Georgia and South Carolina. The apartment sleeps 2 comfortably and is fully equipped with a kitchen and a private laundry facility.

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