
Guest house holiday rentals in Upstate South Carolina
Find and book unique guest house rentals on Airbnb
Top-rated guest house rentals in Upstate South Carolina
Guests agree: these guest house rentals are highly rated for location, cleanliness and more.

Scenic Loft in the Woods
Come relax for a getaway in our elegant guest loft! Located near the end of a quiet road with lots of wide open fields and beautiful tree lines! Our loft features a cute kitchenette, plenty of closet space, TV(YoutubeTV & Roku), an extremely comfortable bed! The loft is kept very clean and neat and will be stocked with all the essentials. Access to a beautiful 33' above ground pool! We are conveniently located about 5 miles from downtown Abbeville, and only a 10 minute drive to Erskine/Due West!

Your Charming Country Cottage
Whether you need a country getaway or a place to lay your head after a football game, our cottage in the foothills of upstate SC is the perfect spot for both. You’ll find us tucked away just outside the quaint little town of Six Mile, 10 miles north of Clemson University and in close proximity to 3 of the upstate's favorite lakes: Lake Keowee, Lake Jocassee and Lake Hartwell. Here you’ll enjoy the serenity of country life without feeling “too far out" or away from all the upstate has to offer.

Campus Cottage
Upstairs two bedroom apartment located in College View area just a short walk across the street to Presbyterian College. Perfect for campus visits, tours, and sporting events. Short driving distance to local restaurants (less than one mile). Unit has two bedrooms (3 twin mattresses available upon request), one full bath, living room, dining room, and kitchen with full fridge, stove, and microwave. Coffee maker provided with coffee, creamer, and sugar during your stay. Plenty of room to relax!

Historic 19th Century Cabin/Guest House
This 19th century cabin is your perfect cozy getaway. This guest house is located on a 3.5 acre property, secluded from the historic neighborhood, though it's just 3 miles from downtown Greenville and the Bon Secours Wellness Arena. Less than a mile to the Swamp Rabbit Trail, this cottage is perfect for jaunts to downtown Greenville, Furman University, Paris Mountain, Travelers Rest and Unity Park! Micro weddings and events are available upon request and approval with applicable fees applied.

Mountain Cabin on Creek at Jocassee Gorge.
Welcome to Laurel Valley. A tiny, sleepy neighborhood at the top of a mountain, hidden from the hustle of civilization. This adorable cabin is nestled in beautiful Jocassee Gorge. Minutes away from multiple attractions including Sassafras Mountain and Twin Falls. Property borders thousands of acres of protected land with 5 star trails . This mountain cabin is in a unique setting that time forgot. The rushing creek outside helps you to peel off the world and get a great night's sleep.

Nishleigh's Nook - West End Downtown Greenville
Welcome to your cozy retreat in the West End of Downtown Greenville! This newly constructed, detached garage studio near the up and coming West End Village, Unity Park, and downtown offers easy access to the city's best entertainment, boutique shops, and vibrant food scene. Enjoy a queen-sized memory foam bed, a fully equipped kitchen, and a dedicated dining area. High-speed Wi-Fi and a smart TV are included. Perfect for a peaceful escape with all the comforts you need for a memorable stay.

The Cottage at Old Oaks Farm
Built in the early 1900's, this serene cottage is located approximately one mile from Furman University at the base of Paris Mt. It has been lovingly improved, but the floors are a bit slanted and no corner is exactly square. Located in a neighborhood on a five acre farm, it consists of three large rooms, comfortably furnished and lots of natural light. The cottage is convenient to downtown Greenville(5 miles),Travelers Rest, Furman, and the Swamp Rabbit Trail. No pet fee or cleaning fee.

MeadowHill Guesthouse - Mountain view-3 mi to town
This charming guesthouse is nestled in a wooded setting with mountain views. Relax on the wraparound porch taking in the fresh air and scenery as you warm up by the outdoor stone fireplace. The vaulted ceilings in the main house with a stone fireplace provide the perfect mountain ambiance. Please note: Kitchenette only - No stovetop. The guesthouse shares the property with the main house which was built in 1930. Just minutes to the shopping and dining of both Highlands and Cashiers.

The Guest House By The River
Our Guest House is a quaint little place perfect for couples getaway. It is located on Chauga River, with a great swimming hole and beach. Perfect location if you are interested in River rafting (Chattooga River rafting is near by). If you enjoy hiking, fishing or just enjoying outdoors this is the place for you. Guest House is located to the right of the main house, but it is private. We would love to have you!! Close to Clemson, Cashiers, Highlands, Chattooga Belle Farms.

The Lodge at Pythian Park
Situated in a 3+ acre gated compound surrounded on three sides by Fairforest Creek, our guest house feels like a mountain hideaway yet it's only a 3 minute drive to downtown Spartanburg. Enjoy the private patio overlooking the creek to relax or prepare a meal on the gas grill. Dogs are welcome, and we have 2 very social dogs that you will probably encounter during your stay. There's ample parking for vehicles and room to roam and enjoy the park-like setting.

Greenville With A View!
ONLY 10-15 MINUTE DRIVE TO THE HEART OF BEAUTIFUL DOWNTOWN GREENVILLE! We are only 11 miles to GSP Airport; 6 miles to Greenville Downtown Airport; and 10 minutes to the Swamp Rabbit Trail. We are minutes to Furman University, Bob Jones University, North Greenville University and Clemson University is only 45 minutes away. We are tucked away open top of Paris Mountain. If you want to bike, hike, paddle, swim, boat or just soak it all in, start here!

Shou-Sugi-Ban Retreat on the Saluda River
The Shou-Sugi-Ban Guest House is 5 miles from Greenville city center and West Greenville, yet you'll feel like you've escaped it all with the rush of the river and surrounding trees. This cozy, custom space has a king-size bed, and two sets of French doors leading out to a private deck. No matter where you are in the space, you'll have views of the 700 ft of Saluda river frontage.
Popular amenities for guest house rentals in Upstate South Carolina
Family-friendly guest house rentals

The Spring Valley Retreat

Casablanca - Walk downtown

Guest House at Lake Hartwell

Brevard barn guesthouse near downtown

Lit'l Bit O' Heaven- Rocky Top Lodge

Private-Lake getaway-7 mile view from dock

Home on the farm

Lisa's Lodge
Guest house rentals with a patio

Modern Studio near downtown

Country-Clubhouse Tiny Home. Close to downtown!

The Nest, Charming Country Setting south of Athens

Starswept Studio–Near GSMNP, BRP, walk to Joey’s.

Cozy Cottage - 5 miles from TIEC

1 bedroom guest house on horse property in Tryon

Foothills Favorite

Downtown guest house with private hot tub & deck
Guest house rentals with a washing machine and dryer

Upscale cottage in Downtown Fountain Inn

The Getaway

Art, Biking, Food, and Shopping in Watkinsville

Horse Haven - 1 Bedroom Loft 8 Miles to TIEC

⭐️⭐️⭐️⭐️⭐️Casita Blanca 🚶🏽➡️Dining, BREWS,SHOPS📍DTWN📍LUX

Just off Main near Taylors Mill - Clean & Comfy

Gorgeous Downtown Studio & Dog Friendly!

Rocking chair porch in Mills River! Relax
Destinations to explore
- Western North Carolina Holiday rentals
- Atlanta Holiday rentals
- Nashville Holiday rentals
- Myrtle Beach Holiday rentals
- Charleston Holiday rentals
- Gatlinburg Holiday rentals
- Charlotte Holiday rentals
- Hilton Head Island Holiday rentals
- Savannah Holiday rentals
- Cape Fear River Holiday rentals
- Pigeon Forge Holiday rentals
- North Myrtle Beach Holiday rentals
- Tiny house rentals Upstate South Carolina
- Nature eco lodge rentals Upstate South Carolina
- Townhouse rentals Upstate South Carolina
- Rentals with a sauna Upstate South Carolina
- Serviced apartment rentals Upstate South Carolina
- Smoking-friendly rentals Upstate South Carolina
- Rentals with a kayak Upstate South Carolina
- Rentals with an EV charger Upstate South Carolina
- Rentals with a cinema Upstate South Carolina
- Pet-friendly rentals Upstate South Carolina
- Rentals with outdoor seating Upstate South Carolina
- Treehouse rentals Upstate South Carolina
- Cottage rentals Upstate South Carolina
- Family-friendly rentals Upstate South Carolina
- Resort rentals Upstate South Carolina
- Fitness-friendly rentals Upstate South Carolina
- Rentals with an accessible-height toilet Upstate South Carolina
- Chalet rentals Upstate South Carolina
- House rentals Upstate South Carolina
- Villa rentals Upstate South Carolina
- Rentals with a hot tub Upstate South Carolina
- Cabin rentals Upstate South Carolina
- Loft rentals Upstate South Carolina
- Farm stay rentals Upstate South Carolina
- Motorhome rentals Upstate South Carolina
- Holiday home rentals Upstate South Carolina
- Rentals with a washing machine and dryer Upstate South Carolina
- Flat rentals Upstate South Carolina
- Rentals with a patio Upstate South Carolina
- Rentals with beach access Upstate South Carolina
- Hotel rooms Upstate South Carolina
- Campsite rentals Upstate South Carolina
- Barn rentals Upstate South Carolina
- Rentals with a fireplace Upstate South Carolina
- Beachfront rentals Upstate South Carolina
- Rentals with a firepit Upstate South Carolina
- Rentals with breakfast Upstate South Carolina
- Boutique hotels Upstate South Carolina
- Apartment rentals Upstate South Carolina
- Rentals with pools Upstate South Carolina
- Bed and breakfasts Upstate South Carolina
- Rentals with lake access Upstate South Carolina
- Private suite rentals Upstate South Carolina
- Waterfront rentals Upstate South Carolina
- Tent rentals Upstate South Carolina
- Guest house rentals South Carolina
- Guest house rentals United States
- Blue Ridge Parkway
- Clemson University
- The North Carolina Arboretum
- Chimney Rock State Park
- Gorges State Park
- Lake Lure Beach and Water Park
- Table Rock State Park
- Tryon International Equestrian Center
- Jump Off Rock
- Ski Sapphire Valley
- Burntshirt Vineyards
- Saint Paul Mountain Vineyards
- Bon Secours Wellness Arena
- Fluor Field at the West End
- Devils Fork State Park
- DuPont State Forest
- Carl Sandburg Home National Historic Site
- Overmountain Vineyards
- Peace Center
- Jones Gap State Park
- Looking Glass Falls
- Fred W Symmes Chapel
- Falls Park On The Reedy
- Whitewater Falls
- Things to do Upstate South Carolina
- Things to do South Carolina
- Sports activities South Carolina
- Tours South Carolina
- Food and drink South Carolina
- Art and culture South Carolina
- Nature and outdoors South Carolina
- Entertainment South Carolina
- Sightseeing South Carolina
- Things to do United States
- Sightseeing United States
- Nature and outdoors United States
- Food and drink United States
- Tours United States
- Art and culture United States
- Sports activities United States
- Wellness United States
- Entertainment United States





