Guest house holiday rentals in Upstate South Carolina

Find and book unique guest house rentals on Airbnb

Top-rated guest house rentals in Upstate South Carolina

Guests agree: these guest house rentals are highly rated for location, cleanliness and more.

%{current} / %{total}1 / 1
Top guest favourite
A comfortable living area features a dark gray sofa and a light gray sleeper sofa, complemented by a decorative area rug. Warm tones are present in the stone wall and wall art, while large windows provide natural light, and a ceiling fan enhances airflow.
Guest house in Rutherfordton
4.96 out of 5 average rating, 247 reviews

Tryon Foothills Getaway - NC wineries! - TIEC

500sq. ft. cottage tucked at foot of the Blue Ridge Mtns. Full Bath, Kitchen, Patio, grill. Washer & Dryer NEW Tryon Equestrian Ctr 5-8 mins - 1 Hwy exit Tryon, Landrum, Saluda, Lake Lure, Chimney Rock, Vineyards, Waterfalls, Hikes, Blue Ridge Parkway, Biltmore Estate, Asheville, Antiques, Kayaking, Tubing, Rail 2 Trail Bike Route (26 miles rt), The Gorge Zip Line & High Rope Course, Food Tours, Defiant Whisky Distillery (25 mins), Boating, Bouldering, Farmers Markets (2 less than 10mins), etc..

Top guest favourite
A gravel path meanders through a grassy area, flanked by low shrubs and tall trees, creating a serene and natural environment. Soft sunlight casts a gentle glow over the scene, highlighting the rich green foliage and the open field stretching out in the distance.
Guest house in Abbeville
4.97 out of 5 average rating, 354 reviews

Scenic Loft in the Woods

Come relax for a getaway in our elegant guest loft! Located near the end of a quiet road with lots of wide open fields and beautiful tree lines! Our loft features a cute kitchenette, plenty of closet space, TV(YoutubeTV & Roku), an extremely comfortable bed! The loft is kept very clean and neat and will be stocked with all the essentials. Access to a beautiful 33' above ground pool! We are conveniently located about 5 miles from downtown Abbeville, and only a 10 minute drive to Erskine/Due West!

Top guest favourite
A charming log cabin is nestled among lush greenery, featuring wooden walls and a sloping roof. The front door is framed by two windows adorned with flower boxes. Two white chairs sit on a stone pathway, inviting relaxation in the serene outdoor setting.
Guest house in Greenville
4.93 out of 5 average rating, 707 reviews

Historic 19th Century Cabin/Guest House

This 19th century cabin is your perfect cozy getaway. This guest house is located on a 3.5 acre property, secluded from the historic neighborhood, though it's just 3 miles from downtown Greenville and the Bon Secours Wellness Arena. Less than a mile to the Swamp Rabbit Trail, this cottage is perfect for jaunts to downtown Greenville, Furman University, Paris Mountain, Travelers Rest and Unity Park! Micro weddings and events are available upon request and approval with applicable fees applied.

Guest favourite
A modern cabin is nestled among tall trees, featuring a wooden exterior and a sloped metal roof. A small porch with wooden railing is visible, providing an inviting entryway. Surrounding foliage includes lush ferns and greenery, enhancing the natural setting.
Guest house in Ashville
4.95 out of 5 average rating, 432 reviews

Modern Cabin Retreat w/ Sauna

This space was designed with love and care and the hope that all who stay here feel relaxed and connected to nature. We recently added a cedar barrel sauna that heats up quickly and is user friendly. Often we don’t see guests but I’m always available for questions and recommendations. We live "next door" on the same property with our two young sons. The cabin is located in a neighborhood, so while it hopefully feels removed from any hustle and bustle, there is access to many conveniences.

Top guest favourite
The serene cottage is surrounded by lush greenery and colorful flowers, with pink azaleas and white dogwoods blooming prominently in the foreground. A charming red barn is nestled among the trees, enhancing the peaceful rural setting.
Guest house in Greenville
5 out of 5 average rating, 440 reviews

The Cottage at Old Oaks Farm

Built in the early 1900's, this serene cottage is located approximately one mile from Furman University at the base of Paris Mt. It has been lovingly improved, but the floors are a bit slanted and no corner is exactly square. Located in a neighborhood on a five acre farm, it consists of three large rooms, comfortably furnished and lots of natural light. The cottage is convenient to downtown Greenville(5 miles),Travelers Rest, Furman, and the Swamp Rabbit Trail. No pet fee or cleaning fee.

Guest favourite
The front entrance of the loft features a welcoming red door framed by large planters filled with vibrant flowers. A wooden porch is visible, providing access to the space beneath a rustic roof supported by wooden beams. Lush greenery surrounds the area.
Guest house in Sylva
4.97 out of 5 average rating, 292 reviews

Windcrest Loft- charming retreat near the river.

Welcome to Windcrest Loft! If you’re looking for a homey place to stay while visiting the mountains, this is it! Kids and pets are welcome too. Centrally located, within minutes to shops and restaurants in Dillsboro and Sylva, 10 mins to WCU and 20 to Franklin, Bryson City & Waynesville. Convenient Tuckasegee river access across the street and close to many hiking spots! When not touring the area, relax outdoors and enjoy the antics of our resident goats, donkeys, geese and chickens.

Guest favourite
The open loft features a spacious bed and a striped couch adorned with decorative pillows. Natural light floods through large windows that frame views of the surrounding woods. Natural wood floors and a small side table complete the cozy atmosphere.
Guest house in Salem
4.88 out of 5 average rating, 322 reviews

Mountain Edge Loft

Private loft apartment on 25 wooded acres, sits separate from main farm house. Private deck overlooking the woods. Everything you need for a cozy stay. Located on the edge of the Blue Ridge Escarpment with lakes Jocassee and Keowee just a few miles away. Numerous state parks, hiking, biking , waterfalls and kayaking or just peace and quiet. We are a sustainable homestead with an organic garden, chickens ,quail, dogs and cats. Our water comes from a natural spring.

Top guest favourite
The exterior of the guest house is showcased, featuring a sturdy wooden door adorned with decorative hardware. The structure is framed by light-colored stone walls and has two small windows flanking the entrance, with a sloped roof that complements the rustic design.
Guest house in Spartanburg
5 out of 5 average rating, 119 reviews

The Lodge at Pythian Park

Situated in a 3+ acre gated compound surrounded on three sides by Fairforest Creek, our guest house feels like a mountain hideaway yet it's only a 3 minute drive to downtown Spartanburg. Enjoy the private patio overlooking the creek to relax or prepare a meal on the gas grill. Dogs are welcome, and we have 2 very social dogs that you will probably encounter during your stay. There's ample parking for vehicles and room to roam and enjoy the park-like setting.

Top guest favourite
A comfortable living area is presented with a mix of seating options, including a couch and two armchairs. Natural light enters through the windows, which are dressed in soft curtains. A coffee table sits in the center, complemented by tasteful decor on the walls.
Guest house in Donalds
4.99 out of 5 average rating, 390 reviews

Home on the farm

aprox. 4 miles to Erskine College and aprox. 15 miles to Greenwood sc. You’ll love the farm setting, good for couples, solo adventurers, business travelers, families (with kids), and furry friends (pets).we are aprox. 11 miles from Abbeville SC birth place of the confederacy. aprox. 60 miles to Augusta GA the masters golf tour. aprox. 40 miles to CLEMSON U. The Diamond Hill Mine in Abbeville is about 17 miles from here.

Top guest favourite
The interior features a cozy living area with a dark gray sectional sofa, complemented by decorative pillows. A circular coffee table sits in front, holding a tray with books and a remote. The kitchen appears in the background, showcasing a modern design with white cabinetry.
Guest house in Inman
4.99 out of 5 average rating, 146 reviews

Foothills Favorite

Custom designed 1 bedroom suite in the Lake Bowen/Landrum/Inman area. Comfortable yet sleek space tucked above a semi-detached garage; private entry & stairway to suite. Private deck overlooks green spaces, wooded area & Lake Bowen (best views late fall and winter). Enjoy mountain views at nearby Lake Bowen park, local wineries, and scenic highways. Minutes from Landrum & Tryon & Equestrian Center.

Guest favourite
The exterior view of the Shou-Sugi-Ban Guest House features a dark wooden facade with a sloped roof. A spacious deck is present, furnished with two orange chairs and a potted plant. Lush greenery surrounds the area, providing a natural feel.
Guest house in Piedmont
4.98 out of 5 average rating, 124 reviews

Shou-Sugi-Ban Retreat on the Saluda River

The Shou-Sugi-Ban Guest House is 5 miles from Greenville city center and West Greenville, yet you'll feel like you've escaped it all with the rush of the river and surrounding trees. This cozy, custom space has a king-size bed, and two sets of French doors leading out to a private deck. No matter where you are in the space, you'll have views of the 700 ft of Saluda river frontage.

Top guest favourite
A charming cottage is set among lush greenery, featuring a spacious deck that extends from the front. Large windows provide natural light, while surrounding trees and plants create a serene atmosphere.
Guest house in Greenville
5 out of 5 average rating, 163 reviews

Sally's Cottage

Couples retreat located 6 miles from downtown Greenville and the Swamp Rabbit Trail in a comfortable country setting. Wake up to a beautiful woods view through a large bay window and wildlife that surrounds the cottage (deer, birds and squirrels). Experience the beauty of the country in the city! Enjoy the eclectic collection of art and design in this cute little cottage.

Popular amenities for guest house rentals in Upstate South Carolina

Destinations to explore